Device for rapidly detecting concentration of endocrine disrupter in serum

Abstract

The utility model discloses a device for rapidly detecting the concentration of endocrine disrupter in serum, and relates to the technical field of serum detection. The device comprises a [-shaped seat, a driving seat, a detector body, a sampling head, a rotating support and an ultrasonic cleaning pool, the driving seat is fixedly mounted at the upper end of the middle of the [-shaped seat, a guide groove for a moving block to horizontally move is formed in the middle of the lower end of the driving seat, and a detection box is fixed at the bottom of the moving block; the lower end of the detection box is provided with an external thread sleeve for mounting the sampling head, and the upper end of the sampling head is communicated with the extraction end of a hose of the micro peristaltic pump through a guide pipe. Cleaning liquid in the liquid storage tank is injected into the cleaning pipe through the booster liquid pump, enters the conveying pipe for cleaning, then is discharged from the guide pipe to the sampling head, and is discharged into the waste liquid pool, so that samples remained in the guide pipe, the sampling head and the conveying pipe are washed, and the next detection is prevented from being influenced.

Description

Technical Field

[0001] The utility model belongs to the field of serum detection, and in particular relates to a device for rapidly detecting the concentration of endocrine disruptors in serum. Background Art

[0002] Serum refers to the pale yellow, transparent liquid separated from plasma after blood coagulation, after fibrinogen and certain coagulation factors have been removed. It also refers to plasma from which fibrinogen has been removed. Its primary functions are to provide essential nutrients, hormones, various growth factors, binding proteins, contact-promoting and growth factors that protect cells from mechanical damage and adherence, and to provide some protective effects on cells in culture.

[0003] The patent with publication number CN202220007065.9 includes a mounting frame, a cylinder is provided on the top of the mounting frame, a telescopic rod is provided on the bottom of the cylinder, a test box is provided on the bottom end of the telescopic rod, and a slide column is provided on the top of the mounting frame. A plurality of placement slots are rotated slowly and uniformly above the test table, and tests can be carried out simultaneously and sequentially, thereby improving the efficiency of the test. The test table is movably set above the first mounting plate through bearings, which is convenient for disassembly and installation, thereby improving the installation efficiency. The test box is set to slide on the outside of the slide column to limit the test box so that it moves in the vertical direction. The input end of the motor is electrically connected to the output end of the external power supply, driving the gear to rotate, so that the test table rotates slowly according to the meshing connection between the gear and the gear ring, and the catheter extracts and tests the serum test tubes inside the placement slots one by one, thereby improving the detection efficiency.

[0004] However, the method of using a force extraction pump to sample serum does not have a structure for cleaning the residual serum in the tube. Therefore, during the detection process, when there is residual sample in the catheter, it will affect the accuracy of the detection. In view of this, the present invention is specially proposed. Utility Model Content

[0005] The technical problem to be solved by the utility model is to overcome the deficiencies of the prior art and provide a device for rapidly detecting the concentration of endocrine disruptors in serum.

[0006] In order to solve the above technical problems, the basic concept of the technical solution adopted by the present invention is:

[0007] A device for rapidly detecting the concentration of endocrine disruptors in serum comprises a U-shaped seat, a driving seat, a detector body, a sampling head, a rotating support and an ultrasonic cleaning pool, wherein the driving seat is fixedly installed at the upper middle end of the U-shaped seat, a guide groove for horizontal movement of a moving block is opened in the middle of the lower end of the driving seat, a detection box is fixed at the bottom of the moving block, the lower end of the detection box is provided with an external screw sleeve for installation of the sampling head, the upper end of the sampling head is connected with the hose extraction end of a micro peristaltic pump through a catheter, the hose delivery end of the peristaltic pump is connected with the detection end of the detector body through a delivery pipe, the detector body is fixed inside the sampling box, the upper end of the delivery pipe is also connected with a cleaning pipe, a one-way valve is provided in the middle of the cleaning pipe, the upper end of the one-way valve is connected with the delivery end of a booster liquid pump through a pipeline, the other end of the booster liquid pump is connected with a telescopic tube, the other end of the telescopic tube passes through the detection box and is connected with the interior of a liquid storage tank at the top of the U-shaped seat;

[0008] A rotating support is also provided on the lower middle side of the 匚-shaped seat, and a plurality of countersunk holes for placing sample test tubes are passed through the middle of the rotating support. The inner wall of the countersunk hole is provided with an anti-slip ring that contacts the outer surface of the sample test tube. A waste liquid pool is provided on one side of the rotating support, and an ultrasonic cleaning pool is provided on one side of the waste liquid pool.

[0009] Optionally, a positioning ring is fixed to the outside of the sampling head, the positioning ring is placed inside the external screw sleeve, and the external thread of the external screw sleeve is connected to a positioning cover, the interior of the positioning cover is provided with a thread groove that is compatible with the external thread of the external screw sleeve, and the middle of the positioning cover is provided with a clearance hole that is compatible with the external size of the sampling head.

[0010] Optionally, the interior of the drive seat is respectively provided with cavities for placing the first motor and the screw rod, one end of the screw rod is rotatably connected to the inner wall of the cavity through a bearing, and the other end of the screw rod is fixedly connected to the output shaft of the first motor through a coupling, and a threaded block is installed on the outside of the screw rod, the lower end of the threaded sleeve is fixed to the moving block, and the upper end of the threaded sleeve is fixed with a guide block, the upper end of the guide block is provided with a guide groove adapted to the outer contour of the guide rail, and the guide rail is fixedly installed inside the cavity for installing the screw rod.

[0011] Optionally, a liquid level sensor is installed at the upper end of the liquid storage tank, the detection of the liquid level sensor is located inside the liquid storage tank, and the front end of the liquid storage tank is connected to a liquid replenishing pipe, and a liquid replenishing valve is provided in the middle of the liquid replenishing pipe.

[0012] Optionally, an electric lifting column is fixed to the lower middle side of the 匚-shaped seat, and the top of the electric lifting column is fixed to the bottom of the ultrasonic cleaning tank by screws. The front ends of the ultrasonic cleaning tank and the waste liquid tank are connected to drain valves through pipes, and the drain valve connected to the ultrasonic cleaning tank is connected to the interior of the waste liquid tank through an extended stretching tube.

[0013] Optionally, four support columns are further fixed to the lower side of the middle part of the C-shaped seat. A pen-type electric push rod is arranged inside each support column, and the telescopic end of each pen-type electric push rod penetrates to the top of the support column and is fixed to the tray. A second motor is installed at the middle part of the bottom end of the tray through the machine box. The output shaft of the second motor penetrates through the middle part of the tray and is fixed to the bottom of the rotating tray. A guide ring is fixed to the bottom of the rotating tray, and the lower end of the guide ring is located inside the annular groove at the upper end of the tray. A plurality of balls in contact with the middle part of the annular groove are arranged at the bottom of the guide ring.

[0014] Optionally, a discharge cover is further fixed to the lower side of the middle part of the C-shaped seat, and the discharge cover is sleeved outside the four support columns. A plurality of grooves for placing the bottom of the sample test tube are equidistantly arranged on the top surface of the discharge cover, and a protective pad is fixed on the surface of each groove.

[0015] After adopting the above technical solution, the utility model has the following beneficial effects compared with the prior art. Of course, any product implementing the utility model does not necessarily need to achieve all the advantages described below at the same time:

[0016] 1. After each sampling head extracts a sample and sends it to the detector body for detection, the cleaning liquid in the liquid storage tank will be injected into the cleaning pipe through the pressurized liquid pump, enter the delivery pipe for cleaning, and then be discharged through the conduit to the sampling head and discharged into the waste liquid pool, so as to flush the samples remaining in the conduit, sampling head and delivery pipe, avoiding affecting the next detection.

[0017] 2. The utility model protects the surface of the groove in contact with the bottom of the sample test tube by setting a protective pad, preventing the problem that the surface of the bottom of the sample test tube is easily damaged when contacting the surface of the groove. The presence of the discharge cover facilitates the tester to quickly take out the sample test tube after detection. That is, when the pen-type electric push rod contracts, the tray descends, causing the rotating tray to descend. The bottoms of the multiple sample test tubes on the rotating tray will contact the protective pad. At this time, the multiple sample test tubes are forced to move upward, facilitating the tester to take out the sample test tubes that have been detected.

[0018] 3. The utility model considers that after the sampling head is internally rinsed with the cleaning liquid, since the surface of the sampling head is attached with the sample residue from the previous sampling, pure water will be injected into the ultrasonic cleaning pool at this time, and then ultrasonic waves will be generated by the ultrasonic exciter inside the ultrasonic cleaning pool itself to cooperate with the pure water to clean the residue on the surface of the sampling head. After cleaning, the liquid enters the waste liquid pool through the drain valve and the extended stretching pipe.

[0019] The following further describes in detail the specific implementation manners of the utility model with reference to the drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The accompanying drawings in the following description are only some embodiments. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without creative efforts. In the attached

[0021] In the figures:

[0022] Figure 1 is the front view sectional structure schematic diagram of the present utility model;

[0023] Figure 2 is the internal combined parts structure diagram of the detection box in the present utility model;

[0024] Figure 3 is Figure 1 the structure schematic diagram of part A in

[0025] Figure 4 is Figure 1 the structure schematic diagram of part B in

[0026] Figure 5 is Figure 1 the structure schematic diagram of part C in

[0027] Figure 6 is Figure 1 the structure schematic diagram of part D in

[0028] In the accompanying drawings, the list of components represented by each reference numeral is as follows:

[0029] 1. C-shaped seat; 2. Driving seat; 3. Moving block; 4. Detection box; 5. Sampling head; 6. External screw thread sleeve; 7. Conduit; 8. Micro peristaltic pump; 9. Delivery pipe; 10. Detector body; 11. Cleaning pipe; 12. Check valve; 13. Booster liquid pump; 14. Telescopic pipe; 15. Liquid storage tank; 16. Rotating support; 17. Sample test tube; 18. Counterbore; 19. Anti-slip ring; 20. Waste liquid pool; 21. Ultrasonic cleaning pool; 22. Positioning ring; 23. Positioning cover; 24. First motor; 25. Lead screw; 26. Threaded sleeve; 27. Guide block; 28. Guide rail; 29. Liquid level sensor; 30. Liquid supplement valve; 31. Electric lifting column; 32. Drain valve; 33. Extended stretching pipe; 34. Support column; 35. Pen-type electric push rod; 36. Support plate; 37. Second motor; 38. Guide ring; 39. Ball; 40. Discharge cover; 41. Protective pad.

[0030] It should be noted that these drawings and text descriptions are not intended to limit the scope of the concept of the present utility model in any way, but to illustrate the concept of the present utility model to those skilled in the art by referring to specific embodiments. Detailed implementation manners

[0031] Now, the present utility model will be further described in detail with reference to the accompanying drawings.

[0032] See also Figures 1 to 6 The utility model provides a technical solution: a device for quickly detecting the concentration of endocrine disruptors in serum, comprising a 匚-shaped seat 1, a driving seat 2, a detector body 10, a sampling head 5, a rotating support 16 and an ultrasonic cleaning pool 21. The driving seat 2 is fixedly installed on the upper middle end of the 匚-shaped seat 1, and a guide groove for horizontal movement of the moving block 3 is provided in the middle of the lower end of the driving seat 2. A detection box 4 is fixed on the bottom of the moving block 3, and an external screw sleeve 6 for installation of the sampling head 5 is provided at the lower end of the detection box 4. The upper end of the sampling head 5 is connected to the hose extraction end of the micro peristaltic pump 8 through a catheter 7, and the hose delivery end of the peristaltic pump is connected to the detection end of the detector body 10 through a delivery pipe 9. The detector body 10 is fixed inside the sampling box, and the upper end of the delivery pipe 9 is also connected to a cleaning pipe 11, and a one-way valve 12 is provided in the middle of the cleaning pipe 11. The upper end of the one-way valve 12 The tube 14 is connected to the delivery end of the booster liquid pump 13 through a pipeline, and the other end of the booster liquid pump 13 is connected to a telescopic tube 14. The other end of the telescopic tube 14 passes through the detection box 4 and is connected to the interior of the liquid storage tank 15 on the top of the 匚-shaped seat 1. Considering that it adopts a force extraction pump to sample the serum, there is no structure for cleaning the serum residue in the tube 11. Therefore, during the detection process, when there is a residual sample in the catheter 7, it will affect the accuracy of the detection. In the present invention, each time the sampling head 5 extracts the sample to the detector body 10 for detection, the cleaning liquid in the liquid storage tank 15 is injected into the cleaning tube 11 through the booster liquid pump 13 and enters the delivery pipe 9 for cleaning. After cleaning, it is discharged to the sampling head 5 through the catheter 7 and discharged to the interior of the waste liquid pool 20, thereby flushing the samples retained in the catheter 7, the sampling head 5 and the delivery pipe 9 to avoid affecting the next detection;

[0033] A rotating support 16 is also provided on the lower middle side of the 匚-shaped seat 1. A plurality of countersunk holes 18 for placing sample test tubes 17 are passed through the middle of the rotating support 16. The inner wall of the countersunk hole 18 is provided with an anti-slip ring 19 that contacts the outer surface of the sample test tube 17. A waste liquid pool 20 is provided on one side of the rotating support 16. An ultrasonic cleaning pool 21 is provided on one side of the waste liquid pool 20. By setting the rotating support 16 in conjunction with the second motor 37 to drive, it is convenient for the sampling head 5 to sample multiple sample test tubes 17 separately.

[0034] Among them, a positioning ring 22 is fixed to the outside of the sampling head 5, and the positioning ring 22 is placed inside the external screw sleeve 6, and the external thread of the external screw sleeve 6 is connected to a positioning cover 23, and the interior of the positioning cover 23 is provided with a thread groove adapted to the external thread of the external screw sleeve 6, and the middle part of the positioning cover 23 is provided with a clearance hole adapted to the external size of the sampling head 5. By setting the positioning cover 23 and cooperating with the positioning ring 22 on the outside of the external screw sleeve 6, a fixing effect is achieved. When the positioning ring 22 of the sampling head 5 is fixed, the sampling head 5 can be fixed to the lower end of the sampling box.

[0035] Among them, cavities for placing the first motor 24 and the lead screw 25 are respectively formed inside the driving seat 2. One end of the lead screw 25 is rotatably connected to the inner wall of the cavity through a bearing, and the other end of the lead screw 25 is fixedly connected to the output shaft of the first motor 24 through a coupling. A threaded block is installed outside the lead screw 25. The lower end of the threaded sleeve 26 is fixed to the moving block 3, and the upper end of the threaded sleeve 26 is fixed with a guiding block 27. A guiding groove adapted to the outer contour of the guiding rail 28 is formed at the upper end of the guiding block 27, and the guiding rail 28 is fixedly installed inside the cavity for installing the lead screw 25. By setting the first motor 24 to cooperate with the lead screw 25, the moving block 3 is driven. The movement of the moving block 3 drives the sampling box to displace along the guiding groove. During this process, it will be convenient for the sampling head 5 to displace in the working areas of the ultrasonic cleaning tank 21, the waste liquid tank 20, and the sample test tube 17.

[0036] Among them, a liquid level sensor 29 is installed at the upper end of the liquid storage tank 15. The detection position of the liquid level sensor 29 is inside the liquid storage tank 15, and a liquid supplement pipe is connected to the front end of the liquid storage tank 15. A liquid supplement valve 30 is provided in the middle of the liquid supplement pipe. By setting the liquid storage tank 15, the cleaning liquid is stored, and the liquid level sensor 29 facilitates the user to know the liquid level height of the cleaning liquid inside the liquid storage tank 15.

[0037] Among them, an electric lifting column 31 is fixedly installed on the lower side of the middle part of the U-shaped seat 1. The top of the electric lifting column 31 is fixedly connected to the bottom of the ultrasonic cleaning tank 21 through screws. Drain valves 32 are connected to the front ends of both the ultrasonic cleaning tank 21 and the waste liquid tank 20 through pipes, and the drain valve 32 connected to the ultrasonic cleaning tank 21 is communicated with the inside of the waste liquid tank 20 through an extended stretching pipe 33. By setting the drain valve 32, it is convenient for the testing personnel to centrally discharge the cleaning waste liquid inside the waste liquid tank 20 later. By setting the electric lifting column 31, the ultrasonic cleaning tank 21 is lifted. When the sampling head 5 is internally rinsed through the cleaning liquid, since the surface of the sampling head 5 adheres to the sample residue from the previous sampling, pure water will be injected into the ultrasonic cleaning tank 21 at this time, and then ultrasonic waves are generated by the ultrasonic exciter inside the ultrasonic cleaning tank 21 itself to cooperate with the pure water to clean the residue on the surface of the sampling head 5. After cleaning, the liquid enters the inside of the waste liquid tank 20 through the drain valve 32 and the extended stretching pipe 33.

[0038] Among them, four support columns 34 are further fixed to the lower side of the middle part of the C-shaped seat 1. A pen-type electric push rod 35 is arranged inside each support column 34, and the telescopic end of each pen-type electric push rod 35 penetrates to the top of the support column 34 and is fixed to the support plate 36. A second motor 37 is installed at the middle part of the bottom end of the support plate 36 through the chassis. The output shaft of the second motor 37 penetrates the middle part of the support plate 36 and is fixed to the bottom of the rotating tray 16. A guide ring 38 is fixed to the bottom of the rotating tray 16, and the lower end of the guide ring 38 is located inside the annular groove at the upper end of the support plate 36. A plurality of balls 39 in contact with the middle part of the annular groove are arranged at the bottom of the guide ring 38.

[0039] Among them, a discharge cover 40 is further fixed to the lower side of the middle part of the C-shaped seat 1, and the discharge cover 40 is sleeved outside the four support columns 34. A plurality of grooves for placing the bottom of the sample test tube 17 are equidistantly arranged on the top surface of the discharge cover 40, and a protective pad 41 is fixed on the surface of each groove. By arranging the protective pad 41, it plays a role in protecting the contact between the surface of the groove and the bottom of the sample test tube 17, preventing the problem that the bottom surface of the sample test tube 17 is easily damaged when contacting the surface of the groove. The presence of the discharge cover 40 facilitates the tester to quickly take out the tested sample test tube 17. That is, when the pen-type electric push rod 35 contracts, the support plate 36 descends, causing the rotating tray 16 to descend. The bottoms of the plurality of sample test tubes 17 on the rotating tray 16 will contact the protective pad 41. At this time, the plurality of sample test tubes 17 are forced to move upward, thus facilitating the tester to take out the tested sample test tube 17.

[0040] The present utility model is not limited to the above embodiments. Anyone should know that structural changes made under the inspiration of the present utility model, as long as they have the same or similar technical solutions as the present utility model, fall within the protection scope of the present utility model. The technologies, shapes, and structures not detailedly described in the present utility model are all well-known technologies.

Claims

1. A device for rapidly detecting the concentration of endocrine disruptors in serum, comprising a C-shaped seat (1), a driving seat (2), a detector body (10), a sampling head (5), a rotating support (16) and an ultrasonic cleaning tank (21), characterized in that, At the upper end of the middle part of the U-shaped seat (1), a driving seat (2) is fixedly installed. A guiding groove for the horizontal movement of the moving block (3) is provided in the middle of the lower end of the driving seat (2). A detection box (4) is fixed to the bottom of the moving block (3). An external screw thread sleeve (6) for installing the sampling head (5) is provided at the lower end of the detection box (4). The upper end of the sampling head (5) is communicated with the hose extraction end of the micro peristaltic pump (8) through a conduit (7). The hose delivery end of the peristaltic pump is communicated with the detection end of the detector body (10) through a delivery pipe (9). The detector body (10) is fixed inside the sampling box. The upper end of the delivery pipe (9) is also communicated with a cleaning pipe (11). A one-way valve (12) is provided in the middle of the cleaning pipe (11). The upper end of the one-way valve (12) is communicated with the delivery end of the pressurized liquid pump (13) through a pipe. The other end of the pressurized liquid pump (13) is communicated with a telescopic pipe (14). The other end of the telescopic pipe (14) penetrates through the detection box (4) and is communicated with the inside of the liquid storage tank (15) at the top of the U-shaped seat (1); A rotating support (16) is also provided on the lower side of the middle part of the U-shaped seat (1). A plurality of counterbores (18) for placing the sample test tubes (17) penetrate through the middle of the rotating support (16). Anti-slip rings (19) that contact the outer surface of the sample test tubes (17) are provided on the inner walls of the counterbores (18). A waste liquid pool (20) is provided on one side of the rotating support (16). An ultrasonic cleaning pool (21) is provided on one side of the waste liquid pool (20).

2. The device for rapidly detecting the concentration of endocrine disruptors in serum according to claim 1, characterized in that, A positioning ring (22) is fixed to the outside of the sampling head (5). The positioning ring (22) is placed inside the external screw thread sleeve (6). And the external screw thread of the external screw thread sleeve (6) is connected with a positioning cover (23). A thread groove adapted to the external thread of the external screw thread sleeve (6) is provided inside the positioning cover (23). And a relief hole adapted to the external dimension of the sampling head (5) is provided in the middle of the positioning cover (23).

3. The device for rapidly detecting the concentration of endocrine disruptors in serum according to claim 1, characterized in that, A cavity for placing the first motor (24) and the lead screw (25) is respectively provided inside the driving seat (2). One end of the lead screw (25) is rotatably connected to the inner wall of the cavity through a bearing. The other end of the lead screw (25) is fixedly connected to the output shaft of the first motor (24) through a coupling. A threaded block is installed on the outside of the lead screw (25). The lower end of the threaded sleeve (26) is fixed to the moving block (3). And a guiding block (27) is fixed to the upper end of the threaded sleeve (26). A guiding groove adapted to the external contour of the guiding rail (28) is provided at the upper end of the guiding block (27). And the guiding rail (28) is fixedly installed inside the cavity for installing the lead screw (25).

4. A device for rapidly detecting the concentration of endocrine disruptors in serum according to claim 1, characterized in that, A liquid level sensor (29) is installed at the upper end of the liquid storage tank (15). The detection position of the liquid level sensor (29) is inside the liquid storage tank (15). And a liquid supplement pipe is communicated with the front end of the liquid storage tank (15). A liquid supplement valve (30) is provided in the middle of the liquid supplement pipe.

5. The device for rapidly detecting the concentration of endocrine disruptors in serum according to claim 1, wherein, A motorized lifting column (31) is fixed to the lower side of the middle part of the U-shaped seat (1). The top of the motorized lifting column (31) is fixed to the bottom of the ultrasonic cleaning tank (21) by screws. Drain valves (32) are connected to the front ends of both the ultrasonic cleaning tank (21) and the waste liquid tank (20) through pipes. The drain valve (32) connected to the ultrasonic cleaning tank (21) is communicated with the inside of the waste liquid tank (20) through an extended stretching pipe (33).

6. The device for rapidly detecting the concentration of serum endocrine disruptors according to claim 1, characterized in that, Four support columns (34) are also fixed to the lower side of the middle part of the U-shaped seat (1). A pen-type electric push rod (35) is arranged inside each support column (34). The telescopic end of each pen-type electric push rod (35) penetrates to the top of the support column (34) and is fixed to a support plate (36). A second motor (37) is installed on the middle part of the bottom end of the support plate (36) through a machine case. The output shaft of the second motor (37) penetrates through the middle part of the support plate (36) and is fixed to the bottom of a rotating support (16). A guide ring (38) is fixed to the bottom of the rotating support (16). The lower end of the guide ring (38) is located inside the annular groove at the upper end of the support plate (36). A plurality of balls (39) contacting the middle part of the annular groove are arranged at the bottom of the guide ring (38).

7. The device for rapidly detecting the concentration of endocrine disruptors in serum according to claim 1, characterized in that, A discharge cover (40) is also fixed to the lower side of the middle part of the U-shaped seat (1). The discharge cover (40) is sleeved outside the four support columns (34). A plurality of grooves for placing the bottom of the sample test tube (17) are equidistantly formed on the top surface of the discharge cover (40). A protective pad (41) is fixed to the surface of each groove.

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