Reaction kettle for preparing 5-fluorouracil intermediate

Abstract

The utility model relates to the technical field of preparation of 5-fluorouracil intermediates, in particular to a reaction kettle for preparing 5-fluorouracil intermediates, which comprises a main body mechanism, an auxiliary mechanism and a moving mechanism. When the reaction kettle for preparing the 5-fluorouracil intermediate is used, firstly, the device is pushed to a proper position through a pushing device, then the device is fixed through a foot brake, raw materials for preparing the 5-fluorouracil intermediate are added into the reaction kettle body through a feeding port, then the feeding port is closed, and the reaction kettle is put into the reaction kettle body. An explosion-proof motor runs to drive a rotating shaft to rotate, so that a stirring rod and a scraping rod are driven to rotate, meanwhile, a water inlet valve is started, water is sprayed out of a spray head, then the water inlet valve is closed, intermediate raw materials in the device are fully reacted, and the raw materials cannot be attached to the inner wall of a reaction kettle through the arranged scraping rod; therefore, the reaction can be fully carried out.

Description

Technical Field

[0001] The utility model relates to the technical field of 5-fluorouracil intermediate preparation, in particular to a reaction kettle for preparing 5-fluorouracil intermediate. Background Art

[0002] Fluorouracil, also known as 5-fluorouracil, has the chemical formula C₄H₃FN₂O₂. It is a pyrimidine analog and an antimetabolite used primarily for the treatment of tumors. The preliminary list of carcinogens published by the World Health Organization's International Agency for Research on Cancer on October 27, 2017, placed fluorouracil on the Class 3 list. A reactor is essential for the preparation of 5-fluorouracil intermediates.

[0003] Chinese utility model patent application publication CN205886851U discloses a reactor comprising a reactor body and a jacket disposed outside the reactor body. The reactor body is provided with a stirring device at the top, a feed inlet at the top of the reactor body, and a discharge outlet at the bottom of the reactor body. The reactor body is characterized by a temperature measuring device at the top of the reactor body, the lower end of which extends to the lower portion of the reactor body. The inner surface of the reactor body is provided with a glass-lined layer that is resistant to low temperatures and acid and alkali corrosion. While this reactor is both low-temperature and acid- and alkali-resistant, it is susceptible to residual reaction materials on the inner wall, leading to incomplete reaction. Therefore, a reactor for the preparation of 5-fluorouracil intermediates has been proposed. Utility Model Content

[0004] The purpose of the utility model is to provide a reactor for preparing a 5-fluorouracil intermediate, so as to solve the problems raised in the above background technology.

[0005] To achieve the above purpose, the present invention provides the following technical solutions:

[0006] A reactor for preparing a 5-fluorouracil intermediate comprises a main mechanism, an auxiliary mechanism and a moving mechanism, wherein the auxiliary mechanism is fixedly arranged on the main mechanism, and the moving mechanism is fixedly arranged at the bottom of the main mechanism. The main mechanism comprises a reactor body, an explosion-proof top cover, an explosion-proof motor, a rotating shaft, a stirring rod, a scraping rod, a bearing, a tilting platform and a base, wherein the explosion-proof top cover is fixedly arranged on the top of the reactor body, the explosion-proof motor is fixedly arranged on the top of the explosion-proof top cover, the rotating shaft is fixedly arranged at the output end of the explosion-proof motor, the stirring rod is fixedly arranged on the rotating shaft, the scraping rod is fixedly arranged at one end of the stirring rod, the bearing is fixedly arranged at the bottom of the rotating shaft, the tilting platform is fixedly arranged on both sides of the bearing, and the base is fixedly arranged at the bottom of the tilting platform.

[0007] Preferably, the auxiliary mechanism includes a feed port, a discharge port, an observation window, a pressure gauge, a water inlet valve, a water pipe, a nozzle and a pressure relief valve, and the feed port is opened on one side of the reactor body.

[0008] According to the above solution, the feeding port is provided to facilitate feeding of the device.

[0009] Preferably, the discharge port is opened on one side of the reactor body, the observation window is opened on the reactor body, the pressure gauge is fixedly arranged on the top of the reactor body, and the water inlet valve is fixedly arranged on one side of the reactor body.

[0010] According to the above solution, the reaction situation inside the reactor body can be observed conveniently by setting an observation window, the pressure situation inside the reactor body can be observed by setting a pressure gauge, and the water inlet valve can be used to control the water inlet.

[0011] Preferably, the water pipe is fixedly arranged inside the reactor body and is connected to the water pipe, the nozzle is fixedly arranged at the bottom of the water pipe, and the pressure relief valve is fixedly arranged at the top of the reactor body.

[0012] According to the above scheme, by setting the pressure relief valve, the pressure is relieved when the reaction is completed, or when it is observed that the internal pressure of the reactor body is too high during the reaction process.

[0013] Preferably, the moving mechanism includes a mounting block, a support column, a bracket, a pulley and a brake pad, and the mounting block is fixedly arranged on one side of the reactor body.

[0014] According to the above solution, the supporting column is fixedly arranged on the bottom of the mounting block by arranging the mounting block.

[0015] Preferably, the support column is fixedly arranged at the bottom of the mounting block, and the bracket is fixedly arranged at the bottom of the support column.

[0016] Through the above solution, the device can be supported by providing support columns.

[0017] Preferably, the pulley is fixedly arranged at the bottom of the bracket, and the brake pad is fixedly arranged at one end of the bracket.

[0018] With the above solution, the pulley can be kept stationary by providing the brake pads.

[0019] Compared with the prior art, the beneficial effects of the present invention are:

[0020] 1. A reactor for preparing a 5-fluorouracil intermediate. When in use, first push the device to a suitable position, then fix the device with the foot brake, add the preparation raw materials of the 5-fluorouracil intermediate into the reactor body through the feed port, then close the feed port, and drive the rotating shaft to rotate by the explosion-proof motor, thereby driving the stirring rod and the scraper to rotate, and at the same time, open the water inlet valve to spray water from the nozzle, and then close the water inlet valve to allow the intermediate raw materials in the device to fully react. The scraper rod is provided to prevent the raw materials from adhering to the inner wall of the reactor, so that the reaction can proceed fully.

[0021] 2. This reactor for preparing a 5-fluorouracil intermediate is convenient for observing the reaction situation inside the reactor body by setting an observation window, observing the pressure situation inside the reactor body by setting a pressure gauge, and controlling the water inlet by setting a water inlet valve. The above design improves the practicality of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0023] Figure 2 This is a schematic diagram of the internal structure of the reactor body of the present invention;

[0024] Figure 3 This is a schematic diagram of the mobile mechanism of the utility model;

[0025] Figure 4 For this utility model Figure 2 Enlarged schematic diagram of point A in the middle.

[0026] In the figure: 1. Main mechanism; 101. Reactor body; 102. Explosion-proof top cover; 103. Explosion-proof motor; 104. Rotating shaft; 105. Stirring rod; 106. Scraper rod; 107. Bearing; 108. Tilting table; 109. Base; 2. Auxiliary mechanism; 201. Feed inlet; 202. Discharge outlet; 203. Observation window; 204. Pressure gauge; 205. Water inlet valve; 206. Water pipe; 207. Nozzle; 208. Pressure relief valve; 3. Moving mechanism; 301. Mounting block; 302. Support column; 303. Brake; 304. Pulley; 305. Brake pad. DETAILED DESCRIPTION

[0027] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0028] See also Figure 1 - Figure 4 As shown, the utility model provides a technical solution:

[0029] A reactor for preparing a 5-fluorouracil intermediate comprises a main mechanism 1, an auxiliary mechanism 2 and a moving mechanism 3. The auxiliary mechanism 2 is fixedly arranged on the main mechanism 1, and the moving mechanism 3 is fixedly arranged at the bottom of the main mechanism 1. The main mechanism 1 comprises a reactor body 101, an explosion-proof top cover 102, an explosion-proof motor 103, a rotating shaft 104, a stirring rod 105, a scraping rod 106, a bearing 107, a tilting platform 108 and a base 109. The explosion-proof top cover 102 is fixedly arranged on the top of the reactor body 101, the explosion-proof motor 103 is fixedly arranged on the top of the explosion-proof top cover 102, the rotating shaft 104 is fixedly arranged at the output end of the explosion-proof motor 103, the stirring rod 105 is fixedly arranged on the rotating shaft 104, the scraping rod 106 is fixedly arranged at one end of the stirring rod 105, the bearing 107 is fixedly arranged at the bottom of the rotating shaft 104, the tilting platform 108 is fixedly arranged on both sides of the bearing 107, and the base 109 is fixedly arranged at the bottom of the tilting platform 108.

[0030] In this embodiment, preferably, the auxiliary mechanism 2 includes a feed port 201, a discharge port 202, an observation window 203, a pressure gauge 204, a water inlet valve 205, a water pipe 206, a nozzle 207 and a pressure relief valve 208, and the feed port 201 is opened on one side of the reactor body 101.

[0031] According to the above solution, the feeding port 201 is provided to facilitate feeding of the device.

[0032] In this embodiment, preferably, the discharge port 202 is opened on one side of the reactor body 101, the observation window 203 is opened on the reactor body 101, the pressure gauge 204 is fixedly set on the top of the reactor body 101, and the water inlet valve 205 is fixedly set on one side of the reactor body 101.

[0033] According to the above solution, the reaction situation inside the reactor body 101 is observed conveniently by setting the observation window 203, the pressure situation inside the reactor body 101 is observed by setting the pressure gauge 204, and the water inlet valve 205 is used to control the water inlet.

[0034] In this embodiment, preferably, the water pipe 206 is fixedly arranged inside the reactor body 101 and connected to the water pipe 206 , the nozzle 207 is fixedly arranged at the bottom of the water pipe 206 , and the pressure relief valve 208 is fixedly arranged on the top of the reactor body 101 .

[0035] According to the above solution, by providing the pressure relief valve 208 , pressure relief is performed when the reaction is finished, or when it is observed that the internal pressure of the reactor body 101 is too high during the reaction.

[0036] In this embodiment, preferably, the moving mechanism 3 includes a mounting block, a support column 302 , a bracket 303 , a pulley 304 and a brake pad 305 , and the mounting block is fixedly arranged on one side of the reactor body 101 .

[0037] According to the above solution, the support column 302 is fixedly arranged on the bottom of the mounting block by arranging the mounting block.

[0038] In this embodiment, preferably, the support column 302 is fixedly disposed on the bottom of the mounting block, and the bracket 303 is fixedly disposed on the bottom of the support column 302 .

[0039] According to the above solution, the device can be supported by providing the support column 302 .

[0040] In this embodiment, preferably, the pulley 304 is fixedly arranged at the bottom of the bracket 303 , and the brake pad 305 is fixedly arranged at one end of the bracket 303 .

[0041] According to the above solution, the pulley 304 can be kept stationary by providing the brake pad 305 .

[0042] When using a reactor for preparing a 5-fluorouracil intermediate of this embodiment, the device is first pushed to a suitable position, and then the device is fixed by the foot brake. The raw materials for preparing the 5-fluorouracil intermediate are added into the reactor body 101 through the feed port 201. Then, the feed port 201 is closed, and the rotation shaft 104 is driven to rotate by the explosion-proof motor 103, thereby driving the stirring rod 105 and the scraper rod 106 to rotate. At the same time, the water inlet valve 205 is opened to spray water from the nozzle 207. Then, the water inlet valve 205 is closed to allow the intermediate raw materials in the device to fully react. The scraper 106 is provided to prevent the raw materials from adhering to the inner wall of the reactor, so that the reaction can proceed fully. The observation window 203 is provided to facilitate observation of the reaction situation inside the reactor body 101, the pressure condition inside the reactor body 101 is observed through the pressure gauge 204, and the water inlet valve 205 is provided to control water inlet. The above design improves the practicality of the device.

[0043] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely preferred examples of the present invention and are not intended to limit the present invention. Various changes and improvements may be made to the present invention without departing from the spirit and scope of the present invention, and such changes and improvements fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

Claims

1. A reactor for preparing a 5-fluorouracil intermediate, comprising a main mechanism (1), an auxiliary mechanism (2) and a moving mechanism (3), characterized in that: The auxiliary mechanism (2) is fixedly arranged on the main mechanism (1), and the moving mechanism (3) is fixedly arranged at the bottom of the main mechanism (1). The main mechanism (1) comprises a reactor body (101), an explosion-proof top cover (102), an explosion-proof motor (103), a rotating shaft (104), a stirring rod (105), a scraping rod (106), a bearing (107), a tilting platform (108) and a base (109). The explosion-proof top cover (102) is fixedly arranged on the top of the reactor body (101), and the explosion-proof motor (103) is fixedly arranged on the bottom of the main mechanism (109). 03) is fixedly arranged on the top of the explosion-proof top cover (102), the rotating shaft (104) is fixedly arranged on the output end of the explosion-proof motor (103), the stirring rod (105) is fixedly arranged on the rotating shaft (104), the scraping rod (106) is fixedly arranged on one end of the stirring rod (105), the bearing (107) is fixedly arranged on the bottom of the rotating shaft (104), the tilting platform (108) is fixedly arranged on both sides of the bearing (107), and the base (109) is fixedly arranged on the bottom of the tilting platform (108).

2. A reactor for preparing a 5-fluorouracil intermediate according to claim 1, characterized in that: The auxiliary mechanism (2) comprises a feed port (201), a discharge port (202), an observation window (203), a pressure gauge (204), a water inlet valve (205), a water pipe (206), a nozzle (207) and a pressure relief valve (208); the feed port (201) is provided on one side of the reactor body (101).

3. A reactor for preparing a 5-fluorouracil intermediate according to claim 2, characterized in that: The discharge port (202) is provided on one side of the reactor body (101), the observation window (203) is provided on the reactor body (101), the pressure gauge (204) is fixedly provided on the top of the reactor body (101), and the water inlet valve (205) is fixedly provided on one side of the reactor body (101).

4. A reactor for preparing a 5-fluorouracil intermediate according to claim 2, characterized in that: The water pipe (206) is fixedly arranged inside the reactor body (101) and is connected to the water pipe (206), the nozzle (207) is fixedly arranged at the bottom of the water pipe (206), and the pressure relief valve (208) is fixedly arranged at the top of the reactor body (101).

5. A reactor for preparing a 5-fluorouracil intermediate according to claim 1, characterized in that: The moving mechanism (3) comprises a mounting block (301), a support column (302), a bracket (303), a pulley (304) and a brake pad (305); the mounting block (301) is fixedly arranged on one side of the reactor body (101).

6. A reactor for preparing a 5-fluorouracil intermediate according to claim 5, characterized in that: The support column (302) is fixedly arranged at the bottom of the mounting block (301), and the bracket (303) is fixedly arranged at the bottom of the support column (302).

7. A reactor for preparing a 5-fluorouracil intermediate according to claim 5, characterized in that: The pulley (304) is fixedly arranged at the bottom of the bracket (303), and the brake pad (305) is fixedly arranged at one end of the bracket (303).

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