Drug fermentation device for biosynthesis

Abstract

The utility model discloses a medicine fermentation device for biosynthesis, which is characterized in that a stirring shaft is of a hollow pipe structure, a stirring blade is of a jacket structure communicated with the inside of the stirring shaft, and a plurality of exhaust gaps are formed in the stirring blade; a rotary sealing joint is arranged at the lower end of the stirring shaft and is hermetically communicated with an air pump through an air guide pipe; wherein liquid stored in the buffering agent storage box and liquid stored in the weak base storage box are fed into the tank body through a micropump and a guide pipe respectively. According to the utility model, aeration and the stirrer are integrated together, specifically, the air pump is used for providing air for the stirring shaft, the stirring motor is used for driving the stirring shaft to rotate at the same time, and in the process that the stirring shaft drives the stirring blades to rotate, the air in the stirring blades is dispersed into the fermentation liquid through the exhaust gaps; through the hidden design of the aeration structure, the complexity of the aeration equipment is reduced, and subsequent cleaning is facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of drug fermentation, in particular to a drug fermentation device for biosynthesis. Background Art

[0002] Patent application No. 202220214126.9 discloses a biosynthetic drug fermentation device, comprising a tank body, wherein a rotating shaft is rotatably connected between the top and bottom ends of the inner wall of the tank body, and a plurality of first stirring rods are fixedly connected to the surface of the rotating shaft, and the top end of the rotating shaft passes through the top of the tank body and is fixedly installed with a cold air blower, and the top surface of the rotating shaft is also fixedly connected to a first gear, and a driving machine is installed on one side of the top of the tank body, and the output shaft of the driving machine is fixedly connected to a second gear meshing with the first gear, and the output end of the cold air blower is fixedly connected to a main pipe, and a plurality of branch pipes corresponding to the first stirring rods are fixedly connected on both sides of the main pipe, and one end of the branch pipe passes through the interior of the first stirring rod and is fixedly installed with a plurality of air nozzles. The utility model can quickly make the raw materials to be fermented in a low-temperature or high-temperature environment to achieve the required temperature for raw material fermentation.

[0003] The microorganisms used in drug fermentation need to be in an aerated environment to improve the efficiency of drug fermentation. However, the above technology does not install aeration equipment. In addition, if the conventional aeration disc structure is directly installed in the drug fermentation device, after the fermentation liquid is discharged, the aeration structure is relatively complex, making it difficult to clean, affecting subsequent fermentation use. Utility Model Content

[0004] The purpose of the utility model is to provide a biosynthetic drug fermentation device to solve the problem that the aeration structure of conventional biosynthetic drug fermentation devices affects the fermentation efficiency.

[0005] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0006] The utility model provides a biosynthetic drug fermentation device, which includes a tank body, a stirring shaft arranged in the tank body and a stirring blade arranged on the stirring shaft, a stirring motor arranged on the top of the tank body and used to drive the stirring shaft, a water bath jacket arranged on the outer peripheral wall of the tank body, a heat exchange water tank connected to the water bath jacket through a delivery pipe, and a circulation pump arranged on the delivery pipe;

[0007] The stirring shaft is a hollow tube structure, and the stirring blade is a jacket structure connected to the interior of the stirring shaft, wherein a plurality of exhaust slits are provided on the stirring blade; a rotary sealing joint is provided at the lower end of the stirring shaft, and the rotary sealing joint is sealed and connected to an air pump through an air guide pipe;

[0008] An online pH detector for detecting the pH of the fermentation liquid is also provided in the tank body;

[0009] A buffer tank and a weak base tank are also provided outside the tank body; wherein the liquid stored in the buffer tank and the weak base tank is respectively delivered into the tank body through a micro pump and a catheter.

[0010] Furthermore, a feed pipe and a pressure relief valve are provided on the top of the tank body, and a discharge pipe is provided on the bottom thereof;

[0011] A temperature sensor for detecting the temperature of the fermentation liquid is provided in the tank body, and the temperature sensor is connected to the controller on the circulation pump as a signal input end.

[0012] Furthermore, an upper connecting plate and a lower connecting plate are provided in the tank body, and a distance is maintained between the upper connecting plate and the lower connecting plate;

[0013] The stirring shaft is respectively arranged on the upper connecting plate and the lower connecting plate through bearings; wherein the stirring shaft is provided with upper and lower layers of stirring blades.

[0014] Furthermore, a gas delivery pipe extending out of the tank body is provided at the lower end of the rotary sealing joint; the gas delivery pipe is connected to the air pump through a gas delivery hose; a one-way valve or a solenoid valve is provided on the gas delivery hose.

[0015] Furthermore, a hot water heating module is provided in the water exchange tank, and the lower end side of the water bath jacket returns the heat exchange medium to the water exchange tank through a return water pipe.

[0016] Furthermore, the temperature sensor is arranged on the upper connecting plate, and its detection probe extends below the liquid surface.

[0017] Furthermore, the buffer tank is provided with a first micro pump connected to the interior thereof, and the weak base tank is provided with a second micro pump connected to the interior thereof.

[0018] Furthermore, the online pH detector is connected to a controller as a signal acquisition terminal, and the controller controls the connection of the first micropump and the second micropump respectively.

[0019] Compared with the prior art, the beneficial technical effects of the present invention are:

[0020] The present invention integrates aeration with a stirrer, specifically by providing air to the stirring shaft through an air pump, while simultaneously utilizing the stirring motor to drive the stirring shaft to rotate. The stirring shaft drives the stirring blades to rotate, allowing the internal air to be dispersed into the fermentation liquid through the exhaust slits. The present invention reduces the complexity of the aeration equipment through the concealed design of the aeration structure, facilitating subsequent cleaning. Furthermore, the online pH detector transmits the detected pH data to the controller, and based on the controller's coded set value, the first micropump or the second micropump is controlled to perform the delivery operation, thereby achieving automatic adjustment of the fermentation liquid pH. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The present invention will be further described below with reference to the accompanying drawings.

[0022] Figure 1 This is a schematic diagram of the main structure of the utility model's biosynthetic drug fermentation device;

[0023] Figure 2 This is a schematic diagram of the stirring blade in the biosynthetic drug fermentation device of the present invention.

[0024] Explanation of the accompanying reference numerals: 100, tank body; 101, feed pipe; 102, pressure relief valve; 103, water bath jacket; 104, discharge pipe; 200, stirring motor; 201, upper connecting plate; 202, lower connecting plate; 203, stirring shaft; 204, stirring blade; 2041, exhaust slit; 205, rotary sealing joint; 300, air pump; 301, gas hose; 302, gas pipe; 400, heat exchange water tank; 401, circulation pump; 402, delivery pipe; 500, temperature sensor; 600, buffer tank; 601, first micropump; 700, weak base tank; 701, second micropump; 800, online pH detector; 801, controller. DETAILED DESCRIPTION

[0025] This embodiment discloses a biosynthetic pharmaceutical fermentation apparatus, which includes a tank body 100, a stirring shaft 203 installed in the tank body 100, a stirring blade 204 installed on the stirring shaft 203, a stirring motor 200 installed on the outer top of the tank body 100 and used to drive the stirring shaft 203, a water bath jacket 103 installed on the outer peripheral wall of the tank body 100, a heat exchange water tank 400 connected to the water bath jacket 103 via a delivery pipe 402, and a circulation pump 401 installed on the delivery pipe 402. A feed pipe 101 and a pressure relief valve 102 are installed at the top of the tank body 100, and a discharge pipe 104 for discharging the fermentation liquid is installed at the bottom.

[0026] In this embodiment, Figure 1 and Figure 2As shown, the stirring shaft 203 is a hollow tube structure, and the stirring blade 204 is a jacket structure connected to the interior of the stirring shaft 203, wherein a plurality of exhaust slits 2041 are opened on the stirring blade 204; a rotary sealing joint 205 is installed at the lower end of the stirring shaft 203, and the rotary sealing joint 205 is sealed and connected to an air pump 300 through an air guide pipe.

[0027] During use, the air pump 300 provides air to the stirring shaft 203, and the stirring motor 200 is used to drive the stirring shaft 203 to rotate. During the process of the stirring shaft 203 driving the stirring blade 204 to rotate, the air inside the stirring blade 204 is dispersed into the fermentation liquid through the exhaust slit 2041.

[0028] During specific implementation, a gas delivery rigid pipe 302 extending out of the tank body 100 is installed at the lower end of the rotary sealing joint 205; the gas delivery rigid pipe 302 can be a metal pipe fixed to the bottom of the tank body 100 to avoid rotation with the rotary sealing joint 205; the gas delivery rigid pipe 302 is connected to the air pump 300 through a gas delivery hose 301; a one-way valve or a solenoid valve is installed on the gas delivery hose 301 to prevent the fermentation liquid from entering.

[0029] In this embodiment, an upper connecting plate 201 and a lower connecting plate 202 are fixedly installed in the tank body 100, and the upper connecting plate 201 and the lower connecting plate 202 are kept at a distance; the stirring shaft 203 is respectively installed on the upper connecting plate 201 and the lower connecting plate 202 through bearings; wherein the stirring shaft 203 is installed with upper and lower layers of stirring blades 204; wherein Figure 1 As shown, the rotation radius of the upper stirring blade is smaller than the rotation radius of the lower stirring blade 204, wherein the lower stirring blade 204 has more air slits, so as to fully improve the aeration efficiency.

[0030] In this embodiment, an online pH detector 800 for detecting the pH of the fermentation liquid is also installed in the tank body 100; a buffer storage tank 600 and a weak base storage tank 700 are also installed outside the tank body 100; the liquid stored in the buffer storage tank 600 and the weak base storage tank 700 is respectively delivered into the tank body 100 through a micropump and a catheter.

[0031] A first micropump 601 connected to the interior of the buffer tank 600 is installed, and a second micropump 701 connected to the interior of the weak base tank 700 is installed. The liquid outlet ends of the first micropump 601 and the second micropump 701 respectively introduce the buffer or weak base solution into the tank body 100 through microtubes to adjust the pH inside the tank body.

[0032] Specifically, the online pH detector 800 is connected to a controller 801 as a signal acquisition end, and the controller 801 controls the connection of the first micropump 601 and the second micropump 701 respectively; in this embodiment, the online pH detector 800 is used to transmit the detected pH data to the controller 801, and based on the coded setting value of the controller 801, the first micropump 601 or the second micropump 701 is respectively regulated to perform the delivery work; in order to achieve the precise injection of buffer or weak alkaline solution, a flow meter or a flow solenoid valve can be installed on the delivery microtube of the first micropump 601 or the second micropump 701.

[0033] In this embodiment, a temperature sensor 500 for detecting the fermentation liquid temperature is installed within the tank 100. This temperature sensor 500 serves as a signal input and is connected to the controller on the circulating pump 401. A hot water heating module (electric heater) is installed within the heat exchange tank 400. The lower end of the water bath jacket 103 returns the heat exchange medium to the heat exchange tank 400 via a return pipe. The temperature sensor 500 is mounted on the upper connecting plate 201, with its detection probe extending below the liquid level.

[0034] In this embodiment, the temperature sensor 500 is used to timely monitor the temperature of the solution in the tank body 100 and to control and adjust the water temperature and flow rate in the water bath jacket 103 so that the temperature of the solution in the tank body 100 meets the fermentation requirements.

[0035] The above embodiments are only descriptions of the preferred methods of the present invention and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should fall within the scope of protection determined by the claims of the present invention.

Claims

1. A biosynthetic pharmaceutical fermentation device, comprising a tank body (100), a stirring shaft (203) disposed in the tank body (100), a stirring blade (204) disposed on the stirring shaft (203), a stirring motor (200) disposed on the top of the tank body (100) and used to drive the stirring shaft (203), a water bath jacket (103) disposed on the outer peripheral wall of the tank body (100), a heat exchange water tank (400) connected to the water bath jacket (103) through a delivery pipe (402), and a circulation pump (401) disposed on the delivery pipe (402); characterized in that: The stirring shaft (203) is a hollow tube structure, and the stirring blade (204) is a jacket structure connected to the interior of the stirring shaft (203), wherein a plurality of exhaust slits (2041) are provided on the stirring blade (204); a rotary sealing joint (205) is provided at the lower end of the stirring shaft (203), and the rotary sealing joint (205) is sealed and connected to an air pump (300) through an air guide pipe; An online pH detector (800) for detecting the pH of the fermentation liquid is also provided in the tank (100); A buffer storage tank (600) and a weak base storage tank (700) are also provided outside the tank body (100); wherein the liquid stored in the buffer storage tank (600) and the weak base storage tank (700) is respectively delivered into the tank body (100) via a micro pump and a catheter.

2. The biosynthetic drug fermentation device according to claim 1, characterized in that: A feed pipe (101) and a pressure relief valve (102) are provided at the top of the tank body (100), and a discharge pipe (104) is provided at the bottom thereof; A temperature sensor (500) for detecting the temperature of the fermentation liquid is provided in the tank body (100). The temperature sensor (500) is connected to the controller on the circulation pump (401) as a signal input terminal.

3. The biosynthetic drug fermentation device according to claim 2, characterized in that: An upper connecting plate (201) and a lower connecting plate (202) are provided in the tank body (100), and a distance is maintained between the upper connecting plate (201) and the lower connecting plate (202); The stirring shaft (203) is respectively arranged on the upper connecting plate (201) and the lower connecting plate (202) through bearings; wherein the stirring shaft (203) is provided with upper and lower layers of stirring blades (204).

4. The biosynthetic drug fermentation device according to claim 3, characterized in that: A gas delivery hard pipe (302) extending out of the tank body (100) is provided at the lower end of the rotary sealing joint (205); the gas delivery hard pipe (302) is connected to the air pump (300) through a gas delivery hose (301); a one-way valve or a solenoid valve is provided on the gas delivery hose (301).

5. The biosynthetic drug fermentation device according to claim 4, characterized in that: A hot water heating module is provided in the water exchange tank (400), and the lower end side of the water bath jacket (103) returns the heat exchange medium to the water exchange tank (400) through a return water pipe.

6. The biosynthetic drug fermentation device according to claim 5, characterized in that: The temperature sensor (500) is arranged on the upper connecting plate (201), and its detection probe extends below the liquid surface.

7. The biosynthetic drug fermentation device according to claim 6, characterized in that: The buffer tank (600) is provided with a first micro pump (601) in communication with the interior thereof, and the weak base tank (700) is provided with a second micro pump (701) in communication with the interior thereof.

8. The biosynthetic drug fermentation device according to claim 7, characterized in that: The online pH detector (800) is connected to a controller (801) as a signal acquisition terminal, and the controller (801) controls the connection of the first micropump (601) and the second micropump (701) respectively.

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