Hemostatic hydrogel patch containing silicate

Abstract

The utility model provides a hemostatic hydrogel patch containing silicate, and relates to the technical field of medical dressings. Comprising a non-woven fabric layer, a silica gel layer, a gel moisturizing functional composite layer and a protective layer which are sequentially laminated, the protective layer comprises two sheet bodies, and the two sheet bodies cover the left side and the right side of the upper surface of the gel moisturizing functional composite layer respectively; wherein one ends and two sides of the two sheet bodies are adhered to the edge of the non-woven fabric layer, and the other ends of the two sheet bodies extend to the gel moisturizing function composite layer and cover the gel moisturizing function composite layer in a staggered manner. According to the hydrogel patch, the poloxamer is combined with the mesoporous bioactive glass, so that a moist environment is provided for a wound, meanwhile, hemostatic substances are firstly released to stop bleeding of the wound, then substances such as silicone oil are released to promote wound healing, and scars are prevented from being generated.

Description

Technical Field

[0001] The utility model relates to the technical field of medical dressings, in particular to a hemostatic hydrogel patch containing silicate. Background Art

[0002] Currently, uncontrolled bleeding in surgeries and traffic accidents has led to a significant increase in mortality, so reducing bleeding time and early blood loss is a necessary strategy in treatment. Bleeding usually occurs when normal human skin and tissues are damaged. This is a physiological response caused by vascular damage. Mesoporous bioactive glass has a high specific surface area and high porosity. When used on the wound, it can absorb blood and concentrate coagulation factors to achieve a therapeutic effect. Its solid structure is obviously brittle, and it is usually used in the form of powder and needs to be fixed with a sponge or gauze. When used alone as a powder, it is easily washed away by the blood on the wound and cannot effectively act on the wound. It also does not have the function of keeping the wound moist, which is not conducive to subsequent wound healing and can easily cause infection and scar formation.

[0003] Studies have shown that hydrogel dressings have excellent water absorption, moisture retention, and flexible shape and use. However, their adhesion to wounds with high blood flow is poor, making them ineffective in sealing wounds. Poloxamer, a typical amphiphilic triblock copolymer, can self-assemble into micelles under mild physiological conditions, capable of loading hemostatic, anti-inflammatory, and antibacterial drugs for controlled release.

[0004] Hypertrophic scars or keloids that appear after wound healing caused by surgery or accidental trauma can cause patients to have subsequent problems such as poor physical sensation, itching, and aesthetic problems. In the middle and late stages of scar formation, medical silicone can significantly inhibit or reduce scar formation. Chinese Patent 202310337739.0 discloses a method for preparing a slow-release growth factor thermosensitive gel, but the steps are numerous and the operation is complicated, and there is no obvious hemostatic effect. In addition, Chinese Patent 202310225721.1 discloses a self-adhesive multifunctional composite hydrogel dressing and a preparation method, but its adhesion is insufficient, it cannot be fixed around the treated tissue, and it is easy to fall off, resulting in poor treatment effect. Chinese Patent 202310618425.8 introduces a hydrogel wound dressing and a preparation method thereof, but the hemostatic effect needs to be further improved.

[0005] To this end, we propose a dressing that has strong adhesion and provides a moist environment for the wound, thereby achieving rapid hemostasis, promoting wound healing, and effectively preventing the formation of scars at the wound site. Utility Model Content

[0006] In order to address the deficiencies in the background technology, the utility model provides a silicate-containing hemostatic hydrogel patch. The hydrogel patch provides a moist environment for the wound by combining poloxamer with mesoporous bioactive glass. At the same time, it first releases hemostatic substances to stop bleeding, and then releases substances such as silicone oil to promote wound healing and prevent the formation of scars.

[0007] A hemostatic hydrogel patch containing silicate, comprising a non-woven fabric layer, a silicone gel layer, a gel moisturizing function composite layer and a protective layer stacked in sequence;

[0008] The protective layer includes two sheets, which respectively cover the left and right sides of the upper surface of the gel moisturizing functional composite layer; wherein, one end and both sides of the two sheets are adhered to the edge of the non-woven fabric layer, and the other end extends to the gel moisturizing functional composite layer and is staggered to cover the gel moisturizing functional composite layer.

[0009] Preferably, the silicone gel layer is located in the middle of the non-woven fabric layer; the surface area of ​​the silicone gel layer is smaller than the surface area of ​​the non-woven fabric layer;

[0010] The gel moisturizing function composite layer is located on the silicone gel layer and has the same area as that of the silicone gel layer.

[0011] Preferably, the non-woven fabric layer is provided with a plurality of breathable micropores.

[0012] Preferably, the protective layer is release paper.

[0013] Preferably, the direction in which the other end extends is the direction of the long side of the non-woven fabric layer;

[0014] The width of the staggered coverage is the same as the width of the non-woven fabric layer.

[0015] Preferably, the material of the silicone gel layer is silicone gel prepared by hydrogenated silicone oil, vinyl silicone oil and platinum catalyst.

[0016] Preferably, the material of the gel moisturizing functional composite layer is a gel prepared by configuring 22.0% by mass of poloxamer, 3.0% by mass of mesoporous bioactive glass, 5.0% by mass of calcium chloride, and the balance being water.

[0017] Preferably, the protective layer is release paper.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] The utility model provides a hemostatic hydrogel patch containing silicates. The hemostatic hydrogel patch provided by the utility model has a multi-layer structure, comprising, from the outside to the inside, a non-woven fabric layer, a silicone gel layer, a gel hemostatic and moisturizing composite layer, and a protective layer. The non-woven fabric layer is a transparent, waterproof structure, and is covered with breathable micropores. The silicone gel layer is slightly smaller in area than the non-woven fabric layer. The gel hemostatic and moisturizing composite layer is the same size as the silicone gel layer and is disposed in the center of the silicone gel layer. By combining poloxamer with mesoporous bioactive glass, the utility model not only provides a moist environment for the wound, but also releases hemostatic substances to stop bleeding, and then releases substances such as silicone oil to promote wound healing and prevent scarring.

[0020] The silicate-containing hemostatic hydrogel patch provided by the utility model has the characteristics of stopping bleeding, not adhering to the wound, and promoting wound healing. At the same time, it provides a moist environment for the wound, accelerates wound healing, and relieves the patient's pain. After the wound heals, the silicone oil is slowly released to prevent the formation of scars. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is the main view of the utility model;

[0022] Figure 2 It is a structural diagram of the present utility model. DETAILED DESCRIPTION

[0023] Several specific implementations of the present invention are described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific implementations.

[0024] The utility model provides a hemostatic hydrogel patch containing silicate, see Figures 1 and 2 As shown, it includes a non-woven fabric layer 1, a silicone gel layer 2, a gel moisturizing function composite layer 3 and a protective layer 4 which are stacked in sequence;

[0025] The protective layer 4 comprises two sheets, each covering the left and right sides of the upper surface of the gel moisturizing functional composite layer 3. One end and both sides of each sheet are adhered to the edge of the non-woven fabric layer 1, while the other ends extend onto the gel moisturizing functional composite layer 3 and overlap the latter in a staggered manner. The other ends extend in the direction of the long side of the non-woven fabric layer, and the width of the overlapped overlap is the same as the width of the non-woven fabric layer.

[0026] The silicone gel layer 2 is located in the middle of the non-woven fabric layer 1; the surface area of ​​the silicone gel layer 2 is smaller than the surface area of ​​the non-woven fabric layer 1;

[0027] The gel moisturizing function composite layer 3 is located on the silicone gel layer 2 and has the same area as the silicone gel layer 2 .

[0028] The non-woven fabric layer 1 is provided with a plurality of breathable micropores.

[0029] The material of the protective layer 4 is release paper.

[0030] The silicone gel layer 2 is made of silicone gel prepared from hydrogenated silicone oil, vinyl silicone oil and platinum catalyst.

[0031] In this embodiment, the silicone gel layer 2 is obtained by mixing hydrogenated silicone oil, vinyl silicone oil, and a platinum catalyst in a ratio of 100,000:100,000:1. The mixture is placed in a vacuum mixer and stirred at a speed of 400-800 rpm for 30 minutes. The mixture is then degassed in a vacuum chamber at a pressure of ≥0.08 MPa for 5 minutes to obtain the silicone gel layer. The silicone gel is used to prevent scar formation after wound healing.

[0032] The material of the gel moisturizing functional composite layer is a gel prepared by mixing 22.0% poloxamer, 3.0% mesoporous bioactive glass, 5.0% calcium chloride, and the balance water. Specific steps for preparing the gel moisturizing functional composite layer are as follows:

[0033] 1) Disperse 40 g of poloxamer in 100 mL of distilled water and dissolve thoroughly in an ice bath to obtain a 40% poloxamer solution.

[0034] 2) Disperse 15 g of bioactive glass in 100 mL of distilled water and ultrasonically disrupt and mix thoroughly to obtain a 15% bioactive glass suspension.

[0035] 3) Disperse 20 g of calcium chloride in 100 mL of distilled water and allow it to fully dissolve to obtain a 20% calcium chloride solution.

[0036] 4) Mix 55 mL of poloxamer solution, 20 mL of bioactive glass solution, and 25 mL of calcium chloride solution, and rapidly stir in an ice bath to obtain a uniform gel, thereby obtaining a gel moisturizing functional composite layer.

[0037] In this embodiment, the composition of the gel moisturizing composite layer 3 is: 22.0% poloxamer, 3.0% mesoporous bioactive glass, 5.0% calcium chloride, and the balance is water. The poloxamer absorbs wound exudate, immobilizes the mesoporous bioactive glass powder, and provides a moist gel environment for the wound. The mesoporous bioactive glass stops bleeding and promotes wound healing. The calcium chloride lowers the gelation temperature of the poloxamer, maintaining the gel in a stable state at low temperatures while also promoting coagulation.

[0038] In this embodiment, the hemostatic patch has a multi-layer structure, consisting, from the outside in, of a non-woven fabric layer, a silicone gel layer, a gel hemostatic and moisturizing composite layer, and a protective layer. The non-woven fabric layer is transparent and waterproof, with breathable micropores throughout. The silicone gel layer is slightly smaller than the non-woven fabric layer. The gel hemostatic and moisturizing composite layer is the same size as the silicone gel layer and is positioned in the center of the silicone gel layer. The protective layer is release paper to prevent the hydrogel from drying out and deteriorating. The protective layer consists of two pieces, attached to both ends of the non-woven fabric and extending to the center to cross over each other, with the left side draped over the right side.

[0039] In this embodiment, a method for preparing a silicate-containing hemostatic hydrogel patch is provided as follows: a silicone gel layer is first fixed on a non-woven fabric layer, a gel moisturizing functional composite layer is then fixed on the silicone gel layer, and finally a protective layer is applied.

[0040] The present embodiment provides a hemostatic hydrogel patch containing silicate. When in use, first clean and disinfect the wound, then tear off the two protective layers of the hemostatic patch, align the gel protective functional composite layer 3 with the wound, and stick the surrounding sticky non-woven fabric on the skin.

[0041] The utility model provides a silicate-containing hemostatic hydrogel patch. Human wound exudate contains sodium chloride. Calcium ions in the calcium chloride in the gel portion of the patch are displaced with sodium ions in the blood. The displaced calcium ions and the mesoporous bioactive glass activate the coagulation mechanism, achieving a hemostatic effect. Simultaneously, the mesoporous bioactive glass promotes wound healing. The poloxamer in the upper layer slowly releases the mesoporous bioactive glass, providing a long-lasting moist environment for the wound. The poloxamer has a high water retention rate and adheres to the skin without clinging to the wound. Furthermore, the silicone gel layer in the patch can prevent the appearance of scars after the wound has healed and healed.

[0042] Obviously, those skilled in the art may make various modifications and variations to the present invention without departing from the spirit and scope of the present invention. Thus, if such modifications and variations fall within the scope of the claims of the present invention and their equivalents, the present invention is intended to include such modifications and variations.

Claims

1. A hemostatic hydrogel patch containing silicate, characterized in that: It includes a non-woven fabric layer, a silicone gel layer, a gel moisturizing function composite layer and a protective layer which are stacked in sequence; The protective layer comprises two sheets, which respectively cover the left and right sides of the upper surface of the gel moisturizing functional composite layer; wherein one end and both sides of the two sheets are adhered to the edge of the non-woven fabric layer, and the other ends extend onto the gel moisturizing functional composite layer and cover the gel moisturizing functional composite layer in an alternating manner; The silicone gel layer is located in the middle of the non-woven fabric layer; the surface area of ​​the silicone gel layer is smaller than the surface area of ​​the non-woven fabric layer; The gel moisturizing function composite layer is located on the silicone gel layer and has the same area as the silicone gel layer; The silicone gel layer is a silicone gel layer containing hydrogenated silicone oil, vinyl silicone oil and platinum catalyst; The gel moisturizing functional composite layer is a gel layer containing poloxamer, mesoporous bioactive glass and calcium chloride.

2. The hemostatic hydrogel patch containing silicate according to claim 1, characterized in that: The non-woven fabric layer is provided with a plurality of breathable micropores.

3. The hemostatic hydrogel patch containing silicate according to claim 1, characterized in that: The protective layer is release paper.

4. The hemostatic hydrogel patch containing silicate according to claim 1, characterized in that: The direction in which the other end extends is the direction of the long side of the non-woven fabric layer; The width of the staggered coverage is the same as the width of the non-woven fabric layer.

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