Semi-permeable membrane replacement mechanism and colloid osmotic pressure tester

Abstract

The utility model discloses a semi-permeable membrane replacement mechanism, which comprises a bottom plate, and an installation platform, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism which are arranged above the bottom plate, a semi-permeable membrane fixing device is detachably arranged on the installation platform, and a semi-permeable membrane is arranged in the semi-permeable membrane fixing device. A conveying mechanism communicated with the interior of the semipermeable membrane fixing device is arranged below the mounting platform, the reagent driving structure is connected with the conveying mechanism through a flow control mechanism and used for inputting or discharging different reagents into or out of the interior of the semipermeable membrane fixing device, and the replacement driving mechanism is connected with the mounting platform through a transmission mechanism. The mounting platform is driven by the replacement driving mechanism and the transmission mechanism to drive the semipermeable membrane fixing device to turn over, so that the semipermeable membrane fixing device is convenient to replace, the internal semipermeable membrane is further replaced, the mounting process is simplified, automatic control is realized, and the working efficiency is improved. The utility model further discloses a colloid osmotic pressure tester comprising the semipermeable membrane replacement mechanism.

Description

Technical Field

[0001] The utility model relates to the field of medical equipment, in particular to a semipermeable membrane replacement mechanism. In addition, the utility model also relates to a colloid osmotic pressure measuring instrument comprising the semipermeable membrane replacement mechanism. Background Art

[0002] The colloid osmotic pressure meter is a widely used medical device used to detect the osmotic pressure of colloids. The semipermeable membrane is an important component to achieve the above function. The protein in the sample cannot pass through the semipermeable membrane. Therefore, in the process of measuring the colloid osmotic pressure value of the sample, due to the existence of the colloid osmotic pressure, the sample will absorb ions and small molecules on the other side of the semipermeable membrane to offset the colloid osmotic pressure value. Therefore, the semipermeable membrane must be replaced when it reaches the end of its service life.

[0003] In the prior art, the method for replacing the semipermeable membrane is: first soak the semipermeable membrane until it is completely wet, then manually unscrew the screw cap above the semipermeable membrane, remove the sealing ring and the old semipermeable membrane, clean the cavity below the semipermeable membrane, and inject reference solution, then install the new semipermeable membrane, install the sealing ring, and then tighten the screw cap.

[0004] The above-mentioned semipermeable membrane replacement method makes the process of replacing the semipermeable membrane complicated, has a high failure rate caused by excessive human operations, and takes a long time to replace.

[0005] Therefore, how to provide a semipermeable membrane replacement mechanism that can quickly and efficiently replace the semipermeable membrane is a technical problem that those skilled in the art currently need to solve. Utility Model Content

[0006] The present invention provides a semipermeable membrane replacement mechanism that, by replacing a drive mechanism and a transmission mechanism, drives the mounting platform to flip the semipermeable membrane fixture, thereby facilitating replacement of the semipermeable membrane fixture and, in turn, the internal semipermeable membrane. This simplifies the installation process, enables automated control, and improves work efficiency. Another object of the present invention is to provide a colloidal osmotic pressure measuring instrument including the aforementioned semipermeable membrane replacement mechanism.

[0007] In order to solve the above technical problems, the present invention provides a semipermeable membrane replacement mechanism, including a base plate and a mounting platform installed above the base plate, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism. A semipermeable membrane fixing device is detachably mounted on the mounting platform, a semipermeable membrane is installed inside the semipermeable membrane fixing device, and a conveying mechanism connected to the interior of the semipermeable membrane fixing device is arranged under the mounting platform. The reagent driving structure is connected to the conveying mechanism through the flow control mechanism, and is used to input or discharge different reagents into or out of the interior of the semipermeable membrane fixing device. The replacement driving mechanism is connected to the mounting platform through the transmission mechanism, and is used to drive the mounting platform to flip forward so that the upper end of the semipermeable membrane fixing device tilts forward, or to drive the mounting platform to flip backward so that the semipermeable membrane fixing device is restored to a vertical state.

[0008] The replacement drive mechanism is a vertically arranged linear motor, and the transmission mechanism includes a base, a transmission plate and a connecting rod. The mounting platform is located at the front end of the base plate, and the base is located at the rear end of the base plate. The mounting platform is hinged to the base plate, and the rear end of the transmission plate is hinged to the base. A slide groove is provided on the lower surface of the middle part of the transmission plate. The upper end of the screw rod of the linear motor is connected to a transmission shaft, and the transmission shaft is installed in the slide groove. The upper end of the connecting rod is hinged to the front end of the transmission plate, and the lower end of the connecting rod is hinged to the rear end of the mounting platform.

[0009] Preferably, a downwardly extending sealing column is provided at the front end of the transmission plate, and when the semipermeable membrane fixing device is in a vertical state, the lower end of the sealing column is inserted into the upper end opening of the semipermeable membrane fixing device.

[0010] Preferably, the reagent driving structure is a peristaltic pump.

[0011] Preferably, the flow control mechanism includes a pinch valve and a sample loading handle, the sample loading handle is provided with a sample loading needle, the pinch valve is a two-position three-way valve, the three interfaces of the pinch valve are respectively connected to the inside of the semipermeable membrane fixing device, the reagent pack and the external environment, and the sample loading handle manually controls the working status of the peristaltic pump and the pinch valve.

[0012] Preferably, the peristaltic pump, the pinch valve and the sample adding handle are located on the same side of the linear motor, and the pinch valve and the sample adding handle are located in front of the peristaltic pump.

[0013] Preferably, a reagent pack is detachably mounted below the bottom plate, a puncture needle below the bottom plate is inserted into the reagent pack, and the flow control mechanism is connected to the reagent pack via the puncture needle.

[0014] Preferably, a movable buckle is provided under the bottom plate, and the movable buckle is engaged with the upper end of the reagent pack. The lower end of the screw rod of the linear motor can trigger the movable buckle to unlock, so as to pop out the reagent pack.

[0015] Preferably, a guide hook matching the slide at the upper end of the reagent pack is provided under the bottom plate.

[0016] The utility model provides a colloid osmotic pressure measuring instrument, comprising the semipermeable membrane replacement mechanism as described in any one of the above items.

[0017] The utility model provides a semipermeable membrane replacement mechanism, comprising a base plate and a mounting platform mounted above the base plate, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism. A semipermeable membrane fixing device is detachably mounted on the mounting platform, a semipermeable membrane is mounted inside the semipermeable membrane fixing device, a conveying mechanism communicating with the interior of the semipermeable membrane fixing device is arranged below the mounting platform, the reagent driving structure is connected to the conveying mechanism via the flow control mechanism, and is used for inputting or discharging different reagents into or out of the interior of the semipermeable membrane fixing device, and the replacement driving mechanism is connected to the mounting platform via the transmission mechanism.

[0018] When the semipermeable membrane needs to be replaced, the drive mechanism and the transmission mechanism are replaced to drive the installation platform to flip forward, and drive the upper end of the semipermeable membrane fixing device to tilt forward and extend out of the installation position to facilitate the removal of the old semipermeable membrane fixing device, and then install a new semipermeable membrane fixing device. The drive mechanism and the transmission mechanism are replaced to drive the installation platform to flip backward, and drive the upper end of the semipermeable membrane fixing device to flip backward. The semipermeable membrane fixing device returns to a vertical state and continues the corresponding work.

[0019] By replacing the driving mechanism and the transmission mechanism, the installation platform drives the semipermeable membrane fixing device to flip, which facilitates the replacement of the semipermeable membrane fixing device and then the replacement of the internal semipermeable membrane, simplifies the installation process, realizes automatic control, and improves work efficiency.

[0020] The present invention also provides a colloid osmotic pressure measuring instrument including the above-mentioned semipermeable membrane replacement mechanism. Since the above-mentioned semipermeable membrane replacement mechanism has the above-mentioned technical effects, the above-mentioned colloid osmotic pressure measuring instrument should also have the same technical effects, which will not be described in detail here. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a structural schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention;

[0022] Figure 2 A cross-sectional schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention;

[0023] Figure 3This is a bottom view schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention.

[0024] Among them, the base plate 1, the mounting platform 2, the semipermeable membrane fixing device 3, the linear motor 4, the base 5, the transmission plate 6, the connecting rod 7, the slide 8, the screw 9, the transmission shaft 10, the sealing column 11, the peristaltic pump 12, the clamping valve 13, the sample adding handle 14, the movable buckle 15, the puncture needle 16, and the guide hook 17. DETAILED DESCRIPTION

[0025] The core of this utility model is to provide a semipermeable membrane replacement mechanism. By replacing the drive mechanism and the transmission mechanism, the mounting platform drives the semipermeable membrane fixture to flip, facilitating the replacement of the semipermeable membrane fixture and, in turn, the internal semipermeable membrane. This simplifies the installation process, enables automated control, and improves work efficiency. Another core of this utility model is to provide a colloidal osmotic pressure measuring instrument including the aforementioned semipermeable membrane replacement mechanism.

[0026] In order to enable those skilled in the art to better understand the present invention, the present invention will be described in further detail below with reference to the accompanying drawings and specific implementation methods.

[0027] Please refer to Figures 1 to 3 , Figure 1 This is a structural schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention; Figure 2 A cross-sectional schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention; Figure 3 This is a bottom view schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention.

[0028] The specific embodiment of the present invention provides a semipermeable membrane replacement mechanism, comprising a horizontally arranged base plate 1 and a mounting platform 2 mounted above the base plate 1, a reagent drive structure, a flow control mechanism, a replacement drive mechanism, and a transmission mechanism, wherein a semipermeable membrane fixture 3 is detachably mounted on the mounting platform 2, and a semipermeable membrane is mounted inside the semipermeable membrane fixture 3, which is a key component for performing osmotic pressure testing. A conveying mechanism connected to the interior of the semipermeable membrane fixture 3 is provided below the mounting platform 2, for conveying reagents into the interior of the semipermeable membrane fixture 3, or for discharging reagents from the interior of the semipermeable membrane fixture 3. Furthermore, the reagent drive structure is connected to the conveying mechanism via a flow control mechanism, for inputting or discharging different reagents into or out of the interior of the semipermeable membrane fixture 3. The reagent drive structure provides power for the flow of the reagent, and the flow control mechanism controls the flow direction of the reagent, that is, the specific flow mode.

[0029] The replacement drive mechanism is connected to the installation platform 2 through the transmission mechanism. When the semipermeable membrane needs to be replaced, the replacement drive mechanism and the transmission mechanism drive the installation platform 2 to flip forward, and drive the upper end of the semipermeable membrane fixing device 3 to tilt forward and extend out of the installation position to facilitate the removal of the old semipermeable membrane fixing device 3, and then install the new semipermeable membrane fixing device 3. The replacement drive mechanism and the transmission mechanism drive the installation platform 2 to flip backward, and drive the upper end of the semipermeable membrane fixing device 3 to flip backward, and the semipermeable membrane fixing device 3 returns to a vertical state, and continues the corresponding work.

[0030] By replacing the driving mechanism and the transmission mechanism, the installation platform 2 drives the semipermeable membrane fixing device 3 to flip, which facilitates the replacement of the semipermeable membrane fixing device 3 and then the replacement of the internal semipermeable membrane, simplifies the installation process, realizes automatic control, and improves work efficiency.

[0031] Specifically, the replacement drive mechanism is a vertically arranged linear motor 4. The transmission mechanism includes a base 5, a transmission plate 6, and a connecting rod 7. The front and rear ends are defined according to the position of the mounting platform 2. The mounting platform 2 is located at the front end of the base plate 1, and the base 5 is located at the rear end of the base plate 1. The front end of the mounting platform 2 is hinged to the base plate 1, and the rear end of the transmission plate 6 is hinged to the base 5. A connecting structure is provided on the lower surface of the middle part of the transmission plate 6, and a slide groove 8 is provided on the connecting structure. The upper end of the screw rod 9 of the linear motor 4 is connected to the transmission shaft 10, and the transmission shaft 10 is installed in the slide groove 8. The upper end of the connecting rod 7 is hinged to the front end of the transmission plate 6, and the lower end of the connecting rod 7 is hinged to the rear end of the mounting platform 2. Among them, the extension direction of the slide groove 8 is parallel to the transmission plate 6. The connecting rod 7 is a bent part, and the lower end of the connecting rod 7 is bent forward.

[0032] When the semipermeable membrane inside the semipermeable membrane fixture 3 reaches service life, it is necessary to replace the semipermeable membrane.Now, linear motor 4 drives screw rod 9 to move upward, drives transmission shaft 10 to move upward, and when transmission shaft 10 slides in chute 8, pushes transmission plate 6 to move upward, and then drives connecting rod 7 to move upward, and when connecting rod 7 transmits power, mounting platform 2 and semipermeable membrane fixture 3 can realize flipping motion, swing forward, and will stop motion after being flipped to corresponding angle.Now, take out the semipermeable membrane fixture 3 that reaches service life, and replace with new semipermeable membrane fixture 3, now, semipermeable membrane fixture 3 flips back to original position and has just completed the replacement of semipermeable membrane fixture 3.When hearing the sound of ball plunger and the prompt of the touch switch below semipermeable membrane fixture 4 during the replacement process, then represent and complete replacement.

[0033] Preferably, a sealing column 11 extending downward is provided at the front end of the transmission plate 6. When the semipermeable membrane needs to be replaced, the replacement drive mechanism and the transmission mechanism drive the mounting platform 2 to flip forward, and drive the upper end of the semipermeable membrane fixing device 3 to tilt forward. At the same time, the front end of the mounting platform 2 drives the sealing column 11 to move upward, so that the sealing column 11 is separated from the upper end opening of the semipermeable membrane fixing device 3. When the replacement is completed, the replacement drive mechanism and the transmission mechanism drive the mounting platform 2 to flip backward, and drive the upper end of the semipermeable membrane fixing device 3 to flip backward. The semipermeable membrane fixing device 3 returns to a vertical state. At the same time, the front end of the mounting platform 2 drives the sealing column 11 to move downward, so that the sealing column 11 is inserted into the upper end opening of the semipermeable membrane fixing device 3, and the corresponding work continues.

[0034] In the semipermeable membrane replacement mechanism provided in this embodiment of the present invention, the reagent drive structure is a peristaltic pump 12. The peristaltic pump 12 comprises a stepper motor and a peristaltic pump head, and primarily injects the sample and cleaning fluid into the measurement chamber within the semipermeable membrane fixture 3. The peristaltic pump 12 has adjustable speed and high precision, offering advantages such as high accuracy and low cross-contamination.

[0035] Specifically, the flow control mechanism includes a pinch valve 13 and a sample loading handle 14. The sample loading handle 14 is equipped with a sample loading needle. The pinch valve 13 is a two-position, three-way valve. Its three interfaces connect to the interior of the semipermeable membrane fixture 3, the reagent pack, and the external environment, respectively. The sample loading handle 14 manually controls the operating states of the peristaltic pump 12 and the pinch valve 13. The pinch valve 13 functions as a two-position, three-way valve in conjunction with a Y-shaped connector. One of the pipes in the pinch valve 13 connects to the interior of the semipermeable membrane fixture 4, while the other two pipes connect to the puncture needle 16 and the air, respectively. When connected to the puncture needle 16, cleaning fluid can be aspirated from the reagent pack to clean the measurement chamber of the semipermeable membrane fixture 3. When connected to the air, the sample inside the sample loading needle can be aspirated into the measurement chamber of the semipermeable membrane fixture 4, achieving the sample loading function.

[0036] Preferably, the peristaltic pump 12, the pinch valve 13, and the sample addition handle 14 are located on the same side of the linear motor 4, and the pinch valve 13 and the sample addition handle 14 are located in front of the peristaltic pump 12. The installation position and connection method of each component can also be adjusted according to the situation, all within the scope of protection of the present invention.

[0037] Building on the semipermeable membrane replacement mechanisms provided in the aforementioned embodiments, a reagent pack is detachably mounted below the base plate 1. A puncture needle 16 located below the base plate 1 is inserted into the pack, and the flow control mechanism connects to the pack via the puncture needle 16. The puncture needle 16 is fixed below the base plate 1 and primarily punctures the sealing rubber stopper of the reagent pack. Once puncture is successful, it connects to the reagent bag within the pack, enabling cleaning of the measurement chamber of the semipermeable membrane fixture 4 and recovery of measurement waste liquid.

[0038] Preferably, a movable snap 15 is provided below the base plate 1. The movable snap 15 engages with the upper end of the reagent pack. The lower end of the screw rod 9 of the linear motor 4 can trigger the unlocking of the movable snap 15 to eject the reagent pack. The linear motor 4 is a through-type linear motor. The upper end of the linear motor 4 is connected to the transmission shaft 10. When the linear motor 4 moves upward, the screw rod 9 drives the transmission shaft 10 upward. When the linear motor 4 moves downward, the lower end of the screw rod 9 contacts the spring rod of the movable snap 15. The corresponding snap of the reagent pack is linked with the spring rod and lifted, thereby ejecting the reagent pack. The snap torsion spring engages with the snap through the snap rotating shaft, pressing the snap downward to secure the reagent pack. A guide hook 17 is provided below the base plate 1 to match the slideway at the upper end of the reagent pack. This guide hook 17 is provided to guide the reagent pack during replacement and prevent positional displacement during replacement.

[0039] When replacing the reagent pack, align the QR code on the reagent pack with the barcode scanner on the colloid osmotic pressure measuring instrument, input the information of the new reagent pack into the colloid osmotic pressure measuring instrument, and then the new reagent pack can be installed in the colloid osmotic pressure measuring instrument. Place the reagent pack at the corresponding position inside the colloid osmotic pressure measuring instrument and push the reagent pack into the colloid osmotic pressure measuring instrument with force. At this time, the linear motor 4 moves upward, and the movable buckle 15 applies downward pressure under the action of the buckle torsion spring to lock the reagent pack, thereby completing the fixation of the reagent pack.

[0040] When it is time to add a sample, the sample handling handle 14 is lifted. The peristaltic pump 12 provides power to complete the sample aspiration, with the sample now present in the sample needle and tubing. When the sample handling handle 14 is lowered, the pinch valve 13 is connected to the air, allowing the sample in the sample needle and tubing to be injected into the measurement chamber within the semipermeable membrane fixture 3. After the measurement is completed, the pinch valve 13 is switched to connect to the reagent bag within the reagent pack, allowing the measurement chamber within the semipermeable membrane fixture 3 to be cleaned. After the cleaning is completed, the waste liquid in the measurement chamber of the semipermeable membrane fixture 3 is injected into the vacuum reagent belt within the reagent pack to complete the waste liquid recovery.

[0041] Through the above method, automatic sample addition and cleaning are achieved, ensuring accurate sample addition amount and improving control accuracy.

[0042] In addition to the above-mentioned semipermeable membrane replacement mechanism, the specific embodiment of the present invention also provides a colloid osmotic pressure measuring instrument including the above-mentioned semipermeable membrane replacement mechanism. For the structures of other parts of the colloid osmotic pressure measuring instrument, please refer to the prior art and will not be described in detail herein.

[0043] The above is a detailed introduction to the semipermeable membrane replacement mechanism and colloid osmotic pressure measuring instrument provided by the present invention. Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only intended to help understand the method and core concept of the present invention. It should be pointed out that for ordinary technicians in this technical field, without departing from the principles of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.

Claims

1. A semipermeable membrane replacement mechanism, characterized in that: The invention comprises a base plate (1) and a mounting platform (2) mounted above the base plate (1), a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism, wherein a semipermeable membrane fixing device (3) is detachably mounted on the mounting platform (2), a semipermeable membrane is mounted inside the semipermeable membrane fixing device (3), a conveying mechanism communicating with the interior of the semipermeable membrane fixing device (3) is provided below the mounting platform (2), the reagent driving structure is connected to the conveying mechanism via the flow control mechanism, and is used to input or discharge different reagents into or out of the interior of the semipermeable membrane fixing device (3), the replacement driving mechanism is connected to the mounting platform (2) via the transmission mechanism, and is used to drive the mounting platform (2) to flip forward so that the upper end of the semipermeable membrane fixing device (3) tilts forward, or to drive the mounting platform (2) to flip backward so that the semipermeable membrane fixing device (3) returns to a vertical state.

2. The semipermeable membrane replacement mechanism according to claim 1, characterized in that: The replacement drive mechanism is a vertically arranged linear motor (4), and the transmission mechanism includes a base (5), a transmission plate (6) and a connecting rod (7). The mounting platform (2) is located at the front end of the base plate (1), and the base (5) is located at the rear end of the base plate (1). The mounting platform (2) is hinged to the base plate (1), and the rear end of the transmission plate (6) is hinged to the base (5). A slide groove (8) is provided on the lower surface of the middle part of the transmission plate (6). The upper end of the lead screw (9) of the linear motor (4) is connected to a transmission shaft (10), and the transmission shaft (10) is installed in the slide groove (8). The upper end of the connecting rod (7) is hinged to the front end of the transmission plate (6), and the lower end of the connecting rod (7) is hinged to the rear end of the mounting platform (2).

3. The semipermeable membrane replacement mechanism according to claim 2, characterized in that: A downwardly extending sealing column (11) is provided at the front end of the transmission plate (6); when the semipermeable membrane fixing device (3) is in a vertical state, the lower end of the sealing column (11) is inserted into the upper end opening of the semipermeable membrane fixing device (3).

4. The semipermeable membrane replacement mechanism according to claim 2, characterized in that: The reagent driving structure is a peristaltic pump (12).

5. The semipermeable membrane replacement mechanism according to claim 4, characterized in that: The flow control mechanism includes a pinch valve (13) and a sample addition handle (14). The sample addition handle (14) is provided with a sample addition needle. The pinch valve (13) is a two-position three-way valve. The three interfaces of the pinch valve (13) are respectively connected to the interior of the semipermeable membrane fixing device (3), the reagent pack and the external environment. The sample addition handle (14) manually controls the working states of the peristaltic pump (12) and the pinch valve (13).

6. The semipermeable membrane replacement mechanism according to claim 5, characterized in that: The peristaltic pump (12), the pinch valve (13) and the sample adding handle (14) are located on the same side of the linear motor (4), and the pinch valve (13) and the sample adding handle (14) are located in front of the peristaltic pump (12).

7. The semipermeable membrane replacement mechanism according to any one of claims 2 to 6, characterized in that: A reagent pack is detachably mounted below the base plate (1), a puncture needle (16) below the base plate (1) is inserted into the reagent pack, and the flow control mechanism is connected to the reagent pack via the puncture needle (16).

8. The semipermeable membrane replacement mechanism according to claim 7, characterized in that: A movable buckle (15) is provided below the base plate (1), and the movable buckle (15) is engaged with the upper end of the reagent pack. The lower end of the screw rod (9) of the linear motor (4) can trigger the movable buckle (15) to unlock, so as to eject the reagent pack.

9. The semipermeable membrane replacement mechanism according to claim 8, characterized in that: A guide hook (17) is provided below the bottom plate (1) and matches the slideway at the upper end of the reagent pack.

10. A colloid osmotic pressure measuring instrument, characterized in that: It comprises the semipermeable membrane replacement mechanism according to any one of claims 1 to 9.

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