Miniature extracorporeal membrane lung oxygenation device

Abstract

The utility model provides a miniature extracorporeal membrane lung oxygenation device which comprises a circulating pump, an oxygenator and a heat preservation device which are respectively arranged on a base, a liquid medium to be tested is filled in the heat preservation device, the liquid medium to be tested is kept at a constant temperature through the heat preservation device, and an outlet end of the heat preservation device is communicated to an inlet end of the oxygenator through a first pipeline. The outlet end of the oxygenator is communicated to the inlet end of the heat preservation device through a second pipeline, a circulating pump is installed on the first pipeline, an oxygen passing hole is formed in the middle of the oxygenator, an air inlet pipe is installed in the oxygen passing hole, and the air inlet pipe is connected to air supply equipment. According to the miniature extracorporeal membrane oxygenation device, blood to be tested is subjected to heat preservation through the heat preservation device, then blood circulation of a human body is simulated in vitro through the circulating pump, important data support is provided for research and development of an ECMO oxygenator, meanwhile, the research and development progress of an ECMO overall sleeve bag can be greatly accelerated, the test cost is reduced, and the test efficiency is improved. The test efficiency is improved.

Description

Technical Field

[0001] The utility model belongs to the field of membrane lung oxygenation, in particular to a miniature extracorporeal membrane oxygenation device. Background Art

[0002] ECMO mainly includes intravascular cannulae, connecting tubes, a power pump (artificial heart), an oxygenator (artificial lung), an oxygen supply tube, and a monitoring system. The oxygenator (artificial lung) oxygenates the input blood and outputs oxygenated arterial blood. Hollow fiber membrane oxygenators, currently the most commonly used form of extracorporeal oxygenator, are characterized by easy exhaust, high gas flux, and strong oxygenation capacity. During the production, development, and optimization of oxygenators, it is necessary to conduct extracorporeal circulation simulation experiments on oxygenators with different parameters and specifications. The performance indicators of the oxygenators are then evaluated by testing the parameters of blood samples in the simulation experiments. Existing membrane oxygenation systems are relatively complex, inconvenient to operate, and have high equipment costs. Utility Model Content

[0003] In view of this, the present invention aims to provide a miniature extracorporeal membrane oxygenation device to solve the problems of the existing membrane oxygenation test system being relatively complex, inconvenient to operate, and high equipment cost.

[0004] In order to achieve the above-mentioned purpose, the technical solution of the utility model is achieved as follows:

[0005] A miniature extracorporeal membrane oxygenation device comprises a circulating pump, an oxygenator and an insulator respectively arranged on a base; the insulator is filled with a liquid medium to be tested, and the liquid medium to be tested is kept at a constant temperature by the insulator; the outlet end of the insulator is connected to the inlet end of the oxygenator through a first pipe, and the outlet end of the oxygenator is connected to the inlet end of the insulator through a second pipe; the circulating pump is installed on the first pipe; an oxygenation hole is provided in the middle of the oxygenator, an air inlet pipe is installed in the oxygenation hole, and the air inlet pipe is connected to an air supply device.

[0006] Furthermore, the insulator includes an inner shell and an outer shell arranged in sequence from the inside to the outside, the upper end of the inner shell and the upper end of the outer shell are respectively fixedly connected to the lower end of the upper cover, and the lower end of the inner shell and the lower end of the outer shell are respectively fixedly connected to the upper end of the lower cover, and an insulation cavity is provided between the outer periphery of the inner shell, the inner ring of the outer shell, the lower end of the upper cover and the upper end of the upper cover, an insulation medium is provided in the insulation cavity, and the liquid medium to be tested is filled in the inner shell, a first through hole is provided on the upper cover, one end of the second pipe is installed in the first through hole, a second through hole is provided on the lower cover, and one end of the first pipe is installed in the second through hole.

[0007] Furthermore, a controller is provided on the base, and a heat exchanger is provided in the controller, a water outlet pipe and a water inlet pipe are respectively provided on the outer shell, and the water outlet pipe and the water inlet pipe are respectively connected to the insulation cavity, the water outlet pipe and the water inlet pipe are respectively connected to the heat exchanger, the insulation cavity is filled with water, the water circulates between the heat exchanger and the insulation cavity through the water outlet pipe and the water inlet pipe, and the heat exchanger maintains a constant temperature of the insulation cavity and the inner shell through the water.

[0008] Furthermore, a water tank is provided on one side of the heat exchanger, and the water tank is made of transparent material. The water in the water tank can enter the insulation cavity through the heat exchanger and the water inlet pipe, and the water in the insulation cavity can enter the water tank through the water outlet pipe.

[0009] Furthermore, an injection tube and an adapter tube are respectively provided at the upper end of the upper cover. The injection tube is used to fill the liquid medium to be tested into the inner shell. A temperature sensor is installed in the adapter tube. The temperature sensor is used to detect the temperature of the liquid medium to be tested and transmit the signal to the controller.

[0010] Furthermore, a clamp is provided on the periphery of the heat insulator, and the clamp is detachably connected to the first support rod, and the lower end of the first support rod is mounted to the upper end of the base.

[0011] Furthermore, the periphery of the oxygenator is detachably mounted on a splint, a sliding hole is provided on the splint, the periphery of the second support rod is slidably connected to the sliding hole, and the second support rod is mounted to the upper end of the base.

[0012] Furthermore, the gas supply device is connected to the inlet end of the oxygenator through an air pipe, and a regulating valve is provided on the air pipe.

[0013] Compared with the existing technology, the miniature extracorporeal membrane oxygenation device described in the present invention has the following beneficial effects: the miniature device insulates the test blood through an insulator, and then simulates human blood circulation in vitro through a circulating pump, and tests the performance of the oxygenator, a key component of the ECMO overall package in vitro, focusing on the oxygen-carbon dioxide exchange performance of the hollow fiber oxygenation membrane in the oxygenator. Through this miniaturized device, oxygenator materials with good blood compatibility and excellent gas exchange performance can be quickly screened, providing important data support for the research and development of ECMO oxygenators. At the same time, it can greatly accelerate the research and development progress of the overall ECMO package, reduce testing costs, and improve testing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The accompanying drawings, which constitute part of the present invention, are intended to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are intended to explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0015] Figure 1 This is a schematic structural diagram of a miniature extracorporeal membrane oxygenation device according to an embodiment of the present utility model;

[0016] Figure 2 This is a schematic structural diagram of the oxygenator and the second support rod according to an embodiment of the present invention;

[0017] Figure 3 This is a schematic structural diagram of the assembly of the heat retainer and the first support rod according to an embodiment of the present utility model;

[0018] Figure 4 This is a cross-sectional schematic diagram of the heat retainer described in an embodiment of the present utility model.

[0019] Description of reference numerals:

[0020] 1-base; 2-controller; 3-circulating pump; 4-water tank; 5-oxygenator; 51-regulating valve; 6-insulator; 61-inner shell; 62-outer shell; 63-insulation chamber; 64-upper cover; 65-lower cover; 66-injection pipe; 67-adapter pipe; 7-first support rod; 71-clamp; 8-second support rod; 81-splint. DETAILED DESCRIPTION

[0021] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features therein can be combined with each other.

[0022] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, features defined as "first", "second", etc. may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, "multiple" means two or more.

[0023] In the description of this utility model, it should be noted that, unless otherwise expressly specified or limited, the terms "installed," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; mechanical connections, electrical connections; direct connections, indirect connections through an intermediate medium, and internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in this utility model based on specific circumstances.

[0024] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0025] like Figures 1-4 As shown, a miniature extracorporeal membrane oxygenation device includes a circulating pump 3, an oxygenator 5 and an insulator 6 respectively arranged on a base 1. The insulator 6 is filled with a liquid medium to be tested, and the liquid medium to be tested is kept at a constant temperature by the insulator 6. In this embodiment, the liquid medium to be tested is blood. The outlet end of the insulator 6 is connected to the inlet end of the oxygenator 5 through a first pipe, and the outlet end of the oxygenator 5 is connected to the inlet end of the insulator 6 through a second pipe. The circulating pump 3 is installed on the first pipe. An oxygenation hole is provided in the middle of the oxygenator 5. An air inlet pipe is installed in the oxygenation hole. The air inlet pipe is connected to the air supply equipment. The miniaturized device uses an insulator 6 to keep the test blood warm, and then simulates human blood circulation in vitro through a circulation pump 3 to test the performance of the oxygenator 5, a key component of the ECMO overall package, in vitro, with a focus on the oxygen-carbon dioxide exchange performance of the hollow fiber oxygenation membrane in the oxygenator 5. Through this micro-device, oxygenator 5 materials with good blood compatibility and excellent gas exchange performance can be quickly screened, providing important data support for the research and development of the ECMO oxygenator 5. At the same time, it can greatly accelerate the research and development progress of the overall ECMO package, reduce testing costs, and improve testing efficiency.

[0026] The insulator 6 includes an inner shell 61 and an outer shell 62 arranged in sequence from the inside to the outside. The upper end of the inner shell 61 and the upper end of the outer shell 62 are respectively fixedly connected to the lower end of the upper cover 64, and the lower end of the inner shell 61 and the lower end of the outer shell 62 are respectively fixedly connected to the upper end of the lower cover 65. A heat preservation chamber 63 is provided between the outer periphery of the inner shell 61, the inner circle of the outer shell 62, the lower end of the upper cover 64 and the upper end of the upper cover 64. A heat preservation medium is provided in the heat preservation chamber 63, the inner shell 61 is filled with the test liquid medium, and the upper cover 64 is provided with a There is a first through hole, one end of the second pipe is installed in the first through hole, a second through hole is provided on the lower cover 65, one end of the first pipe is installed in the second through hole, the outer shell 62 and the inner shell 61 of this embodiment are made of glass, and the outer shell 62, the inner shell 61, the water outlet pipe, the water inlet pipe, and the lower cover 65 are an integrated structure, the upper cover 64 can be detachably installed to the inner ring of the outer shell 62, and the lower end of the upper cover 64 abuts against the upper end of the inner shell 61 to facilitate cleaning of the inner shell 61 and the outer shell 62.

[0027] A controller 2 is also provided on the base 1, and a heat exchanger is provided in the controller 2. A water outlet pipe and a water inlet pipe are respectively provided on the outer shell 62, and the water outlet pipe and the water inlet pipe are respectively connected to the insulation chamber 63, and the water outlet pipe and the water inlet pipe are respectively connected to the heat exchanger. The insulation chamber 63 is filled with water, and the water circulates between the heat exchanger and the insulation chamber 63 through the water outlet pipe and the water inlet pipe. The heat exchanger maintains a constant temperature of the insulation chamber 63 and the inner shell 61 through the water. The heat exchanger is a prior art, and the control method of this embodiment is controlled by the controller 2. The control circuit of the controller 2 can be realized by simple programming by technicians in this field. The provision of power is also common knowledge in this field, and this article is mainly used to protect mechanical devices. This article does not explain the control method and circuit connection in detail.

[0028] A water tank 4 is provided on one side of the heat exchanger, and the water tank 4 is made of transparent material. The water in the water tank 4 can enter the insulation chamber 63 through the heat exchanger and the water inlet pipe, and the water in the insulation chamber 63 can enter the water tank 4 through the water outlet pipe. An injection pipe 66 and an adapter pipe 67 are respectively provided at the upper end of the upper cover 64. The injection pipe 66 is used to fill the liquid medium to be tested into the inner shell 61. A temperature sensor is installed in the adapter pipe 67. The temperature sensor is an existing technology. The temperature sensor is used to detect the temperature of the liquid medium to be tested and transmit the signal to the controller 2. The detection probe of the temperature sensor is located in the inner shell 61 but does not contact the liquid medium to be tested or is located in the insulation chamber 63 and probes into the water body.

[0029] A clamp 71 is provided on the periphery of the warmer 6, and the clamp 71 is detachably connected to the first support rod 7. The lower end of the first support rod 7 is mounted to the upper end of the base 1. The periphery of the oxygenator is detachably mounted on the splint 81. The splint 81 is provided with a sliding hole. The periphery of the second support rod 8 is slidably connected to the sliding hole, and the second support rod 8 is mounted to the upper end of the base 1. The first support rod 7 and the second support rod 8 are respectively detachably mounted on the base 1 to facilitate disassembly and assembly of the equipment. At the same time, the gas supply equipment is connected to the inlet end of the oxygenator 5 through the air pipe, and a regulating valve 51 is provided on the air pipe. The regulating valve 51 is used to control the rate of gas supply to the oxygenator 5, and the gas supply described in this embodiment is oxygen.

[0030] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A miniature extracorporeal membrane oxygenation device, characterized in that: The invention comprises a circulating pump (3), an oxygenator (5) and a warmer (6) respectively arranged on a base (1); a liquid medium to be tested is filled in the warmer (6); the liquid medium to be tested is kept at a constant temperature by the warmer (6); the outlet end of the warmer (6) is connected to the inlet end of the oxygenator (5) through a first pipe; the outlet end of the oxygenator (5) is connected to the inlet end of the warmer (6) through a second pipe; the circulating pump (3) is installed on the first pipe; an oxygenation hole is provided in the middle of the oxygenator (5); an air inlet pipe is installed in the oxygenation hole; and the air inlet pipe is connected to the air supply equipment; The heat insulator (6) comprises an inner shell (61) and an outer shell (62) which are sequentially arranged from the inside to the outside. The upper end of the inner shell (61) and the upper end of the outer shell (62) are respectively fixedly connected to the lower end of the upper cover (64). The lower end of the inner shell (61) and the lower end of the outer shell (62) are respectively fixedly connected to the upper end of the lower cover (65). A heat preservation cavity (63) is provided between the outer periphery of the inner shell (61), the inner ring of the outer shell (62), the lower end of the upper cover (64) and the upper end of the upper cover (64). A heat preservation medium is provided in the heat preservation cavity (63). The inner shell (61) is filled with a liquid medium to be tested. The upper cover (64) is provided with a first through hole. One end of the second pipe is installed in the first through hole. The lower cover (65) is provided with a second through hole. One end of the first pipe is installed in the second through hole.

2. A miniature extracorporeal membrane oxygenation device according to claim 1, characterized in that: A controller (2) is also provided on the base (1), and a heat exchanger is provided in the controller (2). A water outlet pipe and a water inlet pipe are respectively provided on the outer shell (62), and the water outlet pipe and the water inlet pipe are respectively connected to the heat exchanger. The heat preservation chamber (63) is filled with water, and the water circulates between the heat exchanger and the heat preservation chamber (63) through the water outlet pipe and the water inlet pipe. The heat exchanger maintains a constant temperature of the heat preservation chamber (63) and the inner shell (61) through the water.

3. The miniature extracorporeal membrane oxygenation device according to claim 2, characterized in that: A water tank (4) is provided on one side of the heat exchanger, and the water tank (4) is made of a transparent material. Water in the water tank (4) can enter the heat preservation chamber (63) through the heat exchanger and the water inlet pipe, and water in the heat preservation chamber (63) can enter the water tank (4) through the water outlet pipe.

4. The miniature extracorporeal membrane oxygenation device according to claim 1, characterized in that: A liquid injection pipe (66) and an adapter pipe (67) are respectively provided at the upper end of the upper cover (64). The liquid injection pipe (66) is used to fill the liquid medium to be tested into the inner shell (61). A temperature sensor is installed in the adapter pipe (67). The temperature sensor is used to detect the temperature of the liquid medium to be tested and transmit the signal to the controller (2).

5. The miniature extracorporeal membrane oxygenation device according to claim 1, characterized in that: A hoop (71) is provided on the periphery of the heat insulator (6), and the hoop (71) is detachably connected to the first support rod (7), and the lower end of the first support rod (7) is mounted on the upper end of the base (1).

6. The miniature extracorporeal membrane oxygenation device according to claim 1, characterized in that: The outer periphery of the oxygenator is detachably mounted on the splint (81), and a sliding hole is provided on the splint (81). The outer periphery of the second support rod (8) is slidably connected to the sliding hole, and the second support rod (8) is mounted on the upper end of the base (1).

7. The miniature extracorporeal membrane oxygenation device according to claim 1, characterized in that: The gas supply device is connected to the inlet end of the oxygenator (5) through an air pipe, and a regulating valve (51) is provided on the air pipe.

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