Experimental mouse fixing device

Abstract

The utility model belongs to the field of animal experiments, and particularly relates to an experimental mouse fixing device which comprises a weighing scale, a frame and an adjusting mechanism. Wherein the frame is arranged on the weighing scale, the frame is provided with a transversely-arranged grabbing rod, the top of the frame is provided with a top cover, the top cover is provided with an opening, the grabbing rod is located below the opening, and at least one face of the frame is provided with a plate body; the adjusting mechanism is used for adjusting the size of the opening, the front claw of the mouse grabs the grabbing rod, the head of the mouse is led out from the opening, then the linear reciprocating adjusting piece is operated to drive the four movable plates to enable the area of the surrounding area to be gradually reduced until the head of the mouse is controlled, then the tail of the mouse is led out from the through hole of the plate body, and the weight information of the mouse can be obtained through the weight scale. An operator only needs to slightly pull the scalp of a mouse to carry out gavage and carry out caudal vein injection operation, so that the experimental animal does not need to be fixed and loosened for multiple times, then gavage, weight measurement and caudal vein injection operation can be continuously carried out, and the operation process is greatly simplified.

Description

Technical Field

[0001] The utility model belongs to the field of animal experiments, and in particular relates to a rodent fixing device for experiments. Background Art

[0002] Mice play a vital role in animal experiments. Regular gavage, weight measurement, and tail vein injections are required during these procedures, all of which require the animals to be restrained. Currently, these procedures are performed using different restraint devices, requiring multiple restraint and release procedures, making the process cumbersome. Utility Model Content

[0003] The technical problem to be solved by the utility model is to provide a rodent fixing device for experiments, which can continuously perform gavage, body weight measurement and tail vein injection operations, thereby greatly simplifying the operation process.

[0004] The utility model provides a rodent fixing device for experiments, comprising:

[0005] scales;

[0006] A frame is provided on the scale, the frame is provided with a horizontal gripping rod, the top of the frame is provided with a top cover, the top cover is provided with an opening, the gripping rod is located below the opening, and at least one side of the frame is provided with a plate body, the plate body is provided with a through hole for leading out the rat tail; and

[0007] An adjustment mechanism is used to adjust the size of the opening. The adjustment mechanism includes four movable plates hinged at the head and tail and a linear reciprocating adjustment member. The four movable plates form an enclosing structure. One of the four hinge axes of the four movable plates is fixed. The linear reciprocating adjustment member is arranged at a position opposite to the fixed hinge axis and is used to adjust the enclosed area of ​​the enclosed structure to achieve fixation of the mouse's head.

[0008] Optionally, the top cover is provided with two symmetrical guide grooves located on both sides of the opening, and two of the four hinge shafts of the four movable panels that are adjacent to the fixed hinge shaft are slidably disposed in the two guide grooves respectively.

[0009] Optionally, the inner side of the movable plate is a curved surface.

[0010] Optionally, the linear reciprocating adjustment member includes a gear disposed on the top plate for damping rotation and a rack having one end connected to the end of the movable plate, the rack being embedded and slidably connected to the top plate, and the rack being meshed with the gear.

[0011] Optionally, a hand-held portion is provided at the end of the rack.

[0012] Optionally, the linear reciprocating adjustment member includes an internal threaded sleeve fixed to the top cover and a screw rod with one end rotatably connected to the end of the movable plate, and the screw rod is threadedly connected to the internal threaded sleeve.

[0013] Optionally, the weight scale is provided with a switch, a display screen and a zero-setting and tare key.

[0014] Optionally, the frame has a rectangular parallelepiped structure.

[0015] Optionally, the gripping rod is cylindrical in shape and has anti-slip patterns on its surface.

[0016] Optionally, the support rods constituting the frame are composed of fixed rods, movable rods and limiting fasteners, the limiting fasteners are screws, pins or clamps, and the movable rods are adjusted up and down along the fixed rods and are locked and fixed by the limiting fasteners.

[0017] The beneficial effect of the present invention is that a mouse is placed in the frame so that its front paws grasp the grasping rod and its head is led out from the opening. Under the instinctive reaction of the animal to protect itself, it will firmly grasp the grasping rod, and then the linear reciprocating adjustment member is operated to drive the four movable plates to gradually reduce the area of ​​the enclosed area until the head of the mouse is controlled. Then, the mouse's tail is led out from the through hole of the plate body. The mouse's weight information can be obtained by a weight scale. The operator only needs to gently pull the mouse's scalp to perform gavage and tail vein injection operations, so there is no need to fix and release the experimental animal multiple times, and gavage, weight measurement and tail vein injection operations can be performed continuously, which greatly simplifies the operation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a schematic diagram of the structure of the experimental rodent fixation device of the present invention;

[0019] Figure 2 This is a top view of the experimental rodent fixation device of the utility model;

[0020] Figure 3 This is a structural diagram of the support rods that make up the frame of the utility model.

[0021] In the figure: 110, weight scale; 111, switch; 112, display screen; 113, zero-set and tare key; 210, frame; 211, fixed rod; 212, movable rod; 213, limit fastener; 220, grip rod; 230, top cover; 231, opening; 232, guide groove; 240, plate; 241, through hole; 310, movable plate; 311, hinge shaft; 320, linear reciprocating adjustment member; 321, gear; 322, rack; 323, hand-held part. DETAILED DESCRIPTION

[0022] like Figure 1 and Figure 2As shown, the present invention provides an experimental mouse fixation device, comprising: a weight scale 110, a frame 210 and an adjustment mechanism; wherein the frame 210 is arranged on the weight scale 110, and a horizontal gripping rod 220 is provided on the frame 210, a top cover 230 is provided on the top of the frame 210, an opening 231 is provided on the top cover 230, and the gripping rod 220 is located below the opening 231, and a plate body 240 is provided on at least one side of the frame 210, and a through hole 241 for leading out the mouse tail is opened on the plate body 240; the adjustment mechanism is used to adjust the size of the opening 231, and the adjustment mechanism includes four movable plates 310 hinged at the head and tail and a linear reciprocating adjustment member 320, the four movable plates 310 forming an enclosing structure, one of the four hinge shafts 311 of the four movable plates 310 being fixed, and the linear reciprocating adjustment member 320 is provided at a position opposite to the fixed hinge shaft 311, and is used to adjust the area of ​​the enclosed area of ​​the enclosed structure to achieve fixation of the mouse's head.

[0023] Compared with the prior art, the experimental rodent fixation device provided by the present invention places the rodent in the frame 210 so that its front paws grasp the gripping rod 220 and its head is led out from the opening 231. Under the animal's instinctive reaction of self-protection, it will firmly grasp the gripping rod 220, and then operate the linear reciprocating adjustment member 320 to drive the four movable plates 310 to gradually reduce the area of ​​the enclosed area until the rodent's head is controlled. Then, the rodent's tail is led out from the through hole 241 of the plate body 240. The rodent's weight information can be obtained by the weight scale 110. The operator only needs to gently pull the rodent's scalp to perform gavage and tail vein injection operations, so there is no need to fix and release the experimental animal multiple times. Gavage, weight measurement and tail vein injection operations can be performed continuously, greatly simplifying the operation process.

[0024] In one embodiment, the top cover 230 is provided with two symmetrical guide slots 232 located on both sides of the opening 231 , and two of the four hinge shafts 311 of the four movable panels 310 adjacent to the fixed hinge shaft 311 are slidably disposed in the two guide slots 232 .

[0025] Specifically, see Figure 1 During the operation of the linear reciprocating adjustment member 320, when the hinge shaft 311 at the position opposite to the fixed hinge shaft 311 moves to the left, the four movable plates 310 move symmetrically in pairs, so that the area of ​​the enclosed area gradually decreases, thereby fixing the mouse's head; when the hinge shaft 311 at the position opposite to the fixed hinge shaft 311 moves to the right, the area of ​​the enclosed area gradually increases, thereby releasing the fixation of the mouse's head. It can be seen that the two guide grooves 232 play a role in stabilizing the moving direction of the four movable plates 310.

[0026] Further, Figure 1The movement trajectories of the two hinge shafts 311 at the upper and lower positions are arc-shaped, so the guide grooves 232 are correspondingly arc-shaped. Of course, the guide grooves 232 can also be linear. It should be noted that the width of the guide grooves 232 is greater than the diameter of the hinge shafts 311 to allow the hinge shafts 311 to have sufficient free movement space.

[0027] In one embodiment, the inner side of the movable plate 310 is an arc-shaped surface, so that it can fit the neck of the mouse and ensure fixation stability.

[0028] In one embodiment, see Figure 2 The linear reciprocating adjustment member 320 includes a gear 321 that is provided on the top plate for damping rotation and a rack 322 with one end connected to the end of the movable plate 310. The rack 322 is embedded and slidably connected to the top plate, and the rack 322 is meshed with the gear 321. Specifically, when in use, the rack 322 is pulled to the left to drive the gear 321 to rotate. Accordingly, the four movable plates 310 move symmetrically in pairs, so that the area of ​​the enclosed area gradually shrinks. The mouse's head is fixed, and the rack 322 is released. The rotation damping force of the gear 321 is sufficient to keep the rack 322 stationary. After the experimental operation is completed, the rack 322 is pushed to the right. Compared with the general screw linear adjustment mechanism, the method of directly pulling the rack 322 is faster and more convenient. In order to facilitate the operation of pulling the rack 322, a handle 323 is provided at the end of the rack 322.

[0029] In another embodiment, the linear reciprocating adjustment member 320 includes an internally threaded sleeve fixed to the top cover 230 and a screw with one end fixedly connected to the end of the movable plate 310. The screw is threadedly connected to the internally threaded sleeve. By rotating the screw and engaging the internally threaded sleeve, the screw moves linearly to adjust the four movable plates 310.

[0030] In one embodiment, the weight scale 110 is provided with a switch 111 , a display screen 112 and a zero-set / tare key 113 , and the switches are arranged on the same side.

[0031] In one embodiment, the frame 210 is in the shape of a rectangular parallelepiped. Preferably, the frame 210 has a length of 15.00 cm, a width of 10.00 cm, and a height of 13.00 cm to 25.00 cm.

[0032] In one embodiment, the gripping rod 220 is cylindrical in shape and has anti-slip grooves on its surface. Preferably, the gripping rod 220 has a diameter of 0.5 cm and a length of 8.00 cm. The anti-slip grooves are composed of multiple annular protrusions or annular grooves distributed along the gripping rod 220. In another embodiment, the anti-slip grooves are spiral protrusions or spiral grooves along the gripping rod 220.

[0033] In one embodiment, the through hole 241 is a semicircular hole or a circular hole. Furthermore, the radius of the through hole 241 is 1-3 cm.

[0034] In one embodiment, see Figure 3 The height of the frame 210 can be adjusted, that is, the support rods that make up the frame 210 are composed of a fixed rod 211, a movable rod 212 and a limiting fastener 213. The limiting fastener 213 is a screw, a pin or a clamp. The movable rod 212 is adjusted up and down along the fixed rod 211 and is locked and fixed by the limiting fastener 213, so that the distance from the grasping rod 220 to the opening 231 can adapt to experimental animals of different body lengths.

[0035] Those skilled in the art should understand that the discussion of any of the above embodiments is merely illustrative and is not intended to imply that the scope of protection of the present application is limited to these examples. In line with the present application, the technical features in the above embodiments or different embodiments may be combined, the steps may be implemented in any order, and there are many other variations of different aspects of one or more embodiments of the present application as described above, which are not provided in detail for the sake of simplicity.

[0036] The one or more embodiments of this application are intended to encompass all such substitutions, modifications, and variations that fall within the broad scope of this application. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of one or more embodiments of this application should be included in the scope of protection of this application.

Claims

1. A rodent fixing device for an experiment, characterized in that: include: Scales (110); A frame (210) is provided on the weight scale (110), a horizontal gripping rod (220) is provided on the frame (210), a top cover (230) is provided on the top of the frame (210), an opening (231) is provided on the top cover (230), the gripping rod (220) is located below the opening (231), and a plate (240) is provided on at least one side of the frame (210), and a through hole (241) for leading out the rat tail is provided on the plate (240); and An adjusting mechanism is provided for adjusting the size of the opening (231), the adjusting mechanism comprising four movable plates (310) hinged at their ends and a linear reciprocating adjusting member (320), the four movable plates (310) forming an enclosing structure, one of the four hinge shafts (311) of the four movable plates (310) being fixed, the linear reciprocating adjusting member (320) being provided at a position opposite to the fixed hinge shaft (311) and being used for adjusting the enclosed area of ​​the enclosed structure to achieve fixation of the rodent's head.

2. The experimental rodent fixing device according to claim 1, characterized in that: The top cover (230) is provided with two symmetrical guide grooves (232) located on both sides of the opening (231), and two of the four hinge shafts (311) of the four movable plates (310) adjacent to the fixed hinge shaft (311) are slidably disposed in the two guide grooves (232).

3. The experimental rodent fixing device according to claim 1, characterized in that: The inner side of the movable plate (310) is a curved surface.

4. The experimental rodent fixing device according to claim 1, characterized in that: The linear reciprocating adjustment member (320) comprises a gear (321) provided on the top plate for damping rotation and a rack (322) connected at one end to the end of the movable plate (310); the rack (322) is embedded and slidably connected to the top plate, and the rack (322) is meshed with the gear (321).

5. The experimental rodent fixing device according to claim 4, characterized in that: A hand-held portion (323) is provided at the end of the rack (322).

6. The experimental rodent fixing device according to claim 1, characterized in that: The linear reciprocating adjustment member (320) comprises an internal threaded sleeve fixed to the top cover (230) and a screw rod with one end rotatably connected to the end of the movable plate (310), wherein the screw rod is threadedly connected to the internal threaded sleeve.

7. The experimental rodent fixing device according to any one of claims 1 to 6, characterized in that: The weight scale (110) is provided with a switch (111), a display screen (112) and a zero setting and tare key (113).

8. The experimental rodent fixing device according to any one of claims 1 to 6, characterized in that: The frame (210) has a rectangular parallelepiped structure.

9. The experimental rodent fixing device according to any one of claims 1 to 6, characterized in that: The gripping rod (220) is cylindrical in shape, and has anti-slip lines on its surface.

10. The experimental rodent fixing device according to any one of claims 1 to 6, characterized in that: The support rods constituting the frame (210) are composed of a fixed rod (211), a movable rod (212) and a limiting fastener (213). The limiting fastener (213) is a screw, a pin or a clamp. The movable rod (212) is adjusted up and down along the fixed rod (211) and is locked and fixed by the limiting fastener (213).

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