Lung drug delivery device for animal experiment

Abstract

The utility model discloses a lung administration device for animal experiments, which comprises a medicine storage tube, the lower surface of the medicine storage tube is fixedly connected with a medicine outlet, the bottom of the medicine outlet is detachably connected with a connecting sleeve, and the lower surface of the connecting sleeve is fixedly connected with a medicine outlet tube; a flow guide block is arranged in the pesticide outlet pipe, a spiral hole is formed in the flow guide block, a straight pipe is arranged at the bottom of the spiral hole and located at the bottom of the flow guide block, a mounting base is arranged in the pesticide outlet pipe, a mounting groove is formed in the mounting base, and a bearing is fixedly connected to the upper side wall of the mounting groove. A rotating disc is fixedly connected to the interior of the bearing, and medicine outlet holes are formed in the rotating disc and are inclined. By means of the device, the flow guide block, the spiral hole, the bearing, the rotating disc and the medicine outlet are matched, the rotating disc rotates through the pressure of the spiral hole, full mixing and even distribution of medicine in the injection process are achieved, and the medicine feeding effect is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental appliances, in particular to a pulmonary drug delivery device for animal experiments. Background Art

[0002] Animal experiments play a crucial role in biomedical research, particularly in new drug development, disease model development, and treatment validation. Their results often directly influence subsequent human clinical trials. Pulmonary drug delivery is a common method of drug delivery in animal experiments and is widely used to study respiratory diseases such as asthma, chronic obstructive pulmonary disease, and lung cancer. However, existing experimental equipment technology mostly uses straight needles for injection, but with this method, the drug cannot be evenly distributed during the injection process, which can easily lead to poor drug administration effect. For example, a Chinese patent discloses "an animal lung drug administration auxiliary device", and its application number is "CN202120257633.6". It uses an open sleeve. Before intubation, the front end of the open sleeve can be inserted into the glottis of the experimental mouse. The support of the open sleeve keeps the mouth of the experimental mouse open. At the same time, a conical guide portion is provided at the end of the open sleeve to facilitate the insertion of the open sleeve, and the guide portion can press the tongue of the experimental mouse to prevent the tongue of the experimental mouse from swinging during intubation and affecting the intubation. At the same time, the curved surface is pressed against the tongue of the experimental mouse, which can reduce damage to the tongue of the experimental mouse, but it prevents the drug from being fully mixed before entering the lungs, affecting the accuracy of the experimental results. Utility Model Content

[0003] The purpose of the present utility model is to solve at least one of the technical problems existing in the prior art and to provide a pulmonary drug delivery device for animal experiments. Through the cooperation of a guide block, a spiral hole, a bearing, a rotating disk and a medicine outlet hole, a pressing plate is squeezed to allow the medicine to enter the spiral hole of the guide block, narrowing the path and thereby increasing the pressure. The straight tube shape at the bottom of the spiral hole fully flows on the rotating disk. Since the medicine outlet hole on the rotating disk is inclined, when the medicine flows to the medicine outlet hole, the shower-like design of the medicine outlet hole causes the rotating disk to rotate due to pressure. The bearing facilitates the rotating disk to rotate more easily, and the pressure of the injection rotates, which plays a role in mixing and evenly discharging the medicine, thereby improving the drug delivery effect.

[0004] The present invention also provides a pulmonary drug delivery device for animal experiments as described above, comprising: a drug storage tube, a drug outlet fixedly connected to the lower surface of the drug storage tube, a connecting sleeve detachably connected to the bottom of the drug outlet, a drug outlet tube fixedly connected to the lower surface of the connecting sleeve; a guide block is provided inside the drug outlet tube, a spiral hole is provided on the guide block, the bottom of the spiral hole is a straight tube, the straight tube is located at the bottom of the guide block, a mounting seat is provided inside the drug outlet tube, a mounting groove is provided inside the mounting seat, a bearing is fixedly connected to the upper side wall of the mounting groove, a rotating disk is fixedly connected to the inside of the bearing, a drug outlet hole is provided on the rotating disk, and the drug outlet hole is inclined. Through the above device, through the cooperation of the guide block, the spiral hole, the bearing, the rotating disk, and the drug outlet hole, the rotating disk is rotated by the pressure of the spiral hole, thereby achieving full mixing and uniform distribution of the drug during the injection process, thereby improving the drug delivery effect.

[0005] According to the pulmonary drug delivery device for animal experiments described in the utility model, the drug storage tube is provided with a push rod, and a pressure plate is fixedly connected to the lower surface of the push rod. Through the above device, pressure is conveniently provided through the push rod and the pressure plate.

[0006] According to the pulmonary drug delivery device for animal experiments described in the utility model, a rubber pad is provided on the lower surface of the pressing plate, and the pressing plate is interference-fitted inside the drug storage tube. Through the above device, the rubber pad prevents the internal drug from leaking.

[0007] According to the pulmonary drug delivery device for animal experiments described in the present invention, the connecting sleeve is located outside the drug outlet, and the inside of the connecting sleeve is interference-fitted with the outside of the drug outlet.

[0008] According to the pulmonary drug delivery device for animal experiments described in the present invention, the guide block is located above the rotating disk and is cylindrical in shape. Through the above device, the position of the guide block facilitates pressurization of the drug solution.

[0009] According to the pulmonary drug delivery device for animal experiments described in the utility model, the spiral hole is spiral-shaped, and the spiral hole and the straight tube pass through the guide block. Through the above device, the drug solution can be concentrated through the spiral hole.

[0010] According to the pulmonary drug delivery device for animal experiments described in the present invention, the mounting seat is convex in shape, and the bearing is located at the convex position of the mounting seat. Through the above device, the shape of the mounting seat facilitates the support of the bearing.

[0011] According to the pulmonary drug delivery device for animal experiments described in the present invention, the drug outlet hole penetrates the rotating disk and surrounds the rotating disk. Through the above device, the position of the drug outlet hole facilitates the full rotation of the rotating disk.

[0012] Beneficial effects

[0013] Compared with the existing technology, the pulmonary drug delivery device for animal experiments, through the cooperation of the guide block, spiral hole, bearing, rotating disk, and medicine outlet hole, squeezes the pressure plate, so that the medicine enters the spiral hole of the guide block, narrows the path, and thus increases the pressure. The straight tube shape at the bottom of the spiral hole fully flows on the rotating disk. Since the medicine outlet hole on the rotating disk is inclined, when the medicine flows to the medicine outlet hole, the shower-like design of the medicine outlet hole causes the rotating disk to rotate due to pressure. The bearing makes it easier for the rotating disk to rotate. The injection pressure rotates, which plays a role in mixing and uniformly discharging the medicine, thereby improving the drug delivery effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The present invention will be further described below with reference to the accompanying drawings and embodiments;

[0015] Figure 1 This is a front view of the pulmonary drug delivery device for animal experiments of the utility model;

[0016] Figure 2 This utility model is a lung drug delivery device for animal experiments. Figure 1 vertical section view;

[0017] Figure 3 This utility model is a lung drug delivery device for animal experiments. Figure 1 transverse cross-sectional view;

[0018] Figure 4 This is the utility model of the lung drug delivery device for animal experiments Figure 2 Enlarged view of point A in the middle.

[0019] Figure 5 This is a graph of the results obtained for a conventional experimental drug delivery device.

[0020] Figure 6 This is the result diagram obtained for the drug delivery device of the present invention.

[0021] Legend:

[0022] 1. Medicine storage tube; 2. Push rod; 3. Press plate; 4. Rubber pad; 5. Medicine outlet; 6. Connecting sleeve; 7. Medicine outlet tube; 8. Mounting seat; 9. Guide block; 10. Spiral hole; 11. Mounting groove; 12. Bearing; 13. Rotating disk; 14. Medicine outlet. DETAILED DESCRIPTION

[0023] This section will describe in detail the specific embodiments of the present invention. The preferred embodiments of the present invention are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and overall technical solution of the present invention, but it cannot be understood as a limitation on the scope of protection of the present invention.

[0024] Reference Figure 1-4 The embodiment of the present invention is a pulmonary drug delivery device for animal experiments, which includes: a drug storage tube 1, which stores drugs. A push rod 2 is provided on the drug storage tube 1. The push rod 2 can push a pressure plate 3 to prevent failure. The lower surface of the push rod 2 is fixedly connected to a pressure plate 3. The pressure plate 3 squeezes the inside of the drug storage tube 1. A rubber pad 4 is provided on the lower surface of the pressure plate 3 to prevent the leakage of the medicine. The pressure plate 3 is interference fit inside the drug storage tube 1. A drug outlet 5 is fixedly connected to the lower surface of the drug storage tube 1. The drug outlet 5 facilitates the leakage of the medicine. The bottom of the drug outlet 5 is detachably connected to a connecting sleeve 6. The connecting sleeve 6 is convenient for connecting to a drug outlet pipe 7. The connecting sleeve 6 is located outside the drug outlet 5. The inside of the connecting sleeve 6 is interference fit with the outside of the drug outlet 5. The lower surface of the connecting sleeve 6 is fixedly connected to a drug outlet pipe 7. The drug outlet pipe 7 facilitates the discharge of the medicine.

[0025] The medicine outlet pipe 7 is provided with a guide block 9, which is located above the rotating disk 13. The guide block 9 is cylindrical in shape and is provided with a spiral hole 10. The spiral hole 10 facilitates the concentration of the medicine. The bottom of the spiral hole 10 is a straight tube. The straight tube is located at the bottom of the guide block 9. The spiral hole 10 is a spiral shape. The spiral hole 10 and the straight tube pass through the guide block 9. A mounting seat 8 is provided inside the medicine outlet pipe 7. The mounting seat 8 is a convex shape. The bearing 12 is located at the convex position of the mounting seat 8. A mounting groove 11 is provided on the top of the housing, which is convenient for supporting the bearing 12. The upper side wall of the mounting groove 11 is fixedly connected to the bearing 12, and the bearing 12 drives the rotating disk 13 to rotate. The rotating disk 13 is fixedly connected to the inside of the bearing 12. The rotating disk 13 fully mixes the medicine by rotating. A medicine outlet hole 14 is provided on the rotating disk 13, and the medicine outlet hole 14 drives the rotating disk 13 to rotate through pressure. The medicine outlet hole 14 is inclined, and the medicine outlet hole 14 passes through the rotating disk 13 and surrounds the rotating disk 13.

[0026] Working principle: When in use, first add medicine into the medicine storage tube 1, push the push rod 2, drive the pressure plate 3 to squeeze downward, so that the medicine inside the medicine storage tube 1 generates pressure, and the rubber pad 4 prevents the medicine inside the medicine storage tube 1 from leaking out from the side of the pressure plate 3, ensuring that the medicine leaks out from the medicine outlet 5 at the bottom of the medicine storage tube 1 and flows into the medicine outlet pipe 7. After passing through the guide block 9, all the medicine is concentrated and discharged from the spiral hole 10 of the guide block 9, thereby generating a larger pressure and fully flowing into the rotating disk 13. The shower-like design of the medicine outlet hole 14 makes the medicine rush to the medicine outlet hole 14. The medicine outlet hole 14 is inclined, so that due to the pressure of the medicine, the rotating disk 13 is driven to rotate, and the bearing 12 makes it easier for the rotating disk 13 to rotate. Due to the rotation of the rotating disk 13, the medicine can be fully mixed and the medicine amount is uniform. The medicine can be evenly distributed to the lung tissue, thereby improving the accuracy of the experimental results.

[0027] like Figure 5 , the existing equipment was used to model the experimental mice, and the lung tissue lesions were mild, the range was staged, and the scope of drug efficacy was small; Figure 6 As shown, the animal experiments in this example, using the pulmonary drug delivery device in experimental mice, revealed disordered lung tissue structure and obvious inflammatory changes. Inflammatory cell infiltration, alveoli of varying sizes, severe structural damage, partial cystic dilatation, alveolar wall rupture, thickening or collapse, and fibrosis were all pathological changes. The associated lesions were more pronounced, more diffuse, and widespread, with severe and diffuse pulmonary fibrosis and lung inflammation. The drug was widely distributed, achieving a positive effect.

[0028] The embodiments of the present invention are described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Various changes can be made within the scope of knowledge possessed by ordinary technicians in the relevant technical field without departing from the purpose of the present invention.

Claims

1. A pulmonary drug delivery device for animal experiments, characterized in that: include: A medicine storage tube (1), wherein the lower surface of the medicine storage tube (1) is fixedly connected to a medicine outlet (5), the bottom of the medicine outlet (5) is detachably connected to a connecting sleeve (6), and the lower surface of the connecting sleeve (6) is fixedly connected to a medicine outlet tube (7); A guide block (9) is provided inside the medicine outlet pipe (7), a spiral hole (10) is provided on the guide block (9), the bottom of the spiral hole (10) is a straight tube, and the straight tube is located at the bottom of the guide block (9), a mounting seat (8) is provided inside the medicine outlet pipe (7), a mounting groove (11) is provided inside the mounting seat (8), a bearing (12) is fixedly connected to the upper side wall of the mounting groove (11), a rotating disk (13) is fixedly connected inside the bearing (12), a medicine outlet hole (14) is provided on the rotating disk (13), and the medicine outlet hole (14) is inclined.

2. The pulmonary drug delivery device for animal experiments according to claim 1, characterized in that: The medicine storage tube (1) is provided with a push rod (2), and the lower surface of the push rod (2) is fixedly connected with a pressure plate (3).

3. The pulmonary drug delivery device for animal experiments according to claim 2, characterized in that: A rubber pad (4) is provided on the lower surface of the pressing plate (3), and the pressing plate (3) is interference-fitted inside the medicine storage tube (1).

4. The pulmonary drug delivery device for animal experiments according to claim 1, characterized in that: The connecting sleeve (6) is located outside the medicine outlet (5), and the interior of the connecting sleeve (6) is interference-fitted with the exterior of the medicine outlet (5).

5. The pulmonary drug delivery device for animal experiments according to claim 1, characterized in that: The guide block (9) is located above the rotating disk (13), and the guide block (9) is cylindrical in shape.

6. The pulmonary drug delivery device for animal experiments according to claim 1, characterized in that: The spiral hole (10) is in a spiral shape, and the spiral hole (10) and the straight pipe penetrate the guide block (9).

7. The pulmonary drug delivery device for animal experiments according to claim 1, characterized in that: The mounting seat (8) is in a convex shape, and the bearing (12) is located at the convex position of the mounting seat (8).

8. The pulmonary drug delivery device for animal experiments according to claim 1, characterized in that: The medicine outlet hole (14) passes through the rotating disk (13), and the medicine outlet hole (14) surrounds the rotating disk (13).

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