Conveniently-sampled centrifugal machine for research and development of medical organic intermediates

Abstract

The utility model relates to the technical field of medicine product research and development, and discloses a medicine organic intermediate research and development centrifugal machine facilitating sampling, which comprises a processing table, a centrifugal device is arranged at the top of the processing table, and a sampling device is arranged on the back of the top of the processing table. The centrifugal device comprises a centrifugal tank, a treatment barrel, a bottom end box piece, a connecting pipe body, a limiting ring piece, a feeding barrel piece, a feeding pipe, a threaded end, a connecting pipe, a magnet plate piece, a magnet connecting wafer, a magnetic attraction connecting wafer, a bottom plate and a sealing plate piece. According to the medicine organic intermediate research and development centrifugal machine convenient to sample, the centrifugal device is arranged, a centrifugal stepping motor below the centrifugal device is started, a bottom end box piece is driven to rotate, and a connecting pipe body located at the top of the bottom end box piece rotates along with the centrifugal device so as to drive a centrifugal tank and a feeding barrel piece on the surface to synchronously rotate for centrifugal treatment; and the processed tablets can be matched with the sampling device for use during sampling.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical product research and development, in particular to a centrifuge for the research and development of pharmaceutical organic intermediates which is convenient for sampling. Background Art

[0002] Pharmaceutical organic intermediates are key raw materials for drug synthesis, and their quality and performance directly impact the efficacy and safety of the final drug. Accurate analysis of the purity, structure, and properties of these organic intermediates is crucial in pharmaceutical R&D. Centrifuges, as a commonly used separation equipment, play a crucial role in the R&D of pharmaceutical organic intermediates.

[0003] The prior art discloses a centrifuge for pharmaceutical product research and development, with announcement number CN114192289A, comprising a motor case, a shaft sleeve fixedly connected to the top of the motor case, a drive motor mounted on the inner side of the motor case, a housing fixedly connected to the top of the shaft sleeve, a cover plate threadedly connected to the outer side of the housing, a turntable movably connected to the inner side of the housing, and a circular groove formed on the inner wall of the turntable. The centrifuge for pharmaceutical product research and development, during operation, utilizes a threaded swivel and a cooperating clamping plate. When in use, the threaded swivel is rotated to drive the movement of the clamping plate, thereby clamping a pharmaceutical test tube. This prevents the centrifuge from being limited to clamping test tubes of a single caliber, thereby improving the practicality of the centrifuge and eliminating the limitations of the centrifuge. This avoids the need to prepare multiple models of centrifuges for medical research experiments, thereby reducing the cost of medical research.

[0004] The above-mentioned centrifuge for the research and development of pharmaceutical organic intermediates that is easy to sample avoids the centrifuge being able to clamp only test tubes of a single caliber, improves the practicality of the centrifuge, eliminates the limitations of the centrifuge's use, avoids the need to prepare a large number of centrifuge models during medical research experiments, and reduces the cost of medical research. However, the above-mentioned device is not provided with a component that facilitates sampling. After the drugs are poured into the centrifuge and processed, multiple test tubes need to be unscrewed and poured out one by one to achieve sampling. The sampling time is long and the effect during use is poor, which needs to be improved. Utility Model Content

[0005] The purpose of the present invention is to provide a centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling, so as to solve the problems raised in the above-mentioned background technology.

[0006] To achieve the above objectives, the present invention provides the following technical solutions: a centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling, comprising a processing table, a centrifugal device is provided on the top of the processing table, and a sampling device is provided on the back of the top of the processing table.

[0007] The centrifugal device includes a centrifugal tank, a processing cylinder, a bottom box, a connecting tube, a limiting ring, a feeding cylinder, a feeding tube, a threaded end, a connecting tube, a magnet plate, a magnet connecting disc, a magnetic connection disc, a bottom plate and a sealing plate. The top of the processing table is provided with a groove, the top of the processing table is fixedly connected to a centrifugal stepping motor, the processing cylinder is fixedly connected to the top of the processing table, the bottom of the processing cylinder is provided with a through groove, the output shaft of the centrifugal stepping motor is fixedly connected to a rotating rod body, the diameter of the rotating rod body is adapted to the diameter of the through groove, the inner bottom end of the processing cylinder is provided with a sealing ring, and the rotating rod body is slidably connected The inner ring of the sealing ring, the rotating rod body extends through the bottom of the processing cylinder and is connected to the inside of the processing cylinder, the bottom box part is fixedly connected to the output shaft of the rotating rod body, the bottom box part is fixedly connected to the top of the bottom box part, the connecting tube body is fixedly connected to the top of the bottom box part, the bottom plate is connected to the top of the connecting tube body, the bottom plate is magnetically connected to the connecting tube body, the limiting ring is fixedly connected to the top of the connecting tube body, the sealing plate is fixedly connected to the top of the bottom plate, the feeding cylinder is fixedly connected to the surface of the centrifuge tank, the surface of the connecting pipe is provided with a threaded groove, and the threaded end is threadedly connected to the bottom of the connecting pipe.

[0008] Preferably, the sampling device includes a back-end connecting box, a stand, a connecting table, a rotating shaft, a placement frame, a magnetic sheet, a magnet patch, a hydraulic telescopic rod and a magnetic plate. The back-end connecting box is fixedly connected to the top back of the processing table, the stand is fixedly connected to the top front of the back-end connecting box, the connecting table is fixedly connected to the top of the stand, the rotating shaft is slidably connected to the inside of the connecting table, the magnetic sheet is fixedly connected to the top of the placement frame, the hydraulic telescopic rod is fixedly connected to the inside of the placement frame, the magnetic plate is fixedly connected to the bottom of the hydraulic telescopic rod, and a support block is provided on the top back of the processing cylinder, and the placement frame is connected to the top of the support block.

[0009] Preferably, the top area of ​​the magnet plate is equal to the bottom area of ​​the magnetic plate, and the magnet plate is magnetically connected to the magnetic plate.

[0010] Preferably, a connecting circular groove is provided at the bottom of the feeding cylinder, the area of ​​the connecting circular groove is smaller than the area of ​​the sealing plate, the magnet plate is fixedly connected to the top of the connecting pipe, the connecting circular groove is provided for discharging and the sealing plate is provided for blocking during centrifugation to ensure the normal use of the device.

[0011] Preferably, the magnet connection disc is fixedly connected to the top of the bottom plate, the magnetic connection disc is fixedly connected to the bottom of the centrifuge tank, and the magnetic connection disc is magnetically connected to the magnet connection disc.

[0012] Preferably, a connecting bearing is fixedly connected to the left side of the connecting platform, the rotating shaft is fixedly connected to the inner ring of the connecting bearing, and the placement frame is fixedly connected to the surface of the rotating shaft.

[0013] Preferably, the magnetic patch is fixedly connected to the top front of the connecting platform, and the magnetic sheet is magnetically connected to the magnetic patch. After sampling, it can be flipped backwards until the magnetic sheet is attached to the front of the magnetic patch. The two are in contact and magnetically connected together, and the placement rack is fixed to a vertical upward position to complete the centrifugal processing and sampling operations.

[0014] Compared with the prior art, the beneficial effects of the present invention are:

[0015] The centrifuge for the research and development of pharmaceutical organic intermediates, which is convenient for sampling, is provided with a centrifugal device. The centrifugal stepping motor below is started to drive the bottom box to rotate. The connecting pipe body located on the top of the bottom box rotates accordingly, thereby driving the centrifugal tank and the feeding cylinder on the surface to rotate synchronously for centrifugal treatment. The treated tablets can be used in conjunction with the sampling device when sampling.

[0016] The centrifuge for the research and development of pharmaceutical organic intermediates, which is convenient for sampling, is provided with a sampling device. The hydraulic telescopic rod is started to drive the magnetic plate to move downward until it contacts the top of the magnet plate. After contact, the magnet plate and the magnetic plate are magnetically attracted together. Then the hydraulic telescopic rod is started to move upward to pull up the centrifuge tank and the feeding cylinder on the surface. After pulling a sufficient distance, the threaded end can be screwed to remove the centrifuge tank. Then, the bottom plate can be pulled downward to complete the discharge at one time. The device is provided with a component convenient for sampling. After the medicine is poured into the centrifuge and processed, there is no need to unscrew multiple test tubes and pour them out one by one to achieve sampling. The time required for sampling is short. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the overall three-dimensional side view structure of the utility model;

[0018] Figure 2 For this utility model Figure 1 A in the middle is an enlarged structural diagram;

[0019] Figure 3 For this utility model Figure 1 The enlarged structural diagram at B in the middle;

[0020] Figure 4 This is a schematic diagram of the overall three-dimensional structure of the utility model;

[0021] Figure 5 It is a schematic diagram of the three-dimensional structure of part of the centrifugal device of the utility model.

[0022] In the figure: 1. processing table; 2. sampling device; 201. back end connecting box; 202. stand; 203. connecting table; 204. rotating shaft; 205. placing shelf; 206. magnetic sheet; 207. magnet patch; 208. hydraulic telescopic rod; 209. magnetic plate; 3. centrifugal device; 301. centrifugal tank; 302. processing cylinder; 303. bottom end box; 304. connecting pipe body; 305. limiting ring; 306. feeding cylinder; 307. feeding pipe; 308. threaded end; 309. connecting pipe; 310. magnet plate; 311. magnet connecting disc; 312. magnetic connecting disc; 313. bottom plate; 314. sealing plate. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0024] See also Figure 1-5 , the utility model provides the following technical solutions:

[0025] A centrifuge for the research and development of pharmaceutical organic intermediates with convenient sampling comprises a processing platform 1, a centrifugal device 3 is arranged on the top of the processing platform 1, and a sampling device 2 is arranged on the back of the top of the processing platform 1.

[0026] The centrifugal device 3 includes a centrifugal tank 301, a processing cylinder 302, a bottom box 303, a connecting tube 304, a limiting ring 305, a feeding cylinder 306, a feeding tube 307, a threaded end 308, a connecting tube 309, a magnet plate 310, a magnet connecting disc 311, a magnetic connection disc 312, a bottom plate 313 and a sealing plate 314. A groove is provided on the top of the processing table 1, and a centrifugal stepping motor is fixedly connected to the top of the processing table 1. The processing cylinder 302 is fixedly connected to the top of the processing table 1, and the bottom of the processing cylinder 302 is fixedly connected to the top of the processing table 1. A through slot is provided at the bottom, and the output shaft of the centrifugal stepper motor is fixedly connected to the rotating rod body. The diameter of the rotating rod body is adapted to the diameter of the through slot. A sealing ring is provided at the bottom end of the processing cylinder 302. The rotating rod body is slidably connected to the inner ring of the sealing ring. The rotating rod body extends through the bottom of the processing cylinder 302 and is connected to the interior of the processing cylinder 302. The bottom box part 303 is fixedly connected to the output shaft of the rotating rod body. The bottom box part 303 is fixedly connected to the top of the bottom box part 303. The connecting pipe body 304 is fixedly connected to the top of the bottom box part 303. The plate 313 is connected to the top of the connecting tube body 304, the bottom plate 313 is magnetically connected to the connecting tube body 304, the limiting ring 305 is fixedly connected to the top of the connecting tube body 304, the sealing plate 314 is fixedly connected to the top of the bottom plate 313, the feeding cylinder 306 is fixedly connected to the surface of the centrifugal tank 301, the surface of the connecting tube 309 is provided with a threaded groove, the threaded end 308 is threadedly connected to the bottom of the connecting tube 309, the top area of ​​the magnet plate 310 is equal to the bottom area of ​​the magnetic plate 209, and the magnet plate 310 is magnetically connected to the magnetic plate 209. Plate 209 and the bottom of the feed cylinder 306 are provided with a connecting circular groove, the area of ​​which is smaller than the area of ​​the sealing plate 314. The magnet plate 310 is fixedly connected to the top of the connecting tube 309. The connecting circular groove is provided for discharging and the sealing plate 314 is provided for blocking during centrifugation to ensure the normal use of the device. The magnet connecting disc 311 is fixedly connected to the top of the bottom plate 313, and the magnetic connecting disc 312 is fixedly connected to the bottom of the centrifuge tank 301. The magnetic connecting disc 312 is magnetically connected to the magnet connecting disc 311.

[0027] The sampling device 2 includes a back-end connecting box 201, a stand 202, a connecting platform 203, a rotating shaft 204, a placement shelf 205, a magnetic sheet 206, a magnet patch 207, a hydraulic telescopic rod 208 and a magnetic plate 209. The back-end connecting box 201 is fixedly connected to the top back of the processing table 1, the stand 202 is fixedly connected to the top front of the back-end connecting box 201, the connecting platform 203 is fixedly connected to the top of the stand 202, the rotating shaft 204 is slidably connected to the inside of the connecting platform 203, the magnetic sheet 206 is fixedly connected to the top of the placement shelf 205, the hydraulic telescopic rod 208 is fixedly connected to the inside of the placement shelf 205, and the magnetic plate 209 is fixedly connected to the hydraulic A support block is provided at the bottom of the telescopic rod 208 and the top back of the processing cylinder 302. The placement frame 205 is connected to the top of the support block. The magnetic patch 207 is fixedly connected to the top front of the connecting platform 203. The magnetic sheet 206 is magnetically connected to the magnetic patch 207. After sampling, it can be flipped backwards until the magnetic sheet 206 is attached to the front of the magnetic patch 207. The two are in contact and magnetically connected together, and the placement frame 205 is fixed to a vertical position facing upward to complete the centrifugal processing and sampling operations. A connecting bearing is fixedly connected to the left side of the connecting platform 203, the rotating shaft 204 is fixedly connected to the inner ring of the connecting bearing, and the placement frame 205 is fixedly connected to the surface of the rotating shaft 204.

[0028] When in use, the bottom plate 313 is placed on the bottom of the centrifugal tank 301. When placing, the magnetic connecting disc 311 needs to be aligned with the magnetic connecting disc 312, and then the two are pressed together. After the two are in contact, they can be magnetically attracted together, so that the sealing plate 314 is aligned with the connecting groove at the bottom of the feeding cylinder 306 for sealing. Then the bottom plate 313 is placed on the top of the connecting tube body 304, so that the two are magnetically connected together, and then the tablets that need to be centrifuged can be poured into the interior of the feeding cylinder 306 through the feeding pipe 307. Then the centrifugal stepper motor below can be started to drive the bottom box part 303 to rotate, and the connecting tube body 304 located at the top of the bottom box part 303 follows the rotation, thereby driving the centrifugal tank 301 and the feeding cylinder 306 on the surface to rotate synchronously for centrifugal treatment. When sampling, the processed tablets can be used in conjunction with the sampling device 2, and the placement shelf 205 is pulled forward so that the bottom of the placement shelf 205 is close to the support block, such as Figure 1The position shown, at this time, the magnetic plate 209 at the bottom of the hydraulic telescopic rod 208 is aligned with 30, and then the hydraulic telescopic rod 208 is started to drive the magnetic plate 209 to move downward until it contacts the top of the magnet plate 310. After contact, the magnet plate 310 and the magnetic plate 209 are magnetically adsorbed together, and then the hydraulic telescopic rod 208 is started to move upward to pull up the centrifugal tank 301 and the feed cylinder 306 on the surface. After pulling enough distance, the threaded end 308 can be screwed to remove the centrifugal tank 301, and then the bottom plate 313 can be pulled downward to make the magnet connect the disc 311 and the magnetic The connecting disc 312 is separated, and then the sealing plate 314 no longer blocks the connecting groove body, allowing the tablets to fall out, completing the sampling process. The device is provided with a component for convenient sampling. After the medicine is poured into the centrifuge and processed, there is no need to unscrew multiple test tubes and pour them out one by one to achieve sampling. The sampling time is short and the effect is good when used. The sampling device 2 is used for sampling, and after sampling, it can be flipped backward until the magnetic sheet 206 is attached to the front of the magnet patch 207. The two are in contact and magnetically connected together, and the placement rack 205 is fixed to a vertical position facing upward to complete the centrifugal processing and sampling operations.

[0029] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling, comprising a processing table (1), characterized in that: A centrifugal device (3) is provided on the top of the processing table (1), and a sampling device (2) is provided on the back of the top of the processing table (1); The centrifugal device (3) comprises a centrifugal tank (301), a processing cylinder (302), a bottom box member (303), a connecting tube body (304), a limiting ring member (305), a feeding cylinder member (306), a feeding tube (307), a threaded end (308), a connecting tube (309), a magnet plate member (310), a magnet connecting disc (311), a magnetic connection disc (312), a bottom plate (313) and a sealing plate member (314). The top of the processing table (1) is provided with a groove, the top of the processing table (1) is fixedly connected to a centrifugal stepping motor, the processing cylinder (302) is fixedly connected to the top of the processing table (1), the bottom of the processing cylinder (302) is provided with a through groove, the output shaft of the centrifugal stepping motor is fixedly connected to a rotating rod body, the diameter of the rotating rod body is adapted to the diameter of the through groove, the bottom end of the inner portion of the processing cylinder (302) is provided with a sealing ring, and the rotating rod body is slidably connected to the sealing ring. The inner ring of the sealing ring, the rotating rod body extends through the bottom of the processing cylinder (302) and is connected to the inside of the processing cylinder (302), the bottom box member (303) is fixedly connected to the output shaft of the rotating rod body, the bottom box member (303) is fixedly connected to the top of the bottom box member (303), the connecting pipe body (304) is fixedly connected to the top of the bottom box member (303), and the bottom plate (313) is connected to the top of the connecting pipe body (304). The bottom plate (313) is magnetically connected to the connecting tube body (304); the limiting ring (305) is fixedly connected to the top of the connecting tube body (304); the sealing plate (314) is fixedly connected to the top of the bottom plate (313); the feeding cylinder (306) is fixedly connected to the surface of the centrifugal tank (301); a threaded groove is provided on the surface of the connecting tube (309); and the threaded end (308) is threadedly connected to the bottom of the connecting tube (309).

2. The centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling according to claim 1, characterized in that: The sampling device (2) comprises a back-end connecting box (201), a stand (202), a connecting platform (203), a rotating shaft (204), a placement frame (205), a magnetic sheet (206), a magnet patch (207), a hydraulic telescopic rod (208) and a magnetic plate (209), wherein the back-end connecting box (201) is fixedly connected to the top back of the processing table (1), the stand (202) is fixedly connected to the top front of the back-end connecting box (201), and the connecting platform (203) is fixedly connected to the top front of the processing table (1). It is fixedly connected to the top of the stand (202), the rotating shaft (204) is slidably connected to the inside of the connecting platform (203), the magnetic sheet (206) is fixedly connected to the top of the placement rack (205), the hydraulic telescopic rod (208) is fixedly connected to the inside of the placement rack (205), the magnetic plate (209) is fixedly connected to the bottom of the hydraulic telescopic rod (208), and a support block is provided on the top back of the processing cylinder (302), and the placement rack (205) is connected to the top of the support block.

3. The centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling according to claim 2, characterized in that: The top area of ​​the magnet plate (310) is equal to the bottom area of ​​the magnetic attraction plate (209), and the magnet plate (310) is magnetically connected to the magnetic attraction plate (209).

4. The centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling according to claim 1, characterized in that: A communicating circular groove is provided at the bottom of the feeding cylinder (306), the area of ​​the communicating circular groove being smaller than the area of ​​the sealing plate (314), and the magnet plate (310) is fixedly connected to the top of the connecting pipe (309).

5. The centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling according to claim 1, characterized in that: The magnet connection disc (311) is fixedly connected to the top of the bottom plate (313), the magnetic connection disc (312) is fixedly connected to the bottom of the centrifugal tank (301), and the magnetic connection disc (312) is magnetically connected to the magnet connection disc (311).

6. The centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling according to claim 2, characterized in that: A connecting bearing is fixedly connected to the left side of the connecting platform (203), the rotating shaft (204) is fixedly connected to the inner ring of the connecting bearing, and the placement frame (205) is fixedly connected to the surface of the rotating shaft (204).

7. The centrifuge for the research and development of pharmaceutical organic intermediates that is convenient for sampling according to claim 2, characterized in that: The magnetic patch (207) is fixedly connected to the top front of the connecting platform (203), and the magnetic attraction sheet (206) is magnetically connected to the magnetic patch (207).

Images