Detachable combined type plasma filtering clamping shell

Abstract

The utility model provides a detachable combined type plasma filtering card shell, which comprises a card shell, the card shell comprises an upper cover and a bottom shell clamped with the upper cover, the bottom shell is internally provided with a test paper card slot, and the upper cover is provided with a first sample adding hole facing the test paper card slot; the plasma separator is clamped on the upper cover, and the plasma separator comprises a supporting plate, a liquid storage cavity and a second sample adding hole, and the liquid storage cavity and the second sample adding hole are formed in the supporting plate. According to the detachable combined type plasma filtering clamping shell provided by the utility model, the plasma separator is clamped on the clamping shell, whole blood is added into the second sample adding hole, and then the pressurizing cover is bent to block the second sample adding hole, so that the filtering speed of the whole blood on the filter membrane is accelerated; the filtered plasma flows into the first sample adding hole from the liquid storage cavity to react with the test paper strip on the test paper clamping groove, so that the detection accuracy is improved, and further, the plasma separator and the clamping shell can be separated and independently used.

Description

Technical Field

[0001] The utility model relates to the technical field of filtering devices, in particular to a detachable and combined plasma filtering cartridge. Background Art

[0002] In existing technologies, immunochromatographic testing consists of a test strip and a cartridge with an observation window. During the test, the test substance binds to specific antibodies on the test strip, detecting different colors in the observation window. Color comparison is then performed to obtain simple test data. However, when testing blood samples, since blood consists of plasma and red blood cells, if not properly processed, the red blood cells in the blood will interfere with the color development of the test strip, thereby affecting the test results. Utility Model Content

[0003] The purpose of the present utility model is to address the above-mentioned problems in the existing technology and to solve the problem that red blood cells in the blood may interfere with the detection values ​​of the test strip. The corresponding treatment mentioned above is: whole blood is centrifuged to extract the upper layer of plasma, and a certain amount is aspirated with a pipette and then placed on the test strip for reaction. This can reduce the interference of red blood cells, but the additional centrifugation operation increases the detection time and is not suitable for rapid detection.

[0004] In order to achieve the above-mentioned purpose, the present invention can be implemented through the following technical solutions: a detachable and combined plasma filtration cartridge, comprising:

[0005] The card shell includes an upper cover and a bottom shell engaged with the upper cover, wherein a test paper slot is provided in the bottom shell, and a first sample injection hole is opened on the upper cover toward the test paper slot;

[0006] A plasma separator, the plasma separator being snap-connected to the upper cover and comprising a support plate, a liquid storage cavity and a second sample loading hole respectively disposed on the support plate, the second sample loading hole being in communication with the liquid storage cavity, and the liquid storage cavity being located directly above the first sample loading hole;

[0007] Wherein, a pressure cover for sealing the second sample addition hole is provided on the support plate, and a filter membrane is clamped in the second sample addition hole.

[0008] In an embodiment of the present invention, a groove is provided on the upper cover, and a clamping portion is provided in the groove to be engaged with the support plate.

[0009] In an embodiment of the present utility model, a flow channel is provided on the support plate, and two ends of the flow channel are respectively connected to the second sample addition hole and the liquid storage cavity.

[0010] In an embodiment of the present invention, the pressure cover includes a first pressing block. A guide groove is formed on the first pressing block, and the guide groove is engaged with the pressure cover.

[0011] In an embodiment of the present utility model, the upper cover is provided with cylindrical slots in a linear array, and the bottom shell is provided with raised columns that engage with the cylindrical slots;

[0012] The upper cover is provided with an observation window facing the test paper slot.

[0013] In an embodiment of the present utility model, a liquid accumulation hole is provided on the test paper slot.

[0014] In an embodiment of the present utility model, a triangular protrusion is provided on the test paper slot.

[0015] In an embodiment of the present utility model, a circular channel is provided on the pressure cover, and the first pressing block is engaged in the circular channel.

[0016] In an embodiment of the present utility model, a film is provided on the support plate.

[0017] In an embodiment of the present invention, an arc-shaped portion is provided at one end of the pressure cover, and the pressure cover is a rubber cover.

[0018] Compared with the existing technology, the advantages of the present application are: the plasma separator is connected to the cartridge, whole blood is added to the second sample addition hole, and then the pressure cover is bent to seal the second sample addition hole, thereby accelerating the filtration speed of the whole blood on the filter membrane, and then the filtered plasma flows from the liquid storage chamber to the first sample addition hole to react with the test strip on the test paper slot to improve the accuracy of the test. Furthermore, the plasma separator and the cartridge can be separated and used separately. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall structure;

[0020] Figure 2 It is a structural diagram of the front side of the card shell;

[0021] Figure 3 It is a schematic diagram of the structure of a plasma separator;

[0022] Figure 4 It is a structural diagram of the front and back of the upper cover;

[0023] Figure 5 It is a structural diagram of the front and back of the bottom shell;

[0024] Figure 6 It is a structural schematic diagram of the plasma separator flow channel;

[0025] Figure 7It is a schematic diagram of the explosion structure of the plasma separator;

[0026] Figure 8 is a schematic diagram of the structure between the support plate and the film;

[0027] Figure 9 This is a schematic diagram of the internal structure assembly of the plasma separator in half section;

[0028] Figure 10 It is an overall plan view.

[0029] Description of reference numerals:

[0030] 1. Card shell; 11. Upper cover; 110. Observation window; 111. First sample loading hole; 112. Groove; 113. Clamping part; 114. Cylindrical slot; 12. Bottom shell; 121. Raised column; 122. Test paper slot; 123. Liquid accumulation hole; 124. Triangular raised part; 2. Plasma separator; 21. Pressurized cover; 211. Arc-shaped part; 212. Circular channel; 22. First pressing block; 221. Guide groove; 23. Support plate; 231. Flow channel; 232. Thin film; 233. Circular hole; 24. Liquid storage chamber; 25. Second sample loading hole; 251. Filter membrane. DETAILED DESCRIPTION

[0031] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solution of the present invention.

[0032] like Figure 1-10 As shown, a detachable combined plasma filtration cartridge comprises:

[0033] The card housing 1 includes an upper cover 11 and a bottom housing 12 engaged with the upper cover 11. A test paper slot 122 is provided in the bottom housing 12, and a first sample injection hole 111 is opened on the upper cover 11 and faces the test paper slot 122.

[0034] A plasma separator 2 is snap-fitted to the upper cover 11 and includes a support plate 23 and a liquid storage chamber 24 and a second sample loading hole 25 respectively disposed on the support plate 23. The second sample loading hole 25 is connected to the liquid storage chamber 24. The liquid storage chamber 24 is located directly above the first sample loading hole 111.

[0035] The support plate 23 is provided with a pressure cover 21 for sealing the second sample addition hole 25 , and a filter membrane 251 is clamped in the second sample addition hole 25 .

[0036] Specifically, the cartridge 1 and the plasma separator 2 can be combined or separated for use separately. The cartridge 1 is divided into an upper cover 11 and a bottom shell 12. The bottom shell 12 is used to fix the test strip, and the upper cover 11 is provided with a first loading hole 111 and an observation window 110. The test liquid flows into the cartridge 1 through the first loading hole 111 and reacts with the test strip. When the test strip changes color, the color change is observed through the observation window 110. The plasma separator 2 is used to filter whole blood. The whole blood is placed in the second loading hole 25, and then the pressure cover 21 is fitted with the second loading hole 25 to form a closed space. As the pressure cover 21 is continuously pressed into the second loading hole 25, the pressure in the closed space increases, thereby increasing the filtration speed of the whole blood on the filter membrane 251. The filtered plasma flows into the first loading hole 111 through the liquid storage chamber 24. When the plasma flow speed is too high, it will accumulate in the liquid storage chamber 24.

[0037] As a further embodiment provided by the present invention, a groove 112 is provided on the upper cover 11, and a clamping portion 113 is provided in the groove 112 to engage with the support plate 23. The groove 112 is in contact with the support plate 23, and the support plate 23 is fixed to the upper cover 11 through the clamping portion 113. When the support plate 23 swings and is subjected to excessive force, the support plate 23 will be separated from the groove 112.

[0038] As an embodiment further provided by the present invention, a flow channel 231 is provided on the support plate 23, and the two ends of the flow channel 231 are respectively connected to the second sample addition hole 25 and the liquid storage chamber 24. Figure 6 As shown, the flow channel 231 is narrow and curved in an arc shape. The flow channel 231 and the pressure cover 21 increase the internal pressure of the second sample addition hole 25, further improving the filtering speed of the whole blood.

[0039] As an embodiment further provided by the present invention, the pressure cover 21 includes a first pressing block 22, and a guide groove 221 is provided on the first pressing block 22. The guide groove 221 is engaged with the pressure cover 21. The guide groove 221 is specifically a triangular groove 112, which improves the engagement effect between the first pressing block 22 and the pressure cover 21.

[0040] As an embodiment further provided by the present invention, the upper cover 11 is provided with cylindrical slots 114 in a linear array, and the bottom shell 12 is provided with a raised column 121 engaged with the cylindrical slots 114, and the upper cover 11 is provided with an observation window 110 facing the test paper slot 122. A plurality of groups of cylindrical slots 114 are provided on the upper cover 11, and the raised column 121 is engaged with the cylindrical slots 114, so that the upper cover 11 and the bottom shell 12 are fully engaged, and the observation window 110 can observe the color change of the test paper strip.

[0041] As a further embodiment provided by the present invention, a liquid accumulation hole 123 is provided on the test paper slot 122. When there is too much liquid on the test paper strip, the liquid will accumulate in the liquid accumulation hole 123, reducing the dispersed flow of the liquid. The liquid accumulation hole 123 is located directly below the observation window 110.

[0042] As a further embodiment provided by the present invention, the test paper slot 122 is provided with a triangular protrusion 124 , and at least two groups of triangular protrusions 124 are provided. The protrusions can limit the test paper strip to reduce the phenomenon of the test paper strip escaping from the test paper slot 122 .

[0043] As a further embodiment provided by the present invention, a circular channel 212 is provided on the pressure cover 21, and a first pressing block 22 is slidably provided in the circular channel 212. The circular channel 212 is longer, which improves the firm connection between the pressure cover 21 and the first pressing block 22.

[0044] As an embodiment further provided by the present invention, an arc-shaped portion 211 is provided at one end of the pressure cover 21, and the pressure cover 21 is a rubber cover. The arc-shaped portion 211 improves the combination efficiency of the pressure cover 21 and the second sample loading hole 25. At the same time, the rubber material improves the sealing performance when the pressure cover 21 is connected to the second sample loading hole 25.

[0045] Working principle: First, install the test strip into the test strip slot 122, close the upper cover 11 and the bottom shell 12 to fix the test strip, then place the plasma separator 2 in the groove 112, and snap the plasma separator 2 and the card shell 1 together through the snap-on portion 113, and make the liquid storage cavity 24 of the plasma separator 2 communicate with the first sample addition hole 111 accordingly. A film 232 is provided between the support plate 23 and the card shell 1, and a circular hole 233 (such as Figure 8As shown), whole blood is then added to the second sample addition hole 25, and the pressure cover 21 is turned to block the second sample addition hole 25, thereby increasing the pressure inside the second sample addition hole 25, accelerating the filtration speed of the whole blood on the filter membrane 251, and the filtered plasma flows to the liquid storage chamber 24 through the flow channel 231, and then flows into the first sample addition hole 111 through the liquid storage chamber 24 to complete the reaction with the test strip on the test paper slot 122, thereby reducing the interference of red blood cells on the detection and improving the accuracy of the detection. Further, the plasma separator 2 can be separated from the card shell 1, and the two can be separated. When used alone, the plasma separator 2 can be used as a filtering device alone. Before filtering, a film 232 needs to be added to the support plate 23. This film 232 fully covers the flow channel 231, so that the filtered plasma flows along the flow channel 231, wherein the circular hole 233 in the film 232 is intertwined with the flow channel under the liquid storage chamber 24, and then whole blood is added to the second sample addition hole 25 for filtration. The filtered plasma is stored in the liquid storage chamber 24 through the flow channel 231, thereby filtering out substances such as red blood cells in the whole blood, and the cartridge 1 can be used to install different test strips for testing.

[0046] The technical solution of the above-mentioned utility model provides a solution that is significantly different from the existing technology to address the technical problem that the existing technology solution is too single. The parts not involved in the technical solution of this application are the same as the existing technology or can be implemented by using the existing technology, and will not be repeated here.

[0047] The technical solutions in the above embodiments have clearly and completely described the contents of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

Claims

1. A detachable combined plasma filtration cartridge, characterized in that: include: The card shell includes an upper cover and a bottom shell engaged with the upper cover, wherein a test paper slot is provided in the bottom shell, and a first sample injection hole is opened on the upper cover toward the test paper slot; A plasma separator, the plasma separator being snap-connected to the upper cover and comprising a support plate, a liquid storage cavity and a second sample loading hole respectively disposed on the support plate, the second sample loading hole being in communication with the liquid storage cavity, and the liquid storage cavity being located directly above the first sample loading hole; Wherein, a pressure cover for sealing the second sample addition hole is provided on the support plate, and a filter membrane is clamped in the second sample addition hole.

2. The detachable combined plasma filtration cartridge according to claim 1, characterized in that: A groove is formed on the upper cover, and a clamping portion engaged with the support plate is provided in the groove.

3. The detachable and combined plasma filtration cartridge according to claim 1, characterized in that: The support plate is provided with a flow channel, and both ends of the flow channel are respectively connected with the second sample addition hole and the liquid storage cavity.

4. The detachable combined plasma filtration cartridge according to claim 1, characterized in that: The pressure cover includes a first pressing block. The first pressing block is provided with a guide groove, and the guide groove is engaged with the pressure cover.

5. The detachable and combined plasma filtration cartridge according to claim 1, characterized in that: The upper cover is provided with cylindrical slots in a linear array, and the bottom shell is provided with raised columns engaged with the cylindrical slots; The upper cover is provided with an observation window facing the test paper slot.

6. The detachable and combined plasma filtration cartridge according to claim 5, characterized in that: The test paper slot is provided with a liquid accumulation hole.

7. The detachable combined plasma filtration cartridge according to claim 5, characterized in that: The test paper slot is provided with a triangular protrusion.

8. The detachable combined plasma filtration cartridge according to claim 4, characterized in that: The pressure cover is provided with a circular channel, and the first pressing block is engaged in the circular channel.

9. The detachable and combined plasma filtration cartridge according to claim 1, characterized in that: A film is arranged on the support plate.

10. The detachable and combined plasma filtration cartridge according to claim 1, characterized in that: One end of the pressure cover is provided with an arc portion, and the pressure cover is a rubber cover.

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