Etherification reaction rectification device for isoflurane

Abstract

The utility model discloses an etherification reaction rectification device for isoflurane, and belongs to the field of rectification devices.The etherification reaction rectification device comprises a connecting pipe, a mounting device is arranged on the connecting pipe and comprises a supporting plate, the supporting plate is fixedly connected to the outer wall of the connecting pipe, a sleeve is fixedly connected to the top of the supporting plate, and a sliding rod is slidably connected to the inner wall of the sleeve; the top of the sliding rod is fixedly connected with a fixing rod, the bottom of the fixing rod is fixedly connected with an inserting rod, a sliding groove is formed in the front face of the sleeve, the front face of the sliding rod is rotationally connected with a pulley through a bearing, and the sliding rod movably penetrates through the supporting plate and extends to the bottom. The bottom of a connecting plate at the bottom of a sliding rod is pushed, the sliding rod moves towards the top, a spring is stretched, the sliding rod drives an inserting rod to reset and be installed in an inserting hole, the stability and safety of the reaction kettle pipeline in the using process are ensured through spring resetting and clamping mechanisms, and the reaction kettle pipeline is convenient to replace.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of rectification device, in particular to an etherification reaction rectification device for isoflurane. BACKGROUND

[0002] 1-chloro-2,2,2-trifluoroethyldifluoromethyl ether, also known as isoflurane, can be used for induction and maintenance of general anesthesia, isoflurane is a colorless transparent liquid, has a special fragrance, the blood / gas distribution coefficient is small, the anesthesia induction is stable, rapid, comfortable, the recovery is fast, the muscle relaxation is good, there is no sympathetic nervous system excitation, the metabolic rate of the product in the liver is low, so the liver toxicity is small, repeated use has no obvious side effects, and there are occasional nausea and vomiting, which is a commonly used inhaled anesthetic in clinical practice. There are many reported synthesis methods of isoflurane, but generally it needs to go through etherification and chlorination two steps, in the prior art, the direct heating reaction kettle is directly distilled, and the distillate is collected by ice salt water cooling.

[0003] The patent document with publication number CN211585264U discloses an etherification reaction rectification device for isoflurane, which comprises an etherification reaction reaction kettle, and the bottom valve of the reaction kettle is connected to an ice salt water collecting device through a shunt heating device; the shunt heating device comprises a hot water bath bin; the inside of the hot water bath bin is respectively provided with an inlet pipe and an outlet pipe; the top of the inlet pipe is sealingly connected to the bottom valve of the reaction kettle, and the bottom of the inlet pipe is sealed; the bottom of the outlet pipe is sealingly connected to the buffer bin inside the hot water bath bin; the bottom of the buffer bin is connected to the rectification tower through an outer valve; a plurality of thin-walled pipes with arc shape are sealingly connected between the inlet pipe and the outlet pipe; the etherification reaction rectification device for isoflurane can obtain a higher product yield by directly shunting and heating the reaction liquid after the etherification reaction of the raw material in the reaction kettle and sealingly distilling the heated reaction liquid, although the etherification reaction rectification device for isoflurane can obtain a higher product yield by directly shunting and heating the reaction liquid after the etherification reaction of the raw material in the reaction kettle and sealingly distilling the heated reaction liquid in the above-mentioned application document, but the pipe at the position of the reaction kettle and the hot water bath bin will be corroded after long-term use, thereby causing toxic gas leakage. Content of the utility model

[0004] The utility model provides a kind of etherification reaction rectification device for isoflurane, solve the problem raised in the above background art.To achieve the above object, the utility model is realized by the following technical solutions: a kind of etherification reaction rectification device for isoflurane, including connecting pipe, installation device is arranged on the connecting pipe, the installation device includes supporting plate, the supporting plate is fixedly connected in the connecting pipe outer wall, the supporting plate top is fixedly connected with sleeve, the sleeve inner wall is slidably connected with slide rod, the slide rod top is fixedly connected with fixed rod, the fixed rod bottom is fixedly connected with plug rod, the sleeve front is provided with sliding slot, the slide rod front is rotatably connected with pulley by bearing, the slide rod extends to bottom and is movably penetrated supporting plate, spring is movably sheathed on the slide rod outer wall, the slide rod bottom is fixedly connected with connecting plate.

[0005] Preferably, the connecting pipe is provided with a reaction kettle pipeline, and the reaction kettle pipeline top is provided with a insertion hole.

[0006] Preferably, the connecting pipe bottom is fixedly connected with a hot water bath bin, the hot water bath bin right side is fixedly connected with a pipeline, and the pipeline right side is fixedly connected with a rectification tower.

[0007] Preferably, the rectification tower is internally provided with a reactor, a condenser, a separator and a collection bottle.

[0008] Preferably, the connecting pipe is provided with a sealing assembly, the sealing assembly includes a sealing gasket, the sealing gasket is arranged on the top of the supporting plate, the sealing gasket bottom is fixedly connected with a connecting ring, and the connecting ring front is fixedly connected with a protruding block.

[0009] Preferably, the connecting pipe inner wall is provided with an L-shaped sliding slot.

[0010] The application has the following advantages:

[0011] Firstly, the installation device is arranged to push the connecting plate bottom at the bottom of the slide rod, move the slide rod to the top, stretch the spring, drive the plug rod to reset, install into the insertion hole, use the spring reset and clamping mechanism to ensure the stability and safety of the reaction kettle pipeline during use, facilitate the replacement of the reaction kettle pipeline, thereby solving the problem that the reaction kettle and the hot water bath bin have no foundation in the background technology, and the pipeline will be corroded after long-term use, resulting in toxic gas leakage.

[0012] Secondly, the sealing assembly is arranged to insert the connecting ring and the protruding block into the inner wall of the L-shaped sliding slot, twist the sealing gasket counterclockwise, drive the protruding block to clamp into the bottom of the L-shaped sliding slot inner wall, ensure the effective sealing between the inside and outside of the reaction kettle, and avoid gas leakage. BRIEF DESCRIPTION OF DRAWINGS

[0013] The drawings that constitute part of this application are used to provide a further understanding of this application and make other features, objects and advantages of this application more apparent. The illustrative embodiment drawings of this application and their descriptions are used to explain this application and do not constitute an improper limitation of this application. In the drawings:

[0014] Figure 1 This is a schematic diagram of the overall structure of the utility model;

[0015] Figure 2 This is a schematic diagram of the front structure of the utility model;

[0016] Figure 3 This is a schematic diagram of the back structure of the utility model;

[0017] Figure 4 For this utility model Figure 2 Enlarged structural diagram at point A in the middle.

[0018] In the above figure,

[0019] 1. Connecting pipe; 2. Mounting device; 21. Support plate; 22. Sleeve; 23. Slide rod; 24. Fixing rod; 25. Insert rod; 26. Pulley; 27. Slide groove; 28. Spring; 29. ​​Connecting plate; 210. Reactor pipe; 211. Socket; 3. Sealing assembly; 31. Sealing gasket; 32. Connecting ring; 33. Bump; 34. L-shaped slide groove; 4. Hot water bath; 5. Pipeline; 6. Distillation tower. DETAILED DESCRIPTION

[0020] In order to enable those skilled in the art to better understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of this application.

[0021] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments in this application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments. Example 1

[0022] See also Figures 1-4The embodiment provides an etherification reaction rectification device for isoflurane, which comprises a connecting pipe 1, a mounting device 2 is arranged on the connecting pipe 1, the mounting device 2 comprises a supporting plate 21, the supporting plate 21 is fixedly connected to the outer wall of the connecting pipe 1, a sleeve 22 is fixedly connected to the top of the supporting plate 21, a sliding rod 23 is slidably connected to the inner wall of the sleeve 22, a fixing rod 24 is fixedly connected to the top of the sliding rod 23, a plug rod 25 is fixedly connected to the bottom of the fixing rod 24, a sliding groove 27 is formed in the front of the sleeve 22, a pulley 26 is rotatably connected to the front of the sliding rod 23 through a bearing, the sliding rod 23 extends to the bottom and is movably penetrated through the supporting plate 21, springs 28 are movably arranged on the outer wall of the sliding rod 23, a connecting plate 29 is fixedly connected to the bottom of the sliding rod 23, the connecting pipe 1 is a main channel in the reaction system and is responsible for conveying reactants and products. The mounting device 2 provides support for the equipment, ensures stability and operability. The supporting plate 21 is fixed to the outer wall of the connecting pipe 1, providing a reliable installation foundation. The combination of the sleeve 22 and the sliding rod 23 allows for adjustment during operation, facilitating maintenance and replacement of parts. In addition, the spring 28 design allows the sliding rod 23 to automatically return to the initial position when needed, improving the flexibility and safety of the equipment. The connecting pipe 1 is provided with a reaction kettle pipeline 210, the top of the reaction kettle pipeline 210 is provided with a jack 211, and the reaction kettle pipeline 210 on the connecting pipe 1 is an important channel for mixing reactants and catalysts. The design of the jack 211 allows easy access to other equipment or sensors for real-time monitoring of reaction conditions such as temperature, pressure, flow rate, etc. This design improves the controllability of the reaction, helping to optimize reaction conditions and thus improve product yield and purity. The bottom of the connecting pipe 1 is fixedly connected with a hot water bath bin 4, the right side of the hot water bath bin 4 is fixedly connected with a pipeline 5, the right side of the pipeline 5 is fixedly connected with a rectifying tower 6, and the hot water bath bin 4 at the bottom of the connecting pipe 1 is used to provide heat required for the reaction, ensuring that the reaction can be carried out within a suitable temperature range, avoiding slow reaction rate or occurrence of side reactions. The arrangement of the pipeline 5 allows the hot water bath bin 4 to be effectively connected with the rectifying tower 6, and heat can be efficiently transferred during the reaction and separation process, enhancing the overall energy efficiency of the system. The rectifying tower 6 is internally provided with a reactor, a condenser, a separator and a collection bottle, and the combination of the reactor, the condenser, the separator and the collection bottle in the rectifying tower 6 realizes effective separation and purification. The reactor provides the necessary reaction conditions, the condenser is responsible for cooling gaseous products into liquid state, the separator effectively separates different components, and finally the collection bottle is used to collect the separated products. The design of this system greatly improves the separation efficiency, ensuring the purity and yield of the final product.

[0023] In specific use of the above device, the connecting plate 29 at the bottom of the slide rod 23 is pushed, the slide rod 23 moves to the top, the spring 28 is stretched, the slide rod 23 drives the pulley 26 of the outer wall to rotate along the moving track of the sliding groove 27, the slide rod 23 rotates along the direction of the sliding groove 27, the slide rod 23 drives the fixed rod 24 to move to the left, the fixed rod 24 drives the back of the plug rod 25 to rotate counterclockwise, the reactor pipe 210 is inserted into the groove at the top of the supporting plate 21, the connecting plate 29 is loosened, the spring 28 drives the plug rod 25 to reset, is installed into the plug hole 211, and the spring reset and clamping mechanism are used. The required raw materials for the reaction, such as hydrogen fluoride or chlorofluoride and alcohol such as isopropyl alcohol, are prepared, the raw materials are added into the reactor according to the proportion, stirring is started, and heating is gradually added to the required reaction temperature, usually between 50-100°C. During the reaction process, volatile gas can be collected through the condenser and made to reflow into the reactor, thereby improving the reaction efficiency. After the reaction is completed, the reactor is cooled, the reaction product is separated from the unreacted raw materials and impurities by using a separator, the separated liquid is sent to the rectifying column 6 for further separation, the rectifying column 6 is started, and the feed flow and reflux ratio are controlled. Through the cycle of heating and condensation, isoflurane and other volatile impurities are separated. During the rectification process, different fractions are collected, the purity is distinguished, isoflurane is collected after rectification, and purity detection such as gas chromatography analysis is performed. According to the needs, subsequent purification treatment is performed. Example Two

[0024] Referring to Figures 1-4 On the basis of example one, the connecting pipe 1 is provided with a sealing assembly 3, the sealing assembly 3 comprises a sealing gasket 31, the sealing gasket 31 is arranged at the top of the supporting plate 21, the bottom of the sealing gasket 31 is fixedly connected with a connecting ring 32, the front surface of the connecting ring 32 is fixedly connected with a protruding block 33, so as to ensure that there is no leakage during operation. The sealing gasket 31 is arranged at the top of the supporting plate 1, thereby providing a good sealing effect, and the connecting ring 32 further enhances the stability of the connection. The design of the protruding block 33 not only improves the sealing effect, but also provides a positioning function when the device needs to be disassembled or maintained, thereby facilitating the accurate alignment of the operator. The inner wall of the connecting pipe 1 is provided with an L-shaped sliding groove 34.

[0025] In specific use of the above device, the connecting ring 32 and the protruding block 33 are inserted into the inner wall of the L-shaped sliding groove 34, the sealing gasket 31 is twisted to rotate counterclockwise, the sealing gasket 31 drives the protruding block 33 to be clamped into the bottom of the inner wall of the L-shaped sliding groove 34, thereby ensuring the effective sealing between the inside and the outside of the reactor, and avoiding gas leakage.

[0026] The above is only a preferred specific implementation manner of the present application, but the protection scope of the present application is not limited to this. Any person skilled in the art, according to the technical scheme and the application concept of the present application, makes equivalent replacement or change within the technical range disclosed by the present application, should be covered within the protection scope of the present application.

Claims

1. An etherification reaction distillation device for isoflurane, comprising a connecting pipe (1), characterized in that: The connecting tube (1) is provided with a mounting device (2), the mounting device (2) comprising a supporting plate (21), the supporting plate (21) being fixedly connected to the outer wall of the connecting tube (1), the top of the supporting plate (21) being fixedly connected to a sleeve (22), the inner wall of the sleeve (22) being slidably connected to a slide rod (23), the top of the slide rod (23) being fixedly connected to a fixed rod (24), the bottom of the fixed rod (24) being fixedly connected to an insertion rod (25), a sliding groove (27) being provided on the front of the sleeve (22), the front of the slide rod (23) being rotatably connected to a pulley (26) through a bearing, the slide rod (23) being movably passed through the supporting plate (21) and extending to the bottom, the outer wall of the slide rod (23) being movably sleeved with a spring (28), and the bottom of the slide rod (23) being fixedly connected to a connecting plate (29).

2. The etherification reaction and distillation device for isoflurane according to claim 1, characterized in that: A reactor pipe (210) is provided on the connecting pipe (1), and a socket (211) is provided on the top of the reactor pipe (210).

3. The etherification reaction and distillation device for isoflurane according to claim 2, characterized in that: The bottom of the connecting pipe (1) is fixedly connected to a hot water bath chamber (4), the right side of the hot water bath chamber (4) is fixedly connected to a pipeline (5), and the right side of the pipeline (5) is fixedly connected to a distillation tower (6).

4. The etherification reaction and distillation device for isoflurane according to claim 3, characterized in that: A reactor is provided inside the distillation tower (6), a condenser is provided inside the distillation tower (6), a separator is provided inside the distillation tower (6), and a collecting bottle is provided inside the distillation tower (6).

5. The etherification reaction and distillation device for isoflurane according to claim 4, characterized in that: A sealing assembly (3) is provided on the connecting pipe (1), and the sealing assembly (3) includes a sealing gasket (31). The sealing gasket (31) is provided on the top of the supporting plate (21), a connecting ring (32) is fixedly connected to the bottom of the sealing gasket (31), and a protrusion (33) is fixedly connected to the front of the connecting ring (32).

6. The etherification reaction and distillation device for isoflurane according to claim 5, characterized in that: An L-shaped sliding groove (34) is provided on the inner wall of the connecting pipe (1).

Images