Filtering system

Abstract

The utility model provides a filtering system, and belongs to the field of liquid medicine preparation. The problems that filtering precision is not high, a filtering device is prone to being blocked, and flow direction distribution of filtered liquid is unreasonable are solved. The device comprises a liquid preparation tank, the liquid outlet end of the liquid preparation tank is connected with the liquid inlet end of a filtering assembly through a conveying assembly, the liquid outlet end of the filtering assembly comprises a pre-filtering liquid outlet end and a post-filtering liquid outlet end, and the pre-filtering liquid outlet end is connected with the liquid inlet end of the liquid preparation tank. Liquid flowing out of the filtered liquid outlet end is filtered by at least one ultrafiltration membrane group arranged in the filtering assembly and then is discharged; the liquid inlet end of the flow dividing assembly is connected with the filtered liquid outlet end, the flow dividing assembly is provided with at least two flow dividing liquid outlet ends, opening and closing control assemblies are arranged in at least part of the flow dividing liquid outlet ends and used for controlling opening and closing of the corresponding flow dividing liquid outlet ends, one flow dividing liquid outlet end is connected with the application end, and the other flow dividing liquid outlet end is connected with the liquid inlet end of the liquid preparation tank; the filter is mainly used for filtering liquid medicine.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the field of liquid preparation, especially, relate to a filter system. BACKGROUND

[0002] At present, injection production process generally includes the important working procedure such as preparation of raw and auxiliary materials, preparation, filtration, filling and sealing, sterilization, leak detection, quality inspection and packaging. Among them, the preparation process generally adopts the mode of thick preparation and thin preparation. The purpose of thick preparation is to decolorize, remove impurities and heat source. Thin preparation is mainly to control the drug content, remove particles and microorganisms. Special activated carbon is usually added during thick preparation production, and activated carbon has the effect of adsorbing heat source, impurities and pigment. However, activated carbon can also adsorb some effective components, such as alkaloids and organic acids. In addition, the raw material source and production process of activated carbon are diverse, and it is difficult to effectively control other impurities in activated carbon. It is necessary to filter and remove other impurities in the solution.

[0003] The existing filter system is mainly titanium rod filter, but the titanium rod filter has low filtering precision and is prone to blockage. The liquid from the liquid preparation tank is not reasonably utilized according to the working condition, and the liquid filtering efficiency is low. UTILITY MODEL CONTENT

[0004] Therefore, the utility model aims at providing a filter system, which mainly uses ultrafiltration membrane circulation filtering mode to filter liquid, improves filtering efficiency and precision, reduces the probability of blockage, and flexibly utilizes liquid flow direction to improve system operation efficiency.

[0005] To achieve the above purpose, the utility model adopts the following technical scheme, provides a filter system, which comprises:

[0006] The liquid preparation tank is connected with the liquid outlet end of the filter assembly through the conveying assembly, and the liquid outlet end of the filter assembly comprises a pre-filter liquid outlet end and a post-filter liquid outlet end, the pre-filter liquid outlet end is connected with the liquid inlet end of the liquid preparation tank, and the post-filter liquid outlet end flows out the liquid filtered by at least one ultrafiltration membrane group arranged in the filter assembly.

[0007] The shunt assembly is connected with the post-filter liquid outlet end, and the shunt assembly is provided with at least two shunt outlet ends, at least part of the shunt outlet ends is provided with an opening and closing control assembly for controlling the opening and closing of the corresponding shunt outlet end, one shunt outlet end is connected with the application end, and one shunt outlet end is connected with the liquid inlet end of the liquid preparation tank.

[0008] Furthermore, a plurality of ultrafiltration membrane groups are arranged in series in the filter assembly.

[0009] Furthermore, a plurality of ultrafiltration membrane groups are arranged in parallel in the filter assembly.

[0010] Further, the conveying assembly is a conveying pump.

[0011] Further, the liquid inlet end of the liquid preparation tank is connected with the liquid outlet end of the injection water cooling heat exchanger.

[0012] Further, the liquid preparation tank is internally provided with a liquid preparation cavity, and the liquid preparation cavity is communicated with the air exchange assembly.

[0013] Further, the liquid inlet end of the liquid preparation tank is a main pipeline, and the main pipeline is connected with the water outlet end of the injection water cooling heat exchanger, the air exchange assembly and the liquid outlet end of the pre-filtered liquid.

[0014] Further, the liquid preparation tank is externally provided with a heat exchange part, and the heat exchange part is connected with the temperature adjusting assembly.

[0015] Further, the bottom of the liquid preparation tank is provided with a stirring device.

[0016] Further, the stirring device is provided with an extension shaft, and the extension shaft is provided with a turbine at the end, and the turbine is coupled with any flow path for driving the extension shaft to rotate.

[0017] Compared with the prior art, the beneficial effects of the present application are:

[0018] 1. The liquid preparation tank is used for preparing mixed liquid and receiving pre-filtered liquid and post-filtered liquid backflowed from the filtering assembly.

[0019] 2. The conveying assembly pushes the solution prepared in the liquid preparation tank out through the liquid outlet end of the liquid preparation tank.

[0020] 3. The filtering assembly receives the liquid introduced by the conveying assembly, and the filtering assembly filters the introduced liquid or directly introduces the liquid back into the liquid preparation tank. The ultrafiltration membrane group in the filtering assembly works in the form of tangential flow, that is, the material flow is tangent to the filter membrane. This tangential flow working mode is not easy to block the filter membrane compared with the traditional dead-end filtration, and can achieve higher working efficiency. The filtered liquid can also flow back to the liquid preparation tank and then be filtered again by the filtering assembly to remove impurities and endotoxins.

[0021] 4. The shunt assembly distributes the filtered liquid to flow into the application device or flow back to the liquid preparation tank. BRIEF DESCRIPTION OF DRAWINGS

[0022] The drawings constituting a part of the present application are used to provide a further understanding of the present application, and the schematic embodiments of the present application and the description thereof are used to explain the present application, and do not constitute an improper limitation on the present application. In the drawings:

[0023] Figure 1 It is a whole structure schematic view of the present application.

[0024] The injection water cooling heat exchanger 1; air exchange assembly 2; liquid preparation tank 3; conveying assembly 4; filtering assembly 5; main pipeline 6; application equipment 7; sampling valve 8; temperature adjusting assembly 9; stirring device 10. DETAILED DESCRIPTION

[0025] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict, and the described embodiments are only a part of the embodiments of the present application, not all the embodiments.

[0026] It should be noted that the descriptions of the present application about "left", "right", "left side", "right side", "upper", "lower", "top", "bottom" and the like are defined based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and are not intended to indicate or imply that the described structure must be constructed and operated in a particular orientation, therefore, it cannot be understood as a limitation on the present application. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise explicitly specified and limited.

[0027] In the description of the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be directly connected, or indirectly connected through an intermediate medium, or the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances. DETAILED DESCRIPTION

[0029] Referring to the accompanying drawings, a filtering system is provided, comprising:

[0030] The liquid tank 3 stores the liquid which needs to be mixed and the backflow liquid. The liquid outlet of the liquid tank 3 is connected to the liquid inlet of the conveying assembly 4 and the liquid inlet of the filtering assembly 5. The liquid outlet of the filtering assembly 5 includes the liquid outlet before filtering and the liquid outlet after filtering. The liquid outlet before filtering is connected to the liquid inlet of the liquid tank 3. The liquid outlet after filtering is connected to the liquid inlet of the application device 7. The liquid outlet after filtering is filtered by at least one ultrafiltration membrane group. The conveying assembly 4 conveys the liquid in the liquid tank 3 to the liquid inlet of the filtering assembly 5. The liquid in the filtering assembly 5 is filtered by the ultrafiltration membrane group and discharged through the liquid outlet after filtering. The ultrafiltration membrane group works in the tangential flow mode. The material flow is tangent to the filter membrane. Compared with the traditional dead-end filtration containing filter core and carbon rod, the tangential flow mode is not easy to block the filter membrane and can achieve higher working efficiency. In the production, the endotoxin is usually removed by using the ultrafiltration mode of 5-10kD membrane. The material passes through the flow direction tangent to the membrane to achieve the filtering effect. Because the molecular weight of the chemical medicine is small, the chemical medicine can smoothly pass through the membrane layer and be collected at the permeation end. Because the molecular weight of the endotoxin is large, the endotoxin is intercepted on the surface of the membrane and returns to the backflow end. After multiple cycles, a certain filtering effect is achieved. The ultrafiltration can not only remove the pyrogen but also remove the high molecular substances larger than the membrane pore to improve the clarity and stability of the injection liquid. The smaller the pore size of the ultrafiltration membrane is, the more obvious the decolorization effect is. The ultrafiltration membrane group is cleaned by using alkaline solution. The cleaning water temperature and the cleaning time are strictly limited to prevent the damage of the filter membrane. The ultrafiltration membrane group is not resistant to high temperature and cannot be sterilized at the same time with the liquid tank and the pipeline. The ultrafiltration membrane group needs to be treated separately. Temperature sensors are arranged on the inlet and outlet pipelines. When the temperature exceeds the limit, the valve is closed in time to prevent the hot medium from entering the ultrafiltration membrane assembly. Pressure sensors and temperature sensors are arranged before and after the ultrafiltration membrane group for process detection and filter protection.

[0031] The shunt assembly is connected to the liquid outlet after filtering. The shunt assembly is provided with at least two shunt liquid outlets. At least part of the shunt liquid outlets is provided with an open and close control assembly for controlling the opening and closing of the corresponding shunt liquid outlet. One shunt liquid outlet is connected to the application device 7, and one shunt liquid outlet is connected to the liquid inlet of the liquid tank 3. The shunt liquid outlets connected to the application device 7 and the liquid inlet of the liquid tank 3 are provided with open and close control assemblies, that is, valves, for controlling the opening and closing of the corresponding flow path.

[0032] The shunt assembly is connected to the liquid outlet after filtering. The shunt assembly guides the liquid discharged through the liquid outlet after filtering along the shunt liquid outlet of the shunt assembly. The open and close control assembly is used for controlling whether the liquid is discharged into the application device 7 or backflows into the liquid tank 3.

[0033] In the embodiment, the filtering assembly 5 is provided with a plurality of ultrafiltration membrane groups connected in series. The plurality of ultrafiltration membrane groups connected in series can improve the precision of liquid filtration.

[0034] In the embodiment, the liquid inlet end of the liquid preparation tank 3 is connected with the liquid outlet end of the injection water cooling heat exchanger 1, and the injection water cooling heat exchanger 1 can instantaneously cool the injection water to the required liquid preparation temperature before the injection water enters the liquid preparation tank.

[0035] In the embodiment, the liquid preparation tank 3 is internally provided with a liquid preparation cavity, the liquid preparation cavity is communicated with the air exchange assembly 2, the air exchange assembly 2 is an air breather, and the air breather is arranged to ensure that the air pressure of the liquid preparation cavity inside the liquid preparation tank 3 is balanced.

[0036] In the embodiment, the liquid inlet end of the liquid preparation tank 3 is a main pipeline 6, the main pipeline 6 is connected with the water outlet end of the injection water cooling heat exchanger 1, the air exchange assembly 2 and the liquid outlet end of the pre-filtered liquid, and the main pipeline 6 serves as a whole converging component, which can facilitate the installation of other structures and the later maintenance.

[0037] In the embodiment, the main pipeline 6 is provided with a manhole feeding port, a sight lamp and an anti-explosion sheet. The sight lamp and the anti-explosion sheet are used to ensure the safety of the sight line and operation when the manhole feeding port is used for maintenance and viewing.

[0038] In the embodiment, the lower part of the liquid preparation tank 3 is provided with a sampling valve 8, which can be used to sample and detect the liquid in the liquid preparation tank 3 to check the current state of the liquid in the liquid preparation tank 3.

[0039] In the embodiment, the liquid preparation tank 3 is externally provided with a heat exchange part, the heat exchange part is connected with a temperature adjusting assembly 9, the heat exchange part can be specifically provided as a heat exchange cavity, the temperature adjusting assembly 9 adjusts the temperature of the liquid in the liquid preparation tank 3, the liquid preparation tank 3 is cooled by circulating cooling water when cooling, and the liquid preparation tank 3 is heated by circulating industrial steam when heating is required.

[0040] In the embodiment, the conveying assembly 4 is a conveying pump, and the conveying pump is connected with the pipeline according to the prior art.

[0041] In the embodiment, the bottom of the liquid preparation tank 3 is provided with a stirring device 10, which stirs the liquid in the liquid preparation tank 3 to keep the concentration of the liquid in the liquid preparation tank 3 uniform. The stirring device 10 can be stirred by rotating the impeller driven by the motor, and the stirring device 10 is reasonably arranged according to the prior art.

[0042] In the embodiment, the impeller of the stirring device 10 is provided with an extension shaft, the extension shaft is provided with a turbine at the end, the turbine is coupled with any flow path to drive the extension shaft to rotate, the turbine is driven to rotate by the fluid in the flow path, the turbine drives the extension shaft to rotate, and the rotating extension shaft reduces the energy output of the servo motor matched with the stirring device 10.

[0043] Working principle;

[0044] The injection solution enters into the liquid preparation tank 3 through the cooling heat exchanger 1 by injecting water, the stirring device 10 stirs the liquid in the liquid preparation tank 3 to ensure the uniformity of the liquid concentration, the temperature adjusting assembly 9 adjusts the temperature of the liquid in the liquid preparation tank 3 to keep the temperature of the liquid at a preset temperature, and the conveying assembly 4 guides the liquid in the liquid preparation tank 3 into the filtering assembly 5, according to the actual application condition, when the liquid does not need to be filtered, the liquid directly returns to the liquid preparation tank 3 through the pre-filtered liquid outlet end, when the liquid needs to be filtered, the liquid is filtered through at least one ultrafiltration membrane group and discharged from the post-filtered liquid outlet end, the post-filtered liquid can be controlled by the shunt assembly according to the condition, and subsequent transfer processing or return to the liquid preparation tank 3 is performed, wherein the ultrafiltration membrane group works in the form of tangential flow, that is, the material flow direction is tangent to the filter membrane, and the tangential flow working mode is not easy to block the filter membrane compared with the traditional dead-end filtration containing filter cores, carbon rods and the like, and higher working efficiency can be achieved. In production, the ultrafiltration mode is usually used to remove endotoxins, and a 5-10kD membrane is usually used, the material passes through the flow direction tangent to the membrane to achieve the filtering effect, because the molecular weight of the chemical medicine is small, the chemical medicine can smoothly pass through the membrane layer and be collected at the permeation end, and the endotoxin is intercepted on the surface of the membrane and returned to the return end, and after multiple cycles, a certain filtering effect is achieved. The ultrafiltration can not only remove pyrogens, but also remove high molecular substances larger than the membrane pore, improve the clarity and stability of the injection solution, and the smaller the pore size of the ultrafiltration membrane, the more obvious the decolorization effect, the post-filtered liquid returned to the liquid preparation tank 3 is further filtered by the ultrafiltration membrane group, the impurities and endotoxins in the liquid are filtered to the maximum, the post-filtered liquid can be sampled through the sampling valve 8 and returned to the liquid preparation tank 3 for analysis whether the liquid filtered by the ultrafiltration membrane group next time needs to be further filtered or introduced into the application device 7. Specific implementation method two

[0046] The difference between the embodiment and the specific implementation method one is that the filtering assembly 5 is provided with a plurality of parallel ultrafiltration membrane groups, the plurality of parallel ultrafiltration membrane groups increase the filtering flow of the filtering assembly 5 and improve the filtering efficiency, and the maintenance is convenient, and when any or multiple ultrafiltration membrane groups are replaced, the replacement is more convenient.

[0047] The above disclosed embodiments of the utility model are only used for helping to describe the utility model. The embodiments do not describe all the details exhaustively, and the utility model is not limited to the specific implementation method. According to the content of the specification, many modifications and changes can be made. The specification selects and specifically describes these embodiments in order to better explain the principle and practical application of the utility model, so that the person skilled in the art can well understand and utilize the utility model.

Claims

1. A filtration system, characterized in that: include: A liquid preparation tank (3), wherein the liquid outlet end is connected to the liquid inlet end of the filter assembly (5) via a conveying assembly (4), the liquid outlet end of the filter assembly (5) comprises a pre-filtrate liquid outlet end and a post-filtrate liquid outlet end, the pre-filtrate liquid outlet end is connected to the liquid inlet end of the liquid preparation tank (3), wherein the liquid flowing out of the post-filtrate liquid outlet end is filtered by at least one ultrafiltration membrane group provided in the filter assembly (5) and then discharged; A diversion component, wherein the liquid inlet end is connected to the filtered liquid outlet end, the diversion component is provided with at least two diversion outlet ends, and at least some of the diversion outlet ends are provided with an opening and closing control component for controlling the opening and closing of the corresponding diversion outlet ends, wherein one of the diversion outlet ends is connected to the application end (7), and one of the diversion outlet ends is connected to the liquid inlet end of the liquid distribution tank (3).

2. A filtration system according to claim 1, characterized in that: The filter assembly (5) is provided with a plurality of ultrafiltration membrane groups connected in series.

3. A filtration system according to claim 1, characterized in that: The filter assembly (5) is provided with a plurality of ultrafiltration membrane groups connected in parallel.

4. A filtration system according to claim 1, characterized in that: The delivery component (4) is a delivery pump.

5. The filtration system according to claim 1, characterized in that: The liquid inlet end of the liquid dispensing tank (3) is connected to the liquid outlet end of the injection water cooling heat exchanger (1).

6. A filtration system according to claim 5, characterized in that: A liquid dispensing cavity is provided inside the liquid dispensing tank (3), and the liquid dispensing cavity is communicated with the air exchange component (2).

7. A filtration system according to claim 6, characterized in that: The liquid inlet end of the liquid distribution tank (3) is a main pipeline (6), and the main pipeline (6) is connected to the water outlet end of the injection water cooling heat exchanger (1), the air exchange component (2) and the pre-filtration liquid outlet end.

8. A filtration system according to any one of claims 1 to 7, characterized in that: A heat exchange portion is provided outside the liquid distribution tank (3), and the heat exchange portion is connected to a temperature regulating component (9).

9. The filtration system according to claim 1, characterized in that: A stirring device (10) is provided at the bottom of the liquid preparation tank (3).

10. A filtration system according to claim 9, characterized in that: The stirring device (10) is provided with an extension shaft, a turbine is provided at the end of the extension shaft, and the turbine is coupled with any flow path to drive the extension shaft to rotate.

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