Multi-channel polypeptide synthesizer
By designing a multi-channel peptide synthesizer, the problems of low peptide synthesis efficiency and inconsistent quality in existing technologies have been solved, achieving efficient, large-scale peptide synthesis and reliable experimental results, thus improving synthesis efficiency and stability.
Patent Information
- Application Number
- CN202422924309.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-28
- Publication Date
- 2025-10-24
- Estimated Expiration
- 2034-11-28
AI Technical Summary
Existing peptide synthesizers can only synthesize one peptide chain at a time, resulting in low synthesis efficiency and long synthesis time, making it difficult to meet the needs of high-efficiency, large-scale synthesis. Furthermore, multiple synthesis may lead to inconsistent peptide quality, affecting the reliability and reproducibility of experimental results.
Design a multi-channel peptide synthesizer comprising multiple synthesis flasks and a clamping mechanism. A motor-driven bidirectional screw enables simultaneous fixation and feeding of multiple synthesis flasks, ensuring the stability and efficiency of peptide synthesis.
This has enabled more efficient and stable peptide synthesis, shortened the research cycle, ensured consistent quality in large-scale production, and improved the reliability and efficiency of experiments.
Smart Images
Figure CN223464808U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to polypeptide synthesizer technical field, concretely is a kind of multichannel polypeptide synthesizer. BACKGROUND
[0002] Polypeptide synthesizer is a kind of instrument for synthesizing polypeptide. Polypeptide synthesis is a process of synthesizing polypeptide by repeatedly adding amino acid under certain reaction conditions with resin as carrier. Polypeptide synthesizer can efficiently complete the synthesis of polypeptide through automatic or semi-automatic operation. With the passage of time, polypeptide synthesizer is continuously developed and improved, and various different types of synthesizers appear, including microgram, milligram, gram and kilogram; from the function, it is divided into research type, small test type, pilot type, ordinary production type and GMP production type.
[0003] At present, part of polypeptide synthesizer can only synthesize one polypeptide chain at a time, if different polypeptides need to be synthesized, they must be carried out in turn, which greatly reduces the synthesis efficiency. Since only one polypeptide chain can be synthesized each time, researchers need to spend more time to complete multiple synthesis tasks, which not only prolongs the research period, but also may affect the experimental progress. In the case of large-scale production of polypeptide, the production capacity of single-channel synthesizer is limited, which is difficult to meet the synthesis demand of high efficiency and large quantity. And in the process of multiple separate synthesis, due to the change of operating conditions and environment, the synthesis quality of different batches of polypeptide may be inconsistent, which affects the reliability and repeatability of experimental results. UTILITY MODEL CONTENT
[0004] The utility model aims at providing a kind of multichannel polypeptide synthesizer to solve the problems raised in the above background art.
[0005] To achieve the above object, the utility model provides the following technical scheme: a kind of multichannel polypeptide synthesizer, including shell, still including:
[0006] The placing hole is arranged in the shell, the inner wall of the placing hole is fixed with four limit plates, the inner wall of the limit plate is provided with bottle body, the top of the bottle body is communicated with liquid inlet pipe, the inner wall of the shell is fixed with hook, the liquid inlet pipe is wound on the outer side of the hook, the shell is provided with feeding piece on one side, the end of the liquid inlet pipe away from the bottle body is communicated with the feeding piece, the inner wall of the shell is respectively provided with a plurality of synthesis bottles and clamping mechanism for positioning synthesis bottle.
[0007] Preferably, the clamping mechanism includes a motor fixed to one side of the shell, and a bidirectional screw rod fixed to the output end of the motor.
[0008] Preferably, the bidirectional screw rod is rotatably connected to the inner wall of the shell, and a plurality of limiting rings are fixed to the outer side of the bidirectional screw rod.
[0009] Preferably, the outer side of the bidirectional screw is threadedly connected with a plurality of moving plates, and the moving plates are fixed with clamping plates close to one side of the synthesis bottle.
[0010] Preferably, one side of the moving plate is fixed with a sliding block which is slidingly connected to the inner wall of the shell.
[0011] Preferably, the inner wall of the shell is fixed with a plurality of positioning rods, and one end of the positioning rod is fixed with an elastic snap ring which is clamped to the outer side of the synthesis bottle.
[0012] Preferably, the inner wall of the shell is fixed with a control panel, and the feeding member and the motor are electrically connected with the control panel, and the two sides of the shell are symmetrically provided with through holes, and the four corners of the bottom of the shell are fixed with supporting legs.
[0013] Compared with the prior art, the utility model has the advantages that:
[0014] The utility model discloses a plurality of synthesis bottles can be set up simultaneously, and the plurality of synthesis bottles can be clamped and fixed through the clamping mechanism, so that the stability during polypeptide synthesis is improved, the synthesis efficiency is greatly improved, the working time of researchers is saved, the working efficiency is improved, the synthesis demand of high efficiency and large batch can be reached in the case that polypeptide needs to be produced on a large scale, and the experimental result can be avoided to be influenced by environmental factors during the polypeptide synthesis. BRIEF DESCRIPTION OF DRAWINGS
[0015] Figure 1 A preferred embodiment structure diagram of the polypeptide synthesizer is provided in the utility model.
[0016] Figure 2 A structure diagram of the shell is provided in the utility model.
[0017] Figure 3 A structure diagram of the shell is provided in the utility model. Figure 2 A structure diagram of the shell is provided in the utility model.
[0018] Figure 4 A structure diagram of the shell is provided in the utility model.
[0019] Figure 5 A structure diagram of the shell is provided in the utility model.
[0020] As shown in the figure: 1, the shell; 2, the placement hole; 3, the limiting plate; 4, the bottle body; 5, the liquid inlet pipe; 6, the hook; 7, the feeding piece; 8, the synthetic bottle; 9, the clamping mechanism; 91, the motor; 92, the bidirectional screw rod; 93, the limiting ring; 94, the moving plate; 95, the clamping plate; 96, the sliding block; 10, the positioning rod; 11, the elastic snap ring; 12, the control panel; 13, the through hole; 14, the supporting leg. DETAILED DESCRIPTION
[0021] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all the other embodiments obtained by the ordinary skilled in the art without creative labor fall within the protection scope of the utility model.
[0022] Please refer to Figures 1-5 As shown in the figure, a multi-channel polypeptide synthesizer, comprising a shell 1, by setting the shell 1 can be polypeptide synthesis; also includes the placement hole 2 set in the shell 1 inside, by setting the placement hole 2 can be placed bottle body 4; The inner wall of the placement hole 2 is fixed with four limiting plates 3, by setting the limiting plate 3 can be limited to the bottle body 4; The inner wall of the limiting plate 3 is provided with the bottle body 4, by setting the bottle body 4 can store the stock solution of polypeptide synthesis; The top of the bottle body 4 is communicated with the liquid inlet pipe 5, by setting the liquid inlet pipe 5 can be connected with the feeding piece 7 and the bottle body 4; The inner wall of the shell 1 is fixed with the hook 6, by setting the hook 6 can be fixed to the liquid inlet pipe 5; The liquid inlet pipe 5 is wound on the outer side of the hook 6, one side of the shell 1 is provided with the feeding piece 7, by setting the feeding piece 7 can control the stock solution in the bottle body 4 into the synthetic bottle 8; The end of the liquid inlet pipe 5 away from the bottle body 4 is communicated with the feeding piece 7, the inner part of the shell 1 is respectively provided with a plurality of synthetic bottles 8 and the clamping mechanism 9 for positioning the synthetic bottle 8, by setting a plurality of synthetic bottles 8 can be multi-channel polypeptide synthesis, by setting the clamping mechanism 9 can be positioned simultaneously for a plurality of synthetic bottles 8, prevent damage from falling.
[0023] Please refer to Figure 4 And Figure 5As shown, the clamping mechanism 9 includes a motor 91 fixed to one side of the shell 1, which can drive the bidirectional screw 92 to rotate by setting the motor 91; the output end of the motor 91 is fixed with the bidirectional screw 92, which can drive multiple sets of corresponding two moving plates 94 to move in opposite directions by setting the bidirectional screw 92; the bidirectional screw 92 is rotatably connected to the inner wall of the shell 1, and the outer side of the bidirectional screw 92 is fixed with a plurality of limiting rings 93, which can limit the movement distance of the moving plate 94 by setting the limiting ring 93; the outer side of the bidirectional screw 92 is threadedly connected with a plurality of moving plates 94, which can drive the clamping plate 95 to move by setting the moving plate 94; the side of the moving plate 94 close to the synthetic bottle 8 is fixed with the clamping plate 95, which can clamp and fix a plurality of synthetic bottles 8 by moving the clamping plate 95; the side of the clamping plate 95 close to the synthetic bottle 8 is made of rubber material to avoid damage to the synthetic bottle 8 during clamping; one side of the moving plate 94 is fixed with a sliding block 96, which is slidably connected to the inner wall of the shell 1, and the stability of the moving plate 94 can be improved by setting the sliding block 96.
[0024] As shown in Figure 1 、 Figure 2 、 Figure 3 and Figure 5 , the inner wall of the shell 1 is fixed with a plurality of positioning rods 10, which can fix the elastic snap ring 11 in the shell 1 by setting the positioning rod 10; one end of the positioning rod 10 is fixed with the elastic snap ring 11, which can clamp and temporarily place and fix the synthetic bottle 8 by setting the elastic snap ring 11; the elastic snap ring 11 is clamped on the outer side of the synthetic bottle 8; the inner wall of the shell 1 is fixed with a control panel 12, which can control the work of the feeding part 7 and the motor 91 by setting the control panel 12; the feeding part 7 and the motor 91 are electrically connected with the control panel 12, and the two sides of the shell 1 are symmetrically provided with through holes 13, which can facilitate heat dissipation of the machine and can be disassembled for maintenance; the four corners of the bottom of the shell 1 are fixed with supporting legs 14, which can support and fix the shell 1 by setting the supporting legs 14.
[0025] Working principle: when the device is in use, the workers will temporarily fix a plurality of synthetic bottles 8 in the elastic snap ring 11 in sequence, then control the motor 91 to drive the bidirectional screw 92 to rotate by the control panel 12, the bidirectional screw 92 drives multiple sets of corresponding two moving plates 94 to move in opposite directions, the moving plate 94 drives the clamping plate 95 to move, the clamping plate 95 moves to clamp and fix a plurality of synthetic bottles 8, the side of the clamping plate 95 close to the synthetic bottle 8 is made of rubber material to avoid damage to the synthetic bottle 8 during clamping, and finally the solution in the bottle body 4 is sequentially delivered into the synthetic bottle 8 by the control panel 12 to control the feeding part 7, realizing the feeding and mixing of raw materials, and the rotation of the synthetic bottle 8 is realized by the rotating device in the equipment, which has the same principle as the existing device, realizing the synthesis of polypeptide with multiple channels.
[0026] It has to be noted that, in the present document, the terms "first", "second", etc. merely serve to identify a subject or action from another subject or action, without necessarily requiring or implying any actual such relationship or order between such subjects or actions. Moreover, the terms "comprising", "containing", or any other similar term are intended to encompass non-exclusive inclusions, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can also include other elements not expressly listed or inherent to such process, method, article, or apparatus. An element proceeded by "comprises... a", "contains... a", or "includes... a" does not, without more constraints, exclude the existence of additional identical elements in the process, method, article, or apparatus that comprises the element.
[0027] While the embodiments of the present application have been illustrated and described, it will be understood by those skilled in the art that various changes, modifications, substitutions, and alterations can be made therein without departing from the spirit and scope of the present application, which is defined by the appended claims and their equivalents.
Claims
1. A multichannel polypeptide synthesizer comprising a housing (1), characterized in that Also include: The placing hole (2) is arranged in the shell (1), the inner wall of the placing hole (2) is fixed with four limit plates (3), the inner wall of the limit plate (3) is provided with bottle body (4), the top of the bottle body (4) is communicated with liquid inlet pipe (5), the inner wall of the shell (1) is fixed with hook (6), the liquid inlet pipe (5) is wound on the outer side of the hook (6), the shell (1) is provided with feed member (7) on one side, the end of the liquid inlet pipe (5) away from the bottle body (4) is communicated with the feed member (7), the inner wall of the shell (1) is provided with a plurality of synthetic bottles (8) and clamping mechanism (9) for positioning synthetic bottle (8).
2. A multichannel polypeptide synthesizer according to claim 1, wherein: The clamping mechanism (9) includes a motor (91) fixed to one side of the shell (1), and a bidirectional screw rod (92) fixed to an output end of the motor (91).
3. A multichannel polypeptide synthesizer according to claim 2, wherein: The bidirectional screw rod (92) is rotatably connected to the inner wall of the shell (1), and a plurality of limiting rings (93) are fixed to the outer side of the bidirectional screw rod (92).
4. A multichannel polypeptide synthesizer according to claim 2, wherein: The outer side of the bidirectional screw rod (92) is threadedly connected with a plurality of moving plates (94), and the moving plates (94) are fixed with clamping plates (95) on one side close to the synthetic bottles (8).
5. A multichannel polypeptide synthesizer according to claim 4, wherein: One side of the moving plate (94) is fixed with a sliding block (96), and the sliding block (96) is slidably connected to the inner wall of the shell (1).
6. A multichannel polypeptide synthesizer according to claim 1, wherein: The inner wall of the shell (1) is fixed with a plurality of positioning rods (10), one end of the positioning rod (10) is fixed with an elastic clamping ring (11), and the elastic clamping ring (11) is clamped to the outer side of the synthetic bottle (8).
7. A multichannel polypeptide synthesizer according to claim 1 wherein: The inner wall of the shell (1) is fixed with a control panel (12), the feed member (7) and the motor (91) are electrically connected with the control panel (12), the both sides of the shell (1) are symmetrically provided with through holes (13), and the four corners of the bottom of the shell (1) are fixed with supporting legs (14).