Device for local perfusion of cryogenic liquid through internal carotid artery

Abstract

The utility model discloses a device for local perfusion of cryogenic liquid through internal carotid artery, and relates to the technical field of artery perfusion of cryogenic liquid, the device comprises a heat preservation box body and a heat preservation box cover, a temperature control mechanism is installed on the heat preservation box cover, an injection pump is installed in the heat preservation box body, an injector is installed on the injection pump, and the injector is connected with the heat preservation box cover. A PE injection tube is inserted into a nipple of the injector, a cold insulation mechanism is arranged on one side of the heat preservation box body, and a plurality of ice bags are placed in the heat preservation box body; the injection is kept in a low-temperature state through the ice bag, the temperature control mechanism and the cold insulation mechanism, local injection is performed through the low-temperature injection, complications possibly caused by whole-body cooling are avoided, and compared with traditional local cold compress, the local low-temperature technology can quickly and evenly reduce the temperature of target brain tissue, and the cold compress efficiency is improved. Therefore, the metabolic activity of brain tissues is more efficiently inhibited, the oxidative stress is relieved, and the cell injury is relieved.

Description

Technical Field

[0001] This utility model relates to the field of arterial perfusion cryogenic liquid technology, and in particular to a device for local perfusion of cryogenic liquid via the internal carotid artery. Background Technology

[0002] Cerebral ischemia-reperfusion injury is a common pathophysiological process in clinical practice, which can lead to severe neurological dysfunction. Hypothermia therapy is considered an effective neuroprotective measure.

[0003] Currently, most related studies use whole-body hypothermia or local cold compresses to the head.

[0004] However, systemic hypothermia can cause adverse reactions such as chills, arrhythmia, and electrolyte imbalance. Local cold compresses, on the other hand, are unlikely to penetrate the skull to rapidly lower brain tissue to the target temperature.

[0005] Therefore, in order to solve the above problems, this application proposes a device for local perfusion of cryogenic liquid via the internal carotid artery. Utility Model Content

[0006] This invention provides a device for local perfusion of cryogenic liquid via the internal carotid artery to solve the above-mentioned technical problems.

[0007] To solve the above-mentioned technical problems, this utility model provides a device for local perfusion of cryogenic liquid via the internal carotid artery, comprising an insulated box and an insulated box cover. The insulated box cover covers the top of the insulated box, and a temperature control mechanism is installed on the insulated box cover. An injection pump is installed inside the insulated box, and the injection pump penetrates the insulated box and extends to the front side of the insulated box. A syringe is installed on the injection pump, and a PE injection tube is inserted into the tip of the syringe. The connection between the syringe and the PE injection tube penetrates the insulated box, and the PE injection tube is located on one side of the insulated box. A cold insulation mechanism is provided on one side of the insulated box, and the PE injection tube penetrates the cold insulation mechanism. Multiple ice packs are placed inside the insulated box.

[0008] Preferably, the temperature control mechanism includes a temperature controller and a thermoelectric cooler. The temperature controller is fixedly installed on the top of the insulation box, and the thermoelectric cooler is located in front of the temperature controller. The thermoelectric cooler penetrates the insulation box cover and extends into the interior of the insulation box. The temperature controller and the thermoelectric cooler are electrically connected by wires. An external power supply is electrically connected to one side of the temperature controller, and a temperature sensor is electrically connected to the other side of the temperature controller by wires. The temperature sensor is located inside the insulation box.

[0009] Preferably, the cold insulation mechanism includes a cooling pipe and two sealing plugs, the two sealing plugs being inserted into both sides of the cooling pipe respectively, and the PE injection tube passing through the sealing plugs and the cooling pipe.

[0010] Preferably, the sealing plug has a notch, the PE injection tube passes through the notch, and the portion of the PE injection tube inside the cooling tube is spiral-shaped.

[0011] Preferably, an L-shaped partition is fixedly connected inside the insulated box, and the L-shaped partition is located between the injection pump and multiple ice packs.

[0012] Compared with related technologies, the device for local perfusion of cryogenic liquid via the internal carotid artery provided by this utility model has the following beneficial effects:

[0013] By using an insulated box, insulated lid, ice pack, and temperature control mechanism, the syringe is kept in a low-temperature environment maintained at any temperature between 2 and 15°C. The injection is then driven by an injection pump, and the injection solution in the PE injection tube is kept at a low temperature during the injection. Local injection with low-temperature injection solution avoids the complications that may be caused by systemic cooling. Compared with traditional local cold compresses, local low temperature technology can quickly and evenly reduce the temperature of the target brain tissue, thereby more effectively inhibiting the metabolic activity of brain tissue, reducing oxidative stress, and reducing cell damage. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of a device for local perfusion of cryogenic liquid via the internal carotid artery proposed in this utility model;

[0015] Figure 2 This is a schematic diagram of the temperature control mechanism of a device for local perfusion of cryogenic liquid via the internal carotid artery proposed in this utility model;

[0016] Figure 3 This is a schematic diagram of the internal structure of the insulated box of a device for local perfusion of cryogenic liquid via the internal carotid artery proposed in this utility model.

[0017] Figure 4 This is a schematic diagram of the cold-keeping mechanism of a device for local perfusion of cryogenic liquid via the internal carotid artery proposed in this utility model;

[0018] Figure 5 This is a schematic diagram of the sealing plug structure of a device for local perfusion of cryogenic liquid via the internal carotid artery proposed in this utility model.

[0019] The following are the labels in the diagram: 1. Insulated box body, 2. Insulated box lid, 3. Thermostat, 4. Semiconductor cooler, 5. External thermostat cable, 6. Temperature sensor, 8. Injection pump, 9. Syringe, 10. L-shaped partition, 11. Ice pack, 12. PE injection tube, 13. Cooling pipe, 14. Sealing plug, 15. Notch. Detailed Implementation

[0020] Implementation examples, by Figure 1-5The present invention includes an insulated box body 1 and an insulated box cover 2. The insulated box cover 2 covers the top of the insulated box body 1. A temperature control mechanism is installed on the insulated box cover 2. An injection pump 8 is installed inside the insulated box body 1, and the injection pump 8 penetrates the insulated box body 1 and extends to the front side of the insulated box body 1. A syringe 9 is installed on the injection pump 8. A PE injection tube 12 is inserted into the nipple of the syringe 9. The connection between the syringe 9 and the PE injection tube 12 penetrates the insulated box body 1. The PE injection tube 12 is located on one side of the insulated box body 1. A cold preservation mechanism is provided on one side of the insulated box body 1. The PE injection tube 12 penetrates the cold preservation mechanism. Multiple ice packs 11 are placed inside the insulated box body 1.

[0021] The temperature control mechanism includes a temperature controller 3 and a thermoelectric cooler 4. The temperature controller 3 is fixedly installed on the top of the insulation box 1, and the thermoelectric cooler 4 is located in front of the temperature controller 3. The thermoelectric cooler 4 penetrates the insulation box cover 2 and extends into the interior of the insulation box 1. The temperature controller 3 and the thermoelectric cooler 4 are electrically connected by wires. An external power supply line 5 is electrically connected to one side of the temperature controller 3, and a temperature sensor 6 is electrically connected to the other side of the temperature controller 3 by wires. The temperature sensor 6 is located inside the insulation box 1. The thermoelectric cooler 4 in the temperature control mechanism actively cools the air inside the insulation box 1. During this process, the temperature sensor 6 can monitor the temperature in the insulation box 1. The temperature controller 3 has a display screen that can be used to display the temperature detected by the temperature sensor 6. The temperature in the insulation box 1 needs to be maintained between 2 and 15°C so that the injection liquid in the syringe 9 can maintain a low temperature.

[0022] The cold insulation mechanism includes a cooling pipe 13 and two sealing plugs 14. The two sealing plugs 14 are respectively inserted into both sides of the cooling pipe 13. A PE injection tube 12 passes through the sealing plugs 14 and the cooling pipe 13. A notch 15 is provided on the sealing plug 14, and the PE injection tube 12 passes through the notch 15. The portion of the PE injection tube 12 inside the cooling pipe 13 is spiral-shaped. The cooling pipe 13 in the cold insulation mechanism is filled with an ice-water mixture, and then the sealing plugs 14 are plugged at both ends. The PE injection tube 14 passing through the cooling pipe 13 and the sealing plugs 14... The injection tube 12, through which the injection fluid flows, is kept cold by the ice-water mixture as it passes through the cold insulation mechanism to prevent the temperature from rising. The spiral-shaped PE injection tube 12 can prolong the contact time between the injection fluid and the ice-water mixture, thereby improving the cold insulation effect. The notch 15 on the sealing plug 14 is for the PE injection tube 12 to pass through. However, the sealing plug 14 is made of rubber and has a certain degree of elasticity. Therefore, after the sealing plug 14 is inserted into the cooling tube 13, the sealing plug 14 is squeezed and its notch 15 is squeezed closed, so there will be no leakage.

[0023] An L-shaped partition 10 is fixedly connected inside the insulated box 1. The L-shaped partition 10 is located between the injection pump 8 and multiple ice packs 11. The L-shaped partition 10 is used to separate the injection pump 8 and the ice packs 11 to prevent water from flowing from the ice packs 11 onto the injection pump 8. The height of the L-shaped partition 10 is much lower than the height of the insulated box 1, so there will be no problem of uneven temperature inside the insulated box 1. It only serves as a water-proof protection.

[0024] Working principle:

[0025] Before use, the syringe 9 is installed on the injection pump 8, and multiple ice packs 11 are placed in the insulated box 1 to quickly lower the temperature inside the insulated box 1 to meet the injection temperature requirements. At this time, the syringe 9 and ice packs 11 are both inside the insulated box 1. The insulated box lid 2 is closed, and the thermoelectric cooler 4 is activated. The cold end of the thermoelectric cooler 4 is inside the insulated box 1, which lowers the air temperature inside the insulated box 1. The thermoelectric cooler 4, in conjunction with the ice packs 11, can lower the ambient temperature of the syringe 9 inside the insulated box 1. During this process, the temperature sensor 6 detects the temperature inside the insulated box 1. The temperature is displayed on the screen of the temperature controller 3, so that the syringe 9 in the heat preservation box 1 is in a relatively stable low temperature environment, and the temperature can be maintained between 2 and 15°C. Then, the injection pump 8 is started to control the syringe 9 to inject. The low temperature injection solution in the syringe 9 is injected into the experimental rat through the PE injection tube 12. When the injection solution flows through the cooling tube 13 in the PE injection tube 12, the ice-water mixture in the cooling tube 13 can keep the injection solution in the PE injection tube 12 at a low temperature, avoiding the problem of the injection solution heating up in the PE injection tube 12.

Claims

1. A device for local perfusion of cryogenic liquid via the internal carotid artery, comprising an insulated box body (1) and an insulated box cover (2), wherein the insulated box cover (2) covers the top of the insulated box body (1), characterized in that: A temperature control mechanism is installed on the cover (2) of the insulated box. An injection pump (8) is installed inside the insulated box (1). The injection pump (8) passes through the insulated box (1) and extends to the front side of the insulated box (1). A syringe (9) is installed on the injection pump (8). A PE injection tube (12) is inserted into the nipple of the syringe (9). The connection between the syringe (9) and the PE injection tube (12) passes through the insulated box (1). The PE injection tube (12) is located on one side of the insulated box (1). A cold preservation mechanism is provided on one side of the insulated box (1). The PE injection tube (12) passes through the cold preservation mechanism. Multiple ice packs (11) are placed inside the insulated box (1).

2. The device for local perfusion of cryogenic liquid via the internal carotid artery according to claim 1, characterized in that, The temperature control mechanism includes a temperature controller (3) and a thermoelectric cooler (4). The temperature controller (3) is fixedly installed on the top of the insulation box (1). The thermoelectric cooler (4) is located in front of the temperature controller (3) and extends through the insulation box cover (2) and into the interior of the insulation box (1). The temperature controller (3) and the thermoelectric cooler (4) are electrically connected by wires. An external power supply line (5) is electrically connected to one side of the temperature controller (3), and a temperature sensor (6) is electrically connected to the other side of the temperature controller (3) by wires. The temperature sensor (6) is located inside the insulation box (1).

3. The device for local perfusion of cryogenic liquid via the internal carotid artery according to claim 1, characterized in that, The cold insulation mechanism includes a cooling pipe (13) and two sealing plugs (14), which are respectively inserted into both sides of the cooling pipe (13). The PE injection tube (12) passes through the sealing plugs (14) and the cooling pipe (13).

4. The device for local perfusion of cryogenic liquid via the internal carotid artery according to claim 3, characterized in that, The sealing plug (14) has a notch (15) and the PE injection tube (12) passes through the notch (15). The portion of the PE injection tube (12) inside the cooling tube (13) is spiral-shaped.

5. The device for local perfusion of cryogenic liquid via the internal carotid artery according to claim 1, characterized in that, The insulated box (1) is fixedly connected to an L-shaped partition (10), which is located between the injection pump (8) and multiple ice packs (11).

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