Mouse tail vein injection device

Abstract

The utility model relates to the technical field of medical experiments, and discloses a mouse caudal vein injection device which comprises a base, a fixing mechanism is arranged at one end of the base, an installation frame is connected to the other end of the base in a sliding mode, an injection needle is arranged on the installation frame, a first piston rod penetrating into the injection needle is arranged on the injection needle, and a first piston is arranged at the inner end of the first piston rod. A cavity is formed in the first piston rod, the outer end of the first piston rod is closed, the inner end of the first piston rod is open, a second piston rod is arranged in the first piston rod, a second piston is arranged at the inner end of the second piston rod, and an adjusting assembly used for adjusting the depth of the second piston rod in the first piston rod is arranged on the first piston rod. A driving assembly used for adjusting the depth of the first piston rod in the injection needle is further arranged on the mounting frame. The problems that an existing mouse caudal vein injection device has high requirements for workers, the injection amount cannot be accurately controlled through manual administration, and continuous trace drug supply cannot be achieved within a short time are solved.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical experiment technical field especially, a mouse tail intravenous injection device. BACKGROUND

[0002] Tail intravenous injection is one of the most common methods in mouse experiment operation. Tail intravenous injection is a commonly used experimental animal intravenous administration method in research. In various basic medical researches, in order to observe the drug efficacy and toxicity of drugs and new compounds, in the etiology and pathogenesis and pathology research of diseases, in order to observe the body function, metabolism and morphological changes of animals, certain administration methods are needed for experimental animals.

[0003] The existing mouse tail intravenous injection device usually includes a fixing mechanism and an injection needle. The fixing mechanism is used to fix the mouse and expose its tail. The worker usually pulls the mouse tail tightly straight with the left hand, and inserts the injection needle into the mouse blood vessel with the right hand, and then advances the drug. The whole process needs the worker to operate with both hands simultaneously, which is easy to cause fatigue. Moreover, since the mouse tail blood vessel is thin, the one-time injection amount is small, so the worker's proficiency is required. At the same time, manual drug administration cannot accurately control the injection amount, and continuous micro-dose drug supply in a short time is impossible. UTILITY MODEL CONTENT

[0004] Therefore, the utility model aims at providing a mouse tail intravenous injection device to solve the problems that the existing mouse tail intravenous injection device requires a high worker, and manual drug administration cannot accurately control the injection amount, and continuous micro-dose drug supply in a short time is impossible.

[0005] The utility model solves the above technical problems through the following technical means:

[0006] A mouse tail intravenous injection device, including the base, one end of the base is provided with the fixed mechanism, the other end is slidably connected with the mounting bracket, the mounting bracket is provided with the injection needle, the injection needle is provided with the first piston rod in the injection needle, the first piston rod is provided with the first piston in the inner end, the first piston rod is internally provided with the cavity, the first piston rod is closed in the outer end, and the inner end is open, the first piston rod is internally provided with the second piston rod, the second piston rod is provided with the second piston in the inner end, the first piston rod is provided with the adjusting assembly for adjusting the depth of the second piston rod in the first piston rod, the mounting bracket is also provided with the driving assembly for adjusting the depth of the first piston rod in the injection needle.

[0007] Further, the adjusting assembly comprises an adjusting piece and a sliding block, the sliding block is axially slidably arranged in the first piston rod, the inner end of the sliding block is fixedly connected with the outer end of the second piston rod, the outer end is rotatably connected with the inner end of the adjusting piece, the outer end of the adjusting piece protrudes out of the first piston rod to form an operating end, the adjusting piece is screwed with the first piston rod, and the sliding block cannot rotate in the first piston rod.

[0008] Further, the outer end of the sliding block is provided with a scale on one side of the adjusting piece, and the first piston rod is provided with a through hole for the scale.

[0009] Further, the driving assembly comprises a lead screw and a motor, the mounting frame is provided with a fixed plate below the injection needle, the motor is mounted on the mounting frame, the output end of the motor penetrates through the fixed plate and is fixedly connected with one end of the lead screw, the fixed plate is fixedly provided with a guide rod, the axis of the lead screw and the axis of the guide rod are parallel to the axis of the injection needle, the surface of the lead screw is screw-connected with a sliding plate, the guide rod penetrates through the sliding plate and the two are slidingly connected, and the top of the sliding plate is fixedly connected with the bottom of the outer end of the first piston rod.

[0010] Further, the outer end of the first piston rod is provided with a pressure stabilizing hole, and the pressure stabilizing hole communicates the inside of the first piston rod with the outside.

[0011] Further, the top of the injection needle is fixedly connected with a medicine bottle, a communication pipe is arranged between the medicine bottle and the injection needle, one end of the communication pipe communicates with the medicine bottle, the other end of the communication pipe communicates with the end of the injection needle close to the needle head, a first one-way valve is arranged in the communication pipe, and a second one-way valve is arranged at the end of the injection needle close to the needle head.

[0012] Further, a locking piece is arranged between the mounting frame and the base.

[0013] Further, a knife seat is arranged on the base, and a blade is arranged in the knife seat.

[0014] Further, the fixing mechanism comprises a supporting plate and a cylinder, the supporting plate is fixed on the base, the cylinder is hollow and open at both ends, the cylinder is fixed on the supporting plate, the end of the cylinder away from the injection needle is movably connected with a limiting plate, a fixing piece is arranged between the limiting plate and the cylinder, a baffle is arranged at the end of the cylinder close to the injection needle, and a through hole is arranged in the baffle.

[0015] Further, a limiting groove is arranged at the end of the supporting plate close to the injection needle, and a tail pressing block is movably arranged on the supporting plate.

[0016] The beneficial effects of the utility model are as follows:

[0017] The utility model discloses a mounting frame is set up, and the injection needle is fixed on the mounting frame, when the mouse is fixed on the fixed mechanism, the pillow of injection needle can be just aligned with the mouse tail, and the right hand of the staff is liberated, and through the drive assembly can drive first piston rod, first piston moves, and the mouse is injected medicament, and then through the adjusting assembly drive second piston rod, second piston moves, and can continuously micro -dose to the mouse, and the structure is simple, and convenient operation. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a structure schematic diagram of mouse tail vein injection device of the utility model.

[0019] Figure 2 It is another view structure schematic diagram of mouse tail vein injection device of the utility model

[0020] Figure 3 It is a structure schematic diagram of fixed mechanism in mouse tail vein injection device of the utility model.

[0021] Figure 4 It is the installation structure schematic diagram of injection needle in mouse tail vein injection device of the utility model.

[0022] Figure 5 It is a sectional view of mouse tail vein injection device of the utility model.

[0023] Figure 6 It is Figure 5 Partial enlarged structure schematic diagram.

[0024] Among them,

[0025] 1, base, 2, mounting frame, 3, injection needle, 4, first piston rod, 5, second piston rod, 6, adjusting piece, 7, sliding block, 8, scale, 9, motor, 10, screw rod, 11, fixed plate, 12, guide rod, 13, stabilizing hole, 14, medicament bottle, 15, communication pipe, 16, first check valve, 17, second check valve, 18, locking piece, 19, tool holder, 20, blade, 21, support plate, 22, cylinder, 23, limiting plate, 24, baffle, 25, through -hole, 26, limit slot, 27, tail block, 28, dovetail groove, 29, fixed piece, 30, nut seat, 31, air hole, 32, cotton, 33, support rod, 34, fixed block, 35, sliding plate, 36, handle, 37, first piston, 38, second piston. DETAILED DESCRIPTION

[0026] The advantages and effects of the present application can be understood by those skilled in the art from the disclosure of the present application. It should be noted that the drawings provided in the following examples are only used for exemplary description, and the drawings are only schematic drawings and not actual drawings, and should not be understood as a limitation of the present application. In order to better illustrate the embodiments of the present application, some components in the drawings are omitted, enlarged or reduced, and do not represent the actual size of the product; for those skilled in the art, it is understandable that some well-known structures and their descriptions in the drawings can be omitted.

[0027] The same or similar reference numerals in the drawings of the embodiments of the present application correspond to the same or similar components, and in the description of the present application, it should be understood that if the terms "upper", "lower", "left", "right", "front", "back" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, only for the convenience of describing the present application and simplifying the description, and therefore the terms describing the positional relationship in the drawings are only used for exemplary description, and should not be understood as a limitation of the present application. For those skilled in the art, the specific meaning of the above terms can be understood according to the specific circumstances.

[0028] As Figures 1-6 shown, the mouse tail vein injection device of the present application comprises a base 1, a fixing mechanism is fixedly arranged on the upper surface of the left end of the base 1, the fixing mechanism is used for fixing the mouse, a dovetail groove 28 is arranged on the upper surface of the right end of the base 1 along the length direction of the base 1, a mounting bracket 2 matched with the dovetail groove 28 is slidably connected in the dovetail groove 28, an injection needle 3 is fixedly arranged on the mounting bracket 2, the injection needle 3 can be fixedly arranged on the fixing bracket by gluing or through a bandage. A first piston rod 4 is arranged at the right end of the injection needle 3 and extends into the injection needle 3, a first piston 37 is arranged at the inner end of the first piston rod 4, the first piston 37 is in sliding sealing contact with the inner wall of the injection needle 3, a cavity is arranged in the first piston rod 4, the outer end of the first piston rod 4 is closed and the inner end is open, a second piston rod 5 is arranged in the first piston rod 4, and a second piston 38 is arranged at the inner end of the second piston rod 5. The second piston 38 is in sliding sealing contact with the inner wall of the first piston rod 4, an adjusting assembly for adjusting the depth of the second piston rod 5 in the first piston rod 4 is arranged on the first piston rod 4, and a driving assembly for adjusting the depth of the first piston rod 4 in the injection needle 3 is further arranged on the mounting bracket 2.

[0029] The adjusting assembly comprises an adjusting member 6 and a sliding block 7, the sliding block 7 is axially slidably installed in the first piston rod 4, the inner end of the sliding block 7 is fixedly connected with the outer end of the second piston rod 5, the outer end is rotatably connected with the inner end of the adjusting member 6, the outer end of the adjusting member 6 protrudes out of the first piston rod 4 to form an operating end, the adjusting member 6 is threadedly connected with the first piston rod 4, and the sliding block 7 cannot rotate in the first piston rod 4. In the embodiment, the adjusting member 6 is a bolt, and a crank 36 is fixed to the outer end of the adjusting member 6, so that the staff can operate conveniently.

[0030] A scale 8 is fixed to the outer end of the sliding block 7 on one side of the adjusting member 6, and a through hole is formed in the outer end of the first piston rod 4 for the scale 8 to pass through, so that the depth of the second piston rod 5 in the first piston rod 4 can be observed intuitively, accurately and efficiently, and the scale 8 can limit the circumferential rotation of the sliding block 7.

[0031] In the above embodiment, when injecting, the fixing mechanism fixes the mouse and exposes the tail of the mouse, the needle of the injection needle 3 is just aimed at the tail of the mouse, the staff pulls the mouse tail tight with the left hand, slides the mounting bracket 2 to the injection needle 3 to insert the injection needle 3 into the blood vessel of the mouse tail with the right hand, drives the first piston rod 4 to move leftwards to inject and administer the drug, when the administration amount reaches the required range, the driving assembly stops working, the staff rotates the crank 36 with the right hand to drive the sliding block 7, the second piston rod 5 and the second piston 38 to move leftwards, and the staff can continuously administer the drug by observing the reading of the scale 8.

[0032] The driving assembly comprises a lead screw 10 and a motor 9, two fixed plates 11 are arranged axially and spaced apart below the injection needle 3 along the injection needle 3, the motor 9 is fixedly installed on the mounting bracket 2 by bolts, the output end of the motor 9 penetrates through one of the fixed plates 11 and is fixedly connected with the left end of the lead screw 10, the right end of the lead screw 10 is rotatably connected with the other fixed plate 11, a sliding plate 35 is threadedly connected with the surface of the lead screw 10, a guide rod 12 is fixedly arranged on the fixed plate 11, the axis of the lead screw 10 and the axis of the guide rod 12 are parallel to the axis of the injection needle 3, the sliding plate 35 is threadedly connected with the surface of the lead screw 10, the guide rod 12 penetrates through the sliding plate 35 and the two are slidably connected, and the top of the sliding plate 35 is fixedly connected with the bottom of the outer end of the first piston rod 4. In the embodiment, the motor 9 rotates to drive the lead screw 10 to rotate, thereby driving the sliding plate 35 and the first piston rod 4 to move horizontally.

[0033] A pressure stabilizing hole 13 is formed in the outer end of the first piston rod 4, the pressure stabilizing hole 13 communicates the inside of the first piston rod 4 with the outside, and the inside air pressure of the first piston rod 4 can be balanced by arranging the pressure stabilizing hole 13. In the embodiment, the right end of the injection needle 3 is also closed, and a pressure stabilizing hole 13 is also arranged in the right end section of the injection needle 3 to balance the inside air pressure of the injection needle 3, and the inner wall of the injection needle 3 will not be polluted by long-term exposure to air, and the movement of the first piston rod 4 is not affected.

[0034] The injection needle 3 is fixedly connected with a medicine bottle 14 at the top. The medicine bottle 14 is provided with an opening at the top, and a sealing plug is connected in the opening. A communication pipe 15 is arranged between the medicine bottle 14 and the injection needle 3. One end of the communication pipe 15 communicates with the medicine bottle 14, and the other end communicates with the end of the injection needle 3 close to the needle head. A first one-way valve 16 is arranged in the communication pipe 15. The second one-way valve 17 is arranged at the end of the injection needle 3 close to the needle head. In this embodiment, when the first piston rod 4 moves to the right, the second one-way valve 17 is closed, a negative pressure is generated in the injection needle 3, the first one-way valve 16 is opened, and the liquid medicine in the medicine bottle 14 is sucked into the injection needle 3, so that the automatic medicine feeding is realized. When the first piston rod 4 moves to the left, the first one-way valve 16 is closed, the second one-way valve 17 is opened, and the liquid medicine is injected into the blood vessels of the mouse tail through the needle head.

[0035] A locking piece 18 is arranged between the mounting frame 2 and the base 1. In this embodiment, the locking piece 18 is a bolt. A threaded hole is formed in the side wall of the base 1 and communicates with the dovetail groove 28. The locking piece 18 is screw-connected in the threaded hole. When the mounting frame 2 slides to the position where the injection needle 3 is inserted into the mouse tail, the locking piece 18 is screwed, the locking piece 18 abuts against the side wall of the mounting frame 2, so that the mounting frame 2 and the base 1 are locked and fixed.

[0036] A knife seat 19 is arranged on the base 1. A knife blade 20 is arranged in the knife seat 19 and can be taken out from the knife seat 19. Since some mice have more hair on the tail, the injection is affected. Therefore, after the mouse is fixed, if the tail hair of the mouse is more, the tail hair can be gently scraped off by the knife blade 20, so that the blood vessels are expanded and fully exposed in the field of view of the worker.

[0037] The fixing mechanism includes a support plate 21 and a cylinder 22. The support plate 21 is fixed on the base 1. The cylinder 22 is hollow and open at both ends. The cylinder 22 is fixed on the support plate 21 by a bandage. The end of the cylinder 22 away from the injection needle 3 is movably connected with a limiting plate 23. A fixing piece 29 is arranged between the limiting plate 23 and the cylinder 22. The fixing piece 29 is a bolt. A nut seat 30 is integrally formed on the cylinder 22. The fixing piece 29 is screw-connected in the nut seat 30 and penetrates through the side wall of the cylinder 22. By tightening or loosening the fixing piece 29, the limiting plate 23 and the cylinder 22 can be fixed or loosened. The end of the cylinder 22 close to the injection needle 3 is provided with a baffle 24. The baffle 24 is provided with a through hole 25 for the mouse tail to pass through. The end of the support plate 21 close to the injection needle 3 is provided with a limiting groove 26. The support plate 21 is movably provided with a tail pressing block 27.

[0038] In this embodiment, the cylinder 22 is provided with a plurality of air holes 31, which facilitates the mouse to breathe, the inner end of the limiting plate 23 is provided with cotton 32, and the outer end is fixed with a support rod 33, which facilitates the staff to move the position of the limiting plate 23, after the mouse is put into the cylinder 22, the limiting plate 23 is inserted, and then the fixing piece 29 is tightened, the body of the mouse can be fixed; the fixed block 34 is arranged on the supporting plate 21 at the right end of the cylinder 22, the fixed block 34 is provided with a groove, the baffle 24 can be put into the groove or taken out from the groove, the baffle 24 is used for blocking the body of the mouse, avoiding the mouse to retreat, the tail of the mouse extends from the through hole 25 on the baffle 24 and is clamped into the limiting groove 26, and finally the position of the tail is fixed through the tail pressing block 27.

[0039] Working principle:

[0040] The mouse is taken out from the cage and placed in the cylinder 22, the limiting plate 23 is inserted into the left end of the cylinder 22 and is at an appropriate distance, cannot press the breath of the mouse, the baffle 24 is inserted into the groove, the body of the mouse is fixed, the mouse tail is wiped with an alcohol cotton ball, the blood vessels are expanded, if the mouse tail hair is more and affects the blood vessel field of view, the tail hair is scraped off by using the blade 20, the vein is identified, the mouse tail is placed into the limiting groove 26, the tail pressing block 27 is pressed down, the left hand of the staff pinches the blood vessels at the tail far end, the blood vessels are expanded, at the same time, the mouse tail is kept in a tight and straight state, the right hand moves the mounting frame 2 to the injection needle 3, the locking piece 18 is tightened, the motor 9 is started, the motor 9 drives the first piston rod 4 to move left to inject and dose, when a certain amount of medicine is dosed, the motor 9 is turned off, the right hand of the staff rotates the handle 36, so that the second piston rod 5 moves left to dose, after injection is completed, the locking piece 18 is loosened, the mounting frame 2 is moved right, the fixing mechanism is loosened, the mouse is taken out and put back into the cage.

[0041] The mouse tail vein injection device provided by the utility model is convenient for mouse fixing and loosening, reduces the work amount of the staff, improves the injection success rate, can continuously dose in a small amount, and is high in practicability.

[0042] The above embodiments are only used to illustrate the technical solutions of the utility model and not limit, although the utility model is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solutions of the utility model can be modified or replaced equivalently without departing from the purpose and scope of the technical solutions of the utility model, which should be covered in the claim range of the utility model. The technical, shape and structure parts not described in the utility model are all known technologies.

Claims

1. A mouse tail vein injection device, characterized by: The application relates to a syringe device, which comprises a base, a fixing mechanism arranged at one end of the base, a mounting frame slidably connected to the other end of the base, an injection needle arranged on the mounting frame, a first piston rod arranged in the injection needle, a first piston arranged at the inner end of the first piston rod, a cavity arranged in the first piston rod, a closed outer end of the first piston rod, a second piston rod arranged in the first piston rod, a second piston arranged at the inner end of the second piston rod, an adjusting assembly arranged on the first piston rod and used for adjusting the depth of the second piston rod in the first piston rod, and a driving assembly arranged on the mounting frame and used for adjusting the depth of the first piston rod in the injection needle.

2. The mouse tail vein injection device of claim 1, wherein: The adjusting assembly comprises an adjusting piece and a sliding block, the sliding block is axially slidably arranged in the first piston rod, the inner end of the sliding block is fixedly connected with the outer end of the second piston rod, the outer end of the sliding block is rotatably connected with the inner end of the adjusting piece, the outer end of the adjusting piece protrudes out of the first piston rod to form an operating end, the adjusting piece is threadedly connected with the first piston rod, and the sliding block cannot rotate in the first piston rod.

3. The mouse tail vein injection device of claim 2, wherein: The outer end of the sliding block is provided with a scale on one side of the adjusting piece, and the outer end of the first piston rod is provided with a through hole for the scale.

4. The mouse tail vein injection device of claim 1, wherein: The driving assembly comprises a screw rod and a motor, the mounting frame is provided with a fixed plate below the injection needle, the motor is arranged on the mounting frame, the output end of the motor penetrates through the fixed plate and is fixedly connected with one end of the screw rod, a guide rod is fixedly arranged on the fixed plate, the axis of the screw rod and the axis of the guide rod are parallel to the axis of the injection needle, a sliding plate is threadedly connected with the surface of the screw rod, the guide rod penetrates through the sliding plate and the two are slidably connected, and the top of the sliding plate is fixedly connected with the bottom of the outer end of the first piston rod.

5. The mouse tail vein injection device of claim 1, wherein: The outer end of the first piston rod is provided with a pressure stabilizing hole, and the pressure stabilizing hole is in communication with the inside of the first piston rod and the outside.

6. The mouse tail vein injection device of claim 1, wherein: The top of the injection needle is fixedly connected with a medicine bottle, a communication pipe is arranged between the medicine bottle and the injection needle, one end of the communication pipe is in communication with the medicine bottle, the other end of the communication pipe is in communication with the end of the injection needle close to the needle head, a first one-way valve is arranged in the communication pipe, and a second one-way valve is arranged at the end of the injection needle close to the needle head.

7. The mouse tail vein injection device of claim 1, wherein: Locking pieces are arranged between the mounting frame and the base.

8. The mouse tail vein injection device of claim 1, wherein: A cutter seat is arranged on the base, and a cutter blade is arranged in the cutter seat.

9. The mouse tail vein injection device of claim 1, wherein: The fixing mechanism comprises a supporting plate and a cylinder, the supporting plate is fixed on the base, the cylinder is hollow and has two open ends, the cylinder is fixed on the supporting plate, a limiting plate is movably connected to the end of the cylinder away from the injection needle, fixing pieces are arranged between the limiting plate and the cylinder, a baffle is arranged at the end of the cylinder close to the injection needle, and a through hole is arranged in the baffle.

10. The mouse tail vein injection device of claim 9, wherein: A limiting groove is arranged at the end of the supporting plate close to the injection needle, and a tail pressing block is movably arranged on the supporting plate.

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