Novel magnetic separator

Abstract

The utility model relates to the technical field of magnetic separators, in particular to a novel magnetic separator which comprises a magnetic frame body, the upper surface of the magnetic frame body is in an arch shape, two sets of centrifugal tube holes and centrifugal tube bottom support holes which are distributed at equal intervals are formed in the magnetic frame body, and the centrifugal tube holes correspond to the centrifugal tube bottom support holes. The rectangular strong magnet can be embedded into the groove, then the fixing bottom plate and the abutting strip are matched with each other to be installed in the fixing groove, the rectangular strong magnet is sealed and prevented from being rusted, it is guaranteed that the strong magnet is stable and does not loosen, the strong magnet is an N50 strong magnet, and the strong magnet is not damaged. According to the novel magnetic separator, a plurality of magnetic beads are arranged on the side wall of the centrifugal tube, so that the trace magnetic beads can be adsorbed to the side wall of the centrifugal tube, and the rectangular powerful magnet is adopted, so that the novel magnetic separator can have the same strong magnetism at each angle of the magnetic surface, and the effect that the magnetic beads at the edges and the corners are difficult to adsorb can be avoided.

Description

Technical Field

[0001] This application relates to the technical field of magnetic separators, and in particular to a novel magnetic separator. Background Technology

[0002] With the development of molecular biology, the magnetic bead method for nucleic acid extraction and separation has been widely applied. Specifically, it utilizes the adsorption of nucleic acids by bio-based magnetic beads to extract and purify them. Its applications include nucleic acid extraction, nucleic acid fragment screening, and nucleic acid purification. The bio-based magnetic beads can be thoroughly mixed with the sample solution and bind to the target nucleic acid. Under the influence of an external magnetic field in a magnetic microbead separator, the magnetic beads, bound to the nucleic acid, are adsorbed onto the sidewall of the centrifuge tube, thus achieving nucleic acid separation and purification.

[0003] Disadvantages of existing products:

[0004] 1. Currently available centrifuge tubes with diameters suitable for 1.5ml / 2ml are wider at the top and narrower at the bottom, and are unstable, especially when placed on a magnetic container;

[0005] When the upper part of a centrifuge tube is close to a strong magnet, the lower part is conical and far from the magnetic field, which is not conducive to the adsorption of magnetic beads at the bottom of the centrifuge tube.

[0006] 3. The centrifuge tubes are loosely connected to the test tube wells, requiring operators to be extra careful. Careful experimental procedures reduce work efficiency.

[0007] 4. The close proximity of the centrifuge tube apertures makes cross-contamination easy. The close proximity of the apertures between two rows of centrifuge tubes makes experimental operation inconvenient. Often, the apertures of the two rows cannot be used at the same time, which wastes resources and reduces experimental efficiency.

[0008] 5. Strong magnets are round and exposed, with a small adsorption area and weak edge magnetism, resulting in poor ability to attract magnetic beads. They are also prone to rusting over time, which reduces their magnetism.

[0009] In order to overcome the shortcomings and drawbacks of existing technologies, this application proposes a novel magnetic separator to solve this problem. Utility Model Content

[0010] To avoid the problem of edge and corner magnetic beads being difficult to attract, this application provides a novel magnetic separator.

[0011] This application provides a novel magnetic separator, employing the following technical solution: It includes a magnetic frame body, the upper surface of which is arc-shaped. Inside the magnetic frame body are two sets of equidistantly distributed centrifuge tube holes and centrifuge tube bottom support holes. The centrifuge tube holes correspond to the centrifuge tube bottom support holes, and the two sets of centrifuge tube holes are mirror-distributed on both sides of the arc-shaped surface near the edge, with a symmetrical axis as the center. A fixing groove is formed on the bottom surface of the magnetic frame body, and a recess is formed inside the fixing groove. A powerful magnet is embedded inside the recess, the upper surface of which contacts the inner top wall of the recess. The powerful magnet is an N-type magnet. The internal space of the recess is adapted to the powerful magnet. A fixing base plate is snapped onto the inner wall of the fixing groove, and a pressing strip is fixedly connected to the upper surface of the fixing base plate. The pressing strip snaps onto the interior of the recess, and the pressing strip is adapted to the interior of the recess.

[0012] Optionally, the main body of the magnetic rack is integrally formed from aluminum alloy profiles, and the main body of the magnetic rack has viewing openings on both the front and back sides, and the eight corners of the main body of the magnetic rack are rounded.

[0013] Optionally, the bottom surface of the magnetic frame body is provided with several mounting grooves, and an anti-slip pad is fixedly installed on the inner wall of each mounting groove.

[0014] Optionally, the inner wall of the fixing groove is provided with two sets of threaded grooves. The two sets of threaded grooves are symmetrically arranged on the inner wall of the fixing groove with the groove as the central axis. The outer surface of the fixing base plate is uniformly provided with several slots. Each slot is perpendicular to the hole diameter of the corresponding threaded groove. Each threaded groove is provided with a fixing bolt inside. Each fixing bolt is threadedly connected to the corresponding slot.

[0015] Optionally, the centrifuge tube bottom support holes are located at the bottom of the front and back sides of the powerful magnet, respectively, and the centrifuge tube holes are located at the top of the front and back sides of the powerful magnet, respectively.

[0016] Optionally, the two sets of centrifuge tube holes are designed to fit together in an arc shape, and the two sets of centrifuge tube holes are tilted downward as a whole, forming an angle with the horizontal plane, and the tilt angle is 1-5 degrees.

[0017] Optionally, the bottom surface of the powerful magnet is in contact with the pressure strip, and the position of the powerful magnet is 5mm from the bottom, which effectively prevents the magnetic beads from settling at the bottom of the centrifuge tube. The pressure strip further presses and reinforces the powerful magnet and seals it, and the powerful magnet will not loosen during use.

[0018] In summary, this application includes the following beneficial technical effects:

[0019] This invention comprises a rectangular strong magnet, a fixing groove, a magnetic frame body, a recess, a fixing base plate, and a pressure strip. The rectangular strong magnet is embedded in the recess, and the fixing base plate and pressure strip work together to seal the magnet within the fixing groove, preventing rust and ensuring its stability. The magnet is an N50 strong magnet, ensuring that even small magnetic beads can be attracted to the side wall of the centrifuge tube. The use of a rectangular strong magnet effectively ensures that the new magnetic separator has the same strong magnetism at every angle on the magnetic surface, thus preventing the attraction of edge and corner magnetic beads.

[0020] This invention incorporates components such as centrifuge tube holes, a magnetic frame body, and centrifuge tube base holes. The centrifuge tube holes and base holes are aligned on the same central axis. Test tubes are then inserted through the centrifuge tube holes and into the corresponding base holes, ensuring stable placement of the centrifuge tubes. The arc-shaped design of the magnetic frame body maintains sufficient distance between rows of centrifuge tubes, preventing cross-contamination and overcrowding. Furthermore, the entire magnetic microbead separator is tilted downwards at an angle to the horizontal plane, allowing the integrated film coating of the magnetic frame to ensure that the conical bottom of the centrifuge tubes remains firmly attached to the powerful magnet. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the overall structure in an embodiment of this application;

[0022] Figure 2 This is a schematic diagram of the fixed base plate structure in an embodiment of this application;

[0023] Figure 3 This is a schematic diagram of the fixing groove structure in an embodiment of this application;

[0024] Figure 4 This is a schematic diagram of the powerful magnet structure in an embodiment of this application;

[0025] Figure 5 This is a schematic diagram of the centrifuge tube hole structure in an embodiment of this application.

[0026] Reference numerals: 1. Magnetic frame body; 2. Centrifuge tube hole; 3. Centrifuge tube bottom support hole; 4. Mounting groove; 5. Anti-slip pad; 6. Groove; 7. Fixing groove; 8. Threaded groove; 9. Strong magnet; 10. Fixing base plate; 11. Fixing bolt; 12. Slot; 13. Pressure strip; 14. Viewing port. Detailed Implementation

[0027] The following is in conjunction with the appendix Figures 1-5This application will be further described in detail below. The technical solutions in the embodiments of this application will be clearly described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this application. All other embodiments obtained by those skilled in the art based on the embodiments of this application are within the scope of protection of this application.

[0028] In the description of this application, it should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. For ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following drawings denote similar items; therefore, once an item is defined in one drawing, it need not be further discussed in subsequent drawings.

[0029] This application discloses a novel magnetic separator. For example... Figure 1 , Figure 3 , Figure 4 As shown, the device includes a magnetic rack body 1, which is integrally formed from aluminum alloy profiles. The upper surface of the magnetic rack body 1 is arc-shaped, which effectively increases the distance between the two rows of upper holes. In addition, the centrifuge tube is wide at the top and narrow at the bottom, and it is often difficult for the bottom to be tightly attached to the strong magnet. This design can also make the entire centrifuge tube tightly attached to the strong magnet, which is more conducive to the adsorption of magnetic beads.

[0030] In this embodiment, the main body 1 of the magnetic rack is integrally formed from aluminum alloy profiles, which reduces manufacturing costs, improves the aesthetics of the product, and ensures that the new magnetic separator is sturdy and does not loosen. It is much more convenient, durable, and aesthetically pleasing than assembled parts. The bow-shaped design effectively increases the distance between the two rows of upper apertures. Furthermore, the centrifuge tube is wider at the top and narrower at the bottom, which often makes it difficult for the lower part to fit tightly against the strong magnet 9. This design also allows the entire centrifuge tube to fit tightly against the strong magnet 9, which is more conducive to the adsorption of magnetic beads. The eight corners of the main body 1 of the magnetic rack are set as arcs, which not only makes it easy to handle, but also prevents the sharp corners from accidentally injuring the user during the experiment. The strong magnet 9 is an N50 strong magnet, which can ensure that even a small number of magnetic beads can be adsorbed onto the side wall of the centrifuge tube. More importantly, the strong magnet 9 used is an integrated rectangular strong magnet 9, not a single circular strong magnet 9. This can effectively ensure that the new magnetic separator has the same strong magnetism at every angle on the magnetic surface, and there will be no problem with the edge and corner magnetic beads being difficult to be adsorbed.

[0031] To protect the powerful magnet 9, a fixing groove 7 is provided on the bottom surface of the magnetic frame body 1. A groove 6 is provided on the inner wall of the fixing groove 7. A fixing base plate 10 is inserted into the inner wall of the fixing groove 7. The powerful magnet 9 is placed inside the groove 6. Centrifuge tube holes 2 and centrifuge tube bottom support holes 3 are provided inside the magnetic frame body 1 at equal intervals. The centrifuge tube bottom support holes 3 are located at the bottom of the front and back of the powerful magnet 9, respectively. The centrifuge tube holes 2 are located at the top of the front and back of the powerful magnet 9, respectively. The diameters of the centrifuge tube holes 2 and the centrifuge tube bottom support holes 3 are perpendicularly corresponding one-to-one. The two sets of centrifuge tube holes 2 are mirror-distributed on both sides of the arc-shaped surface near the edge with the axis of symmetry as the center. The diameters of the two sets of centrifuge tube holes 2 fit the arc-shaped design. The two sets of centrifuge tube holes 2 are inclined downward as a whole, with an angle of 1-5 degrees with the horizontal plane.

[0032] In this embodiment, a groove 6 is provided at the bottom of the magnetic rack body 1 for embedding a strong magnet 9, which can ensure that the strong magnet 9 can be firmly embedded. By setting a fixed base plate 10, the strong magnet 9 can be further reinforced and sealed, ensuring that the strong magnet 9 will not loosen during use and preventing the strong magnet 9 from being exposed and rusting. The upper part is provided with sixteen centrifuge tube holes 2, and the lower part is provided with sixteen centrifuge tube bottom support holes 3, which can firmly fix the centrifuge tubes and prevent them from shaking. It can accommodate sixteen 1.5ml centrifuge tubes working at the same time, distributed in two rows, which can improve the work efficiency of the experimenters. The distance between the centrifuge tubes can prevent cross-contamination, and there is also enough distance between the two rows of centrifuge tubes to prevent mutual interference in the experiment.

[0033] In this embodiment, a pressing strip 13 is fixedly connected to the upper surface of the fixed base plate 10. The outer surface of the pressing strip 13 is slidably connected to the groove 6. Specifically, the pressing strip 13 can lift the strong magnet 9 so that the position of the strong magnet 9 is 5mm from the bottom, which can effectively prevent the magnetic beads from settling at the bottom of the centrifuge tube, thereby avoiding the absorption of magnetic beads.

[0034] To prevent the magnetic frame body 1 from slipping or tipping over, several mounting grooves 4 are provided on the bottom surface of the magnetic frame body 1, and an anti-slip pad 5 is fixedly installed on the inner wall of each mounting groove 4.

[0035] In this embodiment, the bottom surface of the entire one-piece molded magnetic frame body 1 has an anti-slip pad 5, which can be stably placed on the experimental table and effectively prevent slipping or tipping.

[0036] In order to make the base plate 10 more stable during the fixing process, the inner wall of the fixing groove 7 is provided with several threaded grooves 8, each threaded groove 8 is evenly arranged on both sides of the groove 6, specifically, the threaded grooves 8 are evenly distributed on the outer side of the groove 6.

[0037] To facilitate the installation of the fixed base plate 10 inside the magnetic frame body 1, a number of slots 12 are evenly provided on the outer surface of the fixed base plate 10, and each slot 12 corresponds perpendicularly to the diameter of the corresponding threaded groove 8.

[0038] In this embodiment, when the fixed base plate 10 is installed in the fixed groove 7, each slot 12 corresponds to the corresponding threaded groove 8, and the diameter of each threaded groove 8 is the same as that of the corresponding slot 12 and is on the same central axis.

[0039] In order to quickly fix the base plate 10, each threaded groove 8 is provided with a fixing bolt 11, and the outer surface of each fixing bolt 11 is inserted into the corresponding slot 12.

[0040] In this embodiment, by inserting the fixing bolt 11 into the corresponding slot 12 and then rotating the fixing bolt 11, the fixing bolt 11 will be tightened and the fixing base plate 10 will be quickly fixed.

[0041] The implementation principle of a novel magnetic separator in this application embodiment is as follows: Integrated molding with aluminum alloy profiles not only reduces manufacturing costs but also enhances product aesthetics. It also ensures the new magnetic separator is sturdy and does not loosen, making it far more convenient, durable, and aesthetically pleasing than assembled parts. Furthermore, the integrated design makes the entire magnetic frame body 1 bow-shaped, effectively preventing the lower part of the conical centrifuge tube from adhering tightly to the strong magnet 9, which is more conducive to magnetic bead adsorption. The four corners of the magnetic separator are rounded, making it easy to handle and preventing accidental injury to users from sharp edges during experiments. First, the strong... The strong magnet 9 is embedded in the groove 6 inside the main body 1 of the magnetic rack, and then the fixed base plate 10 is installed in the fixed groove 7 and fixed with the fixing bolt 11. By using an integrated rectangular strong magnet 9 instead of a single circular strong magnet 9, it can be effectively ensured that the new magnetic separator has the same strong magnetism at every angle of the magnetic surface, and the edge and corner magnetic beads will not be difficult to be attracted. The strong magnet 9 is located 5mm from the bottom, which can effectively prevent the magnetic beads from settling at the bottom of the centrifuge tube, thereby avoiding the attraction of magnetic beads. The test showed that the adsorption time of the magnetic beads using this invention is 3 minutes. However, in order to make the magnetic beads completely adsorbed on the magnetic rack as much as possible, it is recommended to increase the adsorption time. The specific magnetic bead adsorption time can be freely controlled by the experimenter.

[0042] When installing the strong magnet 9, first remove the fixing bolt 11 to remove the fixing base plate 10. At the same time, move the pressing strip 13 to insert the strong magnet 9 into the groove 6. Then, move the fixing base plate 10 and the pressing strip 13 to press the strong magnet 9 in place. Finally, tighten the fixing bolt 11.

Claims

1. A novel magnetic separator, comprising a magnetic frame body (1), characterized in that: The upper surface of the magnetic rack body (1) is arc-shaped. The interior of the magnetic rack body (1) has two sets of equidistantly distributed centrifuge tube holes (2) and centrifuge tube bottom support holes (3). The centrifuge tube holes (2) correspond to the centrifuge tube bottom support holes (3), and the two sets of centrifuge tube holes (2) are mirror-distributed on both sides of the arc-shaped surface near the edge, with the axis of symmetry as the center. The bottom surface of the magnetic rack body (1) has a fixing groove (7), and the interior of the fixing groove (7) has a recess (6). The recess (6) is inlaid with... A strong magnet (9) is provided, the upper surface of which is in contact with the inner top wall of the groove (6). The strong magnet (9) is an N50 strong magnet. The internal space of the groove (6) is adapted to the strong magnet (9). A fixed base plate (10) is snapped into the inner wall of the fixed groove (7). A pressing strip (13) is fixedly connected to the upper surface of the fixed base plate (10). The pressing strip (13) is snapped into the inside of the groove (6). The pressing strip (13) is adapted to the inside of the groove (6).

2. The novel magnetic separator according to claim 1, characterized in that: The main body (1) of the magnetic rack is integrally formed from aluminum alloy profile. The front and back of the main body (1) are provided with viewing ports (14), and the eight corners of the main body (1) are set as arcs.

3. A novel magnetic separator according to claim 2, characterized in that: The bottom surface of the magnetic frame body (1) is provided with several mounting grooves (4), and each mounting groove (4) is fixedly installed with an anti-slip pad (5) on its inner wall.

4. A novel magnetic separator according to claim 1, characterized in that: The inner wall of the fixing groove (7) is provided with two sets of threaded grooves (8). The two sets of threaded grooves (8) are symmetrically arranged on the inner wall of the fixing groove (7) with the groove (6) as the central axis. The outer surface of the fixing base plate (10) is uniformly provided with several slots (12). Each slot (12) is perpendicular to the hole diameter of the corresponding threaded groove (8). Each threaded groove (8) is provided with a fixing bolt (11). Each fixing bolt (11) is threadedly connected to the corresponding slot (12).

5. A novel magnetic separator according to claim 1, characterized in that: The centrifuge tube bottom support hole (3) is located at the bottom of the front and back sides of the powerful magnet (9), and the centrifuge tube hole (2) is located at the top of the front and back sides of the powerful magnet (9).

6. A novel magnetic separator according to claim 1, characterized in that: The two sets of centrifuge tube holes (2) are designed to fit together in an arc shape. The two sets of centrifuge tube holes (2) are tilted downward as a whole, with an angle of 1-5 degrees to the horizontal plane.

7. A novel magnetic separator according to claim 1, characterized in that: The bottom surface of the strong magnet (9) is in contact with the pressure strip (13). The position of the strong magnet (9) is 5mm from the bottom, which effectively prevents the magnetic beads from settling at the bottom of the centrifuge tube. The pressure strip (13) further presses and reinforces the strong magnet (9) and seals it, and the strong magnet (9) will not loosen during use.

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