Penicillin bottle freeze drying equipment

Abstract

The utility model discloses penicillin bottle freeze-drying equipment which is provided with a freeze-drying box body, a freeze-drying chamber door is arranged on one side of the freeze-drying box body, a heating system is arranged at the bottom of the freeze-drying box body, a refrigerating machine, a condenser and a vacuum pump set are further arranged outside the freeze-drying box body, and a bottom layer freeze-drying material tray is arranged at the position, close to the lower portion, in the freeze-drying box body. 3-4 layers of lifting freeze-drying material trays are arranged right above the freeze-drying material tray at the bottom layer, each layer of lifting freeze-drying material tray is driven to lift by a set of independent corresponding lifting mechanism, a gland plate is also arranged right above the lifting freeze-drying material tray at the uppermost layer, and the gland plate is also driven to lift by a set of independent corresponding lifting mechanism; a plurality of temperature measuring probes are arranged at opposite positions on the front side wall and the rear side wall in the freeze-drying box body; according to the freeze-drying equipment, improvement measures are taken on the basis of existing freeze-drying equipment, so that freeze-drying operation of the penicillin bottled medicine is better achieved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical drying equipment technology, and in particular to a vial freeze-drying device. Background Technology

[0002] In the pharmaceutical manufacturing industry, the use of vials for packaging some powdered drugs is a very common method. The vials are sealed with soft rubber stoppers. When dispensing drugs into vials, they generally need to be placed in a freeze-drying chamber to remove moisture, ensuring proper storage and transportation. Otherwise, if the drugs contain moisture, they are prone to spoilage. Currently, the following problems exist when using freeze-drying chambers with varying temperatures for vials: During the pre-feeding shelf cooling process, the temperature difference between the sample on the shelf and the pre-feeding shelf can easily cause condensation at the bottom of the shelf, posing a risk of the vials freezing and falling during the freeze-drying process; existing freeze-drying chambers have few temperature probes, which cannot accurately reflect the temperature distribution during the freeze-drying process; and existing freeze-drying chambers struggle to achieve stable stoppering operations for the vials within the chamber. Utility Model Content

[0003] The purpose of this invention is to provide a vial freeze-drying device in response to the above-mentioned situation. This freeze-drying device is an improvement on the existing freeze-drying device, which enables it to better perform freeze-drying operations on vials of medicine.

[0004] The specific solution of this utility model is as follows: a vial freeze-drying device, comprising a freeze-drying chamber, a freeze-drying chamber door on one side of the freeze-drying chamber, a heating system at the bottom of the freeze-drying chamber, and a freezer, condenser and vacuum pump unit outside the freeze-drying chamber. The freezer and condenser are connected to the freeze-drying chamber. A bottom freeze-drying tray is provided at the lower part of the freeze-drying chamber. Three to four lifting freeze-drying trays are provided directly above the bottom freeze-drying tray. Each lifting freeze-drying tray is driven to rise and fall by an independent corresponding lifting mechanism. A pressure plate is provided directly above the top lifting freeze-drying tray, and this pressure plate is also driven to rise and fall by an independent corresponding lifting mechanism. Several temperature probes are also provided at relatively opposite positions on the front and rear side walls inside the freeze-drying chamber. The temperature probes are evenly spaced from bottom to top, and the temperature probes are communicatively connected to an integrated controller.

[0005] Furthermore, the temperature probes described in this utility model are arranged in horizontal rows from bottom to top, with 4 to 5 rows. Each horizontal row has 3 to 5 temperature probes arranged from left to right. The temperature probes are used to measure the temperature in the freeze-drying chamber in real time.

[0006] Furthermore, the lifting mechanism described in this utility model includes two lifting screws, two screw base plates, four guide rods, and two screw motors. The two screw base plates are respectively fixedly installed at both ends of the lifting freeze-drying tray or pressure plate of the corresponding layer. The two screw motors are respectively installed on the top left and right sides of the freeze-drying chamber. Each screw motor is connected to a corresponding lifting screw. The lifting screw is placed inside the freeze-drying chamber and threadedly connected to the screw base plate on the corresponding side. Each screw base plate is also equipped with two guide rods for lifting guidance.

[0007] Furthermore, in this utility model, the width of the lead screw seat plate increases sequentially from bottom to top.

[0008] Furthermore, the freezer described in this utility model is connected to the bottom freeze-drying tray and the lifting freeze-drying tray respectively, and is also connected to the interior of the freeze-drying chamber for cooling the bottom freeze-drying tray, the lifting freeze-drying tray and the interior of the freeze-drying chamber.

[0009] Furthermore, the freeze-drying chamber described in this utility model is also equipped with a nitrogen supply device, which supplies nitrogen to the freeze-drying chamber through nitrogen pipes and valves, and a venting valve is also provided on the top of the freeze-drying chamber.

[0010] Furthermore, the condenser described in this utility model is connected to the upper part of the freeze-drying chamber and is also connected to the vacuum pump group through pipes and vacuum valves. The condenser is also equipped with a defrost valve and an exhaust valve.

[0011] Furthermore, the frame of the freeze-drying chamber door described in this utility model is sealed using a sterile sealing strip.

[0012] This invention has the following advantages: By setting multiple layered temperature probes at corresponding positions on the front and rear side walls of the freeze-drying chamber, the temperature of the freeze-drying process at different levels inside the chamber can be monitored in real time, providing a real-time basis for adjusting relevant freeze-drying parameters; In this invention, lifting mechanisms are configured for each lifting freeze-drying tray and capping plate within the freeze-drying chamber. These mechanisms control the lifting action in real time, providing an automated process for pressing vial stoppers onto the trays, demonstrating significant practical value; Because multiple temperature probes are designed within the freeze-drying chamber, the temperature control inside the chamber is clearer and more precise, allowing for better adjustment of the pre-freezing temperature, minimizing condensation on the trays, and preventing vials from falling off. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the internal structure of this utility model from the front view.

[0014] Figure 2This is a schematic diagram of the connection structure of relevant parts of the lifting mechanism in this utility model;

[0015] Figure 3 yes Figure 2 A schematic diagram of the structure from a side view;

[0016] Figure 4 This is a schematic diagram showing the state of the lifting freeze-drying tray after it has been loaded with vials in this utility model.

[0017] In the diagram: 1—Nitrogen supply device, 2—Nitrogen pipeline, 3—Heating system, 4—Bottom freeze-drying tray, 5—Lifting freeze-drying tray, 6—Freeze-drying chamber door, 7—Temperature probe, 8—Freeze-drying chamber body, 9—Screw motor, 10—Vent valve, 11—Cover plate, 12—Condenser, 13—Defrosting valve, 14—Vacuum valve, 15—Vacuum pump unit, 16—Exhaust valve, 17—Refrigerator, 18—Lifting screw, 19—Screw seat plate, 20—Guide rod. Detailed Implementation

[0018] The technical solution of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model. In the description of this utility model, it should be noted that the terms "upper," "lower," "inner," "outer," etc., indicating orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the utility model product is in use. They are only for the convenience of describing this utility model or simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed or operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0019] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," and "connect" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0020] See Figures 1-3This utility model relates to a vial freeze-drying device, comprising a freeze-drying chamber 8, with a freeze-drying chamber door 6 on one side of the chamber. Furthermore, the frame of the freeze-drying chamber door is sealed with a sterile sealing strip. A heating system 3 is located at the bottom of the freeze-drying chamber. A freezer 17, a condenser 12, and a vacuum pump unit 15 are also located outside the freeze-drying chamber. The freezer and condenser are connected to the freeze-drying chamber. Furthermore, the condenser is connected to the upper part of the freeze-drying chamber and is also connected to the vacuum pump unit via a pipe and a vacuum valve 14. A defrosting function is also provided on the condenser. The freeze-drying chamber includes valve 13 and exhaust valve 16. A bottom freeze-drying tray 4 is located at the lower part of the chamber. Above the bottom tray are 3-4 layers of lifting freeze-drying trays 5, each driven by an independent lifting mechanism. Above the topmost lifting tray is a pressure plate 11, also driven by an independent lifting mechanism. Several temperature probes 7 are positioned relative to each other on the front and rear side walls of the chamber, evenly spaced from bottom to top. These probes are connected to an integrated controller. Furthermore, the temperature probes are arranged horizontally in 4-5 rows from bottom to top, with 3-5 probes in each row from left to right. These probes are used to measure the temperature inside the freeze-drying chamber in real time. Furthermore, the freezer described in this utility model is connected to the bottom freeze-drying tray and the lifting freeze-drying tray respectively, and is also connected to the interior of the freeze-drying chamber for cooling the bottom freeze-drying tray, the lifting freeze-drying tray and the interior of the freeze-drying chamber.

[0021] Furthermore, in this embodiment, the lifting mechanism includes two lifting screws 18, two screw base plates 19, four guide rods 20, and two screw motors 9. The two screw base plates are respectively fixedly installed at both ends of the corresponding layer's lifting freeze-drying tray or pressure plate. The two screw motors are respectively installed on the top left and right sides of the freeze-drying chamber. Each screw motor is connected to a corresponding lifting screw. The lifting screw is placed inside the freeze-drying chamber and threadedly connected to the corresponding screw base plate. Each screw base plate is also fitted with two guide rods for lifting guidance. Furthermore, in this invention, the width of the screw base plates increases sequentially from bottom to top.

[0022] Furthermore, in this embodiment, a nitrogen supply device 1 is also provided outside the freeze-drying chamber. The nitrogen supply device fills the freeze-drying chamber with nitrogen through a nitrogen pipeline 2 and a valve. A venting valve 10 is also provided on the top of the freeze-drying chamber.

[0023] The following example uses a freeze-dried product (omeprazole sodium for injection) filled in vials, requiring freeze-drying equipment for drying. Freeze-drying parameters are set according to the different freeze-drying processes of various products, such as cooling the lifting freeze-drying tray after feeding (i.e., pre-cooling), freeze control, condenser cooling, pre-vacuuming, primary drying (including primary drying pressure rise test), desorption drying (including secondary drying pressure rise test), stoppering, and discharging. The specific operating steps of the freeze dryer (including the operating interface) are as follows:

[0024] Step 1: Enter the main interface; Step 2: Parameter management; Step 3: Freeze control; Step 4: Pre-cooling the freeze-drying tray as an option for loading at room temperature; Step 5: Pre-freeze; Step 6: Refrigeration condenser; Step 7: Vacuuming the chamber; Step 8: Sublimation drying stage; Step 9: Pressure rise test as an option only; Step 10: Desorption drying stage; Step 11: Pressure rise test to determine the end of the cycle; Step 12: If step 11 has been completed, the secondary drying cycle ends; Step 13: Re-pressurization and plugging operation; Step 14: Plate cooling as an option for product unloading at a certain temperature; Step 15: End control.

[0025] The above process describes the operation of a specific freeze dryer. The working principle of this invention is as follows: At startup, the temperature probes inside the freeze dryer chamber begin measuring the temperature, transmitting the actual temperature of each layer to the backend monitoring equipment in real time. The freezer operates, cooling the lifting freeze dryer trays, the bottom freeze dryer tray, and the freeze dryer chamber through pipelines. This cooling process is relatively rapid, causing the water in the vials to condense. Then, a vacuum pump group evacuates the chamber. Simultaneously, the heating system rapidly heats the chamber, quickly sublimating the frozen water in the medicine, separating the water from the medicine. The vacuum pump group evacuates the chamber, drawing the vaporized water from the medicine into the condenser to frost. Then, a certain amount of nitrogen is introduced into the freeze dryer chamber. After freeze drying, the stoppering operation begins, followed by the condenser defrosting operation.

[0026] Nitrogen is used as a protective gas inside the chamber. When pressing the caps, the number of rotations of each lifting screw is set in advance, which means the distance of each lifting freeze-drying tray and capping plate is predetermined. This allows the upper tray to press down on the lower vial caps. As long as it is tested in advance, pressing the caps down a certain distance will press each cap firmly and tightly. However, do not press too much to avoid damaging the vials.

[0027] This invention utilizes multiple layered temperature probes positioned on the front and rear side walls of the freeze-drying chamber to monitor the freeze-drying process temperature in real time at various levels, providing a basis for adjusting relevant freeze-drying parameters. Furthermore, the invention incorporates lifting mechanisms for each lifting freeze-drying tray and capping plate within the freeze-drying chamber. These mechanisms control the lifting action in real time, automating the capping of vials on the trays and demonstrating significant practical value. Finally, the inclusion of multiple temperature probes within the freeze-drying chamber allows for clearer and more precise temperature control, enabling effective adjustment of pre-freezing temperatures, minimizing condensation on the trays, and preventing vials from falling off.

Claims

1. A vial freeze-drying apparatus, comprising a freeze-drying chamber, a freeze-drying chamber door on one side of the freeze-drying chamber, a heating system at the bottom of the freeze-drying chamber, and a freezer, a condenser, and a vacuum pump assembly externally to the freeze-drying chamber, wherein the freezer and condenser are connected to the freeze-drying chamber, characterized in that: The freeze-drying chamber has a bottom freeze-drying tray located at its lower part. Above the bottom freeze-drying tray are 3 to 4 layers of lifting freeze-drying trays, each of which is driven by an independent lifting mechanism. Above the topmost lifting freeze-drying tray is a cover plate, which is also driven by an independent lifting mechanism. Several temperature probes are also installed at relatively opposite positions on the front and rear side walls inside the freeze-drying chamber. These temperature probes are evenly spaced from bottom to top and are connected to an integrated controller.

2. The vial freeze-drying equipment according to claim 1, characterized in that: The temperature probes are arranged in horizontal rows from bottom to top, with 4 to 5 rows. Each row has 3 to 5 temperature probes arranged from left to right. The temperature probes are used to measure the temperature in the freeze-drying chamber in real time.

3. The vial freeze-drying equipment according to claim 1, characterized in that: The lifting mechanism includes two lifting screws, two screw base plates, four guide rods, and two screw motors. The two screw base plates are fixedly installed at both ends of the corresponding lifting freeze-drying trays or pressure plates. The two screw motors are installed on the top left and right sides of the freeze-drying chamber. Each screw motor is connected to a corresponding lifting screw. The lifting screws are placed inside the freeze-drying chamber and threadedly connected to the screw base plates on the corresponding sides. Each screw base plate is also equipped with two guide rods for lifting guidance.

4. The vial freeze-drying equipment according to claim 3, characterized in that: The width of the lead screw seat plate increases from bottom to top.

5. The vial freeze-drying equipment according to claim 1, characterized in that: The freezer is connected to the bottom freeze-drying tray and the lifting freeze-drying tray respectively, and is also connected to the interior of the freeze-drying chamber, for cooling the bottom freeze-drying tray, the lifting freeze-drying tray and the interior of the freeze-drying chamber.

6. The vial freeze-drying equipment according to claim 1, characterized in that: The freeze-drying chamber is also equipped with a nitrogen supply device, which supplies nitrogen to the freeze-drying chamber through nitrogen pipes and valves. The freeze-drying chamber is also equipped with a vent valve on its top.

7. The vial freeze-drying equipment according to claim 1, characterized in that: The condenser is connected to the upper part of the freeze-drying chamber and is also connected to the vacuum pump group through pipes and vacuum valves. The condenser is also equipped with a defrost valve and an exhaust valve.

8. The vial freeze-drying equipment according to claim 1, characterized in that: The frame of the freeze-drying chamber door is sealed with a sterile sealing strip.

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