Liquid medicine reaction kettle

By designing a stirring assembly with up-and-down shaking and spiral stirring blades in the pharmaceutical reaction vessel, the problems of uneven mixing and insufficient temperature control were solved, achieving efficient mixing of the pharmaceutical solution and improving product quality.

CN223542982UActive Publication Date: 2025-11-14HENAN PROVINCE ZHONGTAI MEDICINE
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Patent Information

Application Number
CN202423008310.6
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-12-06
Publication Date
2025-11-14
Estimated Expiration
2034-12-06

AI Technical Summary

Technical Problem

Traditional pharmaceutical reaction vessels suffer from uneven stirring and insufficient temperature control precision when preparing calcium gluconate injection, which affects the purity and stability of the product.

Method used

A pharmaceutical reaction vessel was designed. By setting a stirring component on the rotating rod, it can be made to shake up and down. Combined with the spiral arrangement of the movable plate and stirring blades, the stirring force and convection effect are enhanced. The polygonal structure of the rotating shaft and the slide groove ensures stable rotation.

Benefits of technology

It improves the mixing uniformity and stirring efficiency of the drug solution, and enhances the purity and stability of the product, especially the quality of calcium gluconate injection.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model provides a liquid medicine reaction kettle, which belongs to the technical field of medicine preparation and comprises a tank body and a rotating shaft arranged at the top of the tank body through a bearing, a rotating rod is arranged at the bottom of the rotating shaft in an up-down sliding manner, a stirring assembly is arranged on the rotating rod, a lantern ring is further fixedly arranged on the rotating rod, and a wavy clamping groove is formed in the lantern ring. A fixing plate corresponding to the lantern ring is further arranged at the bottom of the can cover, a clamping rod is arranged on the fixing plate and can be inserted into the clamping groove, and when the rotating rod rotates, the clamping rod pokes the clamping groove so that the rotating rod can move up and down; the stirring assembly can be driven to shake up and down when liquid medicine is mixed, so that the mixing effect of the liquid medicine is improved to a certain extent, and the quality of finished liquid medicine is improved.
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Description

Technical Field

[0001] This utility model relates to the field of drug preparation equipment technology, specifically to a liquid drug reaction vessel. Background Technology

[0002] In the pharmaceutical industry, the reaction vessel is one of the core pieces of equipment for preparing various injectable solutions. Its design and performance directly affect the quality of the final product and production efficiency. This is especially true for products like calcium gluconate injection, which require strict control of reaction conditions and material mixing uniformity; the selection and optimization of the reaction vessel are therefore crucial.

[0003] Traditional pharmaceutical reaction vessels often face several technical challenges in preparing calcium gluconate injection solutions. First, calcium gluconate has limited solubility in water and is prone to precipitation and clumping during the reaction, leading to uneven mixing and affecting product purity and stability. Second, the control of reaction temperature and time directly impacts product quality and yield; traditional reaction vessels often lack precision in temperature control, making it difficult to achieve precise temperature management.

[0004] To address the aforementioned issues, prior art publication CN221230559U discloses a reaction vessel for preparing chemical raw materials. This device can adjust the distance between the two stirring rods and the axis of the vessel body through a scissor-type design, thereby continuously changing the stirring range and position. This allows the chemical raw materials or pharmaceutical intermediates in different parts of the reaction vessel to have better contact with the stirrer, improving the stirring effect.

[0005] While the aforementioned equipment can increase the mixing effect of materials by changing the position of the stirring rod, the improvement in mixing effect is limited. If the stirring blades could also move up and down during rotation, the liquid materials could be mixed vertically. Therefore, our company focuses on research and development in this direction to further improve the mixing effect of the liquid. Utility Model Content

[0006] In view of this, the present invention provides a pharmaceutical reaction vessel. The present invention can drive the stirring component to shake up and down when mixing pharmaceutical solutions, thereby increasing the mixing effect of pharmaceutical solutions to a certain extent and improving the quality of finished pharmaceutical solutions.

[0007] To solve the above-mentioned technical problems, this utility model provides a pharmaceutical reaction vessel, including a tank body and a rotating shaft mounted on the top of the tank body via a bearing. The rotating shaft can rotate on the tank body. A rotating rod is slidably mounted on the bottom of the rotating shaft. The rotating rod can slide up and down at the bottom of the rotating shaft. A stirring assembly is mounted on the rotating rod. The rotation of the stirring assembly can mix the pharmaceutical solution. A collar is also fixed on the rotating rod. The rotating rod can drive the collar to rotate. The collar has a wave-shaped groove. A fixing plate is also provided at the bottom of the tank cover corresponding to the collar. A locking rod is provided on the fixing plate. The locking rod can be inserted into the groove. When the rotating rod rotates, the locking rod moves the groove, which can make the rotating rod move up and down. The rotating rod can sway up and down when rotating.

[0008] The stirring assembly includes multiple sets of telescopic rods mounted on the outer wall of the rotating rod. The rotating rod can drive the multiple sets of telescopic rods to rotate. Each set of telescopic rods is arranged linearly on the side wall of the rotating rod. A movable plate is connected between the ends of each set of telescopic rods. The telescopic rods can drive the movable plate to rotate. Several stirring blades are provided on the movable plate. The movable plate can drive the stirring blades to rotate. A movable block is also rotatably mounted at the bottom of the tank. The movable block can rotate inside the tank. Multiple movable rods are also hinged on the movable block. The movable block can rotate together with the movable rods. The other ends of the multiple movable rods are respectively hinged to the bottom of multiple movable plates. The ends of the movable rods can rotate at the bottom of the movable plates.

[0009] The stirring blades are inclinedly set on the outer wall of the movable plate, and the multiple stirring blades are spiral in shape, that is, when the stirring blades rotate, the medicine liquid can be stirred in a vortex.

[0010] There are four movable plates arranged in a circular array around the rotating rod, which means that the force on the multiple movable plates is relatively balanced when they rotate.

[0011] The bottom of the rotating shaft is provided with a sliding groove, and a rotating rod is slidably mounted in the sliding groove. The rotating rod can slide up and down in the sliding groove. Both the rotating rod and the sliding groove have polygonal cross-sections. The rotating shaft can drive the rotating rod to rotate.

[0012] Both the rotating rod and the slide are T-shaped structures, and the rotating rod will not fall out of the slide.

[0013] In summary, compared with the prior art, this application includes at least one of the following beneficial technical effects:

[0014] 1. Enhanced Mixing Uniformity: The stirring component on the rotating rod rotates while the rod itself moves up and down due to the interaction between the clamp and the corrugated groove. This dynamic stirring method not only increases the contact area between the stirring blades and the liquid, but also promotes vertical convection of the liquid within the reactor, thereby greatly improving the mixing uniformity of the liquid.

[0015] 2. Improved stirring efficiency: The movable plate in the stirring assembly is connected to the rotating rod via a telescopic rod, and the movable plate is equipped with inclined and spirally arranged stirring blades. This design allows the stirring blades to generate stronger shearing and impact forces when rotating, which helps to break up sediment and clumps in the liquid, further improving stirring efficiency.

[0016] 3. Optimized structural design: The sliding groove at the bottom of the rotating rod and shaft adopts a polygonal structure, ensuring stable rotation and vertical sliding of the rotating rod within the groove. Simultaneously, the T-shaped structure design of the rotating rod and sliding groove effectively prevents the rotating rod from falling off, enhancing the stability and safety of the equipment.

[0017] 4. Improved Product Quality: Because the pharmaceutical reaction vessel provided by this invention can achieve thorough mixing and uniform stirring of the pharmaceutical solution, it helps to improve the quality of the final product. Especially for products such as calcium gluconate injection, which require strict control of reaction conditions and material mixing uniformity, the application of this reaction vessel will significantly improve the purity and stability of the product. Attached Figure Description

[0018] Figure 1 This is a structural schematic diagram of a cross-sectional view of a pharmaceutical reaction vessel according to the present invention;

[0019] Figure 2 This utility model Figure 1 Schematic diagram of the structure at point A;

[0020] Figure 3 This is a schematic diagram of the structure of the stirring assembly of this utility model.

[0021] Explanation of reference numerals in the attached figures:

[0022] 100. Tank body; 101. Shaft; 102. Slide groove;

[0023] 200. Rotating rod; 201. Collar; 202. Slot; 203. Fixing plate; 204. Locking rod;

[0024] 300. Stirring assembly; 301. Telescopic rod; 302. Movable plate; 303. Stirring blades; 304. Movable block; 305. Movable rod. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the following will be described in conjunction with the accompanying drawings of the embodiments of this utility model. Figure 1-3 The technical solutions of the embodiments of this utility model are clearly and completely described herein. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the described embodiments of this utility model are within the protection scope of this utility model.

[0026] like Figure 1 , 3 As shown: The tank includes a tank body 100 and a rotating shaft 101 mounted on the top of the tank body 100 via a bearing. The rotating shaft 101 can rotate on the tank lid. A rotating rod 200 is slidably mounted on the bottom of the rotating shaft 101, and the rotating rod 200 and the rotating shaft 101 are located on the same axis. Thus, the rotating shaft 101 can drive the rotating rod 200 to rotate. A stirring assembly 300 is also mounted on the rotating rod 200, so that when the rotating rod 200 rotates, it can drive the stirring assembly 300 to rotate, thereby mixing the medicine liquid inside the tank body 100. A collar 201 is also fixed on the outer wall of the rotating rod 200, and a groove 202 is provided on the outer surface of the collar 201. The slot 202 has a ring-shaped wave structure, and the bottom of the can lid is also vertically provided with a fixing plate 203. The side of the fixing plate 203 is also provided with a horizontal locking rod 204. The end of the locking rod 204 away from the fixing plate 203 is located in the slot 202. When the rotating rod 200 rotates, the locking rod 204 moves the slot 202, which makes the rotating rod 200 move up and down. In this way, the rotating rod 200 can drive the stirring assembly 300 to shake up and down when it rotates. This dynamic stirring method not only increases the contact area between the stirring blade 303 and the liquid medicine, but also promotes the vertical convection of the liquid medicine in the reaction vessel, thereby greatly improving the mixing uniformity of the liquid medicine.

[0027] like Figure 1 , 3 As shown,

[0028] The stirring assembly 300 includes multiple sets of telescopic rods 301 disposed on the outer side wall of the rotating rod 200. Each set of telescopic rods 301 is arranged in a linear pattern on the side wall of the rotating rod 200. When the rotating rod 200 rotates, it can drive the multiple sets of telescopic rods 301 to rotate. A movable plate 302 is connected between the ends of each set of telescopic rods 301. The rotating rod 200 can drive the movable plate 302 to rotate through the telescopic rods 301. The rotation of the movable plate 302 can stir the liquid medicine to mix it.

[0029] In this embodiment, the movable plate 302 is an arc-shaped structure, which reduces the resistance of the liquid medicine to the movable plate 302 when the movable plate 302 rotates.

[0030] It is worth mentioning that a movable block 304 is also provided at the bottom of the tank body 100 via a bearing, and the movable block 304 is located on the same axis as the rotating shaft 101. Multiple movable rods 305 are also hinged to the outer surface of the movable block 304. The movable rods 305 can rotate on the movable block 304, and the number of movable rods 305 is the same as the number of movable plates 302. The other end of the movable rod 305 is hinged to the bottom of the corresponding movable plate 302, so both ends of the movable rod 305 can be connected to the movable plate 302 and the movable block 304 respectively. The rotating connection allows the rotating rod 200 to rotate the movable plate 302, as well as the movable block 304 and the movable rod 305. When the rotating rod 200 swings up and down, it can indirectly move the movable plate 302 up and down. At this time, the movable rod 305 can pull the bottom of the movable plate 302, causing the movable plate 302 to move closer to the axis of the rotating rod 200. Thus, during rotation, it can not only swing up and down but also change the position and range of the movable plate 302's rotation, thereby further improving the mixing effect of the medicine.

[0031] like Figure 3 As shown,

[0032] The stirring blades 303 are inclinedly arranged on the outer wall of the movable plate 302. The multiple stirring blades 303 are spiral in shape. That is, when the rotating rod 200 drives the multiple movable plates 302 to rotate, the liquid medicine can be stirred in a vortex. When the multiple movable plates 302 shake up and down, it can promote the vertical convection of the liquid medicine in the reaction vessel, thereby greatly improving the mixing uniformity of the liquid medicine.

[0033] like Figure 3 As shown,

[0034] Four movable plates 302 are arranged in a circular array around the rotating rod 200. When multiple movable plates 302 rotate inside the tank 100, the flow resistance received by the multiple movable plates 302 is consistent, which can increase the service life of the stirring assembly 300.

[0035] like Figure 1 , 2 As shown,

[0036] The bottom of the rotating shaft 101 is provided with a vertical groove 102, and the groove 102 and the rotating shaft 101 are located on the same axis. A rotating rod 200 is slidably provided in the groove 102. The rotating rod 200 can slide up and down in the groove 102. The cross-section of the rotating rod 200 and the groove 102 are both polygonal structures, so that the rotating shaft 101 can drive the rotating rod 200 to rotate when rotating, and the rotating rod 200 will not slip in the groove 102.

[0037] Both the rotating rod 200 and the slide 102 are T-shaped structures, meaning that the rotating rod 200 will not fall down from the slide 102 during the up-and-down sliding process.

[0038] Furthermore, it should be noted that, in the description of this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0039] The above description is the preferred embodiment of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of this utility model, and these improvements and modifications should also be considered within the protection scope of this utility model.

Claims

1. A pharmaceutical reaction vessel, comprising a tank body (100) and a rotating shaft (101) mounted on the top of the tank body (100) via a bearing, characterized in that: The bottom of the rotating shaft (101) is provided with a rotating rod (200) that slides up and down. The rotating rod (200) is provided with a stirring assembly (300). The rotating rod (200) is also fixedly provided with a collar (201). The collar (201) is provided with a wave-shaped groove (202). Corresponding to the collar (201), a fixing plate (203) is provided at the bottom of the can lid. The fixing plate (203) is provided with a locking rod (204). The locking rod (204) can be inserted into the groove (202). When the rotating rod (200) rotates, the locking rod (204) moves the groove (202) so that the rotating rod (200) can move up and down.

2. The pharmaceutical reaction vessel as described in claim 1, characterized in that: The stirring assembly (300) includes multiple sets of telescopic rods (301) arranged on the outer wall of the rotating rod (200). Each set of telescopic rods (301) is arranged in a linear pattern on the side wall of the rotating rod (200). A movable plate (302) is connected between the ends of each set of telescopic rods (301). Several stirring blades (303) are provided on the movable plate (302). A movable block (304) is also rotatably provided at the bottom of the tank (100). Multiple movable rods (305) are also hinged on the movable block (304). The other ends of the multiple movable rods (305) are respectively connected to the bottom of the multiple movable plates (302) by hinge.

3. The pharmaceutical reaction vessel as described in claim 2, characterized in that: The stirring blades (303) are inclinedly arranged on the outer wall of the movable plate (302), and the multiple stirring blades (303) are spiral in shape as a whole.

4. The pharmaceutical reaction vessel as described in claim 3, characterized in that: The movable plate (302) has four plates arranged in a circular array with the rotating rod (200) as the axis.

5. The pharmaceutical reaction vessel as described in claim 1, characterized in that: The bottom of the rotating shaft (101) is provided with a sliding groove (102), and a rotating rod (200) is slidably provided in the sliding groove (102). The cross-section of the rotating rod (200) and the sliding groove (102) are both polygonal structures.

6. The pharmaceutical reaction vessel as described in claim 5, characterized in that: Both the rotating rod (200) and the sliding groove (102) are T-shaped structures.

Citation Information

Patent Citations

  • Reaction kettle for preparing chemical raw material medicine

    CN221230559U