Production system for dorzolamide hydrochloride

Abstract

The utility model relates to the technical field of production of dorzolamide hydrochloride, in particular to a production system for dorzolamide hydrochloride. Comprising a first reaction kettle, a first crystallization kettle, a second reaction kettle, a second crystallization kettle, an acidification kettle, a pH adjusting kettle, a first filtering device, a washing kettle, a second filtering device, a first drying device, a crude product storage tank, a dissolving kettle, a third filtering device, a third crystallization kettle, a second drying device and a product storage tank. The production system is reasonable in design, on one hand, materials are promoted to fully react, and the reaction efficiency is improved; on the other hand, the purity, the yield and the yield of the product are also improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to hydrochloric dodecin production technical field especially relates to a production system for hydrochloric dodecin. BACKGROUND

[0002] The chemical name of dodecin hydrochloride is (4S, 6S)-4-ethylamino-5, 6-dihydro-6-methyl-4H-thiopheno [2, 3b] pyran-2-sulfonamide-7, 7-dioxide hydrochloride. In the chemical synthesis of dodecin hydrochloride, the synthesis of chiral intermediates is often involved. The existing synthesis method of chiral intermediates is complex and the conditions are strict. Therefore, after establishing a process method, the requirements for equipment are more strict. The existing technology generally improves the stirring parts of the reaction equipment in the synthesis process to promote the full contact of materials and improve the reaction efficiency. However, the yield, yield and purity of the product are affected by multiple treatment processes. The yield, yield and purity of the obtained product are low by merely improving the stirring parts of the reaction equipment in the synthesis process. Therefore, it is necessary to develop a production system for dodecin hydrochloride in view of the above problems. SUMMARY

[0003] The technical problem to be solved by the utility model is that, in view of the deficiencies of the prior art, a production system for dodecin hydrochloride is provided, which greatly improves the yield, yield and purity of the product.

[0004] To solve the above technical problems, the technical scheme of the utility model is:

[0005] A production system for dodecin hydrochloride, comprising a first reaction kettle, a first crystallization kettle connected to the discharge port of the first reaction kettle, a second reaction kettle connected to the discharge port of the first crystallization kettle, a second crystallization kettle connected to the discharge port of the second reaction kettle, an acidification kettle connected to the discharge port of the second crystallization kettle, a pH adjusting kettle connected to the discharge port of the acidification kettle, a first filter device connected to the discharge port of the pH adjusting kettle, a washing kettle connected to the discharge port of the first filter device, a second filter device connected to the discharge port of the washing kettle, a first drying device connected to the discharge port of the second filter device, and a crude product storage tank connected to the discharge port of the first drying device. The discharge port of the crude product storage tank is connected to a dissolution kettle, the discharge port of the dissolution kettle is connected to a third filter device, the liquid outlet of the third filter device is connected to a third crystallization kettle, the discharge port of the third crystallization kettle is connected to a second drying device, and the discharge port of the second drying device is connected to a product storage tank.

[0006] As an improved technical scheme, the first reaction kettle comprises a kettle body, a feeding port and a solvent inlet are arranged at the top of the kettle body, a discharging port is arranged at the bottom of the kettle body, and a jacket is arranged outside the kettle body; a temperature sensor and a rotating shaft are arranged inside the kettle body, the temperature sensor is electrically connected with a controller, one end of the rotating shaft is connected with a motor, and a plurality of stirring blades are arranged on the rotating shaft.

[0007] As an improved technical scheme, the second reaction kettle comprises a kettle body, a feeding port, an air inlet and a catalyst inlet are arranged at the top of the kettle body, and a discharging port is arranged at the bottom of the kettle body; a jacket is arranged outside the kettle body, a temperature sensor and a rotating shaft are arranged inside the kettle body, and the temperature sensor is electrically connected with a controller; one end of the rotating shaft is connected with a motor, and a first stirring component and a second stirring component are arranged on the rotating shaft.

[0008] As a further improved technical scheme, the first stirring component and the second stirring component each comprise a circular ring body, a plurality of arc-shaped plates are arranged on the circular ring body, and the circular ring body and the arc-shaped plates are fixedly connected with the rotating shaft.

[0009] As an improved technical scheme, the first crystallization kettle, the second crystallization kettle and the third crystallization kettle each comprise a kettle body, a feeding port and an organic solvent inlet are arranged at the top of the kettle body, a discharging port is arranged at the bottom of the kettle body, a liquid outlet is arranged at one side of the lower part of the kettle body, and a filter screen is arranged at a position corresponding to the liquid outlet inside the kettle body; a jacket is arranged outside the kettle body, a stirring shaft is arranged inside the kettle body, one end of the stirring shaft is connected with a motor, and a plurality of stirring rods are arranged on the stirring shaft.

[0010] As an improved technical scheme, the acidification kettle comprises a kettle body, a feeding port and a hydrochloric acid inlet are arranged at the top of the kettle body, a discharging port is arranged at the bottom of the kettle body, a jacket is arranged outside the kettle body, a temperature sensor and a rotating shaft are arranged inside the kettle body, and the temperature sensor is electrically connected with a controller; one end of the rotating shaft is connected with a motor, a plurality of S-shaped stirring plates are arranged on the rotating shaft, and a plurality of stirring teeth are arranged on the S-shaped stirring plates.

[0011] As an improved technical scheme, the washing kettle comprises a kettle body, a feeding port and a discharging port are arranged at the top and the bottom of the kettle body respectively, washing liquid inlet pipes are arranged at two sides of the middle part of the kettle body; a jacket is arranged outside the kettle body, a rotating shaft is arranged inside the kettle body, one end of the rotating shaft is connected with a motor, three stirring frames are arranged on the rotating shaft, a plurality of stirring plates are arranged on the stirring frames; a washing liquid distribution disc is arranged inside the kettle body and communicates with the washing liquid inlet pipes, and a plurality of through holes are arranged on the washing liquid distribution disc.

[0012] As an improved technical scheme, the dissolving kettle comprises a kettle body, a feeding port and a water inlet pipe are arranged at the top of the kettle body, and a discharging port is arranged at the bottom of the kettle body; a jacket is arranged outside the kettle body, and a stirring shaft is arranged inside the kettle body, one end of the stirring shaft is connected with a motor, an upper portion of the stirring shaft is provided with a material distribution disc, and a plurality of material distribution holes are arranged on the material distribution disc; an upper portion of the material distribution disc is provided with a liquid distributor which is communicated with the water inlet pipe, the liquid distributor comprises an annular liquid distribution main pipe, a plurality of liquid distribution branch pipes are arranged on the liquid distribution main pipe, and a plurality of liquid distribution holes are arranged on the lower surfaces of the liquid distribution main pipe and the liquid distribution branch pipes respectively; and a plurality of stirring plates are arranged below the material distribution disc.

[0013] As an improved technical scheme, the liquid outlets of the first crystallization kettle, the second crystallization kettle and the third crystallization kettle are respectively communicated with a crystallization mother liquor storage tank through a suction filter pump.

[0014] After the above technical scheme is adopted, the beneficial effects of the present application are as follows:

[0015] The production system for doxorubicin hydrochloride comprises a first reaction kettle, a first reaction kettle outlet connected with a first crystallization kettle, a first crystallization kettle outlet connected with a second reaction kettle, a second reaction kettle outlet connected with a second crystallization kettle, a second crystallization kettle outlet connected with an acidification kettle, an acidification kettle outlet connected with a pH adjustment kettle, a pH adjustment kettle outlet connected with a first filter device, a first filter device outlet connected with a washing kettle, a washing kettle outlet connected with a second filter device, a second filter device outlet connected with a first drying device, a first drying device outlet connected with a crude product storage tank, a crude product storage tank outlet connected with a dissolution kettle, a dissolution kettle outlet connected with a third filter device, a third filter device outlet connected with a third crystallization kettle, a third crystallization kettle outlet connected with a second drying device, and a second drying device outlet connected with a product storage tank. In actual production, (6S)-4-carbonyl-5,6-dihydro-4H-6-methyl-thieno[2,3b]thiopyran-2-sulfonamide-7,7-dioxide is used as a starting material and added into the first reaction kettle together with ethylamine, the reaction liquid after sufficient reaction is introduced into the first crystallization kettle, crystallization is carried out after adding an organic solvent, the obtained intermediate is introduced into the second reaction kettle, the obtained crystal is introduced into the second crystallization kettle after reaction under the action of a catalyst and a gas, the obtained crystal is introduced into the acidification kettle, the reaction liquid after reaction is introduced into the pH adjustment kettle, the reaction liquid is adjusted to neutral and cooled, then introduced into the first filter device, the obtained solid is introduced into the washing kettle, the washing liquid is introduced into the second filter device, the filtered solid is introduced into the first drying device, the doxorubicin hydrochloride crude product after drying is introduced into the crude product storage tank, then conveyed to the dissolution kettle, the heated and dissolved liquid is introduced into the third filter device, the collected filtrate is introduced into the third crystallization kettle, the collected crystal is introduced into the second drying device for drying, and finally the doxorubicin hydrochloride product is stored in the product storage tank.

[0016] The first reaction kettle comprises a kettle body, a feed inlet and a reagent inlet arranged at the top of the kettle body, a discharge outlet arranged at the bottom of the kettle body, and a jacket arranged outside the kettle body; a temperature sensor and a rotating shaft are arranged inside the kettle body, the temperature sensor is electrically connected with a controller, one end of the rotating shaft is connected with a motor, and a plurality of stirring blades are arranged on the rotating shaft. The reaction material and the reagent are introduced into the kettle body, the heat medium in the jacket provides the required reaction temperature, the motor drives the rotating shaft and the plurality of stirring blades to stir and mix the material and the reagent, and the reaction efficiency is greatly improved.

[0017] The second reaction kettle comprises a kettle body, a feed inlet, an air inlet and a catalyst inlet are arranged on the top of the kettle body, a discharge outlet is arranged on the bottom of the kettle body, a jacket is arranged on the outside of the kettle body, a temperature sensor and a rotating shaft are arranged in the kettle body, the temperature sensor is electrically connected with a controller, one end of the rotating shaft is connected with a motor, and a first stirring part and a second stirring part are arranged on the rotating shaft.

[0018] The first stirring part and the second stirring part each comprise a circular ring body, a plurality of arc plates are arranged on the circular ring body, and the circular ring body and the arc plates are fixedly connected with the rotating shaft.

[0019] The first, the second and the third crystallization kettles each comprise a kettle body, a feed inlet and an organic solvent inlet are arranged on the top of the kettle body, a discharge outlet is arranged on the bottom of the kettle body, a liquid outlet is arranged on one side of the lower part of the kettle body, and a filter screen is arranged in the kettle body at a position corresponding to the liquid outlet; a jacket is arranged on the outside of the kettle body, a stirring shaft is arranged in the kettle body, one end of the stirring shaft is connected with a motor, and a plurality of stirring rods are arranged on the stirring shaft.

[0020] The acidification kettle comprises a kettle body, a feed inlet and a hydrochloric acid inlet are arranged on the top of the kettle body, a discharge outlet is arranged on the bottom of the kettle body, a jacket is arranged on the outside of the kettle body, a temperature sensor and a rotating shaft are arranged in the kettle body, the temperature sensor is electrically connected with a controller, one end of the rotating shaft is connected with a motor, a plurality of S-shaped stirring plates are arranged on the rotating shaft, and a plurality of stirring teeth are arranged on the S-shaped stirring plates.

[0021] The utility model discloses a production system of crude doxium chloride, which comprises a washing kettle, a dissolving kettle, a first crystallization kettle, a second crystallization kettle, a third crystallization kettle, a crystallization mother liquor storage tank and a filter.

[0022] The utility model discloses a production system of crude doxium chloride, which comprises a washing kettle, a dissolving kettle, a first crystallization kettle, a second crystallization kettle, a third crystallization kettle, a crystallization mother liquor storage tank and a filter.

[0023] The utility model discloses a production system of crude doxium chloride, which comprises a washing kettle, a dissolving kettle, a first crystallization kettle, a second crystallization kettle, a third crystallization kettle, a crystallization mother liquor storage tank and a filter. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 It is a structure schematic drawing of the production system of crude doxium chloride.

[0025] Among them, 1-first reaction vessel, 2-first crystallization vessel, 20-first stirring component, 200-ring body, 201-arc plate, 21-second stirring component, 3-second reaction vessel, 4-second crystallization vessel, 5-acidification vessel, 6-pH adjustment vessel, 7-first filtration device, 8-washing vessel, 9-second filtration device, 10-first drying device, 11-crude product storage tank, 12-dissolving vessel, 120-material distribution plate, 121-liquid distributor, 1210-liquid main pipe, 1211-liquid branch pipe, 13-third filtration device, 14-third crystallization vessel, 15-second drying device, 16-product storage tank, 17-vacuum pump, 18-crystallization mother liquor storage tank. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present utility model and are not intended to limit the present utility model.

[0027] A production system for dzodamine hydrochloride, such as Figure 1 As shown, the system includes a first reaction vessel 1, the outlet of which is connected to a first crystallization vessel 2, the outlet of which is connected to a second reaction vessel 3, the outlet of which is connected to a second crystallization vessel 4, the outlet of which is connected to an acidification vessel 5, the outlet of which is connected to a pH adjustment vessel 6 (including a vessel body, with an inlet and an alkali inlet at the top, an outlet at the bottom, a pH sensor and a rotating shaft inside, one end of which is connected to a motor, and multiple stirring plates on the shaft), and the outlet of which is connected to a first filtration device 7 (plate and frame filter). The outlet of the filter device 7 is connected to the washing vessel 8, the outlet of the washing vessel 8 is connected to the second filter device 9 (plate and frame filter), the outlet of the second filter device 9 is connected to the first drying device 10 (oven), the outlet of the first drying device 10 is connected to the crude product storage tank 11; the outlet of the crude product storage tank 11 is connected to the dissolving vessel 12, the outlet of the dissolving vessel 12 is connected to the third filter device 13 (plate and frame filter), the outlet of the third filter device 13 is connected to the third crystallization vessel 14, the outlet of the third crystallization vessel 14 is connected to the second drying device 15 (oven), and the outlet of the second drying device 15 is connected to the product storage tank 16.

[0028] In actual production, (6S)-4-carbonyl-5,6-dihydro-4H-6-methyl-thieno[2,3b]thiopyran-2-sulfonamide-7,7-dioxide is used as a starting material and is added into the inside of the first reaction kettle together with ethylamine, the liquid after sufficient reaction is conveyed along the pipeline into the first crystallization kettle by the action of the conveying pump, crystallization is carried out after adding an organic solvent, the obtained intermediate is conveyed along the pipeline into the second reaction kettle by the action of the conveying pump, the obtained liquid after reaction is conveyed along the pipeline into the inside of the second crystallization kettle by the action of the conveying pump, the obtained crystal is then introduced into the acidification kettle, the liquid after reaction is conveyed along the pipeline into the pH adjusting kettle by the action of the conveying pump, the liquid is adjusted to be neutral and is cooled, then the liquid is conveyed along the pipeline into the inside of the first filtering device by the action of the conveying pump, the obtained solid is filtered and is conveyed into the washing kettle by the conveying belt, the liquid after washing is conveyed along the pipeline into the second filtering device by the action of the conveying pump, the filtered solid is conveyed into the first drying device by the conveying belt, the dried crude dorzolamide hydrochloride is conveyed into the crude product storage tank by the conveying belt, then is conveyed to the dissolving kettle by the conveying belt, the liquid after heating and dissolving is conveyed along the pipeline into the third filtering device by the action of the conveying pump, the collected filtrate is conveyed along the pipeline into the third crystallization kettle by the action of the conveying pump, crystallization is carried out after cooling, the collected crystal is conveyed along the pipeline into the second drying device for drying, and finally the pure dorzolamide hydrochloride is conveyed into the product storage tank by the conveying belt for storage. The above production system is rationally designed, on the one hand, the material is fully reacted, and the reaction efficiency is improved; on the other hand, the purity, yield and production of the product are also improved.

[0029] The first reaction kettle 1 comprises a kettle body, a feeding port and a reagent inlet are arranged at the top of the kettle body, a discharging port is arranged at the bottom of the kettle body, and a jacket is arranged outside the kettle body; a temperature sensor and a rotating shaft are arranged inside the kettle body, the temperature sensor is electrically connected with a controller, one end of the rotating shaft is connected with a motor, and a plurality of stirring blades are arranged on the rotating shaft. The reactants and reagents are introduced into the kettle body, the heat medium in the jacket is used to provide the required temperature for the reaction, and the motor drives the rotating shaft and the plurality of stirring blades to stir and mix the reactants and reagents, so that the reaction efficiency is greatly improved.

[0030] The second reaction kettle 2 comprises a kettle body, a feeding port, a gas inlet and a catalyst inlet are arranged at the top of the kettle body, and a discharging port is arranged at the bottom of the kettle body; a jacket is arranged outside the kettle body, a temperature sensor and a rotating shaft are arranged inside the kettle body, and the temperature sensor is electrically connected with a controller; one end of the rotating shaft is connected with a motor, and a first stirring component 20 and a second stirring component 21 are arranged on the rotating shaft. The material, the gas and the catalyst are introduced into the kettle body, the heat medium in the jacket is used to provide the required temperature for the reaction, and the motor drives the rotating shaft and the first and second stirring components to fully stir and mix the material, the catalyst and the gas, so that the reaction efficiency is greatly improved.

[0031] The first stirring component 20 and the second stirring component 21 each comprise a circular ring body 200, a plurality of arc-shaped plates 201 are arranged on the circular ring body 200, and the circular ring body 200 and the arc-shaped plates 201 are fixedly connected with the rotating shaft respectively. The first and second stirring components with the above structure are rationally designed, so that the materials are fully contacted and reacted, and the reaction efficiency is greatly improved.

[0032] The first crystallization kettle 2, the second crystallization kettle 4 and the third crystallization kettle 15 each comprise a kettle body, the top of the kettle body is provided with a feeding port and an organic solvent inlet, the bottom of the kettle body is provided with a discharging port, one side of the lower part of the kettle body is provided with a liquid outlet, and a filter screen is arranged at a position corresponding to the liquid outlet in the kettle body; a jacket is arranged outside the kettle body, a stirring shaft is arranged inside the kettle body, one end of the stirring shaft is connected with a motor, and a plurality of stirring rods are arranged on the stirring shaft. The liquid and the organic solvent enter the inside of the kettle body, the temperature required for crystallization is provided by the coolant in the jacket, and the stirring shaft and the plurality of stirring rods are driven to stir and mix the liquid and the organic solvent after the motor is started, so that the formation of crystals is promoted.

[0033] The acidification kettle 5 comprises a kettle body, the top of the kettle body is provided with a feeding port and a hydrochloric acid inlet, the bottom of the kettle body is provided with a discharging port, the outside of the kettle body is provided with a jacket, the inside of the kettle body is provided with a temperature sensor and a rotating shaft, and the temperature sensor is electrically connected with a controller; one end of the rotating shaft is connected with a motor, a plurality of S-shaped stirring plates are arranged on the rotating shaft, and a plurality of stirring teeth are arranged on the S-shaped stirring plates. The crystals and the hydrochloric acid enter the inside of the kettle body respectively, the temperature required for the reaction is provided by the heat medium in the jacket, and the rotating shaft, the S-shaped stirring plates and the plurality of stirring teeth are driven to stir and mix the crystals and the hydrochloric acid after the motor is started, so that the mixing efficiency and the reaction efficiency are greatly improved.

[0034] The washing kettle 8 comprises a kettle body, the top and the bottom of the kettle body are respectively provided with a feeding port and a discharging port, and the middle part of the kettle body is provided with washing liquid inlet pipes on both sides; a jacket is arranged outside the kettle body, a rotating shaft is arranged inside the kettle body, one end of the rotating shaft is connected with a motor, three stirring frames are arranged on the rotating shaft, and a plurality of stirring plates are arranged on the stirring frames; a washing liquid distribution disc is arranged in the inside of the kettle body and communicates with the washing liquid inlet pipes, and a plurality of through holes are arranged on the washing liquid distribution disc. The crude dorzolamide hydrochloride enters the inside of the kettle body from the feeding port, the washing liquid enters the washing liquid distribution disc along the washing liquid inlet pipes under the action of the delivery pump, is uniformly dispersed through the through holes, and then the rotating shaft, the three stirring shafts and the plurality of stirring plates are driven to fully stir and mix the washing liquid and the crude dorzolamide hydrochloride after the motor is started, so that the mixing efficiency is greatly improved, and the crude dorzolamide hydrochloride is effectively washed.

[0035] The dissolved kettle 12 comprises a kettle body, a feed inlet and a water inlet pipe are arranged at the top of the kettle body, and a discharge outlet is arranged at the bottom of the kettle body; a jacket is arranged outside the kettle body, and a stirring shaft is arranged inside the kettle body, one end of the stirring shaft is connected with a motor, a material distribution disc 120 (a baffle is arranged outside the material distribution disc 120) is arranged at the upper portion of the stirring shaft, and a plurality of material distribution holes are arranged on the material distribution disc 120; a liquid distributor 121 which is communicated with the water inlet pipe is arranged above the material distribution disc 120, the liquid distributor 121 comprises an annular liquid distribution main pipe 1210 and a plurality of liquid distribution branch pipes 1211, a plurality of liquid distribution holes are arranged on the lower surfaces of the liquid distribution main pipe 1210 and the liquid distribution branch pipes 1211; and a plurality of stirring plates are arranged below the material distribution disc. The crude doxium chloride enters the inside of the kettle body from the feed inlet, the motor is started to drive the rotating shaft, the material distribution disc and the plurality of stirring plates to rotate, the crude doxium chloride is first scattered on the material distribution disc, is uniformly dispersed and then scattered into the inside of the kettle body, water in the water inlet pipe enters the annular liquid distribution main pipe and the plurality of liquid distribution branch pipes, is uniformly dispersed and then fully contacts the crude doxium chloride, and the heat medium in the jacket provides the required temperature for dissolving.

[0036] The liquid outlets of the first crystallization kettle 2, the second crystallization kettle 4 and the third crystallization kettle 15 are respectively communicated with a crystallization mother liquor storage tank 18 through a suction filter pump 17. The crystallization mother liquor is effectively separated from the crystal under the action of the suction filter pump, the crystallization mother liquor is buffered by the crystallization mother liquor storage tank, and subsequent processing is facilitated.

[0037] The above merely describes the preferred embodiments of the present application and is not intended to limit the present application, and any modification, equivalent replacement and improvement within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A production system for dzodamine hydrochloride, characterized in that, The first reaction kettle is connected with the first crystallization kettle, the first crystallization kettle is connected with the second reaction kettle, the second reaction kettle is connected with the second crystallization kettle, the second crystallization kettle is connected with the acidification kettle, the acidification kettle is connected with the pH adjustment kettle, the pH adjustment kettle is connected with the first filtering device, the first filtering device is connected with the washing kettle, the washing kettle is connected with the second filtering device, the second filtering device is connected with the first drying device, and the first drying device is connected with the crude product storage tank.

2. The production system for doxazosin hydrochloride according to claim 1, characterized by, The first reaction kettle comprises a kettle body, a feed inlet and a solvent inlet are arranged on the top of the kettle body, a discharge outlet is arranged on the bottom of the kettle body, and a jacket is arranged on the outside of the kettle body; a temperature sensor and a rotating shaft are arranged in the inside of the kettle body, the temperature sensor is electrically connected with a controller, one end of the rotating shaft is connected with a motor, and a plurality of stirring paddles are arranged on the rotating shaft.

3. The production system for doxazosin hydrochloride according to claim 1, wherein The second reaction kettle comprises a kettle body, a feed inlet, an air inlet and a catalyst inlet are arranged on the top of the kettle body, and a discharge outlet is arranged on the bottom of the kettle body; a jacket is arranged on the outside of the kettle body, a temperature sensor and a rotating shaft are arranged in the inside of the kettle body, and the temperature sensor is electrically connected with a controller; one end of the rotating shaft is connected with a motor, and a first stirring component and a second stirring component are arranged on the rotating shaft.

4. The production system for doxazosin hydrochloride according to claim 3, wherein The first stirring component and the second stirring component both comprise a circular ring body, a plurality of arc-shaped plates are arranged on the circular ring body, and the circular ring body and the arc-shaped plates are fixedly connected with the rotating shaft.

5. The production system for doxazosin hydrochloride according to claim 1, wherein The first crystallization kettle, the second crystallization kettle and the third crystallization kettle all comprise a kettle body, a feed inlet and an organic solvent inlet are arranged on the top of the kettle body, a discharge outlet is arranged on the bottom of the kettle body, a liquid outlet is arranged on one side of the lower part of the kettle body, and a filter screen is arranged in the inside of the kettle body and corresponds to the liquid outlet; a jacket is arranged on the outside of the kettle body, a stirring shaft is arranged in the inside of the kettle body, one end of the stirring shaft is connected with a motor, and a plurality of stirring rods are arranged on the stirring shaft.

6. The production system for doxazosin hydrochloride according to claim 1, wherein The acidification kettle comprises a kettle body, a feed inlet and a hydrochloric acid inlet are arranged on the top of the kettle body, a discharge outlet is arranged on the bottom of the kettle body, a jacket is arranged on the outside of the kettle body, a temperature sensor and a rotating shaft are arranged in the inside of the kettle body, and the temperature sensor is electrically connected with a controller; one end of the rotating shaft is connected with a motor, a plurality of S-shaped stirring plates are arranged on the rotating shaft, and a plurality of stirring teeth are arranged on the S-shaped stirring plates.

7. The production system for doxazosin hydrochloride according to claim 1, wherein The washing kettle comprises a kettle body, a feeding port and a discharging port arranged at the top and bottom of the kettle body respectively, and a washing liquid inlet pipe arranged at the middle of the kettle body; a jacket is arranged outside the kettle body, a rotating shaft is arranged inside the kettle body, one end of the rotating shaft is connected with a motor, three stirring frames are arranged on the rotating shaft, and a plurality of stirring plates are arranged on the stirring frames; a washing liquid distribution disc is arranged inside the kettle body and communicates with the washing liquid inlet pipe, and a plurality of through holes are arranged on the washing liquid distribution disc.

8. The production system for doxazosin hydrochloride according to claim 1, wherein The dissolving kettle comprises a kettle body, a feeding port and a water inlet pipe arranged at the top of the kettle body, and a discharging port arranged at the bottom of the kettle body; a jacket is arranged outside the kettle body, a stirring shaft is arranged inside the kettle body, one end of the stirring shaft is connected with a motor, a material distribution disc is arranged on the upper portion of the stirring shaft, and a plurality of material distribution holes are arranged on the material distribution disc; an liquid distributor is arranged above the material distribution disc and communicates with the water inlet pipe, the liquid distributor comprises an annular liquid distributor main pipe, a plurality of liquid distributor branch pipes are arranged on the liquid distributor main pipe, and a plurality of liquid distribution holes are arranged on the lower surfaces of the liquid distributor main pipe and the liquid distributor branch pipes respectively; a plurality of stirring plates are arranged below the material distribution disc.

9. The production system for doxazosin hydrochloride according to claim 1, wherein The liquid outlets of the first, second and third crystallization kettles are connected with a crystallization mother liquor storage tank through a suction filter pump respectively.

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