Grinding bead sample adding device

Abstract

The utility model provides a grinding bead sample adding device. The grinding bead sample adding device comprises a shell, an adjusting knob and a pressing rod, a limiting assembly for limiting the initial height of the pressing rod is arranged in the shell, the bottom of the shell is connected with a sample storage tank, and a bead outlet is formed in the tail end of the sample storage tank; the adjusting knob comprises a first limiting boss and a screw below the first limiting boss, and the screw is in threaded connection with the top of the shell; channels are formed in the first limiting boss and the screw rod; the pressing rod penetrates through the channel to enter the shell, scales are arranged on a rod body at the top of the pressing rod, and the pressing rod stretches into the sample storage groove by a certain height under the limiting action of external pressure and the first limiting boss to extrude grinding beads with the specified number out of the bead outlet. According to the utility model, the maximum pressing height of the pressing rod is controlled by adjusting the height of the adjusting knob screwed into the top of the shell, so that the flexible adjustment of the number of beads pressed at a time is realized; after each pressing action, a preset number of grinding beads can be added into a centrifugal tube and other containers in batches, so that the operation is simple and convenient, and the experiment efficiency is remarkably improved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the life science experimental instrument technical field, concretely relates to a kind of grinding beads sampling device. BACKGROUND

[0002] Tissue grinder is a kind of experimental instrument commonly used for sample tissue grinding and pretreatment, and is widely used in biological, medical, chemical and other research fields. Its principle is that under high-frequency vibration, grinding beads impact, rub and extrude sample in container at high frequency, so as to realize grinding of tissue sample. Compared with traditional liquid nitrogen freezing and manual grinding, it has the characteristics of high flux, convenient operation, high safety, etc., and has gradually become one of indispensable equipment in laboratory. In the field of life science, the instrument is often used for pretreatment of biological macromolecules such as protein and nucleic acid in tissue cells, to provide high-quality samples for gene expression analysis, protein purification and other experiments. The common method is to add appropriate amount of biological sample to 1.5 or 2.0ml centrifuge tube, and add appropriate amount of grinding beads such as steel ball and zirconium oxide bead, to realize the purpose of rapid homogenization of tissue under the high-frequency vibration of the instrument.

[0003] Grinding beads are spherical and have certain fluidity. In conventional experiments, the use of grinding beads is mainly through the use of tweezers or spoon to add them one by one into the centrifuge tube. Manual operation not only easily causes missing, overloading or grinding bead sliding, but also when the amount of biological sample increases and batch addition of grinding beads is required, manual operation has the disadvantages of long time consumption and low efficiency, which is not conducive to the smooth development and implementation of experiment.

[0004] The utility model patent with publication number CN 219991532 U discloses a kind of pressurized steel ball quick sampling device, two steel balls fall from the lower end of bottle mouth every time completing pressurized action, and the single addition amount of steel ball is accurately controlled to two;The utility model patent with publication number CN 218962831 U discloses a kind of grinding bead distributor, including storage unit and distribution unit, when using, pressurized push hand, the baffle of distribution unit is dislocated, spring is compressed, to realize the distribution and release of single grinding bead. However, the above scheme can only realize the release of 1 or 2 grinding beads by single pressurized operation, and the number of grinding beads added by single pressurized operation cannot be flexibly adjusted, for example, when batch experiment is required and fixed number of grinding beads is required to be added for many times, there is certain inconvenience in operation.

[0005] The utility model discloses a patent for utility model with the publication number CN221132490U discloses a grinding ball pen, which is provided with an ejection device inside. When the rotary button is rotated, the push rod of the ejection device moves backward, the ejection spring is compressed to form an elastic force, and the push rod pushes the grinding ball to the ball outlet by the elastic force. The single ball output of this grinding pen is one, which cannot be flexibly adjusted. In addition, the centrifugal tube and other containers used in biological experiments are usually made of glass. The hard grinding ball will cause a certain impact on the centrifugal tube under the action of the ejection force, which can easily cause damage to the centrifugal tube, thereby affecting the smooth progress of the experiment.

[0006] Therefore, the present application provides a grinding ball sample adding device which can flexibly adjust the number of added grinding balls, which is of great significance for simplifying experimental operations and improving experimental efficiency, and is also a technical problem to be solved. Utility model content

[0007] The utility model discloses a grinding ball sample adding device which can flexibly adjust the number of added grinding balls, which is of great significance for simplifying experimental operations and improving experimental efficiency, and is also a technical problem to be solved.

[0008] To solve the above technical problems, the utility model adopts the following technical scheme: a grinding ball sample adding device is provided, which comprises a shell, an adjusting knob and a pressing rod. The shell is provided with a sample inlet, and a limiting component is arranged in the shell to limit the initial height of the pressing rod. A sample storage groove is connected to the bottom of the shell, and the end of the sample storage groove is provided with a ball outlet. The adjusting knob comprises a first limiting boss and a screw rod below the first limiting boss, and the screw rod is threadedly connected to the top of the shell. The first limiting boss and the screw rod are provided with a channel. The pressing rod passes through the channel and enters the shell. The rod body of the pressing rod near the first limiting boss is provided with a scale corresponding to the number of balls. Under the external pressure and the limiting action of the first limiting boss, the pressing rod is extended into the sample storage groove to a certain height, and a specified number of grinding balls are extruded out of the ball outlet.

[0009] On the basis of the above technical scheme, the screw rod of the adjusting knob is provided with external threads, and the top of the shell is provided with matching internal threads. The height of the first limiting boss protruding from the top of the shell is adjusted by controlling the distance of the screw rod rotating into the top of the shell. By adjusting the specified scale on the first limiting boss to the rod body of the pressing rod, the maximum amount of depression of the pressing rod in each pressing operation is limited, and the number of balls in each pressing operation is controlled.

[0010] On the basis of the above technical scheme, the top of the pressing rod is provided with a pressing part, and the rod body below the pressing part is provided with a scale. The smallest unit of the scale is the diameter of the grinding ball.

[0011] On the basis of the above technical scheme, the middle rod body of the pressing rod is provided with a second limiting boss, the limiting assembly comprises a fixed frame fixed to the inner wall of the shell, and a spring located between the second limiting boss and the fixed frame and sleeved outside the pressing rod, the spring is used for providing a rebound force of pressing, and helps the pressing rod to reset after a single pressing is completed.

[0012] Preferably, the maximum pressing height that the spring can withstand is greater than the maximum scale of the top rod body of the pressing rod, so as to ensure that the pressing rod can be pressed to a state of contacting the first limiting boss in a pressed state under the condition of the maximum scale.

[0013] Preferably, the fixed frame comprises a first fixed frame located below the spring and a second fixed frame located above the second limiting boss. The first fixed frame, the second limiting boss and the spring provide a buffering force in the pressing process of the pressing rod, and the spring provides a rebound force for the reset of the pressing rod; the second fixed frame is used for limiting the height of the pressing rod protruding from the top, that is, controlling the initial height of the pressing rod.

[0014] Preferably, a spring protection shell is further arranged between the first fixed frame and the second fixed frame, so as to avoid the spring and the surface of the grinding beads in the shell interfering with each other during the pressing operation of the pressing rod.

[0015] On the basis of the above technical scheme, the pressing rod is arranged directly above the inlet of the sample storage groove, and the diameter of the pressing rod is less than the inner diameter of the sample storage groove; preferably, the diameter of the rod body of the pressing rod is 0.8-0.95 times the diameter of the grinding beads. When not subjected to external pressure, the distance between the end of the pressing rod and the bottom of the shell is 1-1.25 times the diameter of the grinding beads.

[0016] Preferably, an arc-shaped connecting portion is arranged between the inlet of the sample storage groove and the opening of the bottom of the shell, and the height of the arc-shaped connecting portion is 0.1-0.2 times the diameter of the grinding beads. The design of the arc-shaped connecting portion can increase the width of the inlet of the sample storage groove, so as to prevent the phenomenon of grinding beads being stuck at the inlet.

[0017] On the basis of the above technical scheme, the inner diameter of the sample storage groove is 1.1-1.3 times the diameter of the grinding beads, and the distance from the inlet of the sample storage groove to the bead outlet is an integer multiple of the diameter of the grinding beads. Preferably, the length of the sample storage groove is 5-10 times the diameter of the grinding beads, so as to meet the demand of batch bead discharge in a single pressing.

[0018] On the basis of the above technical scheme, the bead outlet is provided with an elastic bayonet, which is made of rubber or silicone material. The elastic bayonet can be a small section of elastic collar with a diameter smaller than that of the grinding beads, which is sleeved at the end of the sample storage groove, or an elastic piece fixed at the end of the inner wall of the sample storage groove, which can be annular or a plurality of convex elastic particles distributed in a ring shape. The elastic bayonet blocks the grinding beads above it in a natural state. When the pressing rod is pressed down, the grinding beads are pressed to move downward, extruding the elastic bayonet, which deforms and releases the grinding beads.

[0019] On the basis of the above technical scheme, the sample inlet of the shell is provided with a sample inlet cover.

[0020] On the basis of the above technical scheme, the shell and the sample storage groove are made of transparent plastic material, which facilitates the operator to observe the stock of grinding beads in the shell and intuitively master the bead outlet condition of the grinding beads in the sample storage groove, and ensures the continuity of the experiment.

[0021] On the basis of the above technical scheme, the material of the grinding beads includes one or a combination of stainless steel, chromium steel, zirconia and tungsten carbide.

[0022] Compared with the prior art, the utility model has the advantages that:

[0023] (1) The grinding bead sample adding device provided by the utility model is provided with an adjusting knob between the top of the shell and the pressing part of the pressing rod. The height of the first limiting boss protruding from the top of the shell is adjusted by adjusting the height of the screw rod of the adjusting knob and the threaded connection with the top of the shell, so as to control the maximum pressing height of the pressing rod and realize the adjustment of the number of beads pressed at a time.

[0024] (2) The grinding bead sample adding device provided by the utility model is provided with a limiting assembly for limiting the initial height of the pressing rod, so that the pressing rod protrudes from the top of the shell by a fixed height in a non-pressed state. The top rod body of the pressing rod is provided with a scale corresponding to the number of beads. The height of the adjusting knob is adjusted to correspond to the corresponding scale of the pressing rod. The addition of a specified number of grinding beads can be realized in single pressing, and the processing speed and efficiency of the sample can be significantly improved in batch experiments.

[0025] (3) The grinding bead sample adding device provided by the utility model is connected with the sample storage groove below the shell, and the sample storage groove is provided with a bead outlet at the end, and the grinding beads are added in an extrusion mode. Compared with some devices that add grinding beads by using the ejection mode, the bead outlet provided by the utility model is more gentle, the impact force on the container such as a centrifugal tube is smaller, the container is not easy to be damaged, and the smooth progress of the experiment is facilitated. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figure 1The schematic diagram of the overall structure of the grinding bead sample adding device provided for the embodiment 1 is shown in the figure;

[0027] Figure 2 The schematic diagram of the structure of the pressing rod in the grinding bead sample adding device provided for the embodiment 1 is shown in the figure;

[0028] Figure 3 The schematic diagram of the local structure of the connection relationship between the top of the pressing rod, the adjusting knob and the top of the shell in the grinding bead sample adding device provided for the embodiment 1 is shown in the figure;

[0029] Figure 4 The schematic diagram of the local structure of the connection relationship between the second limiting boss, the spring and the fixing frame in the grinding bead sample adding device provided for the embodiment 1 is shown in the figure;

[0030] Figure 5 The schematic diagram of the local structure of the connection relationship between the end of the pressing rod, the bottom of the shell and the sample inlet of the bead storage groove in the grinding bead sample adding device provided for the embodiment 1 is shown in the figure;

[0031] Figure 6 The schematic diagram of one use state of the grinding bead sample adding device provided for the embodiment 2 is shown in the figure; wherein, Figure 6 A, the pressing rod is in the initial state; Figure 6 B, the pressing rod is in the pressing state;

[0032] Figure 7 The schematic diagram of another use state of the grinding bead sample adding device provided for the embodiment 3 is shown in the figure; wherein, Figure 7 A, the pressing rod is in the initial state; Figure 7 B, the pressing rod is in the pressing state.

[0033] Wherein, 1, the shell; 11, the sample inlet; 12, the sample storage groove; 13, the bead outlet; 14, the fixing frame; 15, the spring; 16, the sample cover; 17, the spring protection shell; 18, the arc-shaped connection; 19, the elastic clamping opening; 2, the adjusting knob; 21, the first limiting boss; 22, the screw rod; 23, the channel; 3, the pressing rod; 31, the scale; 32, the pressing part; 33, the second limiting boss. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the embodiments, obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor belong to the scope of protection of the present application.

[0035] It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other.

[0036] Embodiment 1

[0037] As Figure 1 shown, the present embodiment provides a grinding bead sample loading device, which comprises a shell 1, an adjusting knob 2 and a pressing rod 3; the side wall of the shell 1 is provided with a sample inlet 11, and the shell 1 is provided with a limiting assembly for limiting the initial height of the pressing rod 3, and the bottom of the shell 1 is connected with a sample storage groove 12, and the end of the sample storage groove 12 is provided with a bead outlet 13.

[0038] As Figure 2 and 3 shown, the top of the pressing rod 3 is provided with a pressing part 32, and the rod body below the pressing part 32 is provided with a scale 31, and the minimum unit of the scale 31 is the diameter of the grinding bead. The adjusting knob 2 comprises a first limiting boss 21 and a screw rod 22 below the first limiting boss 21, and the screw rod 22 is provided with external threads, and the top of the shell 1 is provided with matching internal threads, and the height of the first limiting boss 21 protruding from the top of the shell 1 is adjusted by controlling the distance of the external threads of the screw rod 22 screwing into the internal threads of the top of the shell 1.

[0039] Further, the first limiting boss 21 and the screw rod 22 are both hollow structures and are provided with a channel 23; the pressing rod 3 passes through the channel 23 and enters the inside of the shell 1, and the rod body of the pressing rod 3 near the first limiting boss 21 is provided with a scale 31 corresponding to the number of beads, and the fixed height of the first limiting boss 21 protruding from the shell is controlled by adjusting the distance of the screw rod 22 screwing into the top of the shell 1 and corresponding to the scale of the rod body. In each pressing process, the pressing rod 3 is limited by the external pressure and the first limiting boss 21 and is inserted into the sample storage groove 12 by a certain height, and a specified number of grinding beads are extruded from the bead outlet 13.

[0040] As Figure 4 shown, the middle rod body of the pressing rod 3 is provided with a second limiting boss 33, and the limiting assembly comprises a fixed frame 14 fixed to the inner wall of the shell 1 and a spring 15 located between the second limiting boss 33 and the fixed frame 14 and sleeved on the outside of the pressing rod 3. Among them, the maximum compression height that the spring 15 can withstand is greater than the maximum scale of the top rod body of the pressing rod 3, which ensures that the pressing rod can be directly pressed to contact the first limiting boss 21 in the pressed state and extrude the specified number of beads.

[0041] Further, in the present embodiment, the fixed frame 14 comprises a first fixed frame below the spring and a second fixed frame above the second limiting boss, and the two are fixed to the inner wall of the shell 1 in the form of a support. Among them, the first fixed frame, the second limiting boss 33 and the spring 15 provide a buffer force in the pressing process of the pressing rod 3 and provide a rebound force for the reset of the pressing rod; the second fixed frame is used to limit the height of the pressing rod 3 protruding from the top, that is, to control the initial height of the pressing rod 3.

[0042] Further, a spring protection shell 17 is arranged between the first and second fixing frames, which can avoid the spring from being scratched by the grinding beads due to frequent pressing operation of the pressing rod 3, avoid interference with the work of the spring 15, and reduce unnecessary friction on the surface of the grinding beads.

[0043] As shown in Figure 5 , the bottom of the shell 1 is provided with a slight inclination, and the grinding beads can automatically fall into the sample storage groove 12 by gravity. The pressing rod 3 is arranged directly above the entrance of the sample storage groove 12, and the diameter of the rod body of the pressing rod 3 is 0.85 times the diameter of the grinding beads. When not subjected to external pressure, the distance between the end of the pressing rod 3 and the opening of the bottom of the shell 1 is equal to the diameter of a grinding bead. In a single pressing process, when the pressing rod 3 is pressed downward, the end of the pressing rod 3 extrudes the grinding beads below and pushes the grinding beads in the sample storage groove to move downward in turn. According to the distance between the pressing part 32 of the pressing rod 3 and the first limiting boss 21 (i.e. the scale indication), the pressing rod 3 moves downward by a fixed distance, and a specified number of grinding beads are extruded out of the bead outlet 13 of the sample storage groove 12.

[0044] Further, as shown in Figure 5 , the present embodiment is provided with an arc-shaped connecting part 18 between the entrance of the sample storage groove 12 and the opening of the bottom of the shell 1, which has a height of 0.15 times the diameter of the grinding beads. The design of the arc-shaped connecting part can increase the width of the entrance of the sample storage groove, preventing the phenomenon of grinding beads being stuck at the entrance.

[0045] Further, in the present embodiment, the inner diameter of the sample storage groove 12 is 1.2 times the diameter of the grinding beads, and the length of the sample storage groove 12 is set to be 10 times the diameter of the grinding beads, which can meet the use demand of single pressing batch bead output. Correspondingly, the scale of the pressing rod, the length of the adjusting knob and the threaded connection at the top of the shell are also matched with the length of the sample storage groove.

[0046] Further, the bead outlet 13 is provided with an elastic clamp 19, as shown in Figure 5As shown, the elastic notch 19 is an elastic ring made of rubber material fixed to the inner wall of the sample storage groove 12 near the opening of the end of the sample storage groove 12. The inner diameter of the elastic notch 19 is smaller than the diameter of the grinding beads. In the natural state, the elastic notch 19 blocks the grinding beads above it to prevent the grinding beads from falling; when the pressing rod 3 is pressed down, the grinding beads move downward under the action of pressure, extruding the elastic notch 19, and the elastic notch 19 deforms and releases the grinding beads. Compared with the device that adds samples by using the ejection method, the grinding beads are extruded out in the form of ejection, which is softer and has less impact on the centrifuge tube and other containers, and is less likely to cause damage to the container, which helps the smooth progress of the experiment. In addition, in this embodiment, the elastic notch 19 is left a small distance from the opening of the end of the sample storage groove 12. After the grinding beads are extruded out by the elastic notch 19, they will continue to fall in the vertical direction, slowing down the falling speed and avoiding the grinding beads from bouncing out after entering the container due to the fast ejection speed.

[0047] Further, the sample inlet 11 of the shell 1 is also provided with a sample cover 16, which is opened when adding grinding beads and is in a closed state during use. The shell 1 and the sample storage groove 12 are both made of transparent plastic material, which facilitates the operator to observe the number of grinding beads in the shell and intuitively understand the ejection situation of the grinding beads in the sample storage groove.

[0048] The principles and use methods of the present application will be further described below in conjunction with specific embodiments, but not as a limitation of the present application.

[0049] Embodiment 2

[0050] As shown, this embodiment demonstrates the method of adding grinding beads using the grinding bead sample adding device provided in embodiment 1, and the sample adding amount of a single pressing is 1. Figure 6

[0051] Step 1: The operator adds grinding beads into the shell 1 from the sample inlet 11 on the side of the shell 1. The grinding beads enter the sample storage groove 12 from the bottom of the shell 1 under the action of gravity, and then fill the bottom of the shell 1, so that the adding height of the grinding beads exceeds the end of the pressing rod 3 (i.e. to ensure that the end of the pressing rod is full of grinding beads to the ejection port);

[0052] Step 2: Rotate the height of the screw rod 22 of the adjusting knob 2 connected with the threads on the top of the shell 1, so that the first limiting boss 21 of the adjusting knob 2 is raised to the position of the rod body scale "1" of the pressing rod 3, as shown in Figure 6 A;

[0053] ​Step 3: The operator holds the grinding bead loading device in hand, presses down the pressing rod 3 until the pressing part 32 contacts the first limiting boss 21. Due to the limiting action of the first limiting boss 21, the pressing rod 3 is pressed down by the height of one grinding bead. The grinding bead below the end of the pressing rod 3 moves downward by the height of one grinding bead under the action of pressure. The grinding bead at the elastic clamp 19 of the sample storage groove 12 is pressed to deform the elastic clamp 19 under the action of pressure, and one grinding bead is released, as shown in Figure 6 B;

[0054] Step 4: After the single-bead ejection is completed, the operator stops pressing, and the pressing rod 3 is reset to the height of the scale "1" under the action of the limiting mechanism spring 15. The elastic clamp 19 returns to its natural state and continues to block the grinding beads above it. With the reset and elevation of the pressing rod 3, the grinding beads around the pressing rod 3 in the shell 1 enter the space below the end of the pressing rod 3.

[0055] Step 5: The operator presses down the pressing rod 3 again, and repeats the pressing of Step 3 and the resetting of Step 4, i.e., the grinding bead loading operation is performed at a frequency of one bead per time.

[0056] Example 3

[0057] As shown in Figure 7 , this embodiment demonstrates the use method of the grinding bead loading device provided in Example 1. The number of beads loaded by single pressing is 5. The steps include:

[0058] Step 1: The operator adds grinding beads into the shell 1 from the sample inlet 11 on the side of the shell 1. The grinding beads enter the sample storage groove 12 from the bottom of the shell 1 under the action of gravity, and then fill the bottom of the shell 1, so that the added height of the grinding beads exceeds the end of the pressing rod 3 (for batch bead ejection operation, the grinding beads are consumed quickly, and some grinding beads can be added at one time in the shell 1).

[0059] Step 2: Rotate the screw rod 22 of the adjusting knob 2 to connect with the threads on the top of the shell 1, so that the first limiting boss 21 of the adjusting knob 2 is lowered to the position of the scale "5" of the rod body of the pressing rod 3, as shown in Figure 7 A;

[0060] Step 3: The operator holds the grinding bead loading device, presses the pressing rod 3 to make the pressing part 32 contact the first limiting boss 21, and because of the limiting effect of the first limiting boss 21, the pressing rod 3 is pressed to a height of 5 grinding beads relative to the shell 1, and extends into the sample storage groove 12; the grinding beads below the end of the pressing rod 3 are moved downward by 5 grinding beads under the action of the pressure, and the 5 grinding beads at the elastic clamping port 19 at the end of the sample storage groove 12 are pressed to deform the elastic clamping port 19 under the action of the pressure, so that the 5 grinding beads are released, as shown in Figure 7 B;

[0061] Step 4: After the single-bead release is completed, the operator stops pressing, the pressing rod 3 is reset to the height of the scale “5” under the action of the limiting mechanism spring 15, the elastic clamping port 19 returns to the natural state, and the grinding beads above the elastic clamping port 19 are continuously blocked; with the pressing rod 3 being reset and raised, the grinding beads around the pressing rod 3 in the shell 1 enter the sample storage groove 12 and fill the space below the end of the pressing rod 3;

[0062] Step 5: The operator presses the pressing rod 3 again, repeats the pressing of step 3 and the resetting of step 4, that is, the batch loading operation of the grinding beads is performed at a frequency of 5 beads / time.

[0063] The above is only the preferred embodiment of the present application, and does not limit the implementation and protection scope of the present application. For those skilled in the art, it should be realized that any equivalent replacement and obvious change of the content of the present application should be included in the protection scope of the present application.

Claims

1. A bead-based sample loading device, comprising: The utility model relates to a kind of ball mill, including: Shell (1), adjusting knob (2) and press bar (3); The shell (1) is provided with sample inlet (11), and the shell (1) is provided with limiting component for limiting initial height of press bar (3) in it, and the bottom of shell (1) is connected with sample storage groove (12), and the end of sample storage groove (12) is equipped with bead outlet (13); The adjusting knob (2) includes first limiting boss (21) and screw rod (22) below it, and screw rod (22) is threadedly connected with the top of shell (1);First limiting boss (21) and screw rod (22) are provided with passageway (23). The press bar (3) passes through passageway (23) into shell (1), and the rod body of press bar (3) near first limiting boss (21) is provided with scale (31) corresponding to the number of beads;Press bar (3) is limited under the action of external pressure and first limiting boss (21), and is inserted into sample storage groove (12) by certain height, and a specified number of grinding beads are extruded from bead outlet (13).

2. The bead-based loading device of claim 1, wherein, The screw rod (22) of the adjusting knob (2) has external thread, and the top of the shell (1) is provided with internal thread matched with it, and the height of the first limiting boss (21) protruding from the top of the shell (1) is adjusted by controlling the distance of the screw rod (22) rotating into the top of the shell (1).

3. The bead-based loading device of claim 1, wherein, The top of the press bar (3) is provided with a pressing part (32), and the rod body below the pressing part (32) is provided with a scale (31), and the smallest unit of the scale (31) is the diameter of the grinding beads.

4. The bead-based loading device of claim 1, wherein, The middle rod body of the press bar (3) is provided with a second limiting boss (33), and the limiting component includes a fixed frame (14) fixed to the inner wall of the shell (1), and a spring (15) arranged between the second limiting boss (33) and the fixed frame (14) and sleeved on the outside of the press bar (3).

5. The bead-based loading device of claim 1, wherein, The press bar (3) is arranged directly above the inlet of the sample storage groove (12), and the diameter thereof is smaller than the inner diameter of the sample storage groove (12);When not subjected to external pressure, the distance between the end of the press bar (3) and the bottom of the shell (1) is 1-1.25 times the diameter of the grinding beads.

6. The bead-based loading device of claim 1, wherein, The inner diameter of the sample storage groove (12) is 1.1-1.3 times the diameter of the grinding beads, and the distance from the inlet of the sample storage groove (12) to the bead outlet (13) is an integer multiple of the diameter of the grinding beads.

7. The bead-based loading device of claim 1, wherein, The diameter of the rod body of the press bar (3) is 0.8-0.95 times the diameter of the grinding beads.

8. The bead-based loading device of claim 1, wherein, The bead outlet (13) is provided with a resilient bayonet (19) made of rubber or silicone material.

9. The bead-based loading device of claim 1, wherein, The sample inlet (11) of the shell (1) is provided with a sample cover (16).

10. The bead-based loading device of claim 1, wherein, The shell (1) and the sample storage groove (12) are made of transparent plastic material.

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