Drug injection detection device for high performance liquid chromatography

Abstract

The utility model provides a drug injection detection device for high performance liquid chromatography, which relates to the technical field of drug analysis equipment and comprises a chromatographic instrument, a mixing drum is arranged on the back of the chromatographic instrument, a sensor is mounted in an interface on one side of the mixing drum, and the surface of the chromatographic instrument is respectively connected with a straight-through pipe and a filter pipe. One end of the filter pipe is in threaded connection with a material receiving barrel, the back of the chromatograph is in threaded connection with a connecting frame, a movable plate is embedded in a sliding groove in the connecting frame, a lantern ring is fixed to the back of the movable plate, a central through hole of the lantern ring is circular, and real-time judgment and distribution are achieved according to whether liquid contains impurities or not, so that the liquid is shunted into a special pipeline; compared with the prior art, pollution risks are reduced, the accuracy and reliability of detection results are ensured, meanwhile, multiple steps such as mixing, detection and filtering are completed on the same equipment, the sample transfer and treatment time is shortened, and the overall detection efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to medicine analysis equipment technical field especially, relates to a medicine injection liquid detection device for high performance liquid chromatography analysis. BACKGROUND

[0002] The medicine injection liquid detection device for liquid chromatography analysis utilizes function chromatography (HPLC) technology, separates different components in the sample to carry out qualitative and quantitative analysis, and mainly includes separation, detection and data analysis.

[0003] According to patent publication No. CN221650298U, a liquid chromatograph belongs to the technical field of chemical analysis, comprising an analysis device for detecting samples, a receiving top cover fixedly connected to the top of the analysis device, a solution bottle placed in the receiving top cover, an outer shell fixedly connected to the inside of the receiving top cover, a supporting plate slidingly connected to the inside of the outer shell, the supporting plate being located at the bottom of the solution bottle and used for supporting the solution bottle, an indicator light installed on the outside of the receiving top cover, a switch installed on the inner wall of the outer shell for controlling the indicator light, the weight of the solution bottle determining the compression degree of the spring, and in turn controlling the height of the supporting plate, as the solution in the solution bottle is consumed, the supporting plate gradually rises until it touches the switch to turn on the indicator light, the indicator light can attract the attention of the operator and prompt the operator that the solution in the solution bottle is insufficient, so that the operator can replace the solution bottle or supplement the solution in the solution bottle in time to ensure the smooth analysis of the analysis device on the sample.

[0004] The above describes the liquid chromatography detection device, the traditional liquid chromatography detection device cannot judge and distribute the diluted injection liquid in real time, and in the detection process, multiple steps such as mixing, dilution and detection are needed for sample processing, which increases the operation complexity and time cost, resulting in low detection efficiency. UTILITY MODEL CONTENTS

[0005] The utility model aims at solving the technical problems that the prior art cannot judge and distribute the diluted injection liquid in real time, and the operation is complex and the efficiency is low, and provides a medicine injection liquid detection device for high performance liquid chromatography analysis.

[0006] In order to achieve the above object, the utility model discloses the following technical scheme: a kind of drug injection detection device for high performance liquid chromatography, including chromatograph, the back of the chromatograph is equipped with mixing cylinder, sensor is installed in the interface of one side of the mixing cylinder, the surface of the chromatograph is connected with straight-through pipe and filter tube respectively, the one end of the filter tube is threadedly connected with material receiving barrel, the back of the chromatograph is screw-connected with connecting frame, the sliding slot of the inside of the connecting frame is embedded with moving plate, the back of the moving plate is fixed with collar, and the center through-hole of the collar is circular.

[0007] It can be seen that, in the above technical solution, the liquid is distributed into the dedicated pipeline according to whether the liquid contains impurities, the risk of pollution is reduced, the accuracy and reliability of the detection result are ensured, and multiple steps such as mixing, detection and filtering are completed on the same equipment, the sample transfer and processing time are reduced, and the overall detection efficiency is improved.

[0008] Preferably, the connecting head is respectively connected with the connecting end of the straight-through pipe and the vertical alignment of the material receiving barrel, and the connecting end of the straight-through pipe is embedded in the inside of the connecting head.

[0009] It can be seen that, in the above technical solution, the connecting head is used as the discharge port of the mixing cylinder, the connecting head can be connected with the straight-through pipe for liquid sampling, and the connecting head can be vertically connected with the mixing cylinder to discharge the liquid into the material receiving barrel.

[0010] Preferably, a lead screw is installed in the sliding slot of the connecting frame, and the moving end of the moving plate is sleeved on the surface of the lead screw and threadedly connected with the surface of the lead screw.

[0011] It can be seen that, in the above technical solution, the lead screw is driven by the driving motor to make the moving plate ascend and descend along the surface of the lead screw, so that the position of the mixing cylinder is changed, and the mixing cylinder is located at a suitable height.

[0012] Preferably, the collar is sleeved on the surface of the mixing cylinder, and the mixing cylinder is rotationally connected with the collar.

[0013] It can be seen that, in the above technical solution, the mixing cylinder can rotate in the collar, and the collar plays a role of installing the mixing cylinder.

[0014] Preferably, the moving plate is T-shaped, and the moving end of the moving plate cooperates with the sliding slot of the connecting frame.

[0015] It can be seen that, in the above technical solution, the moving plate is T-shaped, and the protruding part is located in the sliding slot of the connecting frame and connected with the surface of the lead screw.

[0016] Preferably, a motor is bolted to the back of the moving plate, gears are respectively installed on the surface of the two ends of the mixing cylinder and the rotating end of the motor, and the two adjacent gears are meshed with each other.

[0017] It can be seen that, in the above technical solution, the gear transmission mode can make the mixing cylinder rotate, and complete the position change of the communication head, so that the mixing cylinder can rotate while being lifted along with the moving plate.

[0018] Advantages

[0019] In the utility model, the outlet of the mixing cylinder can be located at different pipelines by adopting the vertical lifting and rotating mode of the mixing cylinder, and the turbidity of the diluted injection liquid in the mixing cylinder can be detected by the turbidity sensor, so that the real-time judgment and distribution are realized according to whether the liquid contains impurities, the liquid is shunted into the special pipeline, the risk of pollution is reduced, the accuracy and reliability of the detection result are ensured, the manual intervention is reduced by automatic operation, and the operation complexity is reduced.

[0020] In the utility model, the mixing cylinder and the chromatograph are integrated, the mixing cylinder can simultaneously perform vertical lifting and rotating motion, so that the mixing and dilution of the injection liquid are quickly completed and the injection liquid is moved to the specified extraction position, sample treatment is not required to be performed in multiple steps, multiple steps such as mixing, detection and filtering can be completed on the same equipment, the sample transfer and processing time are reduced, the overall detection efficiency is improved, and the operation convenience and efficiency are improved. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 It is a perspective view of the utility model;

[0022] Figure 2 It is a schematic view of the overall structure of the utility model;

[0023] Figure 3 It is Figure 2 It is an enlarged view of place A;

[0024] Figure 4 It is a top view of the utility model;

[0025] Figure 5 It is a rear view of the utility model.

[0026] Reference signs: 1, chromatograph; 2, mixing cylinder; 3, sensor; 4, communication head; 5, straight-through pipe; 6, filter pipe; 7, material receiving barrel; 8, connecting frame; 9, lead screw; 10, moving plate; 11, collar; 12, gear; 13, motor. DETAILED DESCRIPTION

[0027] In order to make the technical means, creation characteristics, achieve purposes and effects of the utility model easy to understand, the utility model is further described below in combination with specific embodiments and drawings, but the following embodiments are only preferred embodiments of the utility model, not all. Based on the embodiments in the embodiments, other embodiments obtained by those skilled in the art without creative labor belong to the protection scope of the utility model.

[0028] The specific embodiments of the utility model are described below in combination with the drawings. Specific embodiments:

[0030] Referring to Figures 1-5 A kind of drug injection liquid detection device for high performance liquid chromatography analysis, including chromatograph 1, the back of chromatograph 1 is equipped with mixing cylinder 2, sensor 3 is installed in the interface of one side of mixing cylinder 2, drug injection liquid detection device is liquid chromatograph analyzer, this local wants to utilize functional chromatography HPLC technique, by separating different components in sample, to carry out qualitative and noun analysis, chromatograph 1 is the main part of instrument, wherein chromatograph 1 includes power system, sample introduction system, separation system, detection system and data processing system, and by the detector of detection system heavy, the signal of each component in sample can be converted into electric signal finally data analysis is carried out to obtain result, before injection liquid enters chromatograph 1, liquid usually needs to be diluted and handled, so that liquid meets the requirement of analysis and detection, but in the process of liquid dilution and handling, it can cause some impurities in injection liquid in dilution and mixing process due to the purity or improper mixing of diluent, therefore utilize mixing cylinder 2 as dilution and mixing container, and let mixing cylinder 2 self-rotate and mix liquid in interior, so that liquid completes dilution, simultaneously utilize sensor 3 in the interior of mixing cylinder 2, whether residual impurity in mixed liquid can be judged in real time, sensor 3 is turbidity sensor 3, and located in the interface of the side of mixing cylinder 2, residual impurity of liquid usually increases turbidity, therefore a threshold value can be set to judge the existence of impurity.

[0031] The surface of the chromatograph 1 is respectively connected with the straight-through pipe 5 and the filter pipe 6, one end of the filter pipe 6 is threadedly connected with the receiving barrel 7, the communicating head 4 is respectively connected with the connecting end of the straight-through pipe 5 and the vertical alignment of the receiving barrel 7, and the connecting end of the straight-through pipe 5 is embedded in the inside of the communicating head 4, the sampling pipe on the chromatograph 1 is respectively the straight-through pipe 5 and the filter pipe 6, when the diluted mixed liquid does not contain impurities, the mixing cylinder 2 vertically rises to the connecting end of the straight-through pipe 5, so that the communicating head 4 is connected with the straight-through pipe 5, at this time, the sampling pump in the instrument is started to sample the liquid into the chromatograph 1 for detection and analysis, if the mixing cylinder 2 contains impurities, the mixing cylinder 2 is disposed to descend to the position close to the receiving barrel 7, and the communicating head 4 is vertically downwardly aligned with the receiving barrel 7, at this time, the liquid is discharged into the receiving barrel, and the impurities in the liquid can be filtered through the filtering structure in the inside of the receiving barrel 7 and the filter pipe 6, finally, the sampling is completed, the automatic shunting function is realized, the liquid is shunted to the special pipeline, the impurity liquid is avoided from directly contacting with the clean liquid or the analysis pipeline, so that the risk of pollution is reduced.

[0032] The back of the chromatograph 1 is screw-connected with a connecting frame 8, a sliding groove in the connecting frame 8 is embedded with a moving plate 10, the moving plate 10 is T-shaped, the moving end of the moving plate 10 is matched with the sliding groove of the connecting frame 8, a lead screw 9 is installed in the sliding groove of the connecting frame 8, the moving end of the moving plate 10 is sleeved on the surface of the lead screw 9 and is screw-connected with the surface of the lead screw 9, a collar 11 is fixed on the back of the moving plate 10, the center through hole of the collar 11 is circular, the collar 11 is sleeved on the surface of the mixing cylinder 2 and is rotationally connected with the mixing cylinder 2, further, the communicating head 4 on the mixing cylinder 2 is opened or closed through the electric control valve, when the mixing cylinder 2 does not need to discharge liquid, the valve is closed, the liquid in the mixing cylinder 2 cannot be discharged, as long as the communicating head 4 is adjusted to the position required for discharging liquid, the valve is opened to discharge, similarly, when the injection liquid is injected into the mixing cylinder 2, only the valve is opened, and a certain amount of diluent and injection liquid can be added, it is necessary to point out that the lead screw 9 is installed in the connecting frame 8, the moving plate 10 can rotate along with the lead screw 9 and move linearly along the lead screw 9 and the connecting frame 8, the mixing cylinder 2 is located in the collar 11 of the moving plate 10, the mixing cylinder 2 is connected through the collar 11, the mixing cylinder 2 can rotate in the collar 11, and the mixing cylinder 2 can move along with the moving plate 10 when the moving plate 10 moves up and down, until the mixing cylinder 2 moves to the position of the pipeline, and the liquid is discharged, a motor 13 is bolted on the back of the moving plate 10, gear wheels 12 are installed on the surfaces of the two ends of the mixing cylinder 2 and the rotating end of the motor 13 respectively, and the two adjacent gear wheels 12 are meshed with each other, and the surfaces of the two ends of the mixing cylinder 2 and the rotating end of the motor 13 are both provided with gear wheels 12, and the two gear wheels 12 are meshed with each other, since the motor 13 is connected with the moving plate 10, the mixing cylinder 2 can rotate while moving up and down along with the moving plate 10, and the mixing and dilution of the liquid can be completed in the process of moving up and down of the mixing cylinder 2, the mixing cylinder 2, the connecting frame 8 and other components are located on the chromatograph 1, and the steps of mixing, detecting and filtering can be simultaneously performed on the same equipment, the sample transfer and processing time is reduced, and the overall detection efficiency is improved.

[0033] In the present application, unless otherwise explicitly specified and limited, the first feature is "on" or "under" the second feature, which can include direct contact between the first and second features, or indirect contact between the first and second features through another feature therebetween. Moreover, the first feature "on", "above" and "above" the second feature includes the first feature directly above and obliquely above the second feature, or only indicates that the first feature is higher than the second feature in horizontal height. The first feature "below", "below" and "below" the second feature includes the first feature directly below and obliquely below the second feature, or only indicates that the first feature is lower than the second feature in horizontal height.

[0034] The basic principle, main features and advantages of the present application are shown and described above. It should be understood by those skilled in the art that the present application is not limited by the above examples, and the above examples and descriptions in the specification are only preferred examples of the present application and are not intended to limit the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the claimed present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. A high-performance liquid chromatography (HPLC) device for detecting drug injection solutions, comprising a chromatograph (1), characterized in that: The back of the chromatograph (1) is provided with a mixing cylinder (2), and a sensor (3) is installed in the interface on one side of the mixing cylinder (2). A straight tube (5) and a filter tube (6) are respectively connected to the surface of the chromatograph (1). A receiving bucket (7) is threaded to one end of the filter tube (6). A connecting frame (8) is screwed to the back of the chromatograph (1). A moving plate (10) is fitted into the sliding groove inside the connecting frame (8). A collar (11) is fixed to the back of the moving plate (10), and the central through hole of the collar (11) is circular.

2. The high-performance liquid chromatography (HPLC) device for detecting drug injection solutions according to claim 1, characterized in that: The connecting head (4) is vertically aligned with the connecting end of the straight pipe (5) and the receiving bucket (7), and the connecting end of the straight pipe (5) is fitted into the inside of the connecting head (4).

3. The high-performance liquid chromatography (HPLC) device for detecting drug injection solutions according to claim 1, characterized in that: The connecting frame (8) has a lead screw (9) installed in its groove, and the moving end of the moving plate (10) is sleeved on the surface of the lead screw (9) and threadedly connected to the surface of the lead screw (9).

4. The high-performance liquid chromatography (HPLC) device for detecting drug injection solutions according to claim 1, characterized in that: The collar (11) is sleeved on the surface of the mixing cylinder (2), and the mixing cylinder (2) is rotatably connected to the collar (11).

5. The high-performance liquid chromatography (HPLC) device for detecting drug injection solutions according to claim 1, characterized in that: The movable plate (10) is T-shaped, and the movable end of the movable plate (10) cooperates with the groove of the connecting frame (8).

6. The high-performance liquid chromatography (HPLC) device for detecting drug injection solutions according to claim 1, characterized in that: A motor (13) is bolted to the back of the moving plate (10). Gears (12) are installed on both ends of the mixing cylinder (2) and at the rotating end of the motor (13), and two adjacent gears (12) mesh with each other.

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