Efficient perfusion device
By designing an efficient irrigation device, the irrigation operation for small animals is simplified by using a base plate, flow guiding components, and control valves, solving the problem of complex operation in existing technologies and achieving efficient and convenient irrigation results.
Patent Information
- Application Number
- CN202423234820.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-26
- Publication Date
- 2025-11-21
- Estimated Expiration
- 2034-12-26
AI Technical Summary
Existing small animal perfusion procedures are complex, requiring manual insertion and removal of infusion needles and manual fixation, which is cumbersome and inefficient.
Design an efficient perfusion device, including a base plate, a flow guiding assembly, an infusion needle, and a control valve. Different liquids are infused through a second conduit and a third conduit, and the on/off state is controlled by the control valve, simplifying operation.
It eliminates the need for repeated insertion and removal of the infusion needle, simplifies the operation process, improves perfusion efficiency, facilitates observation, has a simple structure, low cost, and is suitable for perfusion in small animals.
Smart Images
Figure CN223568518U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model belongs to the technical field of perfusion device, specifically relates to high -efficient perfusion device. BACKGROUND
[0002] Perfusion is the process of continuously injecting appropriate perfusion fluid when a certain organ is taken out from the body or is exposed in the body for research, or perfusion fluid is injected into blood vessels through a sleeve connected to the blood vessels.
[0003] Animal experiments, especially small animal heart perfusion, are indispensable experiments for medical basic research. Heart perfusion has important significance for the preservation of histological antigens and is a guarantee for subsequent immunohistochemistry, immunofluorescence and H-E staining.
[0004] At present, most hospital research laboratories or independent research groups generally use perfusion pumps and syringes to perfuse small animals. This perfusion method requires manual operation, and the liquid needs to be repeatedly inserted and pulled out of the infusion needle during perfusion, and manual assistance is required for fixation during perfusion. The operation is complex.
[0005] Therefore, the applicant designs a high-efficiency perfusion device. CONTENT OF THE UTILITY MODEL
[0006] In view of the above-mentioned deficiencies of the prior art, the technical problem to be solved by the present application is how to provide a high-efficiency perfusion device.
[0007] In order to solve the above technical problems, the utility model adopts the following technical scheme:
[0008] The high-efficiency perfusion device comprises a bottom plate, a flow guide assembly, an infusion needle and a control valve, the flow guide assembly is installed on the bottom plate, the flow guide assembly comprises at least one output end and two input ends, a first conduit is arranged in communication between the infusion needle and the output end, a second conduit and a third conduit are respectively arranged in communication on the two input ends, and the control valve is arranged on the flow guide assembly and used for controlling the on-off between the two input ends and the output end.
[0009] Compared with the prior art, the high-efficiency perfusion device has the following advantages:
[0010] The bottom plate, the flow guide assembly, the infusion needle and the control valve are arranged, so that different liquids can be perfused into small animals in steps through the second conduit and the third conduit, the infusion needle does not need to be repeatedly inserted and pulled out, manual assistance is not required for positioning during perfusion, observation is facilitated, and the perfusion efficiency is improved.
[0011] The high-efficiency perfusion device has the advantages of simple structure and easy implementation, is suitable for installation and use in the existing small animal perfusion process, has low use cost, and can improve efficiency. BRIEF DESCRIPTION OF DRAWINGS
[0012] Figure 1 It is a whole structure schematic view of the utility model;
[0013] Figure 2 It is an enlarged structure schematic view of the first three-way pipe, the second three-way pipe or the third three-way pipe;
[0014] Figure 3 It is Figure 2 It is a structure schematic view after cutting off the control valve;
[0015] Figure 4 It is a sectional structure schematic view of the first three-way pipe, the second three-way pipe or the third three-way pipe installed on the bottom plate;
[0016] BRIEF DESCRIPTION OF DRAWINGS
[0017] 100 bottom plate;
[0018] 210 first conduit, 220 second conduit, 230 third conduit, 240 fourth conduit, 250 fifth conduit, 260 infusion needle;
[0019] 300 control valve;
[0020] 410 first three-way pipe, 420 second three-way pipe, 430 third three-way pipe;
[0021] 510 first input port, 520 second input port, 530 output port;
[0022] 610 positioning column, 620 positioning hole;
[0023] 710 first magnet, 720 second magnet;
[0024] 800 rolling flow limiting valve. DETAILED DESCRIPTION
[0025] The utility model will be further explained in detail in combination with the drawings.
[0026] Specific implementation: such as Figures 1-4As shown, the efficient perfusion device comprises a base plate 100, a flow guide assembly, an infusion needle 260 and a control valve 300, the flow guide assembly is installed on the base plate 100, the flow guide assembly comprises at least one output end, two input ends, a first conduit 210 is arranged in communication between the infusion needle 260 and the output end, a second conduit 220 and a third conduit 230 are respectively arranged in communication on the two input ends, and the control valve 300 is arranged on the flow guide assembly and used for controlling the on-off between the two input ends and the output end.
[0027] Compared with the prior art, the efficient perfusion device has the advantages that:
[0028] The base plate 100, the flow guide assembly, the infusion needle 260 and the control valve 300 are arranged, so that different liquids can be perfused to small animals in steps through the second conduit 220 and the third conduit 230, the infusion needle 260 does not need to be repeatedly plugged and unplugged, manual positioning is not needed during perfusion, observation is facilitated, and the perfusion efficiency is improved.
[0029] The efficient perfusion device has the advantages of simple structure and easy implementation, is suitable for installation and use in the existing small animal perfusion process, has low use cost, and can improve efficiency.
[0030] In the embodiment, as shown in the figure, Figures 1-4 The flow guide assembly comprises a first three-way pipe 410, a second three-way pipe 420 and a third three-way pipe 430, the first three-way pipe 410, the second three-way pipe 420 and the third three-way pipe 430 all comprise an output port 530, a first input port 510 and a second input port 520 in communication with each other, the output port 530 of the second three-way pipe 420 is in butt communication with the first input port 510 of the first three-way pipe 410, the output port 530 of the third three-way pipe 430 is in butt communication with the second input port 520 of the first three-way pipe 410, one end of the first conduit 210 is in communication with the output port 530 of the first three-way pipe 410, and the other end is in communication with the infusion needle 260, the second conduit 220 is in communication with the first input port 510 of the second three-way pipe 420, and the third conduit 230 is in communication with the second input port 520 of the third three-way pipe 430.
[0031] In this way, the first three-way pipe 410, the second three-way pipe 420 and the third three-way pipe 430 can be separated out, so that maintenance and replacement can be facilitated in the subsequent use process, and the adaptability is better.
[0032] In the embodiment, as shown in the figure, Figures 1-4As shown, the flow guide assembly has multiple groups, and the multiple groups of flow guide assemblies are arranged in sequence and at intervals along the length direction of the bottom plate 100. The first conduit 210 has multiple, and one end of each of the multiple first conduits 210 is connected to the output port 530 of the multiple first three-way pipes 410 in the multiple groups of flow guide assemblies. The infusion needle 260 has multiple, and each of the multiple infusion needles 260 is connected to the other end of each of the multiple first conduits 210. In the two adjacent groups of flow guide assemblies, the fourth conduit 240 is arranged in communication between the second input port 520 of the second three-way pipe 420 in the former group of flow guide assemblies and the first input port 510 of the second three-way pipe 420 in the latter group of flow guide assemblies. The fifth conduit 250 is arranged in communication between the first input port 510 of the third three-way pipe 430 in the former group of flow guide assemblies and the second input port 520 of the third three-way pipe 430 in the latter group of flow guide assemblies.
[0033] In this way, the multiple groups of flow guide assemblies are arranged, so that multiple small animals can be perfused at the same time, further improving the perfusion efficiency and accelerating the perfusion completion speed.
[0034] In implementation, the group of flow guide assemblies in communication with the second conduit 220 and the third conduit 230 is the first group of flow guide assemblies, and the group of flow guide assemblies in communication with the fourth conduit 240 and the fifth conduit 250 is the latter group of flow guide assemblies, and so on.
[0035] In this embodiment, as shown in Figures 1-4 The control valve 300 has three, and each of the three control valves 300 is arranged on the first three-way pipe 410, the second three-way pipe 420, and the third three-way pipe 430, respectively, for controlling the on-off of the output port 530, the first input port 510, and the second input port 520 of each three-way pipe.
[0036] In this way, the three control valves 300 are arranged, so that the flow on-off of each three-way pipe can be controlled by the three control valves 300, respectively, to better control the type and speed of the perfusion liquid.
[0037] In this embodiment, as shown in Figures 1-4 The flow guide assembly has three groups, and the three groups of flow guide assemblies are arranged in sequence and at intervals along the length direction of the bottom plate 100.
[0038] In this way, the flow guide assembly is arranged in three groups, so that the liquid pressure flowing into the flow guide assembly from the second conduit 220 and the third conduit 230 in the last group of flow guide assemblies arranged in sequence can just meet the test requirements, and the perfusion effect is better.
[0039] In this embodiment, as shown in Figures 1-4As shown, the bottom of the first, second and third three-way pipes 410, 420 and 430 is connected with a positioning column 610, and the bottom plate 100 is provided with three positioning holes 620 corresponding to the three positioning columns 610, and the three positioning columns 610 can be inserted into the three positioning holes 620 respectively.
[0040] In this way, the first, second and third three-way pipes 410, 420 and 430 can be conveniently installed on the floor and conveniently removed from the floor through the positioning column 610 and the positioning hole 620.
[0041] In the embodiment, as shown in the figure, Figures 1-4 The bottom of each positioning column 610 is provided with a first magnet 710, and the bottom of each positioning hole 620 is provided with a second magnet 720, and the first magnet 710 can be tightly combined with the second magnet 720 after the positioning column 610 is inserted into the corresponding positioning hole 620.
[0042] In this way, the first magnet 710 and the second magnet 720 are arranged, so that after the positioning column 610 is inserted into the positioning hole 620, the first magnet 710 and the second magnet 720 can be fixed by mutual attraction, thereby enhancing the positioning stability and reliability.
[0043] In the embodiment, as shown in the figure, Figures 1-4 It also includes a first container and a second container, the first container is communicated with the first input port 510 of the second three-way pipe 420 through the second conduit 220, and the second container is communicated with the second input port 520 of the third three-way pipe 430 through the third conduit 230.
[0044] In implementation, the first container and the second container are both made of glass.
[0045] In this way, the first container and the second container are arranged, so that the liquid to be perfused can be replaced without repeatedly plugging and unplugging the infusion needle 260, and the liquid replacement is more convenient.
[0046] In the embodiment, as shown in the figure, Figures 1-4 The first container contains physiological saline, and the second container contains a solution containing 4% PFA.
[0047] In this way, the physiological saline and the solution containing 4% PFA are selected for use, so that better perfusion effect can be obtained when perfusing small animals.
[0048] In the embodiment, as shown in the figure, Figures 1-4 The second conduit 220 and the third conduit 230 are both provided with a rolling flow limiting valve 800.
[0049] In this way, by setting the rolling flow limiting valve 800, the liquid flow rate in the second conduit 220 and the third conduit 230 can be controlled, and the controllability of the perfusion process is increased.
[0050] The above is only the preferred embodiment of the present application, it should be pointed out that, for the person skilled in the art without departing from the prior art, the technical scheme of several deformation and improvement should also be considered to fall within the scope of the present application.
Claims
1. A high efficiency perfusion device, characterized by: It includes a bottom plate, a flow guide assembly, an infusion needle and a control valve, the flow guide assembly is installed on the bottom plate, the flow guide assembly includes at least one output end, two input ends, a first conduit is arranged in communication between the infusion needle and the output end, a second conduit and a third conduit are respectively arranged in communication on the two input ends, and the control valve is arranged on the flow guide assembly and used to control the on-off between the two input ends and the output end.
2. The high efficiency perfusion device of claim 1, wherein: The flow guide assembly includes a first three-way pipe, a second three-way pipe and a third three-way pipe, the first three-way pipe, the second three-way pipe and the third three-way pipe each include an output port, a first input port and a second input port in communication with each other, the output port of the second three-way pipe is in butt joint communication with the first input port of the first three-way pipe, the output port of the third three-way pipe is in butt joint communication with the second input port of the first three-way pipe, one end of the first conduit is in communication with the output port of the first three-way pipe, and the other end of the first conduit is in communication with the infusion needle, the second conduit is in communication with the first input port of the second three-way pipe, and the third conduit is in communication with the second input port of the third three-way pipe.
3. The high efficiency perfusion device of claim 2, wherein: The flow guide assembly has multiple groups, and the multiple groups of flow guide assemblies are arranged in sequence and at intervals along the length direction of the bottom plate, the first conduit has multiple groups, one end of each of the multiple groups of first conduits is arranged in communication with the output port of the first three-way pipe in the multiple groups of flow guide assemblies, the infusion needle has multiple groups, and each of the multiple groups of infusion needles is arranged in communication with the other end of each of the multiple groups of first conduits, in the two adjacent groups of flow guide assemblies, a fourth conduit is arranged in communication between the second input port of the second three-way pipe in the first group of flow guide assemblies and the first input port of the second three-way pipe in the second group of flow guide assemblies, and a fifth conduit is arranged in communication between the first input port of the third three-way pipe in the first group of flow guide assemblies and the second input port of the third three-way pipe in the second group of flow guide assemblies.
4. The high efficiency perfusion device of claim 3, wherein: The control valve has three groups, and each of the three groups of control valves is arranged on the first three-way pipe, the second three-way pipe and the third three-way pipe respectively, and is used to control the on-off between the output port and the first input port and the second input port on each three-way pipe.
5. The high efficiency perfusion device of claim 3, wherein: The flow guide assembly has three groups, and the three groups of flow guide assemblies are arranged in sequence and at intervals along the length direction of the bottom plate.
6. The high efficiency perfusion device of any one of claims 2-5, wherein: The bottom of the first three-way pipe, the second three-way pipe and the third three-way pipe is connected with a positioning column, the bottom plate is provided with three positioning holes corresponding to the three positioning columns, and the three positioning columns can be respectively inserted into the three positioning holes.
7. The high efficiency perfusion device of claim 6, wherein: Each of the positioning columns is provided with a first magnet at the bottom, each of the positioning holes is provided with a second magnet at the bottom, and the first magnet can be tightly combined with the second magnet after the positioning column is inserted into the corresponding positioning hole.
8. The high efficiency perfusion device of any one of claims 2-5, wherein: It also includes a first container and a second container, the first container is in communication with the first input port of the second three-way pipe through the second conduit, and the second container is in communication with the second input port of the third three-way pipe through the third conduit.
9. The high efficiency perfusion device of claim 8, wherein: The first container is filled with physiological saline, and the second container is filled with a solution containing 4% PFA.
10. The high efficiency perfusion device of claim 9, wherein: Rolling flow limiting valves are arranged on the second conduit and the third conduit.