Multi-imaging animal fixing device, tray, animal cabin and animal imaging system

Abstract

The embodiment of the utility model discloses a multi-imaging animal fixing device, a tray, an animal cabin and an animal imaging system. The multi-imaging animal fixing device comprises a supporting part and trays, wherein the supporting part is configured to support the trays; and the tray is detachably connected with the supporting part. The tray comprises a first end part, the first end part is configured to place the head of an imaging animal, each tray is provided with a detachably connected marker accommodating part, the marker accommodating part is configured to accommodate a marker, and the marker can be developed in an imaging mode of at least one mode.

Description

TECHNICAL FIELD

[0001] The present specification relates to the field of animal imaging, and in particular, to a multi-imaging animal fixing device, a tray, an animal cabin and an animal imaging system. BACKGROUND

[0002] Animal experiment refers to scientific research using animals (e.g., mice) to obtain new knowledge about biology, medicine, etc. or to solve specific problems. In some animal experiments, it is necessary to scan and image animals. In order to ensure image quality (e.g., reduce motion artifacts), it is necessary to fix the imaging animals. However, the existing imaging animal fixing scheme cannot realize the standardization of the positioning of the imaging animals, and the positioning efficiency is low, for example, the experimenter uses adhesive tape to fix the mouse in a random position on a plane, and generally directly fixes the animal in the animal cabin, which requires a high animal cabin itself, and cannot meet the use requirements of animal experiments. The existing animal cabin is basically a customized product based on the scanning device, which cannot meet the diversified experimental requirements, and the structure of the animal cabin and the animal fixing device are provided by the manufacturer, which cannot adapt to different experimental requirements of different users, resulting in low experimental efficiency. SUMMARY

[0003] One or more embodiments of the present specification provide a multi-imaging animal fixing device, which comprises a support part and a plurality of trays, the support part is configured to support the plurality of trays; the tray is detachably connected with the support part, the tray comprises a first end part, the first end part is configured to place the head of an imaging animal, each tray has a detachably connected marker accommodating part, the marker accommodating part is configured to accommodate a marker, the marker is visible in at least one imaging mode.

[0004] In some embodiments, the tray comprises a second end part, the second end part is arranged opposite to the first end part, the support part comprises a first part and a second part arranged opposite to each other; the first part is configured to support the first end part of the tray; the second part is configured to support the second end part of the tray; the support part further comprises a third part between the first part and the second part, the third part is provided with a hollow part.

[0005] In some embodiments, the first end part is provided with an anesthesia interface, the anesthesia interface is configured to deliver anesthetic gas to the imaging animal; the first end part is also provided with a dental bar for occlusal fixation of the teeth of the imaging animal.

[0006] In some embodiments, the support part is configured to support 2-4 trays.

[0007] In some embodiments, the tray is provided with a first hole structure and a second hole structure penetrating through the tray, the first hole structure comprising two through holes configured to pass through two forelimbs of the imaging animal, and the second hole structure comprising two through holes configured to pass through two hindlimbs of the imaging animal.

[0008] In some embodiments, the through hole is a waist-shaped hole.

[0009] In some embodiments, the tray is provided with a fixing structure, and the plurality of the marker accommodating portions are detachably mounted to the tray by the fixing structure.

[0010] In some embodiments, the fixing structure is a clasp structure comprising clasp arms with elasticity configured to fix the marker accommodating portions.

[0011] In some embodiments, the marker accommodating portion comprises a first accommodating channel, a second accommodating channel, and a marker accommodating cavity, the first accommodating channel being configured to inject the marker, the second accommodating channel being configured to discharge gas when the marker is injected, and the marker accommodating cavity being in communication with the first accommodating channel and the second accommodating channel respectively and being configured to accommodate the marker.

[0012] In some embodiments, the first accommodating channel is cylindrical, the marker accommodating cavity is spherical, and the center of the marker accommodating cavity is located on the central axis of the first accommodating channel.

[0013] In some embodiments, the marker is a liquid, the marker is visible in at least one first modality of imaging mode, and the marker accommodating portion is visible in at least one second modality of imaging mode; the first modality comprises at least one of positron emission imaging, single photon emission imaging, or magnetic resonance imaging, and the second modality comprises X-ray imaging.

[0014] In some embodiments, the marker accommodating portion is formed by 3D printing, and the diameter of the first accommodating channel is greater than that of the second accommodating channel.

[0015] In some embodiments, the first portion is provided with an identification for placing a head of the imaging animal.

[0016] In some embodiments, the support portion comprises a first part configured to support the first end portion of the tray, the first part being provided with a clamping structure configured to clamp with the first end portion of the tray; the clamping structure comprises an outwardly protruding clasp boss, the anesthesia interface being provided with an inwardly recessed clasp structure, the clasp boss being configured to be embedded in the clasp structure to achieve clamping of the anesthesia interface and the clamping structure.

[0017] In some embodiments, the anesthesia interface comprises a first anesthesia channel and a second anesthesia channel, the first anesthesia channel comprising a first end and a second end, the second anesthesia channel comprising a third end and a fourth end, the first end being an inlet of the anesthetic gas, the third end being an outlet of the anesthetic gas and being close to a placement position of a nose of the imaging animal, the second end being in communication with the fourth end, and between the second end and the fourth end, there is a preset angle.

[0018] One or more embodiments of the present specification provide a tray for fixing an imaging animal, the tray being configured to accommodate a single imaging animal, the tray comprising a first end portion and a second end portion, the first end portion being configured to fix a head of the imaging animal, the second end portion being provided opposite to the first end portion; the tray being configured to be detachably connected with a support portion of a multi-imaging animal fixing device, the multi-imaging animal fixing device being detachably placed in an animal cabin; the tray being provided with a detachable marker accommodating portion, the marker accommodating portion being configured to accommodate a marker, the marker being visible in at least one imaging mode.

[0019] One or more embodiments of the present specification provide an animal cabin, the animal cabin comprising a cabin body; and a multi-imaging animal fixing device as described in any one of the above embodiments, the multi-imaging animal fixing device being detachably placed in the cabin body.

[0020] One or more embodiments of the present specification provide an animal imaging system, the animal imaging system comprising a scanning imaging device having a scanning cavity; and a multi-imaging animal fixing device as described in any one of the above embodiments, the multi-imaging animal fixing device being capable of entering the scanning cavity; or an animal cabin as described in any one of the above embodiments, the animal cabin being capable of entering the scanning cavity.

[0021] In some embodiments, the scanning imaging device is one or a combination of multiple modalities of an electronic computed tomography device, a magnetic resonance device, a positron emission computed tomography device, and a single photon emission computed tomography device.

[0022] The embodiments of the present specification provide a multi-imaging animal fixing device, a tray, an animal cabin and an animal imaging system. The multi-imaging animal fixing device can realize that multiple imaging animals (for example, multiple mice) are simultaneously scanned in a standardized position. Relying on the tray, a multi-modal image template can be established, thereby establishing a multi-modal image database. The animal cabin includes the tray or the multi-imaging animal fixing device, and the number of imaging animal fixing devices in the animal cabin can be flexibly adjusted according to requirements, and the internal space of the animal cabin can be maximally utilized. BRIEF DESCRIPTION OF DRAWINGS

[0023] The present specification will be further described in the manner of exemplary embodiments, which will be described in detail through the accompanying drawings. These embodiments are not restrictive, and in these embodiments, the same numbers represent the same structures, in which:

[0024] Figure 1 FIG. 1 is a structural schematic diagram of a tray for a multi-imaging animal fixing device according to some embodiments of the present specification;

[0025] Figure 2 FIG. 2 is a schematic diagram of a multi-imaging animal fixing device with a double-layer structure according to some embodiments of the present specification;

[0026] Figure 3 FIG. 3 is a structural schematic diagram of an animal cabin according to some embodiments of the present specification;

[0027] Figure 4A FIG. 4 is a structural schematic diagram of another tray for a multi-imaging animal fixing device according to some embodiments of the present specification;

[0028] Figure 4B FIG. 5 is a structural schematic diagram of region I of the tray for the multi-imaging animal fixing device according to some embodiments of the present specification;

[0029] Figure 5 FIG. 6 is a structural schematic diagram of an anesthesia interface according to some embodiments of the present specification;

[0030] Figure 6A FIG. 7 is a structural schematic diagram of a marker accommodating portion according to some embodiments of the present specification; 6B

[0031] FIG. 8 is a structural schematic diagram of a support portion of the multi-imaging animal fixing device according to some embodiments of the present specification; Figure 7A

[0032] FIG. 9 is a structural schematic diagram of region II of the support portion according to some embodiments of the present specification; Figure 7B ​

[0033] Figure 8A is a structural schematic view of a multi-imaging animal fixation device of yet another double-layer structure according to some embodiments of the present specification;

[0034] Figure 8B is a structural schematic view of a zoomed-in region III according to some embodiments of the present specification;

[0035] Figure 9 is a cross-sectional structural schematic view of a multi-imaging animal fixation device according to some embodiments of the present specification;

[0036] Figure 10 is a structural schematic view of yet another animal chamber according to some embodiments of the present specification.

[0037] Reference Signs: 10 - single-imaging animal fixation device; 20 - multi-imaging animal fixation device; 30 - animal chamber; 40 - single-imaging animal fixation device; 60 - marker accommodating portion; 70 - multi-imaging animal fixation device; 1000 - animal chamber; 100 - tray; 110 - head fixation portion; 111 - head cover; 112 - dental bar; 120 - forelimb fixation portion; 130 - hindlimb fixation portion; 140 - tail fixation portion; 150 - first marker accommodating portion; 160 - second marker accommodating portion; 210 - first portion; 220 - second portion; 230 - third portion; 300 - chamber body; 400 - tray; 410 - first end portion; 411 - anesthesia interface; 411-1 - first anesthesia passage; 411-1A - first end; 411-1B - second end; 411-2 - second anesthesia passage; 411-2A - third end; 411-2B - fourth end; 411-3 - buckle structure; 420 - second end portion; 430 - first hole structure; 440 - second hole structure; 450 - fixation structure; 451 - clasp arm; 460 - clasp groove; 610 - first accommodating passage; 620 - marker accommodating cavity; 630 - second accommodating passage; 640 - shaft; 700 - support portion; 710 - first portion; 711 - identification; 712 - clasp structure; 712-1 - buckle boss; 720 - second portion; 721 - clasp groove structure; 730 - third portion. DETAILED DESCRIPTION

[0038] The following detailed description is presented in terms of examples or embodiments, which are shown in the accompanying drawings. Descriptions of examples or embodiments in this detailed description refer to the accompanying drawings by reference characters shown in the drawings. The examples or embodiments described in the following detailed description are not representative of all embodiments consistent with the present specification. Rather, they are merely examples of devices and methods consistent with some aspects of the present specification as detailed in the appended claims.

[0039] The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to be limiting of this specification. As used in this specification, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

[0040] It should be understood that the use of "first", "second", and "third" words of similar effect in this specification and in the claims which follow are used merely to distinguish one element from another, and are not meant to imply a sequence or order of importance, unless otherwise specifically stated. Likewise, the use of "one" or "a" or "an" or similar referents is intended to mean at least one, unless otherwise indicated. Unless otherwise stated, the use of "front", "back", "top", "bottom" and / or "side" and similar terms is for convenience and are not intended to be limiting as to a particular position or spatial orientation. The use of "include", "includes" and / or "including" is intended to be non-limiting, such that there can be additional items or elements other than those listed in the "include", "includes" and / or "including" clause.

[0041] It should be noted that although the embodiments of the present specification are mainly described by taking mice (e.g., mice, rats) as examples, the fixing device provided by the embodiments of the present specification can also be applied to the fixation of other imaging animals, especially small mammals, such as guinea pigs, hamsters, bamboo rats, ferrets, rabbits, and the like.

[0042] Some embodiments of the present specification provide a multi-imaging animal fixing device, referring to Figure 8A The multi-imaging animal fixing device 70 comprises a support part 700 and a plurality of trays 400, the support part 700 is configured to support the plurality of trays 400; the tray 400 is detachably connected with the support part 700.

[0043] Referring to Figure 4A The tray 400 comprises a first end part 410, the first end part 410 is configured to place the head of the imaging animal, each tray 400 has a detachably connected marker accommodating part, the marker accommodating part is configured to accommodate a marker, the marker is visible in at least one imaging mode.

[0044] The support part is configured to support a plurality of trays. In some embodiments, the support part has a plurality of tray positions. In some embodiments, the number of tray positions is 2-4. Each tray position can be connected with one tray. In some embodiments, the number of tray positions is 2, 3 or 4. In one experiment, the number of trays can be less than or equal to the number of tray positions. For example, the number of tray positions is 4, and the number of trays that can be connected is 1-4. For example, as shown in Figure 8A The four trays 400 are connected together by the support part 700.

[0045] Figure 1 is a structural schematic diagram of a tray for a multi-imaging animal fixing device according to some embodiments of the present specification.

[0046] As shown in Figure 1 , each tray 100 can be used to accommodate a single imaging animal, and each tray 100 can constitute a single-imaging animal fixing device 10. The tray 100 is provided with a head fixing portion 110, a forelimb fixing portion 120, a hindlimb fixing portion 130, and a tail fixing portion 140. In some embodiments, the end of the tray 100 where the head fixing portion 110 is located is referred to as the first end, and the end of the tray 100 where the tail fixing portion 140 is located is referred to as the second end.

[0047] The head fixing portion 110 is used to fix the head of the imaging animal. In some embodiments, the head fixing portion 110 can include a head cover 111 and a dental bar 112. The head cover 111 is a sleeve structure used to accommodate the head of the imaging animal, and the dental bar 112 is a rod structure used to fix the teeth of the imaging animal (e.g., a mouse, a rabbit, or other rodents). The dental bar 112 has an opening (e.g., a circular or other shaped opening) to hook the teeth of the imaging animal (e.g., a mouse, a rabbit, or other rodents). In some embodiments, the head fixing portion 110 can include an ear bar (not shown), which is a rod structure that can achieve fixation of the head of the imaging animal by extending into the ear canal of the imaging animal and abutting against the skull of the imaging animal. The head fixing portion 110 can include two ear bars, one for extending into the left ear canal of the imaging animal and the other for extending into the right ear canal of the imaging animal.

[0048] The forelimb fixing portion 120 is used to fix the forelimb of the imaging animal.

[0049] As shown in Figure 1 , the forelimb fixing portion 120 can be designed as a groove structure, which provides sufficient operating space to facilitate the operator to fix or remove the forelimb of the imaging animal from the forelimb fixing portion 120.

[0050] In some embodiments, the forelimb fixing portion can also be designed as other structures (such as Figure 4A ). For example, the forelimb fixing portion can be designed as a hole structure, which has a cavity that penetrates through the forelimb fixing portion. After the forelimb of the imaging animal is inserted into the cavity of the forelimb fixing portion, the forelimb of the imaging animal can be effectively fixed under the limitation of the cavity. The hole structure not only makes it easier to fix the forelimb of the animal, but also does not form compression on the forelimb of the animal, making it easier to distinguish the subsequent imaging area and achieving better imaging effect.

[0051] The rear leg fixing portion 130 is used to fix the rear legs of the imaging animal.

[0052] As shown in Figure 1 , the rear leg fixing portion 130 can be designed as a groove structure, which provides sufficient operation space for the operator to fix or remove the rear legs of the imaging animal from the rear leg fixing portion 130.

[0053] In some embodiments, the rear leg fixing portion can also be designed as other structures (such as Figure 4A ). For example, the rear leg fixing portion can be designed as a hole structure, which has a cavity penetrating through the rear leg fixing portion. After the rear legs of the imaging animal are inserted into the cavity of the rear leg fixing portion, the rear legs of the imaging animal can be effectively fixed under the limitation of the cavity. The hole structure not only makes it easier to fix the animal's rear legs, but also does not cause compression to the animal's rear legs, so that the subsequent imaging area is easier to distinguish, and better imaging effect can be achieved.

[0054] The animals used in animal experiments are usually quadrupeds, and accordingly, the tray 100 is provided with two front leg fixing portions 120 and two rear leg fixing portions 130 to fix the four limbs (i.e. two front legs and two rear legs) of the imaging animal.

[0055] The tail fixing portion 140 is used to fix the tail of the imaging animal. It should be noted that for some imaging animals without tail (e.g. guinea pigs) or with short tail (the influence of tail movement on imaging can be ignored, e.g. ferrets), the tail fixing portion 140 can be omitted. For some imaging animals with long tail (e.g. mice), the tail fixing portion 140 is necessary.

[0056] As shown in Figure 1 , the tail fixing portion 140 can be designed as a groove structure, which provides sufficient operation space for the operator to fix or remove the tail of the imaging animal from the tail fixing portion 140.

[0057] The tail fixing portion 140 can also be designed as other structures (not shown). For example, the tail fixing portion 140 can also be designed as a hole structure (i.e. a structure with a cavity). After the tail of the imaging animal is inserted into the cavity of the tail fixing portion 140, the tail of the imaging animal can be effectively fixed under the limitation of the cavity.

[0058] It should be noted that in some scenarios, a retention needle needs to be left in the tail of the imaging animal. Due to the fixing effect of the tail fixing portion 140, the retention needle located in the tail of the imaging animal is also fixed. In this way, the retention needle can be prevented from failing due to position change.

[0059] The advantages of using a tray-type single-imaging animal fixation device 10 include, but are not limited to: (1) enabling rapid switching of samples (imaging animals, such as mice) on different scanning devices (e.g., CT devices, MR devices, PET devices, etc.) without changing the relative position between the sample and the tray, thereby achieving the fusion of multimodal images; (2) enabling the establishment of multimodal image templates, thereby establishing a multimodal image database.

[0060] In some embodiments, the shape of the tray 100 is consistent with the shape of the imaging animal. Specifically, the size of the surface of the tray 100 that contacts the imaging animal can be designed according to the body size of the imaging animal. Taking a mouse as an example, based on mouse ergonomic design, when the mouse is placed in the tray 100, the mouse's body can fit better with the tray 100, which helps to achieve rapid fixation of various parts of the mouse, tail vein injection, positioning, and subsequent imaging.

[0061] In some embodiments, such as Figure 1 As shown, the tray 100 is further provided with a first marker receiving portion 150 adjacent to the forelimb fixation portion 120 and a second marker receiving portion 160 adjacent to the hindlimb fixation portion 130. Both the first marker receiving portion 150 and the second marker receiving portion 160 are used to hold markers (sometimes also called tracers), which are visible in the medical images of the imaging animal. The markers can be solid or liquid. The medical images include one or more of magnetic resonance images, positron emission tomography (PET) images, computed tomography (CT) images, and single-photon emission tomography (SPECT) images. In some embodiments, the markers can be visible in multiple imaging modalities. For example, the markers can be visible in both CT and MR images simultaneously. The ability of the markers to be visible in multiple imaging modalities facilitates image localization and registration. In some embodiments, the markers can be placed in a specific location in a feasible manner. Since the markers are visible in medical images, by using the first marker receiving portion 150 and the second marker receiving portion 160, and by setting multiple markers, the fusion accuracy of multimodal images can be improved, enabling rapid positioning and registration. This solves the pain points in existing technologies where image fusion accuracy is limited by the motion accuracy of mechanical structures and the positioning of the imaging animal. Furthermore, since the first marker receiving portion 150 and the second marker receiving portion 160 are located at the four corners of the tray, not only is the space distribution of the tray fully utilized, but interference between the first marker receiving portion 150 and the second marker receiving portion 160 and the body of the imaging animal is also avoided, making the markers more visible in medical images and facilitating positioning. In some embodiments, the structure of the first marker receiving portion 150 and / or the second marker receiving portion 160 is similar to... Figure 6A and 6B The structure of the marker receiving portion 60 shown is the same or similar.

[0062] Figure 4A is a structural schematic view of yet another tray for a multi-imaging animal fixing device according to some embodiments of the present specification. Figure 4B is a structural schematic view of an enlarged area I of the tray.

[0063] As shown in Figure 4A , the tray 400 includes a first end portion 410 and a second end portion 420, and the tray 400 can constitute a single-imaging animal fixing device 40 for accommodating a single imaging animal.

[0064] In some embodiments, the shape of the tray 400 is consistent with the shape of the imaging animal. Specifically, the size of the surface of the tray 400 in contact with the imaging animal can be designed according to the body size of the imaging animal. Taking a mouse as an example, based on the ergonomic design, when the mouse is placed in the tray 400, the body of the mouse can better fit the tray 400, which helps to achieve rapid fixation of each part of the mouse, tail vein injection, positioning, and subsequent imaging.

[0065] The first end portion 410 is configured to fix the head of the imaging animal. The second end portion 420 is oppositely arranged with the first end portion 410. In some embodiments, the second end portion 420 can be configured to fix the tail of the imaging animal. For example only, as shown in Figure 4A , the second end portion 420 is provided with a tail fixing portion 140 for fixing the tail of the imaging animal. In some embodiments, the second end portion 420 further includes a clamping groove configured to be clamped with the clamping groove structure of the support portion.

[0066] In some embodiments, the first end portion 410 is provided with a head fixing portion including a tooth bar 112 for tooth occlusion fixation of the imaging animal (e.g., a mouse, a rabbit, or other rodents).

[0067] In some embodiments, the first end portion 410 is provided with an anesthesia interface 411 configured to deliver anesthetic gas to the imaging animal.

[0068] Figure 5 is a structural schematic view of the anesthesia interface according to some embodiments of the present specification. As shown in Figure 5As shown, the anesthesia interface 411 includes a first anesthesia passage 411-1 and a second anesthesia passage 411-2, the first anesthesia passage 411-1 includes a first end 411-1A and a second end 411-1B, and the second anesthesia passage 411-2 includes a third end 411-2A and a fourth end 411-2B. The first end 411-1A is an inlet of the anesthesia gas, and the third end 411-2A is an outlet of the anesthesia gas and is close to the placement position of the nose of the imaging animal. By setting the third end at the placement position of the nose of the imaging animal, the anesthesia gas can be inhaled by the imaging animal at the outlet position, which is conducive to improving the anesthesia effect.

[0069] In some embodiments, the second end 411-1B is in communication with the fourth end 411-2B, and between the second end 411-1B and the fourth end 411-2B, there is a preset angle. For example, the preset angle can be 30°. In some embodiments, the preset angle can also be other angles, such as 25°, 35°, etc.

[0070] For example only, as Figure 5 shown, the anesthesia gas can be injected into the anesthesia interface 411 through the first end 411-1A, pass through the first anesthesia passage 411-1 and the second anesthesia passage 411-2, flow out from the third end 411-2A and anesthetize the imaging animal.

[0071] In some embodiments of the present specification, by setting the anesthesia interface and setting the preset angle between the second end and the fourth end, the anesthesia gas can be directly aimed at the nose of the imaging animal after passing through the first anesthesia passage and the second anesthesia passage, without the need for additional pipelines or accessories, so that the anesthesia device is more concise, and the anesthesia effect is improved.

[0072] In some embodiments, as Figure 4A shown, the tray 400 is provided with a first hole structure 430 and a second hole structure 440 penetrating the tray 400. The first hole structure 430 includes two through holes configured to pass through the two forelimbs of the imaging animal, and the second hole structure 440 includes two through holes configured to pass through the two hindlimbs of the imaging animal. By passing the forelimbs of the imaging animal into the first hole structure 430 and the hindlimbs of the imaging animal into the second hole structure 440, the forelimbs and hindlimbs of the imaging animal can be effectively fixed under the limitation of the hole structure.

[0073] In some embodiments, the through holes of the first hole structure 430 and the second hole structure 440 can be waist-shaped holes. By setting them as waist-shaped holes, they not only have a simple structure, but also can adapt to the limbs of imaging animals within a certain size range to pass through and be fixed, without the need for additional fixing accessories or the need to replace other sizes or different trays.

[0074] In some embodiments of the present specification, the forelimbs and hindlimbs of the imaged animal are fixed through the hole structure, which can naturally fix the imaged animal after the limbs pass through the hole structure. This not only makes it easier to fix the forelimbs and hindlimbs of the animal, but also does not compress the forelimbs and hindlimbs of the imaged animal, reduces contact between different parts, and facilitates separate imaging and structural analysis of the limbs or body parts of the imaged animal.

[0075] In some embodiments, continuing to refer to Figure 4A , the tray 400 is provided with a fixing structure 450, and the marker accommodating portions (such as Figure 1 the first marker accommodating portion 150 and the second marker accommodating portion 160, Figure 6A and 6B the marker accommodating portion 60) described above are detachably installed on the tray 400 through the fixing structure 450. The marker accommodating portion can be connected with the fixing structure 450 by screw connection, clamping, etc. The number of fixing structures 450 can be multiple. For example, as shown in Figure 4A , the tray 400 can be provided with 2 fixing structures 450 near the first end 410 and the second end 420, respectively.

[0076] In some embodiments, as shown in Figure 4B , the fixing structure 450 is a clasp structure. The clasp structure includes a clasp arm 451 with elasticity, which is configured to fix the marker accommodating portion. The structure of the marker accommodating portion matches the clasp structure. When installed, the marker accommodating portion can be inserted into the clasp structure through the opening of the clasp arm 451, and the marker accommodating portion is clamped by the clasp arm 451, thereby achieving the fixation of the marker accommodating portion. For example, as shown in Figure 8A , the second accommodating channel 630 of the marker accommodating portion 60 cooperates with the clasp structure, thereby fixing the marker accommodating portion 60 on the fixing structure 450. Through the fixing mode of the clasp structure, the marker accommodating portion can be conveniently disassembled and installed, and the marker accommodating portion can be temporarily configured according to the experimental needs, which can be set as disposable or reusable, while the main structure of the tray itself can be used all the time.

[0077] Figure 6A and 6B are structural schematic diagrams of the marker accommodating portion according to some embodiments of the present specification.

[0078] As shown in Figure 6A and 6BAs shown, the marker accommodating portion 60 includes a first accommodating channel 610, a second accommodating channel 630, and a marker accommodating cavity 620. The first accommodating channel 610 is configured to inject the marker; the second accommodating channel 630 is configured to discharge gas when the marker is injected; and the marker accommodating cavity 620 is in communication with the first accommodating channel 610 and the second accommodating channel 630 respectively, and is configured to accommodate the marker. In some embodiments, the marker is a liquid, and the marker can be of various types, such as water, a positron nuclide labeled glucose solution, etc. The marker is visible in at least one imaging mode.

[0079] In some embodiments, the marker is visible in a medical image of at least one first modality. For example, the first modality includes at least one of positron emission imaging, single photon emission imaging, or magnetic resonance imaging.

[0080] In some embodiments, the marker accommodating portion 60 is visible in a medical image of at least one second modality. The second modality includes X-ray imaging. For example, the marker accommodating portion 60 can be made of plastic.

[0081] In some embodiments of the present specification, since the marker is visible in a medical image of the first modality and the marker accommodating portion is visible in a medical image of the second modality, the fusion accuracy of multi-modal images can be improved by means of the marker and the marker accommodating portion. In addition, since the marker accommodating portion is arranged at the four corners of the tray, not only the spatial distribution of the tray is fully utilized, but also the marker accommodating portion can avoid interfering with the body of the imaged animal, so that the marker is more obvious in the medical image and is convenient for positioning.

[0082] In some embodiments, the first accommodating channel 610 and the second accommodating channel 630 are cylindrical and hollow inside. In some embodiments, the first accommodating channel 610 and the second accommodating channel 630 can also include other shapes, such as a hollow rectangular prism, a triangular prism, etc. In some embodiments, the shapes of the first accommodating channel 610 and the second accommodating channel 630 can be the same or different. In some embodiments, the marker accommodating cavity 620 can be a spherical shape, which is hollow inside. For example, a spherical shape with a diameter of 4 mm. In some embodiments, the marker accommodating cavity 620 can also include other shapes, such as a hollow rectangular prism, a cube, etc.

[0083] In some embodiments, the center of the marker accommodating cavity 620 is located on the central axis of the first accommodating channel 610. As shown in FIG. 1, the center of the marker accommodating cavity 620 is located on the central axis of the first accommodating channel 610. Figure 6BAs shown, the central axis of the first accommodation channel 610 is the shaft 640, and the center of the marker accommodation cavity 620 is also located on the shaft 640. Through the arrangement that the center of the marker accommodation cavity 620 is located on the central axis of the first accommodation channel 610, the registration during multi-modal imaging can be facilitated, and the registration efficiency and accuracy can be improved.

[0084] In some embodiments, the marker accommodation part 60 is formed by 3D printing. In some embodiments, the marker accommodation part 60 can also be formed by other methods, for example, injection molding.

[0085] In some embodiments of the present specification, the first accommodation channel, the second accommodation channel and the marker accommodation cavity are coaxially arranged, so that the marker visualized in the medical image of the first modality and the marker accommodation part visualized in the medical image of the second modality have the same central axis, thereby enabling accurate fusion of multi-modal images by means of the marker and the marker accommodation part.

[0086] In some embodiments, the length of the first accommodation channel 610 is greater than that of the second accommodation channel 630, and the diameter of the first accommodation channel 610 is greater than that of the second accommodation channel 630. For example, the length of the first accommodation channel 610 can be 7.5 mm, and the diameter can be 1.6 mm; the diameter of the second accommodation channel 630 can be 0.6 mm.

[0087] In some embodiments of the present specification, the length of the first accommodation channel is set to be greater than that of the second accommodation channel, and the length of the first accommodation channel is extended, which can help the experimenter to control the injection of the marker more accurately and prevent the marker from overflowing during the injection process. In addition, the diameter of the second accommodation channel is set to be smaller than that of the first accommodation channel, and the diameter of the second accommodation channel is reduced, so that after the gas is smoothly discharged during the injection of the marker, the surface of the marker solution at the outlet of the second accommodation channel can prevent the marker solution from flowing out of the second accommodation channel due to the existence of a certain tension.

[0088] The embodiments of the present specification also provide a multi-imaging animal fixing device, which comprises a plurality (two or more) of single-imaging animal fixing devices (such as the single-imaging animal fixing device 10 or 40) connected together. The single-imaging animal fixing device can be composed of a tray. The plurality of single-imaging animal fixing devices can be arranged in one layer or in multiple layers (at least two layers). Relying on the multi-imaging animal fixing device, the synchronous scanning of multiple imaging animals (for example, multiple mice) can be realized.

[0089] When the plurality of single-imaging animal fixing devices are arranged in at least two layers, the single-imaging animal fixing devices in different layers can be connected together by a support part. The support part comprises a first part and a second part arranged oppositely, the first part is used to support a first end part (such as a head fixing part in the first end part) of the single-imaging animal fixing device, and the second part is used to support a second end part (such as a tail fixing part in the second end part) of the single-imaging animal fixing device.

[0090] In some embodiments, the first part and the single-imaging animal fixing device are connected together by a clamping structure (such as a clamping groove or a clamping buckle). In some embodiments, the second part and the single-imaging animal fixing device are connected together by a clamping structure (such as a clamping groove or a clamping buckle).

[0091] Figure 2 is a schematic diagram of a multi-imaging animal fixing device according to the double-layer structure shown in some embodiments of the present specification. As shown in Figure 2 , the multi-imaging animal fixing device 20 comprises four single-imaging animal fixing devices 10 connected together by a support part, and the four single-imaging animal fixing devices 10 are arranged in two layers, each layer having two single-imaging animal fixing devices 10. The support part comprises a first part 210 and a second part 220. The first part 210 is used to support four head fixing parts 110. The second part 220 is used to fix four tail fixing parts 140.

[0092] In some embodiments, the bottom of the head fixing part 110 is provided with a first groove, and the edge of the first part 210 is embedded in the first groove to achieve support of the single-imaging animal fixing device 10. In some embodiments, the bottom of the tail fixing part 140 is provided with a second groove, and the edge of the second part 220 is embedded in the second groove to achieve support of the single-imaging animal fixing device 10. In some embodiments, the edge of the first part 210 is provided with a first groove, and the head fixing part 110 is embedded in the first groove to obtain support of the first part 210. Similarly, the edge of the second part 220 is provided with a second groove, and the tail fixing part 140 is embedded in the second groove to obtain support of the second part 220.

[0093] Different combinations can be achieved by support parts with different structures to meet different use requirements. For example, referring to Figure 2 , the first part 210 and the second part 220 each only retain the lower half part (for example, omit the T-shaped structure above), to achieve the combination of two single-imaging animal fixing devices 10 in a single layer. For another example, referring to Figure 2 , when the second layer is changed to have only one single-imaging animal fixing device, the upper end of the first part 210 and the upper end of the second part 220 are allowed to be designed to be shorter (for example, simplified from the T-shaped structure to a handle-shaped structure).

[0094] In some embodiments, with reference to Figure 2 , the support portion further comprises a third portion 230 between the first portion 210 and the second portion 220. With the third portion 230, the plurality of single-animal imaging fixation devices 10 can be more stably combined together, and facilitate the overall movement of the multi-animal imaging fixation device 20.

[0095] It should be understood that the multi-animal imaging fixation device 20 can also be used to support other single-animal imaging fixation devices or trays disclosed in this specification, such as Figure 4A the single-animal imaging fixation device 40 shown.

[0096] Figure 7A is a structural schematic view of a support portion of a multi-animal imaging fixation device according to some embodiments of the present specification. Figure 7B is an enlarged structural schematic view of region II of the support portion.

[0097] As shown in Figure 7A , the multi-animal imaging fixation device 70 comprises a support portion 700 configured to support a plurality of trays 400. The trays 400 can constitute single-animal imaging fixation devices 40 for accommodating imaging animals. In some embodiments, the number of trays 400 connected on the support portion 700 can be 2-4. For example only, as shown in Figure 8A , four trays 400 are connected together by the support portion 700. In some embodiments, the support portion 700 and the trays 400 are detachably connected. For example, snap connection, clamping connection, etc.

[0098] The support portion 700 comprises oppositely arranged first and second portions 710 and 720. The first portion 710 is configured to support a first end of the tray 400, and the second portion 720 is configured to support a second end of the tray 400. For example only, as shown in Figure 8A , the first end of the tray 400 cooperates with the first portion 710, and the second end cooperates with the second portion 720 to achieve the connection of the tray 400 and the support portion 700.

[0099] In some embodiments, the first portion 710 is provided with an identifier 711 for placing the head of an imaging animal, which facilitates users to quickly find the position for installing the first end of the tray. The identifier 711 can be represented in various ways, such as by color, by character, by pattern, etc. For example only, as shown in Figure 7A , the identifier 711 is the character "H".

[0100] In some embodiments, as shown in Figure 7AAs shown, the first portion 710 is provided with a clamping structure 712 configured to be clamped with the first end portion 410 of the tray 400. In some embodiments, the second portion 720 is provided with a clamping groove structure 721 configured to be clamped with the second end portion 420 of the tray 400. For example, the clamping groove structure 721 of the second portion 720 is clamped with the clamping groove 460. The clamping groove structure 721 and the clamping groove 460 can have various shapes as long as the shapes of the two are matched to enable clamping.

[0101] In some embodiments, referring to Figure 7B and Figure 4B , the clamping structure 712 includes an outwardly protruding clamping boss 712-1, and the anesthetic interface 411 is provided with an inwardly recessed clamping structure 411-3, the clamping boss 712-1 is configured to be embedded in the clamping structure 411-3 to achieve clamping of the anesthetic interface 411 and the clamping structure 712. The clamping structure 712 has a certain elasticity, and the anesthetic interface 411 can be inserted into the clamping structure 712 through the opening of the clamping structure 712, and the installation is completed when the clamping boss 712-1 is embedded in the clamping structure 411-3.

[0102] As shown in Figure 8B , when the clamping boss 712-1 is embedded in the clamping structure 411-3, the clamping boss 712-1 abuts against the anesthetic interface 411, and the protruding part thereof can limit the movement of the anesthetic interface 411, thereby achieving the purpose of fixing the anesthetic interface 411, and further achieving stable installation of the tray. The clamping boss 712-1 and the clamping structure 411-3 can have various shapes as long as the shapes of the two are matched to enable clamping.

[0103] In some embodiments of the present specification, by providing a clamping boss on the clamping structure and a clamping structure on the anesthetic interface, the cooperation of the clamping boss and the clamping structure can enable the tray to be quickly and conveniently installed to the support portion, and improve the installation stability of the tray.

[0104] In some embodiments, the support portion 700 further includes a third portion 730 located between the first portion 710 and the second portion 720, and the third portion 730 is provided with a hollow portion. The hollow portion can include various shapes, such as square, circular, etc. For example, as shown in Figure 7A , the third portion 730 is provided with a plurality of hollow portions. By providing a hollow portion on the third portion of the support portion, it is beneficial to reduce the weight of the support portion, thereby reducing the weight of the multi-imaging animal fixing device.

[0105] In some embodiments, as shown in Figure 9As shown, the bottom of the bottommost tray 400 is spaced apart from the third part 730 of the support part to ensure that the limbs of the imaged animal are not squeezed and can be stretched naturally.

[0106] The embodiments of the present specification also provide an animal cabin, which comprises a cabin body for accommodating one or more multi-imaging animal fixing devices.

[0107] In some embodiments, the multi-imaging animal fixing device is detachably connected to the cabin body. For example only, the multi-imaging animal fixing device can be detachably fixed to the inner wall of the cabin body by snap connection.

[0108] The conventional animal cabin is provided with a slot for fixing the imaged animal on the inner wall. On the one hand, the slot cannot fix the imaged animal independently of the animal cabin, and the animal cabin cannot prepare the animal to be scanned (for example, fix the animal to be scanned) during use, and the animal cabin occupies a large space in the scanning scene due to its large size. On the other hand, the slot design of the single animal cabin is fixed, which is not conducive to flexible support for multiple synchronous scanning modes (especially multi-layer synchronous scanning modes). The single imaging animal fixing device and the multi-imaging animal fixing device provided by the embodiments of the present specification separate the centralized storage function and the auxiliary imaging function of the conventional animal cabin, which is more space-saving and supports more synchronous scanning modes (especially multi-layer synchronous scanning modes) in the scanning scene. In addition, relying on the flexible multi-imaging animal fixing device (especially the multi-layer structure multi-imaging animal fixing device), the animal cabin provided by the embodiments of the present specification can centrally store more fixed imaged animals. Moreover, the single / multi-imaging animal fixing device of the present specification itself has a fixing function and a positioning function, and has a simple structure and is easy to manufacture, which can be easily placed in the cabin body of the existing animal cabin. It is not only suitable for various types of animal cabin bodies and scanning equipment, but also can configure multiple and / or multiple different types of multi-imaging animal fixing devices for a set of animal imaging system to meet different user needs.

[0109] In some embodiments, one animal cabin comprises one or more multi-imaging animal fixing devices. Each multi-imaging animal fixing device can be configured with multiple trays. Of course, the multiple multi-imaging animal fixing devices can be all the same or partially the same or all different types. The multiple trays can be all the same or partially the same or all different types. When multiple multi-imaging animal fixing devices are placed in an animal cabin, the multiple multi-imaging animal fixing devices can be arranged along the axial direction (i.e. the longitudinal direction) of the animal cabin and placed in the animal cabin. In this way, the number of imaged animals that can be scanned at the same time can be further increased. For example, a multi-imaging animal fixing device has 4 tray positions, and 2 multi-imaging animal fixing devices can be placed in each animal cabin at the same time, so that 8 imaged animals can be scanned at a time.

[0110] Figure 3 is a structural schematic diagram of an animal cabin according to some embodiments of the present specification. As shown in the figure, the animal cabin 30 comprises a cabin body 300 and a multi-imaging animal fixing device 20. Figure 3 is a structural schematic diagram of another animal cabin according to some embodiments of the present specification. As shown in the figure, the animal cabin 1000 comprises a cabin body 1010 and a multi-imaging animal fixing device 70. The multi-imaging animal fixing device 70 shown in the figure and the multi-imaging animal fixing device 20 both have four tray positions, which can accommodate four trays at the same time. Figure 10 Figure 10 is a structural schematic diagram of another animal cabin according to some embodiments of the present specification. As shown in the figure, the animal cabin 1000 comprises a cabin body 1010 and a multi-imaging animal fixing device 70. The multi-imaging animal fixing device 70 shown in the figure and the multi-imaging animal fixing device 20 both have four tray positions, which can accommodate four trays at the same time.

[0111] In some embodiments, for imaging animals of larger size (e.g., guinea pigs), a multi-imaging animal fixing device with two tray positions arranged in two layers can be provided. The animal cabin can only accommodate two trays arranged in two layers.

[0112] In some embodiments, the third part of the support part has an arc-shaped bottom surface which matches the inner wall of the cabin body. In some embodiments, the arc radius of the arc-shaped bottom surface of the support part is the same as the arc radius of the inner wall of the cabin body. The multi-imaging animal fixing device composed of the support part and the tray can be directly placed in the cabin body, without the need for additional fixing structure to fix the multi-imaging animal fixing device, which further improves the assembly efficiency and better applicability.

[0113] In some embodiments, the present specification also provides a tray for an imaging animal fixing device, which can be a tray for the multi-imaging animal fixing device described above. Of course, the tray can also be used as a single-imaging animal fixing device alone. In some embodiments, a single-imaging animal fixing device can also be provided, which comprises a support part with one tray position, and the support part is detachably connected to a tray.

[0114] ​The embodiments of the present specification also provide an animal imaging system, which comprises a scanning imaging device having a scanning cavity. Wherein the scanning imaging device comprises one of a Computed Tomography (CT) device, a Magnetic Resonance (MR) device, a Positron Emission Computed Tomography (PET) device, a Single-Photon Emission Computed Tomography (SPECT) device, or a multi-modal imaging device (such as a PET-CT device, a PET-MR device, etc.) in combination of multiple ones of the CT device, the MR device, the PET device, and the SPECT device. In some embodiments, the animal imaging system further comprises a multi-imaging animal fixing device or an animal cabin. Wherein the multi-imaging animal fixing device or the animal cabin is capable of entering the scanning cavity so that the scanning imaging device performs scanning imaging on the imaging animal.

[0115] The beneficial effects that the embodiments of the present specification can bring include but are not limited to: (1) providing a single imaging animal fixing device or tray, which can realize fast switching of samples (imaging animals, such as mice) on different scanning devices (for example, CT devices, MR devices, PET devices, etc.), without changing the relative position between the sample and the tray, thereby realizing the fusion of multi-modal images; (2) relying on the tray, a multi-modal image template can be established, thereby establishing a multi-modal image database; (3) providing a multi-imaging animal fixing device, which can realize the synchronous scanning of multiple imaging animals (for example, multiple mice); (4) the tray and the multi-imaging animal fixing device separate the centralized storage function and the auxiliary imaging function of the traditional animal cabin, which is more space-saving in the scanning scene and supports more synchronous scanning modes (especially multi-layer synchronous scanning modes); (5) by detachably connecting the marker containing part to the tray, the infusion and discharge of the marker are facilitated, and the imaging efficiency is improved; (6) by setting the anesthesia interface and a preset angle between the second end and the fourth end, the anesthesia gas can be directly aimed at the nose of the imaging animal after passing through the first anesthesia channel and the second anesthesia channel, so that the anesthesia gas can be absorbed by the imaging animal at the outlet position, without the need for additional pipelines or accessories, making the anesthesia device more simple, and also improving the anesthesia effect; (7) the forelimbs and hindlimbs of the imaging animal are fixed through the hole structure, which not only makes it easier to fix the forelimbs and hindlimbs of the animal, but also does not form compression on the forelimbs and hindlimbs of the imaging animal, and also reduces the contact between different parts, while also facilitating separate imaging and structural analysis of the limbs or body parts of the imaging animal; (8) since the marker is visible in the first modal medical image and the marker containing part is visible in the second modal medical image, with the help of the marker and the marker containing part, the fusion accuracy of multi-modal images can be improved. In addition, since the marker containing part is arranged at the four corners of the tray, not only the space distribution of the tray is fully utilized, but also interference between the marker containing part and the body of the imaging animal can be avoided, so that the marker is more obvious in the medical image, which is convenient for positioning. (9) by setting the buckle boss on the clamping structure and the buckle structure on the anesthesia interface, the single imaging animal fixing device can be quickly and conveniently installed on the support part by cooperation of the buckle boss and the buckle structure, and the installation stability of the single imaging animal fixing device is improved; (10) providing an animal cabin, which can freely combine and place the multi-imaging animal fixing device and / or the tray, realize the synchronous scanning of different animal types or quantities, and meet different experimental needs. It should be noted that different embodiments can have different beneficial effects, and in different embodiments, the beneficial effects that can be produced can be any one or a combination of the above, or any other beneficial effects that can be obtained.

[0116] Having described the basic concepts, it is obvious to those skilled in the art that the above detailed disclosure is merely illustrative and not restrictive. Although not explicitly described, modifications, improvements, and alterations can be made to the present disclosure by those skilled in the art. Such modifications, improvements, and alterations are suggested by the present disclosure and are still within the spirit and scope of the exemplary embodiments of the present disclosure.

[0117] Also, the present disclosure has used specific words to describe the embodiments of the present disclosure. As "one embodiment", "an embodiment", and / or "some embodiments" mean a certain feature, structure, or characteristic related to at least one embodiment of the present disclosure. Therefore, it should be emphasized and noted that "one embodiment" or "an embodiment" or "one alternative embodiment" referred to in different places in the present disclosure does not necessarily mean the same embodiment. In addition, some features, structures, or characteristics in one or more embodiments of the present disclosure can be appropriately combined.

Claims

1. A multi-imaging animal immobilization device, comprising: Comprising: a support part and a plurality of trays, the support part being configured to support the plurality of trays; the trays are detachably connected with the support part, the tray comprises a first end part configured to place a head of an imaging animal, the first end part being provided with an anesthesia interface configured to deliver anesthetic gas to the imaging animal; each of the trays has a detachably connected marker accommodating part configured to accommodate a marker, the marker being visible in at least one imaging mode.

2. The multi-imaging animal fixing device according to claim 1, wherein the tray comprises a second end part provided opposite to the first end part, the support part comprises a first part and a second part provided opposite to each other; the first part is configured to support the first end part of the tray; the second part is configured to support the second end part of the tray; the support part further comprises a third part between the first part and the second part, the third part being provided with a hollowed part.

3. The multi-imaging animal fixing device according to claim 1, wherein the first end part is further provided with a dental bar for tooth occlusion fixation of the imaging animal.

4. The multi-imaging animal immobilizing apparatus of claim 1, wherein, The number of trays supported by the support part is 2-4.

5. The multi-imaging animal immobilizing apparatus of claim 1, wherein, The tray is provided with a first hole structure and a second hole structure penetrating through the tray, the first hole structure comprising two through holes configured to pass through two forelimbs of the imaging animal, and the second hole structure comprising two through holes configured to pass through two hindlimbs of the imaging animal.

6. The multi-imaging animal immobilizing apparatus of claim 5, wherein, The through hole is a waist-shaped hole.

7. The multi-imaging animal immobilizing apparatus of claim 1, wherein The tray is provided with a fixing structure, the fixing structure having a plurality of marker accommodating parts detachably mounted to the tray through the fixing structure.

8. The multi-imaging animal immobilizing apparatus of claim 7, wherein, The fixing structure is a clasp structure, the clasp structure comprising a clasp arm having elasticity and being configured to fix the marker accommodating part.

9. The multi-imaging animal immobilizing apparatus of claim 1, wherein, The marker accommodating part comprises a first accommodating channel, a second accommodating channel and a marker accommodating cavity, the first accommodating channel is configured to inject the marker, the second accommodating channel is configured to discharge gas when the marker is injected, the marker accommodating cavity is in communication with the first accommodating channel and the second accommodating channel respectively and is configured to accommodate the marker.

10. The multi-imaging animal immobilizing apparatus of claim 9, wherein, The first accommodating channel is cylindrical, the marker accommodating cavity is spherical, and the center of the marker accommodating cavity is located on the central axis of the first accommodating channel.

11. The multi-imaging animal immobilizing apparatus of claim 1, wherein, The marker is a liquid, the marker being visible in at least one first imaging mode, and the marker accommodating part being visible in at least one second imaging mode; The first mode comprises at least one of positron emission imaging, single photon emission imaging or magnetic resonance imaging, and the second mode comprises X-ray imaging.

12. The multi-imaging animal immobilizing apparatus of claim 9, wherein, The marker accommodating part is formed by 3D printing; the diameter of the first accommodating channel is greater than that of the second accommodating channel.

13. The multi-imaging animal immobilizing apparatus of claim 2, wherein, The first part is provided with an identifier for placing a head of an imaging animal.

14. The multi-imaging animal immobilizing apparatus of claim 3, wherein, The support part comprises a first part configured to support a first end of the tray, the first part being provided with a clamping structure configured to clamp with the first end of the tray; The clamping structure comprises an outwardly protruding clasp boss, and the anesthesia interface is provided with an inwardly recessed clasp structure, The clasp boss is configured to be embedded in the clasp structure to achieve clamping of the anesthesia interface and the clamping structure.

15. The multi-imaging animal immobilizing apparatus of claim 3, wherein, The anesthesia interface comprises a first anesthesia channel and a second anesthesia channel, the first anesthesia channel comprising a first end and a second end, and the second anesthesia channel comprising a third end and a fourth end, The first end is an inlet of the anesthetic gas, and the third end is an outlet of the anesthetic gas and is close to a placement position of the nose of the imaging animal, The second end is in communication with the fourth end, and between the second end and the fourth end, there is a preset angle.

16. A tray characterized in that, The tray is configured to accommodate a single imaging animal, The tray comprises a first end and a second end, the first end being configured to fix the head of the imaging animal, and the second end being provided opposite to the first end, the first end being provided with an anesthesia interface configured to deliver anesthetic gas to the imaging animal; The tray is used for detachable connection with a support part of a multi-imaging animal fixing device, and the multi-imaging animal fixing device is detachably placed in the animal cabin.

17. The tray of claim 16, wherein, The tray is provided with a first hole structure and a second hole structure penetrating the tray, the first hole structure comprising two through holes configured to pass through the two forelimbs of the imaging animal, and the second hole structure comprising two through holes configured to pass through the two hindlimbs of the imaging animal.

18. The tray of claim 16, wherein, The shape of the tray is consistent with the shape of the imaging animal.

19. An animal chamber, characterized in that It comprises: a cabin body; and a multi-imaging animal fixing device, which is detachably placed in the cabin body, the multi-imaging animal fixing device comprising: a support part and a plurality of trays, the support part being configured to support the plurality of trays; the tray is detachably connected with the support part, the tray comprises a first end configured to place the head of the imaging animal, and the first end is provided with an anesthesia interface configured to deliver anesthetic gas to the imaging animal.

20. An animal imaging system, characterized by It comprises: a scanning imaging device having a scanning cavity; and the multi-imaging animal fixing device according to any one of claims 1-15, which can enter the scanning cavity; or the animal cabin according to claim 17, which can enter the scanning cavity.

21. The animal imaging system of claim 20, wherein, The scanning imaging device is one of an electronic computed tomography device, a magnetic resonance device, a positron emission computed tomography device, a single photon emission computed tomography device, or a multi-modal imaging device in combination of multiple of the electronic computed tomography device, the magnetic resonance device, the positron emission computed tomography device, and the single photon emission computed tomography device.

22. A tray characterized in that, The tray is used to accommodate a single imaging animal, and the tray is provided with a head fixing part, a forelimb fixing part, and a hindlimb fixing part; The tray comprises a first end portion, on which an anesthesia interface is arranged, the anesthesia interface being configured to deliver anesthetic gas to the imaging animal; The tray is used to be detachably connected with a support portion of a multi-imaging animal fixing device, which is detachably placed in an animal cabin.

23. The tray of claim 22, wherein, The tray is provided with a first hole structure and a second hole structure penetrating through the tray, the first hole structure comprises two through holes configured to pass through two forelimbs of the imaging animal, and the second hole structure comprises two through holes configured to pass through two hindlimbs of the imaging animal.

24. The tray of claim 22, wherein, The shape of the tray is consistent with the shape of the imaging animal.

Images