Treatment device for reducing extractable product content of medical membrane

Abstract

The utility model provides a treatment device for reducing the extractable product content of a medical membrane, and belongs to the technical field of medical membrane production equipment. The liquid storage tank is connected with a liquid inlet of the liquid tank, and the liquid tank is arranged in the constant-temperature oscillation water bath kettle; the interior of the liquid tank is connected with a plurality of membrane components through clamps; each membrane component is connected with a corresponding circulating pump; a liquid level meter for monitoring a real-time liquid level and online refractometer detection equipment are mounted in the liquid tank; an outlet of the liquid tank is connected with the RO membrane module, and the RO membrane module is communicated with the high-concentration extracting solution collecting container and the pure water collecting tank. According to the utility model, the efficiency and the automation degree of equipment are improved, pure water can be recycled, the utilization rate of water resources is improved, wastewater discharge is reduced, and good economic and environmental benefits are achieved; the concentration of extractable products in the subsequent use process can be remarkably reduced, the safety and quality of medical products can be improved, and the health risk of patients is reduced.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical film production equipment technical field, concretely relates to a kind of processing device for reducing the extractable content of medical film. BACKGROUND

[0002] In recent years, membrane separation technology gradually becomes a research hotspot in the application of medicine, medical treatment and health care industry, especially in improving the utilization rate of pharmaceutical resources and green economy of production process. The application of related medical film products in the field of medicine and health is very wide, including microbial fermentation pharmaceutical, western medicine and biological preparation preparation and traditional Chinese medicine production field. On the one hand, using medical film can effectively improve product yield and purity, on the other hand, it can reduce production cost and environmental pollution. However, in practical application, membrane product faces the problem of extractable pollution, which may affect the production process efficiency, and the extractable substance will become drug impurities, thereby affecting drug quality and patient safety. Therefore, the removal of extractable substance is an important link in pharmaceutical process, especially when using membrane system, it needs to be verified by specific process to ensure that it will not chemically react with drug, adsorb drug or release substance into drug.

[0003] In the production process of medical film, reducing extractable substance is an important link to ensure product quality and safety. In the existing membrane preparation technology, it is generally necessary to remove the residues such as organic solvent and additive remaining in the membrane preparation process by heat treatment, but the extractable substance level in subsequent use cannot be guaranteed. For example, in the purification step of biopharmaceutical process, filtration and membrane adsorption equipment are needed for further removal. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a kind of processing device for reducing the extractable content of medical film to solve at least one technical problem existing in the above background technology.

[0005] In order to achieve the above purpose, the utility model takes the following technical scheme:

[0006] The utility model provides a kind of processing device for reducing the extractable content of medical film, comprising:

[0007] A liquid storage tank for containing solution is connected with the liquid inlet of liquid tank, and the liquid tank is placed in a constant-temperature oscillation water bath; a plurality of membrane assemblies are connected to the liquid tank through clamps; each membrane assembly is connected with a corresponding circulating pump; a liquid level meter for monitoring real-time liquid level is installed in the liquid tank, and an online refractometer detection device for monitoring real-time solution concentration is installed in the liquid tank; the outlet of the liquid tank is connected with an RO membrane block, and the RO membrane block is communicated with a high-concentration extractive liquid collection container and a pure water collection tank.

[0008] Optionally, the liquid tank is communicated with the liquid tank through a suction pump.

[0009] Optionally, the outlet of the liquid tank is communicated with the RO membrane block through a discharge pump.

[0010] Optionally, the online refractometer detection device is connected with a data recorder through a data line.

[0011] Optionally, the data line is connected with a wireless transmission module.

[0012] Optionally, the wireless transmission module is connected with a mobile terminal.

[0013] The utility model discloses beneficial effect: sensor can automatically monitor the extraction liquid concentration to the upper limit, and open pump discharge mode, avoid the secondary pollution of membrane, need not manual intervention, improve the efficiency and the degree of automation of equipment greatly.

[0014] The additional aspects and advantages of the utility model will be partly given in the following description, and these will become obvious from the following description or be understood through the practice of the utility model. BRIEF DESCRIPTION OF DRAWINGS

[0015] In order to more clearly illustrate the technical scheme of the embodiment of the utility model, the following will be to the embodiment description needed to use the drawing briefly introduced, obviously, the drawing in the following description only some embodiments of the utility model, for those skilled in the art, under the premise of not paying creative labor, can also obtain other drawings according to these drawings.

[0016] Figure 1 The device structure schematic diagram of the embodiment of the utility model can significantly reduce the extractable content of the pharmaceutical membrane.

[0017] Wherein: 1-liquid tank;2-suction pump;3-constant temperature oscillation water bath;4-membrane;5-liquid tank;6-liquid level meter;7-online refractometer detection device;8-clamp;9-circulating pump;10-discharge pump;11-RO membrane block;12-pure water collection tank;13-high concentration extraction liquid collection container. DETAILED DESCRIPTION

[0018] The embodiments of the present application will be described in detail below, examples of which are shown in the drawings, wherein the same or similar notations represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with the drawings are exemplary and are for the purpose of explanation only, and are not to be construed as limiting the present application.

[0019] Those skilled in the art can understand that unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present application belongs.

[0020] It should also be understood that terms such as those defined in a general dictionary should be understood to have meanings consistent with those in the context of the present technology, and should not be interpreted in an idealized or overly formal sense unless otherwise defined herein.

[0021] Those skilled in the art can understand that the singular forms "a", "an" and "the" used herein include plural forms unless specifically stated otherwise. It should be further understood that the use of the term "include" in the description of the specification of the present application means that the stated features, integers, steps, operations, elements, and / or components exist, but does not exclude the presence or addition of one or more other features, integers, steps, operations, elements, and / or groups thereof.

[0022] In the description of the present application, the description of the terms "one embodiment", "some embodiments", "an example", "a specific example", or "some examples" means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. Moreover, the specific features, structures, materials or characteristics described can be combined in any appropriate manner in any one or more embodiments or examples. In addition, different embodiments or examples described in the specification and the features of different embodiments or examples can be combined and combined by those skilled in the art without contradiction.

[0023] In the description of the present application, the terms "first", "second" are used only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first", "second" can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise specifically defined.

[0024] In the description of the present specification, the orientation or positional relationship indicated by the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present technology and simplifying the description, and does not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present technology.

[0025] Unless otherwise clearly specified and limited, the terms "mount", "connect", "connect", "set" should be understood broadly, for example, it can be fixedly connected, set, or detachably connected, set, or integrally connected, set. For those skilled in the art, the specific meaning of the above terms in the present technology can be understood according to the specific circumstances.

[0026] In order to facilitate the understanding of the present utility model, the present utility model will be further explained and described in conjunction with the drawings and specific embodiments, and the specific embodiments do not constitute a limitation on the embodiments of the present utility model.

[0027] Those skilled in the art should understand that the drawings are only schematic diagrams of the embodiments, and the components in the drawings are not necessarily necessary for the implementation of the present utility model.

[0028] In order to better reduce the extractable, the present utility model discloses a kind of processing device for reducing the extractable content of pharmaceutical film, by the device to the production pharmaceutical film is post-treated, can significantly reduce the concentration of extractable in subsequent use process.The device includes liquid storage tank, suction pump, constant temperature oscillation water bath, pharmaceutical film, different model clamp and pipeline, circulating pump, liquid tank, refractometer online detection, wireless sensor, liquid level meter, emptying pump, RO membrane block, pure water collection tank, high concentration extract liquid collection container.The device is extracted liquid in the circulation of liquid tank by circulating pump, refractometer online detection is used to monitor solution concentration in real time, and is connected with wireless sensor, to realize automatic control.In addition, the device also includes optional data line, data recorder, wireless transmission module and mobile terminal, and the series connection or parallel connection configuration of multiple membrane blocks.

[0029] Embodiment

[0030] As Figure 1As shown, in this embodiment, a processing device for reducing the extractable content of medical membranes is provided, which comprises a solution storage tank 1, a constant temperature oscillation water bath 3 with a sealing cover, a membrane 4, a liquid tank 5, an RO membrane block 11, a pure water collection tank 12, and a high-concentration extract liquid collection container 13. The solution storage tank 1 is connected to the liquid inlet of the liquid tank 5 through a suction pump 2, and the liquid tank 5 is placed in the constant temperature oscillation water bath 3. After turning on the switch of the constant temperature oscillation water bath 3, the water bath is heated and oscillated. The liquid tank 5 is connected to the membrane 4 through a clamp 8. The membrane 4 is connected to a corresponding circulating pump 9. After turning on the circulating pump, the liquid in the liquid tank 5 circulates in and out of the membrane 4. The liquid tank 5 is provided with a liquid level meter 6 for monitoring the real-time liquid level. The liquid tank 5 is provided with an online refractometer detection device 7 for monitoring the real-time solution concentration. When the solution concentration is higher than the set value, the emptying pump 10 is automatically turned on. When the liquid level meter drops to the low position, the emptying pump 10 is automatically turned off and the suction pump 2 is turned on to add liquid to the liquid tank. The outlet of the emptying pump 10 is connected to the RO membrane block 11, which is used to concentrate the liquid discharged by the emptying pump 10. The concentrated extract liquid is collected into the high-concentration extract liquid collection container 13, and the permeate is collected into the pure water collection tank 12 as pure water for reuse.

[0031] The processing device for reducing the extractable content of medical membranes described in this embodiment can include the following process operation steps in specific applications:

[0032] Extract liquid circulation: The extract liquid is generally selected from 10%-30% ethanol, isopropyl alcohol or pure water, and the water-soluble and fat-soluble extractables are removed by the different solubilities of water and alcohol. The extract liquid is delivered to the liquid tank in the constant temperature oscillation water bath through the suction pump. The constant temperature oscillation water bath provides a stable and sealed temperature environment to ensure that the extract liquid maintains a constant temperature during the circulation process. In addition, the oscillation mode also accelerates the contact and circulation of the extract liquid and the product. The circulation time is generally 1-2h.

[0033] Membrane treatment: The medical membranes (such as membrane filaments, membrane sheets, membrane columns, membrane packages, filter cartridges, etc.) are fixed by different types of clamps and connected to the circulating pump. The circulating pump drives the extract liquid to circulate through the membrane inside the liquid tank, so as to extract and reduce the extractable content in the membrane.

[0034] Solution concentration monitoring: The liquid tank is provided with an online refractometer detection device, which can monitor the concentration of the solution in the liquid tank in real time.

[0035] Automatic control: The online refractometer detection is connected to the suction pump, circulating pump and emptying pump through wireless sensors. When the detected solution concentration exceeds the preset value, the system automatically stops the suction pump and circulating pump, and starts the emptying pump to empty the solution in the liquid tank.

[0036] Solution evacuation and replenishment: After the evacuation pump evacuates the solution in the liquid tank to a set low liquid level, the suction pump is restarted to replenish the extraction liquid to the liquid tank, and the circulation process is restarted.

[0037] Green cycle: The outlet of the evacuation pump is connected to the RO membrane module, and the RO membrane is used to concentrate the evacuated liquid. The concentrated extraction liquid is collected in the high-concentration extraction liquid collection container, and the permeate is collected in the pure water tank and can be reused as pure water.

[0038] Data recording and monitoring: Optional accessories include data lines, data recorders, wireless transmission modules, and mobile terminals, which can be used to record test data and allow users to remotely monitor the operating status of the processing device.

[0039] In summary, the processing device for reducing the extractable content of the pharmaceutical membrane according to the embodiments of the present application can significantly reduce the concentration of extractable substances in the subsequent use process by processing the pharmaceutical membrane. This helps to improve the safety and quality of pharmaceutical products and reduce the health risks of patients. When the sensor automatically monitors the concentration of the extraction liquid to the upper limit, the pump evacuation mode is started, avoiding secondary pollution of the membrane and the need for manual intervention, greatly improving the efficiency and automation level of the equipment. And the extracted extraction liquid is further concentrated by the RO membrane, and the pure water can be recycled. This method not only improves the utilization rate of water resources, but also reduces wastewater discharge, and has good economic and environmental benefits.

[0040] Although the specific embodiments of the present application have been described above in conjunction with the accompanying drawings, it is not a limitation on the scope of protection of the present application. Those skilled in the art should understand that various modifications or variations can be made to the technical solutions disclosed in the present application without creative labor, and all such modifications or variations should be covered within the scope of protection of the present application.

Claims

1. A processing device for reducing the content of extractable substances in pharmaceutical membranes, characterized in that, Comprising: a solution storage tank for containing solution; the solution storage tank is connected with a liquid tank inlet, the liquid tank is placed in a constant temperature oscillation water bath; the liquid tank is connected with a plurality of membrane modules through a clamp; each of the membrane modules is connected with a corresponding circulating pump; a liquid level meter for monitoring real-time liquid level is installed in the liquid tank, an online refractometer detection device for monitoring real-time solution concentration is installed in the liquid tank; the outlet of the liquid tank is connected with an RO membrane module, and the RO membrane module is connected with a high-concentration extract liquid collection container and a pure water collection tank.

2. The pharmaceutical film extractable content reducing treatment apparatus according to claim 1, wherein The solution storage tank is connected with the liquid tank through a suction pump.

3. The pharmaceutical film extractable content reducing treatment apparatus according to claim 1, wherein The outlet of the liquid tank is connected with the RO membrane module through a discharge pump.

4. The pharmaceutical film extractable content reducing treatment apparatus according to claim 1, wherein Further comprising: The online refractometer detection device is connected with a data recorder through a data line.

5. The pharmaceutical film extractable content reducing treatment apparatus according to claim 4, wherein Further comprising: A wireless transmission module connected with the data line.

6. The pharmaceutical film extractable content reducing treatment apparatus according to claim 5, wherein Further comprising: A mobile terminal connected with the wireless transmission module.

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