Diazaspiro-tert-butyl formate medicine building block forming device
By designing a tert-butyl diazaspirocarboxylate drug block forming device with an inner and outer shell structure, continuous production and precise temperature control were achieved using a spiral baffle and a heat transfer system. This solved the problem of unstable product quality in chemical production and enabled efficient temperature regulation and material reaction.
Patent Information
- Application Number
- CN202423042380.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-10
- Publication Date
- 2025-11-21
- Estimated Expiration
- 2034-12-10
AI Technical Summary
In existing chemical production, batch production methods make it difficult to achieve continuous production and real-time parameter adjustment, resulting in unstable product quality.
A device for forming tert-butyl diazaspiroformate drug blocks, comprising a cylindrical shell, was designed. It adopts an inner shell and an outer shell structure, with a spiral baffle installed in the inner shell and a heat medium introduced into the outer shell for heating. Combined with a heat medium tank, heat exchange plate and semiconductor refrigeration chip, it achieves precise temperature control and continuous material conveying.
This enables continuous production with reactions carried out at precise temperatures, ensuring the stability and consistency of product quality.
Smart Images
Figure CN223570684U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The application relates to the technical field of chemical production, in particular to a diazidospiro-methyl acid tert-butyl ester pharmaceutical block forming device. BACKGROUND
[0002] Molecular blocks refer to stable structural units composed of multiple molecules, which are connected to each other through chemical bonds or non-covalent bonds. These molecular blocks can play an important role in the fields of material science, nanoscience, biomedicine and the like. Molecular blocks can be obtained through chemical synthesis, self-assembly or biosynthesis. The chemical synthesis method can realize accurate control of molecular blocks through organic synthesis or inorganic synthesis by adjusting reaction conditions and the selection of reactants. The diazidospiro-methyl acid tert-butyl ester and related derivatives have important applications in medicinal chemistry and organic synthesis.
[0003] In existing chemical production, a reaction kettle is basically used for batch production. If a continuous production mode is adopted, production can be carried out at any time. In addition, if an error occurs during production, the temperature and other parameters can be adjusted to ensure the quality of the product. SUMMARY
[0004] To solve the above problems, the application discloses a diazidospiro-methyl acid tert-butyl ester pharmaceutical block forming device, which comprises a cylindrical shell, the lower part of the shell is a heating chamber, the upper part is a storage chamber, and a reaction chamber is arranged in the middle part of the storage chamber. Each cavity is isolated by a partition plate, and the reaction chamber is isolated by a heat preservation layer.
[0005] The inside of the reaction chamber is provided with a reaction container, the reaction container comprises a tubular inner shell, the top view profile of the inner shell is a circular ring, and a spiral partition plate is arranged in the inner shell, a plurality of connecting ports are fixedly connected to the lower part of the inner shell, a discharge pipe is fixedly connected to the sidewall of the upper part of the inner shell, and an outer shell is sleeved outside the inner shell. The material reacts in the inner shell, and the spiral partition plate increases the flow distance of the material. Hot medium is introduced into the outer shell to reach the temperature condition of the reaction, and the spiral partition plate improves the heat exchange effect.
[0006] A plurality of material tanks are arranged on the storage chamber, the bottom of each material tank is provided with a feeding pipe, and the other end of the feeding pipe is fixedly connected with the connecting port. The material tanks store materials, and the plurality of material tanks store different materials.
[0007] Preferably, the inside of the heating chamber is provided with a heat medium box, the inside of the heat medium box is provided with an electric heating element and a first pump, the output end of the first pump is fixedly connected with a heat medium outlet pipe, the other end of the heat medium outlet pipe is fixedly connected with the lower end of the shell, the upper end of the shell is fixedly connected with a heat medium return pipe, and the other end of the heat medium return pipe is in communication with the heat medium box. The electric heating element generates heat when electrified, the heat medium is heated, and the heat medium is pumped into the inside of the shell by the first pump, so that the heat medium covers the inner shell, and the temperature of the inner shell meets the needs of the reaction under a small volume.
[0008] Preferably, the heat medium outlet pipe is serially connected with a heat exchange plate provided with a flow channel in the inside, semiconductor refrigerating sheets are attached to the two sides of the heat exchange plate, one side of the semiconductor refrigerating sheet is attached to the heat exchange plate in a refrigerating state, and the other side of the semiconductor refrigerating sheet is attached to the inner wall of the groove at the upper end of the heat medium box. The semiconductor refrigerating sheet is used for fine tuning the temperature of the pumped heat medium, that is, the pumped heat medium is cooled by the semiconductor refrigerating sheet in a refrigerating state, so that the material in the inner shell can react at an accurate temperature. Further, temperature sensors are arranged on the inner shell, the heat medium box and the heat exchange plate, and are used for feedback adjustment.
[0009] Preferably, the material tank comprises a tank body, the inside of the tank body is provided with a second pump, the output end of the second pump is fixedly connected with the feeding pipe, and the upper end of the tank body is threadedly connected with an upper cover. The material in the tank body is pumped out by the second pump.
[0010] Preferably, the lower end of the shell body is fixedly connected with a plurality of supporting legs.
[0011] The beneficial effects of the present application are as follows:
[0012] 1. The inner shell and the outer shell are arranged, the material is sent into the inner shell for reaction in a continuous conveying mode, and the purpose of taking and producing at any time can be achieved.
[0013] 2. The heat medium box, the heat exchange plate and the semiconductor refrigerating sheet are arranged, the heat medium is sent into the outer shell and wrapped outside the inner shell, the material in the inner shell is heated through heat transfer, and the temperature of the heat medium entering the inside of the outer shell can be adjusted through the arrangement of the semiconductor refrigerating sheet, so that the material can react at an accurate temperature. BRIEF DESCRIPTION OF DRAWINGS
[0014] Figure 1 It is a perspective view of the present application;
[0015] Figure 2 It is a schematic view of the internal structure of the present application;
[0016] Figure 3 It is a schematic view of the structure of the reaction container of the present application;
[0017] Figure 4 This is a three-dimensional schematic diagram of the material tank of the present invention;
[0018] Figure 5 This is a schematic diagram of the structure of the heat medium outlet pipe of the present invention;
[0019] Figure 6 This is a cross-sectional schematic diagram of the housing of the present invention.
[0020] List of reference numerals in the attached diagram:
[0021] 1. Shell; 2. Discharge pipe; 3. Material tank; 4. Heat medium box; 5. Reaction vessel; 6. Heat medium return pipe; 7. Semiconductor refrigeration chip; 8. Heat exchange plate; 9. Heat medium outlet pipe; 10. Support feet;
[0022] 11. Heating chamber; 12. Storage chamber; 13. Reaction chamber; 31. Tank body; 32. Feed pipe; 33. Top cover; 51. Connection port; 52. Inner shell; 53. Outer shell; 54. Spiral baffle. Detailed Implementation
[0023] The present invention will be further illustrated below with reference to the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. It should be noted that the terms "front," "rear," "left," "right," "up," and "down" used in the following description refer to directions in the accompanying drawings, and the terms "inner" and "outer" refer to directions toward or away from the geometric center of a specific component, respectively.
[0024] like Figures 1 to 6 As shown, a tert-butyl diazaspirocarboxylate drug block forming device includes a cylindrical shell 1, a heating chamber 11 at the bottom and a storage chamber 12 at the top, and a reaction chamber 13 in the middle of the storage chamber 12. The heating chamber 11, the storage chamber 12 and the reaction chamber 13 are separated by partitions, and the reaction chamber 13 is provided with a heat insulation layer for heat preservation.
[0025] The inside of the reaction chamber 13 is provided with a reaction container 5 for the reaction of the material, which comprises a tubular inner shell 52 with a circular annular top view profile and is internally provided with a spiral partition 54, through which a spiral channel is formed in the inner shell 52, the material flows a longer distance in the inner shell 52, ensuring sufficient reaction time, and the lower part of the inner shell 52 is fixedly connected with a plurality of connecting ports 51 for feeding the material into the inner shell 52, and the upper part of the side wall of the inner shell 52 is fixedly connected with a discharge pipe 2, through which the reacted material is discharged, and the discharge pipe 2 extends out of the shell 1, and the outer side of the inner shell 52 is sleeved with an outer shell 53, which is provided with a heat medium, which reaches the required reaction temperature, and the heat medium passes through the middle part of the inner shell 52 and between the outer shell 53 and the inner shell 53, and the spiral partition 54 greatly improves the heat exchange effect.
[0026] A plurality of material tanks 3 are arranged on the storage chamber 12, which is provided with a support plate, and the material tanks 3 store different materials, and the bottom of the material tank 3 is extended to be provided with a feeding pipe 32, and the other end of the feeding pipe 32 is fixedly connected with the connecting port 51, and the material is fed into the inner shell 52 through the feeding pipe 32 to form a reaction system.
[0027] The inside of the heating chamber 11 is provided with a heat medium tank 4 for storing heat medium, which is internally provided with an electric heating element and a first pump, the electric heating element generates heat when electrified to heat the heat medium, and the first pump pumps out the heat medium, the output end of the first pump is fixedly connected with a heat medium outlet pipe 9, the other end of the heat medium outlet pipe 9 is fixedly connected with the lower end of the outer shell 53, the heat medium is fed into the inside of the outer shell 53 through the heat medium outlet pipe 9 to heat the inner shell 52 and the material inside, the upper end of the outer shell 53 is fixedly connected with a heat medium return pipe 6, the other end of the heat medium return pipe 6 is communicated with the heat medium tank 4, and the heat medium returns to the heat medium tank 4 through the heat medium return pipe 6.
[0028] The heat medium outlet pipe 9 is serially connected with a heat exchange plate 8 internally provided with a flow channel, and semiconductor refrigerating fins 7 are arranged on both sides of the heat exchange plate 8, and the side of the semiconductor refrigerating fins 7 that is refrigerated is attached to the heat exchange plate 8, that is, when the heat medium passes through the heat exchange plate 8 and the temperature is too high, the semiconductor refrigerating fins 7 are electrified to cool the heat medium, ensuring that the temperature of the heat medium fed into the outer shell 53 is accurate, and the other side of the semiconductor refrigerating fins 7 is attached to the inner wall of the recess on the upper end of the heat medium tank 4, and at the same time of refrigeration, the side of the semiconductor refrigerating fins 7 that generates heat heats the heat medium in the heat medium tank 4 through heat transfer.
[0029] The material tank 3 comprises a tank body 31, the whole of the tank body 31 is cylindrical, the inside of the tank body 31 is provided with a second pump, and the output end of the second pump and a feeding pipe 32 are fixedly connected, the second pump works to send the material into the inner shell 52, the second pump is a high-precision metering pump, which ensures that the continuous conveying material quantity is accurate, the upper end of the tank body 31 is threadedly connected with an upper cover 33, the upper cover 33 is rotated to open, and the material in the tank body 31 is supplemented.
[0030] The lower end of the shell 1 is fixedly connected with a plurality of supporting legs 10 for supporting the shell.
[0031] The technical means disclosed in the scheme of the present application is not limited to the technical means disclosed in the above-mentioned embodiments, and also includes the technical scheme composed of any combination of the above technical features.
Claims
1. A diazaspiro-methyl ester t-butyl carbonate pharmaceutical building block forming apparatus characterized by: Including cylindrical shell (1), the lower part of the shell (1) is a heating chamber (11), the upper part is a storage chamber (12), and a reaction chamber (13) is arranged in the middle of the storage chamber (12); The inside of the reaction chamber (13) is provided with a reaction container (5), the reaction container (5) comprises a tubular inner shell (52), the top view profile of the inner shell (52) is a circular ring, and the inside of the inner shell (52) is provided with a spiral partition (54), the lower part of the inner shell (52) is fixedly connected with a plurality of connecting ports (51), the sidewall of the upper part of the inner shell (52) is fixedly connected with a discharge pipe (2), and the outer side of the inner shell (52) is sleeved with an outer shell (53); A plurality of material tanks (3) are arranged on the storage chamber (12), the bottom of the material tank (3) is provided with an inlet pipe (32), and the other end of the inlet pipe (32) is fixedly connected with the connecting port (51).
2. A diazaspiro-methyl t-butyl carbamate pharmaceutical tablet forming device according to claim 1, wherein: The inside of the heating chamber (11) is provided with a heat medium tank (4), the inside of the heat medium tank (4) is provided with an electric heating element and a first pump, the output end of the first pump is fixedly connected with a heat medium outlet pipe (9), the other end of the heat medium outlet pipe (9) is fixedly connected with the lower end of the outer shell (53), the upper end of the outer shell (53) is fixedly connected with a heat medium return pipe (6), and the other end of the heat medium return pipe (6) is communicated with the heat medium tank (4).
3. A diazaspiro-methyl t-butyl carbamate pharmaceutical tablet forming device according to claim 2, wherein: The heat medium outlet pipe (9) is serially connected with a heat exchange plate (8) provided with a flow channel inside, the two sides of the heat exchange plate (8) are both provided with a semiconductor refrigeration sheet (7), and the side of the semiconductor refrigeration sheet (7) which is refrigerated is attached to the heat exchange plate (8), and the other side of the semiconductor refrigeration sheet (7) is attached to the inner wall of the groove on the upper end of the heat medium tank (4).
4. A diazaspiro-methyl t-butyl carbamate pharmaceutical tablet forming device according to claim 1, wherein: The material tank (3) comprises a tank body (31), the inside of the tank body (31) is provided with a second pump, and the output end of the second pump is fixedly connected with the inlet pipe (32), and the upper end of the tank body (31) is threadedly connected with an upper cover (33).
5. A diazaspiro-methyl t-butyl carbamate pharmaceutical tablet forming device according to claim 1, wherein: The lower end of the shell (1) is fixedly connected with a plurality of supporting legs (10).