Glass slide flushing device

By designing a slide washing device, automated and light-protected slide washing was achieved, solving the problem of low efficiency of manual washing, protecting the slides, and ensuring the accuracy of fluorescence microscopy observation.

CN223571443UActive Publication Date: 2025-11-21ZHENGZHOU UNIV
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Patent Information

Application Number
CN202422527490.2
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-10-18
Publication Date
2025-11-21
Estimated Expiration
2034-10-18

AI Technical Summary

Technical Problem

Manually rinsing slides is inconvenient, inefficient, and can easily damage them, affecting the results of fluorescence microscopy.

Method used

A slide rinsing device was designed, including a placement box, a liquid storage tank, a delivery pump, and rinsing pipelines. Through the cooperation of the light-shielding box and the placement rack, automated rinsing is achieved, ensuring that slides are rinsed in large quantities in a light-proof environment.

Benefits of technology

It improves the efficiency of slide washing, protects the slides, avoids fluorescence quenching, and reduces experimental costs.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses a glass slide flushing device which is suitable for flushing a glass slide. The glass slide flushing device comprises a placing box, a liquid storage tank, a conveying pump and a flushing pipeline; the placing box comprises a shading box body, a box cover and a placing frame; the shading box body is provided with an opening, and the box cover is suitable for opening or closing the opening of the shading box body; a sliding groove is formed in the box cover, the containing frame is arranged in an inner cavity of the shading box body, and the containing frame is opposite to an opening of the shading box body. The placement rack is suitable for detachably mounting a glass slide; the liquid storage tank is suitable for storing flushing liquid; the conveying pump is suitable for conveying the flushing liquid in the liquid storage tank to the liquid inlet end of the flushing pipeline; the liquid outlet end of the flushing pipeline is slidably arranged in the sliding groove, and the liquid outlet direction of the liquid outlet end of the flushing pipeline is opposite to the to-be-flushed area of the glass slide. Through the cooperation of the placing box, the liquid storage box, the conveying pump and the flushing pipeline, the glass slide flushing device is simple in structure, convenient to operate and suitable for flushing a large number of glass slides, flushing liquid is effectively prevented from splashing, and the flushing efficiency is effectively improved.
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Description

TECHNICAL FIELD

[0001] The utility model relates to biological sample processing technical field, concretely relates to a slide washing device. BACKGROUND

[0002] Fluorescence in situ hybridization (FISH) is a new technology combined with non-radioactive molecular biology and cytogenetics based on cell microscopy, which is a new in situ hybridization method formed by replacing isotope labeling with fluorescent labeling. Its principle is that the nucleic acid probe labeled with fluorescein directly or indirectly hybridizes with the nucleic acid sequence in the sample to be tested according to the principle of base complementary pairing, and then it is observed directly under a fluorescence microscope after washing. The experiment involves repeatedly washing the slide with pure water to remove unbound probes and impurities, thereby reducing the background signal, improving the signal intensity and clarity of the specifically bound probe, and making the hybridization signal of the target region more accurately detected.

[0003] The slide is a glass or quartz sheet used to place samples when observing materials with a microscope. During sample preparation, cells or tissue sections are placed on the slide, and a cover glass is placed on top for observation. In laboratories and related scientific research, medical and other fields, the slide is one of the commonly used experimental equipment. At present, the slide is mostly washed manually, which is low in efficiency, time-consuming and labor-intensive. Due to the thin thickness of the slide, damage to the slide may occur during manual washing, increasing the experimental cost.

[0004] In addition, in order to ensure the stability of the fluorescein, the fluorescein needs to be placed in a light-proof environment. During the manual washing process of the slide, the carrier contained in the slide is not in a light-proof state, which leads to fluorescence quenching and affects the subsequent fluorescence microscope observation results. SUMMARY

[0005] The technical problem to be solved by the utility model is that manual washing of the slide is inconvenient and low in efficiency.

[0006] The utility model discloses a slide washing device, which is suitable for washing the slide, and comprises a placing box, a liquid storage tank, a conveying pump and a washing pipeline.

[0007] The placing box comprises a light-shielding box body, a box cover and a placing rack.

[0008] The light-shielding box body has an opening, and the box cover is suitable for opening or closing the opening of the light-shielding box body. A sliding groove is formed in the box cover, the placing rack is arranged in the inner cavity of the light-shielding box body, and the placing rack is arranged opposite to the opening of the light-shielding box body. The placing rack is suitable for detachably mounting the slide.

[0009] The liquid storage tank is suitable for storing the washing liquid;

[0010] The delivery pump is suitable for delivering the washing liquid in the liquid storage tank to the liquid inlet end of the washing pipeline;

[0011] The liquid outlet end of the washing pipeline is slidably arranged in the sliding groove, and the liquid outlet direction of the liquid outlet end of the washing pipeline is opposite to the area to be washed of the slide glass. Through the cooperation of the placing box, the liquid storage tank, the delivery pump and the washing pipeline, the operation is convenient, and it is suitable for washing a large number of slide glasses.

[0012] Optionally, the placing box further comprises a boss;

[0013] The boss is located between the light-shielding box body and the placing rack, the boss is fixed on the inner cavity side wall of the light-shielding box body, and the placing rack is arranged on the boss; the placing rack is suitable for detachably arranging the slide glass between the boss and the placing rack, so that the slide glass is partially suspended in the light-shielding box body. The above scheme is adopted to detach the slide glass from the placing rack by the experimenter.

[0014] Optionally, the placing rack is a plurality of, and the plurality of placing racks are arranged at intervals along the length direction of the light-shielding box body; and the sliding groove extends along the length direction of the light-shielding box body. The above scheme is adopted to be suitable for washing a large number of slide glasses.

[0015] Optionally, the placing rack comprises a spring clamp and / or a limiting block; the spring clamp is a plurality of, and the plurality of spring clamps are arranged at intervals in the inner cavity of the light-shielding box body; the spring clamp is suitable for clamping the slide glass, so that the side of the slide glass containing the carrier is arranged opposite to the opening of the light-shielding box body; the limiting block is a plurality of, and the plurality of limiting blocks are fixed at intervals in the inner cavity of the light-shielding box body; and the limiting block is suitable for fixing the edge of the slide glass. The above scheme is adopted to fix the position of the slide glass, effectively prevent the translocation of the slide glass during the washing process, and further effectively protect the slide glass.

[0016] Optionally, a waste discharge port is arranged on the side wall of the light-shielding box body, and an inclined surface is arranged on the light-shielding box body, the inclined surface is located in the inner cavity of the light-shielding box body, and the inclined surface is suitable for guiding the washing liquid entering the inner cavity of the light-shielding box body to the waste discharge port. The above scheme is adopted to discharge the washing liquid in the light-shielding box body to the outside of the light-shielding box body.

[0017] Optionally, the liquid inlet end of the flushing pipeline comprises a flushing pipe; the liquid outlet end of the flushing pipeline comprises a sliding block and a spray head; the sliding block is slidably arranged in the sliding groove; the spray head is arranged through the sliding block; the delivery pump is arranged on the liquid storage tank, the liquid inlet end of the flushing pipe is connected with the liquid storage tank through the delivery pump, and the liquid outlet end of the flushing pipe is connected with the spray head. By adopting the above scheme, the flushing pipeline is slidably arranged in the sliding groove.

[0018] Optionally, the slide glass flushing device further comprises a light shielding shell; the liquid storage tank and the delivery pump are arranged on the light shielding shell; and the placing box is detachably arranged on the light shielding shell. By adopting the above scheme, the carrier contained on the slide glass is ensured to be in a light shielding state, thereby avoiding fluorescence quenching.

[0019] Optionally, the light shielding shell comprises a light shielding body and a temporary placing rack; the light shielding body comprises a first panel, a second panel and a third panel; the first panel and the second panel are oppositely arranged, and the third panel is arranged between the first panel and the second panel; the first panel, the second panel and the third panel are formed with a containing cavity adapted to place the placing box; an opening of the light shielding box body is arranged on a side of the light shielding box body away from the third panel; and the temporary placing rack is arranged on the light shielding body, the temporary placing rack is formed with a temporary placing groove, the temporary placing groove is detachably connected with the flushing pipeline, and the temporary placing rack is adapted to temporarily place the liquid outlet end of the flushing pipeline. By adopting the above scheme, the temporary placing of the flushing pipeline is realized.

[0020] Optionally, the placing box further comprises a movable support, the movable support is arranged outside the light shielding box body, and the movable support is hinged to the light shielding box body. By adopting the above scheme, the placing box can be placed on the experimental table top.

[0021] Optionally, the flushing pipeline is detachably connected with the sliding groove. By adopting the above scheme, the flushing pipeline can be flexibly used.

[0022] Compared with the prior art, the utility model has the following beneficial effects by adopting the above technical scheme:

[0023] Through cooperation of the placing box, the liquid storage tank, the delivery pump and the flushing pipeline, the structure is simple, the operation is convenient, a large number of slide glasses can be flushed, and the flushing efficiency is effectively improved.

[0024] The position of the slide glass is fixed through the placing rack, so that the translocation of the slide glass in the flushing process is effectively prevented, and the slide glass is effectively protected.

[0025] The light shielding box body and the light shielding shell are arranged, so that the carrier contained on the slide glass is ensured to be in a light shielding state, thereby avoiding fluorescence quenching.

[0026] The above description and the following description of embodiments of the present disclosure are intended to demonstrate and explain the spirit and principle of the present disclosure, and provide further explanation of the scope of the patent application of the present disclosure. BRIEF DESCRIPTION OF DRAWINGS

[0027] The specific embodiments of the present disclosure will be further described in detail below with reference to the accompanying drawings.

[0028] Figure 1 It is a schematic diagram of the three-dimensional structure of the slide washing device in the present disclosure;

[0029] Figure 2 It is a schematic diagram of the structure of the slide washing device in the present disclosure (one);

[0030] Figure 3 It is a schematic diagram of the three-dimensional structure of the slide washing device in the present disclosure;

[0031] Figure 4 It is a schematic diagram of the three-dimensional structure of the placing box in the present disclosure;

[0032] Figure 5 It is a schematic diagram of the local structure of the placing box in the present disclosure;

[0033] Figure 6 It is a schematic diagram of the placing box in the present disclosure (one);

[0034] Figure 7 It is a schematic diagram of the placing box in the present disclosure (two);

[0035] Figure 8 It is a schematic diagram of the local structure of the slide washing device in the present disclosure;

[0036] Figure 9 It is a schematic diagram of the structure of the slide washing device in the present disclosure (two). Figure 8

[0037] Figure 10

[0038] BRIEF DESCRIPTION OF DRAWINGS

[0039] 10, placing box; 11, light shielding box body; 111, waste discharge port; 112, inclined surface; 12, box cover; 121, sliding groove; 13, placing rack; 131, spring clamp; 132, limiting block; 14, boss; 15, movable support; 16, liquid discharge pipe;

[0040] 20, liquid storage tank;

[0041] ​​30, flush pipe; 31, slider; 32, flush pipe; 33, spray head;

[0042] 40, light shielding housing; 41, light shielding body; 42, temporary storage rack; 43, fixing seat;

[0043] 50, glass slide. DETAILED DESCRIPTION

[0044] The above description is only used to illustrate the specific embodiments of the present application. Those skilled in the art can easily understand other advantages and effects of the present application from the content disclosed in the specification. Although the description of the present application is introduced in combination with the preferred embodiments, it does not mean that the features of the present application are limited to the embodiments. On the contrary, the purpose of introducing the present application in combination with the embodiments is to cover other options or modifications which can be extended based on the claims of the present application. In order to provide a deep understanding of the present application, many specific details will be included in the following description. The present application can also be implemented without using these details. In addition, in order to avoid confusion or obscure the focus of the present application, some specific details will be omitted in the description. It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0045] In the description of the present embodiment, it should be noted that the terms "upper", "lower", "inner", "bottom" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship commonly used when the product of the present application is used, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present application.

[0046] The terms "first", "second", and the like are only used for differentiation in description, and cannot be understood as indicating or implying relative importance.

[0047] In the description of the present embodiment, it should also be noted that, unless otherwise explicitly specified and limited, the terms "provided with", "provided", "connected", "connected" should be broadly understood, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium, or it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present embodiment can be understood according to the specific circumstances.

[0048] Embodiment 1

[0049] The present application discloses a glass slide flushing device, which is suitable for flushing a glass slide 50.

[0050] Referring to Figure 1 As shown in the drawings, the slide washing device comprises a placing box 10, a liquid storage tank 20, a conveying pump and a washing pipeline 30.

[0051] Specifically, the placing box 10 comprises a light-shielding box body 11, a box cover 12 and a placing rack 13. The light-shielding box body 11 has an opening. The box cover 12 is adapted to open or close the opening of the light-shielding box body 11. The box cover 12 is provided with a sliding groove 121. The placing rack 13 is arranged in the inner cavity of the light-shielding box body 11. The placing rack 13 is arranged opposite to the opening of the light-shielding box body 11. The placing rack 13 is adapted to detachably mount the slide 50. The liquid storage tank 20 is adapted to store the washing liquid. The conveying pump is adapted to convey the washing liquid in the liquid storage tank 20 to the liquid inlet end of the washing pipeline 30. The liquid outlet end of the washing pipeline 30 is slidably arranged in the sliding groove 121. The liquid outlet direction of the liquid outlet end of the washing pipeline 30 is opposite to the area to be washed of the slide 50.

[0052] When the slide 50 needs to be washed, the box cover 12 is opened, the slide 50 is mounted on the placing rack 13, and then the box cover 12 is closed; the conveying pump is started to convey the washing liquid in the liquid storage tank 20 to the washing pipeline 30, the washing pipeline 30 sprays the washing liquid to the slide 50 on the placing rack 13, thereby realizing the washing of the slide 50. When a batch of slides 50 are mounted on the placing rack 13 in the placing box 10, the experimental personnel slide the washing pipeline 30 through the sliding connection between the washing pipeline 30 and the sliding groove 121, so that the washing pipeline 30 successively washes the slides 50 in the placing box 10. The slide washing device is simple and convenient to operate, is suitable for washing a large batch of slides 50, and effectively avoids the splashing of the washing liquid.

[0053] In the fluorescent in situ hybridization, the slide washing device is suitable for the repeated washing of the slide in the experiment. Under the light-shielding effect of the light-shielding box body 11, it is ensured that the carrier contained in the slide 50 is in a light-shielding state, thereby avoiding the fluorescence quenching.

[0054] In the embodiment, the washing liquid includes but is not limited to pure water and buffer solution.

[0055] In the embodiment, the light-shielding box body 11 is made of a light-shielding material.

[0056] In the embodiment, the box cover 12 is made of a light-shielding material, and a part of the box cover 12 is provided with a transparent observation window for observing the washing condition of the slide 50 in the placing box 10.

[0057] In the embodiment, the area to be washed of the slide 50 is located at one side of the slide 50 containing the carrier, and is located at the middle part of the slide 50.

[0058] In the embodiment, the placing rack 13 is multiple, and the multiple placing racks 13 are arranged at intervals along the length direction of the light shielding box body 11. The sliding groove 121 extends along the length direction of the light shielding box body 11.

[0059] In the embodiment, the top of the liquid storage tank 20 is provided with a liquid supplementing opening, so that the experimenter can supplement liquid.

[0060] In the embodiment, the light shielding box body 11 is a rectangular box body, and the glass slide 50 placed in the light shielding box body 11 is arranged in parallel with the light shielding box body 11. Please refer to Figure 4 As shown in the figure, the placing box 10 further comprises a movable support 15. The movable support 15 is hinged to the light shielding box body 11 and is used for supporting the light shielding box body 11. When the light shielding box body 11 is placed on the experimental bench top, the light shielding box body 11 is supported by the movable support 15 to be arranged obliquely relative to the experimental bench top, so that the glass slide 50 placed in the light shielding box body 11 is arranged obliquely relative to the experimental bench top.

[0061] Preferably, the movable support 15 is a U-shaped rod. A recess is arranged on the light shielding box body 11 and is used for accommodating the movable support 15.

[0062] Further, please refer to Figures 5-7 As shown in the figure, the placing box 10 further comprises a boss 14. The boss 14 is located between the light shielding box body 11 and the placing rack 13. The boss 14 is fixed to the inner cavity side wall of the light shielding box body 11. The placing rack 13 is arranged on the boss 14. The placing rack 13 is suitable for detachably arranging the glass slide 50 between the boss 14 and the placing rack 13, so that the glass slide 50 is partially suspended in the light shielding box body 11.

[0063] In the embodiment, the bosses 14 are suitable for supporting the end portions of the glass slide 50, so that the middle portion of the glass slide 50 is suspended in the light shielding box body 11. The middle portion of the glass slide 50 is not in contact with the boss 14, so that the experimenter can detach the glass slide 50 from the placing rack 13.

[0064] Further, the placing rack 13 comprises but is not limited to any one of the following structures.

[0065] Structure one: comprising spring clips 131. The spring clips 131 are multiple and are arranged at intervals in the inner cavity of the light shielding box body 11. The spring clips 131 are assembled on the corresponding bosses 14. The spring clips 131 are suitable for clamping the glass slide 50, so that the side of the glass slide 50 on which the carrier is placed is arranged opposite to the opening of the light shielding box body 11.

[0066] Structure two: comprising limit blocks 132. The limit blocks 132 are multiple and are fixed at intervals in the inner cavity of the light shielding box body 11. The limit blocks 132 are fixed in the inner cavity of the light shielding box body 11 through the corresponding bosses 14. The limit blocks 132 are suitable for fixing the edge of the glass slide 50.

[0067] Structure three: including spring clips 131 and limiting blocks 132. The spring clips 131 are multiple. The limiting blocks 132 are multiple.

[0068] In the embodiment, the placing rack 13 is structure three, including multiple spring clips 131 and multiple limiting blocks 132. The spring clips 131 are suitable for clamping one end of the slide 50, and the limiting blocks 132 are suitable for fixing the edge of the other end of the slide 50. Specifically, the spring clips 131 are suitable for clamping the upper end of the slide 50, and the limiting blocks 132 are suitable for limiting the edge of the lower end of the slide 50. The lower end of the same slide 50 can be limited by three limiting blocks 132 to limit the two sides and the lower end face of the slide 50 respectively (as shown in Figure 6

[0069] When the slide 50 is placed on the placing rack 13, the sliding groove 121 is located at the middle upper part of the slide 50.

[0070] Further, the side wall of the light shielding box body 11 is provided with a waste discharge port 111. The light shielding box body 11 is provided with a slope surface 112. The slope surface 112 is located in the inner cavity of the light shielding box body 11, and is suitable for guiding the washing liquid entering the inner cavity of the light shielding box body 11 to the waste discharge port 111. Specifically, the slope surface 112 extends from one side wall where the waste discharge port 111 is located to the other side wall with a height from low to high.

[0071] In the embodiment, the outer part of the light shielding box body 11 is provided with a liquid discharge pipe 16. One end of the liquid discharge pipe 16 is connected with the waste discharge port 111, and the other end is connected with a waste liquid recovery device. The washing liquid entering the inner cavity of the light shielding box body 11 is guided by the slope surface 112, and is sequentially discharged to the waste liquid recovery device through the waste discharge port 111 and the liquid discharge pipe 16.

[0072] Please refer to Figures 8-9 The liquid inlet end of the washing pipeline 30 includes a washing pipe 32. The liquid outlet end of the washing pipeline 30 includes a sliding block 31 and a spray head 33. The sliding block 31 is slidably arranged in the sliding groove 121. The spray head 33 is arranged in the sliding block 31 and is connected with the sliding block 31. A conveying pump is arranged on the liquid storage tank 20. The liquid inlet end of the washing pipe 32 is connected with the liquid storage tank 20 through the conveying pump, and the liquid outlet end of the washing pipe 32 is connected with the spray head 33. The liquid outlet direction of the spray head 33 is opposite to the area to be washed of the slide 50.

[0073] In the embodiment, the washing pipe 32 is a flexible pipe, so that the experimental personnel can slide the sliding block 31 flexibly.

[0074] ​Further, the flushing pipeline 30 is detachably connected to the chute 121. In this embodiment, the slider 31 is detachably connected to the chute 121. Specifically, one end of the box cover 12 is hinged to the light-shielding box body 11, and the other end of the box cover 12 is a free end. One end of the chute 121 is closed, and the other end is open. Among them, the end of the chute 121 close to the free end of the box cover 12 is open, so that the slider 31 can be detachably connected to the chute 121.

[0075] In this embodiment, the slider 31 is in the shape of a "work" character.

[0076] Please refer to Figures 1-3 As shown, the slide glass flushing device further includes a light-shielding housing 40, which provides a light-shielded environment for the light-shielding box body 11. The light-shielding housing 40 includes a light-shielding body 41. Among them, the light-shielding body 41 includes at least three panels.

[0077] When the light-shielding body 41 includes three panels, the light-shielding body 41 includes a first panel, a second panel and a third panel. The first panel and the second panel are arranged oppositely, and the third panel is arranged between the first panel and the second panel. A receiving cavity is formed by the first panel, the second panel and the third panel, and the receiving cavity is suitable for placing the placing box 10. The opening of the light-shielding box body 11 is opened on the side of the light-shielding box body 11 away from the third panel. In this embodiment, the first panel and the second panel are the upper and lower panels, and the third panel is the side panel. The liquid storage tank 20 and the delivery pump are arranged on the first panel. The delivery pump is respectively connected to the liquid outlet of the liquid storage tank 20 and the liquid inlet end of the flushing pipe 32.

[0078] Further, a triangular bracket is provided between the first panel and the third panel. The triangular bracket is used for strengthening between the first panel and the third panel.

[0079] When the light-shielding body 41 includes five panels, the light-shielding body 41 includes an upper panel, an upper panel and three side panels. The light-shielding body 41 has an opening, and the opening of the light-shielding box body 11 is arranged on the same side as the opening of the light-shielding body 41.

[0080] In this embodiment, the light-shielding body 41 is made of a light-shielding material.

[0081] In this embodiment, the cross-section of the receiving cavity of the light-shielding body 41 is rectangular. The placing box 10 is detachably arranged on the light-shielding housing 40.

[0082] Further, the placing box 10 is detachably connected to the light-shielding body 41.

[0083] In this embodiment, please refer to Figures 2-4As shown, the light shielding box 11 is detachably arranged on the light shielding body 41 through the movable support 15. Specifically, the bottom of the accommodating cavity of the light shielding body 41 is provided with a mounting groove for inserting the movable support 15. The relative position of the movable support 15 and the light shielding box 11 is adjusted so that the light shielding box 11 is arranged obliquely relative to the light shielding body 41, and then the slide glass 50 placed in the light shielding box 11 is arranged obliquely relative to the light shielding body 41.

[0084] Further, the light shielding shell 40 further comprises a temporary storage rack 42. The temporary storage rack 42 is arranged on the light shielding body 41. In the embodiment, the temporary storage rack 42 is arranged on the edge of the first panel. The temporary storage rack 42 is provided with a temporary storage groove, and the temporary storage groove is detachably connected with the sliding block 31. The temporary storage rack 42 is suitable for temporarily storing the liquid outlet end of the washing pipeline 30. After the washing of the slide glass 50 is completed, the sliding block 31 is detached from the sliding groove 121, and then the sliding block 31 is placed on the temporary storage rack 42, so that the experimental personnel can take out the washed slide glass 50 from the light shielding box 11, and the washing pipeline 30 does not interfere with the placement and taking out of the washed slide glass 50.

[0085] Further, the light shielding shell 40 further comprises a handle. The handle is fixed to the outer side wall of the light shielding box 11, so as to facilitate the experimental personnel to carry the slide glass washing device.

[0086] In the embodiment, the working principle of the slide glass washing device is as follows:

[0087] The box cover 12 is opened, the slide glass 50 is arranged on the placing rack 13, the sliding block 31 is arranged in the sliding groove 121 of the box cover 12, and then the box cover 12 is closed;

[0088] The placing box 10 is arranged on the light shielding shell 40;

[0089] The conveying pump is started to convey the washing liquid in the liquid storage tank 20 to the washing pipeline 30, the washing pipeline 30 sprays the washing liquid to the slide glass 50 on the placing rack 13, and then the slide glass 50 is washed. During the process, the waste liquid in the light shielding box 11 is guided by the inclined surface 112, and then is sequentially discharged from the waste liquid discharge port 111 and the liquid discharge pipe 16 to the waste liquid recovery device.

[0090] After the washing is completed, the box cover 12 is opened, the sliding block 31 is placed on the temporary storage rack 42, and then the slide glass 50 in the light shielding box 11 is taken out.

[0091] In the embodiment, the slide glass washing device has simple structure and convenient operation, is suitable for washing a large number of slide glasses, effectively avoids the splashing of the washing liquid, and effectively improves the washing efficiency. The position of the slide glass is fixed by the placing rack, which effectively prevents the translocation of the slide glass during the washing process, and then effectively protects the slide glass. The light shielding box and the light shielding shell are arranged to ensure that the carrier contained in the slide glass is in a light shielding state, and then the fluorescence quenching is avoided.

[0092] Embodiment 2

[0093] Embodiment 1 differs from Embodiment 2 in that, in Embodiment 2, the placing box 10 does not comprise the movable support 15, and the light shielding shell 40 further comprises a fixed seat 43.

[0094] Specifically, as shown in Figure 8 and Figure 10 , the light shielding box body 11 is detachably connected with the light shielding body 41 through the fixed seat 43. The fixed seat 43 is fixed on the light shielding body 41. The light shielding box body 11 is a rectangular box body. The fixed seat 43 has a cross section in the shape of a right triangle. The light shielding box body 11 is detachably arranged on the inclined surface of the fixed seat 43, so that the light shielding box body 11 is arranged obliquely relative to the light shielding body 41. Therefore, when the slide 50 is placed in the light shielding box body 11, the slide 50 is arranged obliquely relative to the light shielding body 41.

[0095] The detachable connection structure between the light shielding box body 11 and the fixed seat 43 includes, but is not limited to, a buckle connection, a magnetic attraction connection, etc. Preferably, the detachable connection structure comprises a matching clamping groove and a clamping block. The clamping block is fixed on the inclined surface of the fixed seat 43, and the clamping groove is correspondingly formed on the light shielding box body 11. The light shielding box body 11 and the fixed seat 43 are detachably connected through the cooperation of the clamping block and the clamping groove.

[0096] In this embodiment, the detachable connection between the fixed seat and the light shielding box body is used to fix the light shielding box body, which is simple to operate.

[0097] The above embodiments are only illustrative of the principles and effects of the present application, and are not intended to limit the present application. Any person skilled in the art can modify or change the above embodiments without departing from the spirit and scope of the present application. Therefore, all equivalent modifications or changes made by those skilled in the art without departing from the spirit and technical ideas disclosed by the present application shall still be covered by the claims of the present application.

Claims

1. A slide rinsing apparatus, suitable for rinsing glass slides (50), characterized in that, The slide rinsing device includes: a placement box (10), a liquid storage tank (20), a delivery pump, rinsing pipeline (30), and a light-shielding housing (40). The placement box (10) includes: a light-shielding box body (11), a box cover (12), and a placement rack (13). The light-shielding box (11) has an opening, and the box cover (12) is adapted to open or close the opening of the light-shielding box (11); the box cover (12) is provided with a sliding groove (121), and the placement rack (13) is disposed in the inner cavity of the light-shielding box (11), and the placement rack (13) is disposed opposite to the opening of the light-shielding box (11); the placement rack (13) is adapted to detachably install the glass slide (50). The storage tank (20) is suitable for storing rinsing fluid; The delivery pump is adapted to deliver the flushing liquid in the storage tank (20) to the inlet end of the flushing pipeline (30); The outlet end of the rinsing pipe (30) is slidably disposed in the trough (121), and the outlet direction of the outlet end of the rinsing pipe (30) is opposite to the area to be rinsed on the glass slide (50). The liquid storage tank (20) and the delivery pump are mounted on the light-shielding housing (40); The placement box (10) is detachably mounted on the light-shielding housing (40); The flushing pipe (30) is detachably connected to the chute (121).

2. The slide washing apparatus according to claim 1, characterized in that, The placement box (10) further includes: a boss (14); The boss (14) is located between the light-shielding box (11) and the placement rack (13). The boss (14) is fixed on the inner cavity side wall of the light-shielding box (11). The placement rack (13) is disposed on the boss (14). The placement rack (13) is adapted to detachably place the glass slide (50) between the boss (14) and the placement rack (13) so that the glass slide (50) is partially suspended in the light-shielding box (11).

3. The slide washing apparatus according to claim 1, characterized in that, There are multiple placement racks (13), and the multiple placement racks (13) are spaced apart along the length direction of the light-shielding box (11); The groove (121) extends along the length of the light-shielding box (11).

4. The slide washing apparatus according to claim 1, characterized in that, The placement rack (13) includes: a spring clip (131) and / or a limiting block (132); There are multiple spring clips (131), and the multiple spring clips (131) are spaced apart in the inner cavity of the light-shielding box (11); the spring clips (131) are adapted to clamp the glass slide (50) so that the side of the glass slide (50) that holds the carrier is opposite to the opening of the light-shielding box (11). There are multiple limiting blocks (132), and the multiple limiting blocks (132) are fixed at intervals in the inner cavity of the light-shielding box (11); the limiting blocks (132) are adapted to fix the edge of the glass slide (50).

5. The slide washing apparatus according to claim 4, characterized in that, The side wall of the light-shielding box (11) is provided with a waste discharge port (111), and the light-shielding box (11) is provided with a ramp (112). The ramp (112) is located in the inner cavity of the light-shielding box (11), and the ramp (112) is adapted to guide the rinsing liquid entering the inner cavity of the light-shielding box (11) to the waste discharge port (111).

6. The slide washing apparatus according to claim 1, characterized in that, The inlet end of the flushing pipeline (30) includes: a flushing pipe (32); The outlet end of the flushing pipeline (30) includes: a slider (31) and a nozzle (33); The slider (31) is slidably disposed in the groove (121); The nozzle (33) passes through the slider (31). The delivery pump is installed on the liquid storage tank (20), the inlet end of the flushing pipe (32) is connected to the liquid storage tank (20) through the delivery pump, and the outlet end of the flushing pipe (32) is connected to the nozzle (33).

7. The slide washing apparatus according to claim 1, characterized in that, The light-shielding housing (40) includes: a light-shielding body (41) and a temporary shelf (42). The light-shielding body (41) includes: a first panel, a second panel, and a third panel; The first panel and the second panel are disposed opposite to each other, and the third panel is disposed between the first panel and the second panel; the first panel, the second panel and the third panel form a receiving cavity, which is adapted to place the placement box (10); the opening of the light-shielding box body (11) is opened on the side of the light-shielding box body (11) away from the third panel; The temporary rack (42) is mounted on the light-shielding body (41). The temporary rack (42) has a temporary storage slot. The temporary storage slot is detachably connected to the flushing pipe (30). The temporary rack (42) is suitable for temporarily storing the liquid outlet end of the flushing pipe (30).

8. The slide washing apparatus according to claim 1, characterized in that, The placement box (10) also includes a movable support (15), which is disposed outside the light-shielding box body (11) and is hinged to the light-shielding box body (11).