Valve prosthesis conveying system

Abstract

The utility model relates to the technical field of medical instruments, in particular to a valve prosthesis conveying system which comprises a conveying assembly. The first control part drives the first guide pipe to move in the axial direction; the second guide pipe penetrates through the first guide pipe; the second control part drives the second guide pipe to move in the first guide pipe in the axial direction; the third catheter penetrates through the second catheter, and the valve prosthesis is connected with the far end of the third catheter and contained between the far end of the first catheter and the far end of the second catheter; the third control part drives the third guide pipe to move in the axial direction and rotate in the circumferential direction in the second guide pipe; the fourth catheter is arranged on the second catheter or the first catheter in a penetrating mode, the fourth catheter comprises a catheter piece and a rope arranged on the catheter piece in a penetrating mode, and a ring buckle surrounding the valve prosthesis is formed at the far end of the rope; the fourth control part drives the fourth guide pipe to move in the second guide pipe or the first guide pipe in the axial direction and drives the rope to move in the guide pipe piece in the axial direction. And the recovery of the valve prosthesis can be realized.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical instrument technical field especially, relate to a valve prosthesis delivery system. BACKGROUND

[0002] The human heart is composed of four chambers and four valves, the four chambers are left atrium, left ventricle, right atrium and right ventricle respectively, and the four valves are aortic valve, mitral valve, tricuspid valve and pulmonary valve respectively. Each valve plays the role of one-way valve, controls the flow direction of blood in each chamber.

[0003] Heart valve disease is a heart disease caused by various reasons causing heart valve stenosis or regurgitation. Due to various reasons, the natural heart valve will appear dysfunction, unable to control the one-way flow of blood flow, and the phenomenon of reverse flow of blood flow. The mitral valve is composed of mitral valve leaflet, annulus, chordae tendineae and papillary muscle, and the opening and closing function of the mitral valve is also closely related to the size and function of the left atrium and left ventricle connected thereto. Any part of the above six components can cause dysfunction of the opening and closing function of the mitral valve. Mitral regurgitation has the highest incidence in valvular disease, and with the aging of the population and the increase of the average life expectancy of the population, the incidence is also increasing year by year. Mild mitral regurgitation has no obvious symptoms and no obvious effect on the quality of life of patients. However, severe mitral regurgitation can lead to atrial fibrillation and even heart failure, which has a serious impact on the daily life of patients. Therefore, for moderate and severe mitral regurgitation, timely intervention treatment is needed. The gold standard for treating mitral regurgitation at present is open chest surgery under direct vision, which repairs the mitral valve including the annulus, leaflet and chordae tendineae, or directly replaces the native mitral valve, but this type of surgery has high risk, large trauma and long postoperative recovery period, and is not suitable for high-risk surgical population such as the elderly and patients with complications. With the progress of interventional technology, percutaneous transcatheter mitral valve intervention has developed rapidly, and due to its small trauma and rapid recovery, it is not inferior to surgical treatment effect, and is more and more recognized by doctors and patients.

[0004] Percutaneous transcatheter mitral valve replacement is a new option for patients who are not suitable for surgical thoracotomy and transcatheter repair surgery. The percutaneous path is known as follows: through the apex of the heart, through the femoral artery, through the atrium, through the septum, etc. Among them, the mitral valve replacement product through the septum approach has less trauma and shorter recovery period, and is expected to become the mainstream product of percutaneous transcatheter mitral valve replacement. However, such products need to be guided by DSA or ultrasound to place the valve prosthesis from the femoral vein along the blood vessels to the mitral valve annulus. Compared with traditional surgical open surgery, the doctor cannot directly observe the lesion site and the instrument, and there is a certain delay in the operation of the delivery system on the valve prosthesis, and the valve prosthesis cannot be very accurately positioned and released. Therefore, a delivery system capable of recycling the valve prosthesis is needed to recycle the valve prosthesis into the delivery system for re-release when the valve prosthesis release position is not accurate. Utility model content

[0005] In view of the above defects of the prior art, the technical problem to be solved by the utility model is to provide a valve prosthesis delivery system capable of recycling the valve prosthesis.

[0006] In order to solve the above technical problems, the utility model adopts the following technical scheme:

[0007] The utility model provides a valve prosthesis delivery system, which comprises a delivery assembly, and the delivery assembly comprises: a first catheter; a first control part connected with the proximal end of the first catheter and driving the first catheter to move in the axial direction; a second catheter arranged in the first catheter; a second control part connected with the proximal end of the second catheter and driving the second catheter to move in the axial direction in the first catheter; a third catheter arranged in the second catheter, a valve prosthesis connected with the distal end of the third catheter and accommodated between the distal end of the first catheter and the distal end of the second catheter; a third control part connected with the proximal end of the third catheter and driving the third catheter to move in the axial direction and rotate in the circumferential direction in the second catheter; a fourth catheter arranged in the second catheter or the first catheter, the fourth catheter comprising a catheter piece and a rope arranged in the catheter piece, and the distal end of the rope forming a loop around the valve prosthesis; and a fourth control part connected with the proximal end of the fourth catheter and driving the fourth catheter to move in the axial direction in the second catheter or the first catheter and driving the rope to move in the axial direction in the catheter piece.

[0008] Preferably, the distal end of the first catheter is an enlarged hole section.

[0009] Preferably, the first control part comprises a first outer threaded part, a first inner threaded part, a first knob, a first guide rail and a first housing, the first guide rail is arranged on the first housing along the axial direction of the first catheter, the first knob is rotatably arranged on the first housing and connected with the first inner threaded part, the first outer threaded part is slidably arranged on the first guide rail and threadedly connected with the first inner threaded part, and the proximal end of the first catheter is connected with the first outer threaded part.

[0010] Preferably, the second control part comprises a second outer threaded part, a second inner threaded part, a second knob, a second guide rail and a second housing, the second guide rail is arranged on the second housing along the axial direction of the second catheter, the second knob is rotatably arranged on the second housing and connected with the second inner threaded part, the second outer threaded part is slidably arranged on the second guide rail and threadedly connected with the second inner threaded part, and the proximal end of the second catheter is connected with the second outer threaded part.

[0011] Preferably, the third control part comprises a third outer threaded part, a third inner threaded part, a third knob, a third guide rail, a third housing, a connecting part and a fastening part, the third guide rail is arranged on the third housing along the axial direction of the third catheter, the third knob is rotatably arranged on the third housing and connected with the third inner threaded part, the third outer threaded part is slidably arranged on the third guide rail and threadedly connected with the third inner threaded part, the connecting part is detachably connected with the third outer threaded part through the fastening part, and the proximal end of the third catheter is connected with the connecting part.

[0012] Preferably, the fourth control part comprises a fourth outer threaded part, a fourth inner threaded part, a fourth knob, a fourth guide rail, a fourth housing, a mounting part and a locking part, the mounting part is arranged on the fourth housing, the proximal end of the catheter member is connected with the mounting part, the locking part fixes or loosens the catheter member, the fourth guide rail is arranged on the fourth housing along the axial direction of the fourth catheter, the fourth knob is rotatably arranged on the fourth housing and connected with the fourth inner threaded part, the fourth outer threaded part is slidably arranged on the fourth guide rail and threadedly connected with the fourth inner threaded part, and the proximal end of the rope is connected with the fourth outer threaded part.

[0013] Preferably, the fourth control part further comprises a protection tube, the proximal end of the protection tube is connected with the mounting part, and the distal end of the protection tube is located outside the fourth housing, the locking part acts on the distal end of the protection tube, and the proximal end of the catheter member is arranged in the protection tube and fixed with the protection tube.

[0014] Preferably, the catheter sheath assembly further comprises: a fifth catheter for the first catheter to pass through, the fifth catheter being provided with a pull wire, a distal end of the pull wire being connected with a distal end of the fifth catheter; a fifth control part connected with a proximal end of the pull wire and driving the pull wire to move along an axial direction of the fifth catheter; a sixth catheter provided in the fifth catheter, a distal end of the sixth catheter being a tapered tip; and a sixth control part connected with a proximal end of the sixth catheter and driving the sixth catheter to move along an axial direction in the fifth catheter.

[0015] Preferably, the fifth control part comprises a fifth outer threaded part, a fifth inner threaded part, a fifth knob, a fifth guide rail, a fifth housing and a fixing part, the fixing part being provided on the fifth housing, a proximal end of the fifth catheter being connected with the fixing part, the fifth guide rail being provided on the fifth housing along an axial direction of the fifth catheter, the fifth knob being rotatably provided on the fifth housing and connected with the fifth inner threaded part, the fifth outer threaded part being slidably provided on the fifth guide rail and threadedly connected with the fifth inner threaded part, and a proximal end of the pull wire being connected with the fifth outer threaded part.

[0016] Preferably, the sixth control part comprises a sixth housing, the sixth housing being detachably connected with the fifth control part, and a proximal end of the sixth catheter being connected with the sixth housing.

[0017] Compared with the prior art, the valve prosthesis delivery system has the following advantages:

[0018] The valve prosthesis delivery system can load the valve prosthesis on the delivery system by connecting the valve prosthesis with the distal end of the third catheter and accommodating the valve prosthesis between the distal end of the first catheter and the distal end of the second catheter, can release and recover the valve prosthesis by the mutual cooperation of the first control part driving the first catheter to move along an axial direction, the second control part driving the second catheter to move along an axial direction in the first catheter, the third control part driving the third catheter to move along an axial direction and rotate along a circumferential direction in the second catheter, and the fourth control part driving the fourth catheter to move along an axial direction in the second catheter or the first catheter and driving the rope to move along an axial direction in the catheter member, and can facilitate the release and recovery of the valve prosthesis by the rope of the fourth catheter having a larger or smaller loop at the distal end. Therefore, when the release position of the valve prosthesis is not ideal or the performance of the valve prosthesis is not good after being released, the valve prosthesis can be recovered to the inside of the delivery system for repositioning and releasing or replacing the valve prosthesis. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 is a structure schematic view of the delivery assembly in the valve prosthesis delivery system of the embodiment of the present application.

[0020] Figure 2 is Figure 1 is a structure schematic view of the first catheter in the delivery assembly.

[0021] Figure 3 is Figure 1 A structure diagram of the second catheter in the delivery assembly.

[0022] Figure 4 is Figure 1 A structure diagram of the third catheter in the delivery assembly.

[0023] Figure 5 is Figure 1 A structure diagram of the fourth catheter in the delivery assembly. Figure 5-1 A state of the rope distal end loop being enlarged by extending the catheter member, Figure 5-2 A state of the rope distal end loop being reduced by retracting the catheter member.

[0024] Figure 6 is Figure 1 A sectional view of the delivery assembly.

[0025] Figure 7 is Figure 6 An enlarged view of A part in the delivery assembly.

[0026] Figure 8 is Figure 6 An enlarged view of B part in the delivery assembly.

[0027] Figure 9 is Figure 6 An enlarged view of C part in the delivery assembly.

[0028] Figure 10 is Figure 6 An enlarged view of D part in the delivery assembly.

[0029] Figure 11 is Figure 6 An enlarged view of E part in the delivery assembly.

[0030] Figure 12 is Figure 6 An enlarged view of F part in the delivery assembly.

[0031] Figure 13 is Figure 1 A schematic diagram of the delivery assembly loading the valve prosthesis.

[0032] Figure 14 A schematic diagram of the valve prosthesis delivery system of the embodiment of the present application, when the valve prosthesis is partially released in the human heart.

[0033] Figure 15 A schematic diagram of the valve prosthesis delivery system of the embodiment of the present application, when the valve prosthesis is released in the human heart.

[0034] Figure 16The embodiment of the utility model discloses a valve prosthesis delivery system, the structure schematic drawing of catheter sheath subassembly.

[0035] Figure 17 It is Figure 16 The cutaway schematic diagram of the catheter sheath subassembly shown.

[0036] Figure 18 It is Figure 16 The fifth catheter distal end bending schematic diagram in the catheter sheath subassembly shown.

[0037] Figure 19 It is Figure 16 The fifth shell of the fifth control part and the split schematic diagram of the sixth control part in the catheter sheath subassembly shown.

[0038] Among them, the sign of the drawing is as follows:

[0039] 100 delivery assembly 4a catheter piece

[0040] 1 first catheter 4b rope

[0041] 1a reaming section 4c ring buckle

[0042] 1b first catheter distal end part 40 fourth control part

[0043] 1c first catheter proximal end part 41 fourth outer threaded part

[0044] 10 first control part 42 fourth inner threaded part

[0045] 11 first outer threaded part 43 fourth knob

[0046] 12 first inner threaded part 44 fourth guide rail

[0047] 13 first knob 45 fourth shell

[0048] 14 first guide rail 46 installation part

[0049] 15 first shell 47 locking part

[0050] 2 second catheter 48 protection tube

[0051] 2a second catheter proximal end part 200 catheter sheath subassembly

[0052] 2b second catheter distal end part 5 fifth catheter

[0053] 20 second control part 5a pull wire

[0054] 21 second outer threaded part 50 fifth control part

[0055] 22 second internally threaded component 50 fifth actuating portion

[0056] 23 second knob 51 fifth externally threaded component

[0057] 24 second guide rail 52 fifth internally threaded component

[0058] 25 second housing 53 fifth knob

[0059] 3 third conduit 54 fifth guide rail

[0060] 3a loading section 55 fifth housing

[0061] 30 third actuating portion 56 securing component

[0062] 31 third externally threaded component 57 locking structure

[0063] 32 third internally threaded component 58 protruding structure

[0064] 33 third knob 6 sixth conduit

[0065] 34 third guide rail 6a pointed end

[0066] 35 third housing 60 sixth actuating portion

[0067] 36 connecting component 61 sixth housing

[0068] 37 fastening component 62 recessed structure

[0069] 38 connecting rod 7 valve prosthesis

[0070] 4 fourth conduit 71 internal stent DETAILED DESCRIPTION

[0071] The specific embodiments of the present application will be further described in conjunction with the accompanying drawings. These embodiments are only used to illustrate the present application, and are not intended to limit the present application.

[0072] In the description of the utility model, it is necessary to explain that, the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the utility model. In addition, the terms "first" and "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0073] In the description of the utility model, it should be pointed out that, unless otherwise specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected, it can be mechanically connected, or it can be electrically connected, it can be directly connected, or it can be indirectly connected through an intermediate medium, it can be the communication inside two elements. For ordinary skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0074] In addition, in the description of the utility model, unless otherwise stated, the meaning of "a plurality of" is two or more than two.

[0075] As Figures 1 to 19 In the description of the utility model, for the valve prosthesis delivery system, the "far" side is the side of the valve prosthesis delivery system when used to extend into the human body, and the "far end" is the end close to the far side, and the "near" side is the side of the valve prosthesis delivery system when used outside the human body, and the "near end" is the end close to the near side.

[0076] Referring to Figure 1 The valve prosthesis delivery system of the embodiment comprises a delivery assembly 100, and the delivery assembly 100 comprises a first catheter 1, a first control part 10, a second catheter 2, a second control part 20, a third catheter 3, a third control part 30, a fourth catheter 4 and a fourth control part 40.

[0077] Among them, the first catheter 1 is a braided composite pipe or an extruded pipe or a metal pipe. The first catheter 1 can be uniform hardness, or it can be gradually variable hardness. Referring to Figure 2The first catheter 1 comprises a first catheter proximal end portion 1c and a first catheter distal end portion 1b connected in sequence from proximal end to distal end. The first catheter distal end portion 1b and the first catheter proximal end portion 1c can have the same hardness to realize bending, or the hardness of the first catheter distal end portion 1b and the first catheter proximal end portion 1c can be different, and at least the first catheter distal end portion 1b can realize bending, and the hardness of the first catheter proximal end portion 1c is greater than that of the first catheter distal end portion 1b. Thus, at least the first catheter distal end portion 1b of the first catheter 1 can bend, and the bending radius is preferably between 10 mm and 100 mm, and the length is preferably between 30 mm and 300 mm. In use, the valve prosthesis 7 is accommodated in the distal end of the first catheter 1 (i.e. the distal end of the first catheter distal end portion 1b), which can reduce the bending modulus of the distal end of the valve prosthesis delivery system and facilitate bending in a small anatomical group. Preferably, the distal end of the first catheter 1 is an enlarged-diameter flared section 1a, i.e. the diameter (inner diameter and outer diameter) of the first catheter distal end portion 1b is enlarged to form a flared portion at the flared section 1a. By providing the flared section 1a at the distal end of the first catheter 1, the valve prosthesis 7 can be conveniently accommodated, and the recovery of the valve prosthesis 7 is facilitated.

[0078] The first control portion 10 is connected to the proximal end of the first catheter 1, and the first control portion 10 drives the first catheter 1 to move axially.

[0079] The second catheter 2 is a braided composite tube or an extruded tube or a metal tube. The second catheter 2 is arranged in the first catheter 1 and can move axially in the first catheter 1. Referring to Figure 3 The second catheter 2 comprises a second catheter proximal end portion 2a and a second catheter distal end portion 2b connected in sequence from proximal end to distal end. The second catheter distal end portion 2b and the second catheter proximal end portion 2a can have the same hardness to realize bending, or the hardness of the second catheter distal end portion 2b and the second catheter proximal end portion 2a can be different, and at least the second catheter distal end portion 2b can realize bending, and the hardness of the second catheter proximal end portion 2a is greater than that of the second catheter distal end portion 2b. Thus, at least the second catheter distal end portion 2b of the second catheter 2 can bend, and the bending radius is preferably between 10 mm and 100 mm, and the length is preferably between 30 mm and 300 mm. The second catheter 2 can be a single-lumen tube or a multi-lumen tube.

[0080] The second control portion 20 is connected to the proximal end of the second catheter 2, and the second control portion 20 drives the second catheter 2 to move axially in the first catheter 1. The proximal end of the second catheter 2 penetrates out of the proximal end of the first catheter 1 and is connected to the second control portion 20.

[0081] The third catheter 3 is arranged in the second catheter 2 and can move axially and rotate circumferentially in the second catheter 2. Referring to Figure 4, the distal end of the third catheter 3 is a reduced diameter loading segment 3a for connecting the valve prosthesis 7 to the distal end of the third catheter 3, and the valve prosthesis 7 is contained between the distal end of the first catheter 1 and the distal end of the second catheter 2. The third catheter 3 can be hollow or solid. The second catheter 2 can limit the deformation of the third catheter 3 and prevent the third catheter 3 from losing stability.

[0082] The third control portion 30 is connected to the proximal end of the third catheter 3, and the third control portion 30 drives the third catheter 3 to move axially in the second catheter 2 and to rotate circumferentially in the second catheter 2. The proximal end of the third catheter 3 passes out of the proximal end of the second catheter 2 and is connected to the third control portion 30.

[0083] The fourth catheter 4 is arranged in the second catheter 2 or the first catheter 1. When the second catheter 2 is a multi-lumen tube, the fourth catheter 4 and the third catheter 3 are both arranged in the second catheter 2 and can move axially in the second catheter 2, respectively. When the second catheter 2 is a single-lumen tube, only the third catheter 3 is arranged in the second catheter 2, and the fourth catheter 4 and the second catheter 2 are both arranged in the first catheter 1 and can move axially in the first catheter 1, respectively. When the second catheter 2 is a single-lumen tube, only the third catheter 3 moves axially in the second catheter 2, which can reduce the pressure deformation of the third catheter 3. See Figure 5 The fourth catheter 4 includes a catheter member 4a and a rope 4b. The rope 4b is arranged in the catheter member 4a and can move axially in the catheter member 4a. The distal end of the rope 4b forms a loop 4c, which is used to surround the valve prosthesis 7 and can be placed between the inner stent 71 and the outer stent of the valve prosthesis 7. By moving the rope 4b axially in the catheter member 4a, the loop 4c at the distal end of the rope 4b can be extended out of the catheter member 4a to become larger or retracted into the catheter member 4a to become smaller. When the loop 4c becomes larger, it is beneficial for the release of the valve prosthesis 7. When the loop 4c becomes smaller, the valve prosthesis 7 can be made smaller under the contraction of the loop 4c, which is beneficial for the recovery of the valve prosthesis 7.

[0084] The fourth control portion 40 is connected to the proximal end of the fourth catheter 4, and the fourth control portion 40 drives the fourth catheter 4 to move axially in the second catheter 2 or the first catheter 1 and drives the rope 4b to move axially in the catheter member 4a. The proximal end of the fourth catheter 4 passes out of the proximal end of the second catheter 2 or the proximal end of the first catheter 1 and is connected to the fourth control portion 40.

[0085] The valve prosthesis delivery system of the embodiment can realize the release and recovery of the valve prosthesis 7 through the cooperation of the axial movement of the first catheter 1 driven by the first control part 10, the axial movement of the second catheter 2 in the first catheter 1 driven by the second control part 20, the axial movement of the third catheter 3 in the second catheter 2 driven by the third control part 30, the axial movement of the fourth catheter 4 in the second catheter 2 or the first catheter 1 driven by the fourth control part 40, and the axial movement of the rope 4b in the catheter member 4a driven by the fourth control part 40. When the release position of the valve prosthesis 7 is not ideal or the performance of the valve prosthesis 7 after release is poor, the valve prosthesis 7 can be recovered to the inside of the delivery system for repositioning and release or replacement of the valve prosthesis 7.

[0086] In the embodiment, the axial driving force of the first control part 10 for driving the first catheter 1 to move axially, the axial driving force of the second control part 20 for driving the second catheter 2 to move axially in the first catheter 1, the axial driving force of the third control part 30 for driving the third catheter 3 to move axially in the second catheter 2, the axial driving force of the fourth control part 40 for driving the fourth catheter 4 to move axially in the second catheter 2 or the first catheter 1, and the axial driving force of the fourth control part 40 for driving the rope 4b to move axially in the catheter member 4a can be realized by a threaded pair driving mechanism or a gear driving mechanism or manual pushing and pulling.

[0087] Referring to Figure 1 , Figure 6 and Figure 7 , in the embodiment, preferably, the first control part 10 comprises a first outer threaded part 11, a first inner threaded part 12, a first knob 13, a first guide rail 14 and a first housing 15. The first guide rail 14 is arranged on the first housing 15 along the axial direction of the first catheter 1, and the first guide rail 14 is fixed to the first housing 15. The first knob 13 is rotatably arranged on the first housing 15 and connected with the first inner threaded part 12, the first knob 13 is fixed to the first inner threaded part 12, and the first inner threaded part 12 is provided with internal threads. The first outer threaded part 11 is slidably arranged on the first guide rail 14 and threadedly connected with the first inner threaded part 12, the first outer threaded part 11 is provided with external threads, and the first outer threaded part 11 is connected with the first inner threaded part 12 through the cooperation of the external threads and the internal threads. The proximal end of the first catheter 1 is connected with the first outer threaded part 11, and the proximal end of the first catheter 1 is fixed to the first outer threaded part 11. Rotating the first knob 13 drives the first inner threaded part 12 to rotate and drives the first outer threaded part 11 to move, the first outer threaded part 11 converts the rotary motion into linear motion along the axial direction of the first guide rail 14 under the limitation of the first guide rail 14, and drives the first catheter 1 to move axially, thereby realizing the axial movement of the first catheter 1 driven by the first control part 10.

[0088] Referring to Figure 1 , Figure 6 and Figure 8 In this embodiment, preferably, the second operating part 20 comprises a second outer threaded part 21, a second inner threaded part 22, a second knob 23, a second guide rail 24 and a second housing 25. The second guide rail 24 is arranged on the second housing 25 along the axial direction of the second catheter 2, and the second guide rail 24 is fixed to the second housing 25. The second knob 23 is rotatably arranged on the second housing 25 and connected to the second inner threaded part 22, the second knob 23 is fixed to the second inner threaded part 22, and the second inner threaded part 22 is provided with internal threads. The second outer threaded part 21 is slidably arranged on the second guide rail 24 and threadedly connected to the second inner threaded part 22, the second outer threaded part 21 is provided with external threads, and the second outer threaded part 21 is connected to the second inner threaded part 22 through the cooperation of the external threads and the internal threads. The proximal end of the second catheter 2 is connected to the second outer threaded part 21, and the proximal end of the second catheter 2 is fixed to the second outer threaded part 21. When the second knob 23 is rotated, the second inner threaded part 22 is driven to rotate, thereby driving the second outer threaded part 21 to move. The second outer threaded part 21 converts the rotary motion into linear motion along the axial direction of the second guide rail 24 under the restriction of the second guide rail 24, and drives the second catheter 2 to move along the axial direction, thereby realizing the driving of the second catheter 2 to move along the axial direction by the second operating part 20.

[0089] In this embodiment, the second housing 25 and the first housing 15 can be one part connected as a whole, or can be two independent parts. The second guide rail 24 and the first guide rail 14 can be one part connected as a whole, or can be two independent parts.

[0090] Referring to Figure 1 , Figure 6 , Figure 9 and Figure 10In the embodiment, preferably, the third control part 30 comprises a third outer threaded part 31, a third inner threaded part 32, a third knob 33, a third guide rail 34, a third housing 35, a connecting part 36 and a fastening part 37. The third guide rail 34 is arranged on the third housing 35 along the axial direction of the third catheter 3, and the third guide rail 34 is fixed with the third housing 35. The third knob 33 is rotatably arranged on the third housing 35 and connected with the third inner threaded part 32, the third knob 33 is fixed with the third inner threaded part 32, and the third inner threaded part 32 is provided with internal threads. The third outer threaded part 31 is slidably arranged on the third guide rail 34 and threadedly connected with the third inner threaded part 32, the third outer threaded part 31 is provided with external threads, and the third outer threaded part 31 is connected with the third inner threaded part 32 through the cooperation of the external threads and the internal threads. The connecting part 36 is detachably connected with the third outer threaded part 31 through the fastening part 37, and one end of the third outer threaded part 31 extends out of the third housing 35 to facilitate the connection with the connecting part 36. The proximal end of the third catheter 3 is connected with the connecting part 36, and the proximal end of the third catheter 3 is fixed with the connecting part 36. When the fastening part 37 connects and locks the connecting part 36 with the third outer threaded part 31, rotating the third knob 33 drives the third inner threaded part 32 to rotate and drives the third outer threaded part 31 to move, the third outer threaded part 31 converts the rotary motion into linear motion along the axial direction of the third guide rail 34 under the limitation of the third guide rail 34, and the fastening part 37 and the connecting part 36 move synchronously, the third catheter 3 moves along the axial direction under the drive of the connecting part 36, so as to realize the axial movement of the third catheter 3 in the second catheter 2 driven by the third control part 30. When the fastening part 37 is loosened, the connecting part 36 is no longer connected with the third outer threaded part 31, and rotating the connecting part 36 drives the third catheter 3 to rotate, so as to realize the circumferential rotation of the third catheter 3 in the second catheter 2 driven by the third control part 30.

[0091] In the embodiment, preferably, the third housing 35 of the third control part 30 is connected and fixed with the second outer threaded part 21 of the second control part 20 through the connecting rod 38. When the second outer threaded part 21 moves along the second guide rail 24 to drive the second catheter 2 to move along the axial direction by rotating the second knob 23, the second outer threaded part 21 simultaneously drives the third housing 35 of the third control part 30 to move, so that the third control part 30 as a whole drives the third catheter 3 to move synchronously with the second outer threaded part 21, thereby realizing the axial movement of the third catheter 3 and the second catheter 2 synchronously only by rotating the second knob 23, which can facilitate the loading and recovery of the valve prosthesis 7. Rotating the third knob 33 when the fastening part 37 is locked can realize the axial movement of the third catheter 3 in the second catheter 2, so as to facilitate the release and recovery of the valve prosthesis 7.

[0092] Referring to Figure 1 , Figure 6 ,Figure 11 And Figure 12 In this embodiment, preferably, the fourth operating part 40 comprises a fourth outer threaded part 41, a fourth inner threaded part 42, a fourth knob 43, a fourth guide rail 44, a fourth housing 45, a mounting part 46 and a locking part 47. The mounting part 46 is arranged on the fourth housing 45, and the mounting part 46 is fixed with the fourth housing 45. The proximal end of the catheter part 4a of the fourth catheter 4 is connected with the mounting part 46, and the proximal end of the catheter part 4a is fixed with the mounting part 46. The locking part 47 fixes or loosens the catheter part 4a. When the locking part 47 fixes the catheter part 4a, the catheter part 4a cannot move axially. When the locking part 47 loosens the catheter part 4a, the catheter part 4a can move axially. The fourth guide rail 44 is arranged on the fourth housing 45 along the axial direction of the fourth catheter 4, and the fourth guide rail 44 is fixed with the fourth housing 45. The fourth knob 43 is rotatably arranged on the fourth housing 45 and connected with the fourth inner threaded part 42, and the fourth knob 43 is fixed with the fourth inner threaded part 42. The fourth inner threaded part 42 is provided with internal threads. The fourth outer threaded part 41 is slidably arranged on the fourth guide rail 44 and threadedly connected with the fourth inner threaded part 42. The fourth outer threaded part 41 is provided with external threads, and the fourth outer threaded part 41 is connected with the fourth inner threaded part 42 through the cooperation of the external threads and the internal threads. The proximal end of the rope 4b is connected with the fourth outer threaded part 41, and the proximal end of the rope 4b is fixed with the fourth outer threaded part 41. When the locking part 47 loosens the catheter part 4a, the fourth catheter 4 can be moved as a whole along the axial direction by the fourth operating part 40 as a whole by pushing and pulling the fourth housing 45 of the fourth operating part 40, so as to realize the driving of the fourth catheter 4 in the second catheter 2 or the first catheter 1 along the axial direction by the fourth operating part 40. When the locking part 47 fixes the catheter part 4a, the catheter part 4a does not move. When the fourth knob 43 is rotated, the fourth inner threaded part 42 is driven to rotate, and the fourth outer threaded part 41 is driven to move. The fourth outer threaded part 41 converts the rotary motion into linear motion along the axial direction of the fourth guide rail 44 under the limitation of the fourth guide rail 44, and drives the rope 4b to move axially, so as to realize the driving of the rope 4b in the catheter part 4a along the axial direction by the fourth operating part 40.

[0093] In this embodiment, preferably, the locking part 47 of the fourth operating part 40 is arranged on the side surface of the connecting rod 38. The fourth catheter 4 penetrates into the connecting rod 38 from the side surface of the connecting rod 38, and penetrates into the second catheter 2 or the first catheter 1. The locking part 47 fixes or loosens the catheter part 4a by pressing or leaving the catheter part 4a of the fourth catheter 4. When the locking part 47 fixes the catheter part 4a, the fourth operating part 40 is fixed with the connecting rod 38. At this time, the fourth operating part 40 moves along with the connecting rod 38 by rotating the second knob 23, so as to drive the fourth catheter 4 to move along the axial direction synchronously.

[0094] In the embodiment, preferably, the fourth operating part 40 further comprises a protection tube 48, the proximal end of the protection tube 48 is connected with the mounting part 46, the proximal end of the protection tube 48 is fixed with the mounting part 46, the distal end of the protection tube 48 is located outside the fourth housing 45, the locking part 47 acts on the distal end of the protection tube 48, and the proximal end of the catheter member 4a is arranged in the protection tube 48 and fixed with the protection tube 48. Thus, the locking part 47 directly acts on the protection tube 48 and indirectly acts on the catheter member 4a, and the catheter member 4a can be protected.

[0095] The working principle of the delivery assembly 100 of the valve prosthesis delivery system in the embodiment is as follows.

[0096] In the initial state, referring to Figure 1 , the distal end of the second catheter 2 extends out of the distal end of the first catheter 1, the distal end of the loading segment 3a of the third catheter 3 extends out of the distal end of the second catheter 2, the distal end of the catheter member 4a of the fourth catheter 4 extends out of the distal end of the second catheter 2 or the first catheter 1, and the loop buckle 4c at the distal end of the rope 4b extends out of the distal end of the catheter member 4a.

[0097] When the valve prosthesis 7 is loaded, the valve prosthesis 7 is connected with the distal end of the loading segment 3a of the third catheter 3, and the loop buckle 4c at the distal end of the rope 4b is arranged between the inner stent 71 and the outer stent of the valve prosthesis 7; the locking part 47 is loosened, the locking part 47 is loosened, the fourth housing 45 of the fourth operating part 40 is pulled, the fourth catheter 4 is axially moved in the second catheter 2 or the first catheter 1, the distal end of the fourth catheter 4 is retracted into the distal end of the second catheter 2 or the first catheter 1; the locking part 47 is locked, the locking part 47 is fixed, the fourth knob 43 is rotated, the rope 4b is axially moved in the catheter member 4a, the loop buckle 4c at the distal end of the rope 4b is retracted into the distal end of the catheter member 4a and becomes smaller, so as to shrink and constrain the valve prosthesis 7; the first knob 13 is rotated, the first catheter 1 is axially moved, the second knob 23 is rotated, the second catheter 2 and the third catheter 3 are synchronously axially moved in the first catheter 1 and drive the fourth catheter 4 to synchronously move, so that the distal end of the third catheter 3 and the second catheter 2 is retracted into the distal end of the first catheter 1, and the valve prosthesis 7 is contained between the distal end of the first catheter 1 and the distal end of the second catheter 2. Thus, the loading of the valve prosthesis 7 is completed, and the state of the valve prosthesis 7 after the loading is completed is shown in Figure 13 .

[0098] When the valve prosthesis 7 is released in the human heart, the first knob 13 is rotated to drive the first catheter 1 to move axially towards the proximal end, while the second knob 23 is rotated to drive the second catheter 2 and the third catheter 3 to move axially towards the distal end in the first catheter 1 synchronously and drive the fourth catheter 4 to move synchronously, so that the distal ends of the second catheter 2 and the third catheter 3 extend out of the distal end of the first catheter 1; the fastening component 37 is locked to connect and lock the connecting component 36 with the third external threaded component 31, the third knob 33 is rotated to drive the third catheter 3 to move axially towards the distal end in the second catheter 2, so that the distal end of the third catheter 3 pushes the valve prosthesis 7 to extend out of the distal end of the second catheter 2; the fastening component 37 is unlocked, so that the connecting component 36 is no longer connected with the third external threaded component 31, the connecting component 36 is rotated to drive the third catheter 3 to rotate circumferentially in the second catheter 2, so as to be positioned to the release position; the locking component 47 is unlocked, so that the locking component 47 unlocks the catheter member 4a, the fourth housing 45 of the fourth control component 40 is pulled to drive the fourth catheter 4 to move axially towards the distal end in the second catheter 2 or the first catheter 1, so that the distal end of the fourth catheter 4 extends out of the distal end of the second catheter 2 or the first catheter 1; the locking component 47 is locked, so that the locking component 47 fixes the catheter member 4a, the fourth knob 43 is rotated to drive the rope 4b to move axially towards the distal end in the catheter member 4a, so that the loop buckle 4c at the distal end of the rope 4b extends out of the distal end of the catheter member 4a and becomes larger, thereby unlocking the valve prosthesis 7, and the valve prosthesis 7 is released. The state of the valve prosthesis 7 when partially released is shown in FIG. 8. Figure 14

[0099] When the inner stent 71 of the valve prosthesis 7 is released, the blood flow dynamics of the patient's heart needs to be checked, if the blood flow dynamics is found to be abnormal or unstable, the valve prosthesis 7 needs to be retrieved into the delivery assembly 100 of the delivery system for replacement. When the release position of the valve prosthesis 7 is found to be not ideal, the valve prosthesis 7 can also be retrieved into the delivery assembly 100 of the delivery system by operating the delivery assembly 100, and then repositioned for release, allowing the opportunity for secondary operation. When the valve prosthesis 7 is retrieved, the valve prosthesis 7 is preferably pulled to the left atrium for retrieval, or can be retrieved in situ.

[0100] ​When the valve prosthesis 7 is retrieved, the locking fastening component 37 is unlocked, the connecting component 36 is connected with and locked to the third outer threaded component 31 by the fastening component 37, the third knob 33 is rotated to drive the third catheter 3 to move axially towards the proximal end in the second catheter 2, so that the distal end of the third catheter 3 is withdrawn into the distal end of the second catheter 2; the locking component 47 is unlocked, the fourth housing 45 of the fourth operating part 40 is pulled to drive the fourth catheter 4 to move axially towards the proximal end in the second catheter 2 or the first catheter 1, so that the distal end of the fourth catheter 4 is withdrawn into the distal end of the second catheter 2 or the first catheter 1; the locking component 47 is locked, the fourth knob 43 is rotated to drive the rope 4b to move axially towards the proximal end in the catheter member 4a, so that the loop buckle 4c at the distal end of the rope 4b is withdrawn into the distal end of the catheter member 4a to become smaller, thereby shrinking and restraining the valve prosthesis 7; the second knob 23 is rotated to drive the second catheter 2 and the third catheter 3 to move axially towards the proximal end in the first catheter 1 synchronously and drive the fourth catheter 4 to move synchronously, while the first knob 13 is rotated to drive the first catheter 1 to move axially towards the distal end, so that the distal ends of the third catheter 3 and the second catheter 2 are withdrawn into the distal end of the first catheter 1, and the valve prosthesis 7 is accommodated between the distal end of the first catheter 1 and the distal end of the second catheter 2. Thus, the retrieval of the valve prosthesis 7 is completed. The retrieval process of the valve prosthesis 7 is shown in Figure 15 .

[0101] Referring to Figure 16 and Figure 17 , the valve prosthesis delivery system of the embodiment further comprises a catheter sheath assembly 200, which comprises a fifth catheter 5, a fifth operating part 50, a sixth catheter 6 and a sixth operating part 60.

[0102] The fifth catheter 5 is provided for the first catheter 1 to pass through, and a pull wire 5a is arranged on the fifth catheter 5, with the distal end of the pull wire 5a connected with the distal end of the fifth catheter 5. The fifth catheter 5 is preferably a woven composite tube, and the pull wire 5a is arranged in the middle layer of the tube wall of the fifth catheter 5, with the distal end of the pull wire 5a fixed with the distal end of the fifth catheter 5. When the pull wire 5a is driven to move axially along the fifth catheter 5, the distal end of the fifth catheter 5 can be bent under the action of the pull wire 5a, as shown in Figure 18 . The bending angle of the distal end of the fifth catheter 5 is between 90° and 360°. The fifth operating part 50 is connected with the proximal end of the pull wire 5a, and the fifth operating part 50 drives the pull wire 5a to move axially along the fifth catheter 5.

[0103] The sixth catheter 6 is arranged in the fifth catheter 5, and the distal end of the sixth catheter 6 is a tapered tip 6a, which is easier to enter the human body tissue. The sixth operating part 60 is connected with the proximal end of the sixth catheter 6, and the sixth operating part 60 drives the sixth catheter 6 to move axially in the fifth catheter 5.

[0104] The catheter sheath assembly 200 is used to assist and guide the catheter of the delivery assembly 100 into the human body. In use, the sixth catheter 6 can be first arranged in the fifth catheter 5, and the distal tip 6a of the sixth catheter 6 is extended out of the distal end of the fifth catheter 5; then the fifth catheter 5 and the sixth catheter 6 are synchronously sent into the human body, and through the piercing and guiding action of the distal tip 6a of the sixth catheter 6, the fifth catheter 5 can be more easily sent into the human tissue; after the fifth catheter 5 is sent to the heart of the human body, the sixth catheter 6 is driven to move axially along the proximal end of the fifth catheter 5 by the sixth control part 60, so that the sixth catheter 6 is withdrawn from the fifth catheter 5; then the catheter (the first catheter 1, the second catheter 2, the third catheter 3 and the fourth catheter 4 arranged in the first catheter 1) of the delivery assembly 100 can be arranged in the fifth catheter 5 to enter the heart of the human body. The fifth control part 50 drives the pull wire 5a to move axially along the fifth catheter 5, so that the distal end of the fifth catheter 5 is bent under the action of the pull wire 5a, which can facilitate the positioning of the distal end of the delivery assembly 100 to the release position of the valve prosthesis 7.

[0105] Referring to Figure 16 and Figure 17 In the embodiment, preferably, the fifth control part 50 comprises a fifth outer threaded part 51, a fifth inner threaded part 52, a fifth knob 53, a fifth guide rail 54, a fifth housing 55 and a fixing part 56. The fixing part 56 is arranged on the fifth housing 55, and the fixing part 56 is fixed with the fifth housing 55. The proximal end of the fifth catheter 5 is connected with the fixing part 56, and the proximal end of the fifth catheter 5 is fixed with the fixing part 56. The fifth guide rail 54 is arranged on the fifth housing 55 along the axial direction of the fifth catheter 5, and the fifth guide rail 54 is fixed with the fifth housing 55. The fifth knob 53 is rotatably arranged on the fifth housing 55 and connected with the fifth inner threaded part 52, and the fifth knob 53 is fixed with the fifth inner threaded part 52. The fifth inner threaded part 52 is provided with an inner thread. The fifth outer threaded part 51 is slidably arranged on the fifth guide rail 54 and threadedly connected with the fifth inner threaded part 52. The fifth outer threaded part 51 is provided with an outer thread, and the fifth outer threaded part 51 is connected with the fifth inner threaded part 52 through the cooperation of the outer thread and the inner thread. The proximal end of the pull wire 5a is connected with the fifth outer threaded part 51, and the proximal end of the pull wire 5a is fixed with the fifth outer threaded part 51. Preferably, the proximal end of the pull wire 5a can be connected and fixed with the fifth outer threaded part 51 through the locking structure 57. When the fifth knob 53 is rotated, the fifth inner threaded part 52 is rotated to drive the fifth outer threaded part 51 to move. The fifth outer threaded part 51 converts the rotary motion into linear motion along the axial direction of the fifth guide rail 54 under the limitation of the fifth guide rail 54, and drives the pull wire 5a to move axially, so as to realize the driving of the pull wire 5a by the fifth control part 50 to move axially along the fifth catheter 5, and the distal end of the fifth catheter 5 is bent under the action of the pull wire 5a.

[0106] Referring to Figure 16 ,Figure 17 and Figure 19 In this embodiment, preferably, the sixth operating part 60 comprises a sixth housing 61, which is detachably connected with the fifth operating part 50. The proximal end of the sixth catheter 6 is connected with the sixth housing 61, and is fixed with the sixth housing 61. When the sixth housing 61 is connected and fixed with the fifth operating part 50, the fifth operating part 50 can drive the fifth catheter 5, the sixth housing 61 and the sixth catheter 6 to move along the axis as a whole by pushing and pulling the fifth operating part 50, so as to realize the synchronous movement of the fifth catheter 5 and the sixth catheter 6 along the axis. When the sixth housing 61 is detached from the fifth operating part 50, the sixth catheter 6 can move along the axis in the fifth catheter 5 by pushing and pulling the sixth housing 61, so as to realize the movement of the sixth operating part 60 driving the sixth catheter 6 to move along the axis in the fifth catheter 5.

[0107] In this embodiment, the sixth housing 61 of the sixth operating part 60 is detachably connected with the fifth housing 55 of the fifth operating part 50. Preferably, the detachable connection between the sixth housing 61 and the fifth housing 55 is realized by clamping cooperation. For example, a recess structure 62 can be arranged on the sixth housing 61, and a corresponding protrusion structure 58 can be arranged on the fifth housing 55. The protrusion structure 58 and the recess structure 62 are adapted to form clamping cooperation, and the clamping cooperation between the protrusion structure 58 and the recess structure 62 fixes the sixth housing 61 and the fifth housing 55 along the axis and the circumference, so as to ensure the reliability of the connection between the sixth housing 61 and the fifth housing 55. At the same time, the clamping cooperation between the protrusion structure 58 and the recess structure 62 is easy to detach, which facilitates the detachment of the sixth housing 61 and the fifth housing 55.

[0108] The above only describes the preferred embodiments of the present application, and it should be pointed out that for ordinary skilled in the art, without departing from the technical principles of the present application, a number of improvements and replacements can be made, which should also be considered as the protection scope of the present application.

Claims

1. A valve prosthesis delivery system, characterized in that, Includes a conveying assembly (100), the conveying assembly (100) comprising: First catheter (1); The first control unit (10) is connected to the proximal end of the first catheter (1) and drives the first catheter (1) to move axially. The second catheter (2) is inserted through the first catheter (1); The second control unit (20) is connected to the proximal end of the second conduit (2) and drives the second conduit (2) to move axially within the first conduit (1); The third catheter (3) is inserted through the second catheter (2), and the valve prosthesis (7) is connected to the distal end of the third catheter (3) and accommodated between the distal end of the first catheter (1) and the distal end of the second catheter (2). The third control unit (30) is connected to the proximal end of the third conduit (3) and drives the third conduit (3) to move axially and rotate circumferentially within the second conduit (2); A fourth catheter (4) is inserted through the second catheter (2) or the first catheter (1). The fourth catheter (4) includes a catheter element (4a) and a cord (4b) inserted through the catheter element (4a). The distal end of the cord (4b) forms a loop (4c) around the valve prosthesis (7). The fourth control unit (40) is connected to the proximal end of the fourth conduit (4) and drives the fourth conduit (4) to move axially within the second conduit (2) or the first conduit (1) and drives the rope (4b) to move axially within the conduit member (4a).

2. The valve prosthesis delivery system according to claim 1, characterized in that, The distal end of the first conduit (1) is an enlarged section (1a) with an increased diameter.

3. The valve prosthesis delivery system according to claim 1, characterized in that, The first control unit (10) includes a first external thread component (11), a first internal thread component (12), a first knob (13), a first guide rail (14), and a first housing (15). The first guide rail (14) is disposed on the first housing (15) along the axial direction of the first conduit (1). The first knob (13) is rotatably disposed on the first housing (15) and connected to the first internal thread component (12). The first external thread component (11) is slidably disposed on the first guide rail (14) and threadedly connected to the first internal thread component (12). The proximal end of the first conduit (1) is connected to the first external thread component (11).

4. The valve prosthesis delivery system according to claim 1, characterized in that, The second control unit (20) includes a second external thread component (21), a second internal thread component (22), a second knob (23), a second guide rail (24), and a second housing (25). The second guide rail (24) is disposed on the second housing (25) along the axial direction of the second conduit (2). The second knob (23) is rotatably disposed on the second housing (25) and connected to the second internal thread component (22). The second external thread component (21) is slidably disposed on the second guide rail (24) and threadedly connected to the second internal thread component (22). The proximal end of the second conduit (2) is connected to the second external thread component (21).

5. The valve prosthesis delivery system according to claim 1, characterized in that, The third control unit (30) includes a third external thread component (31), a third internal thread component (32), a third knob (33), a third guide rail (34), a third housing (35), a connecting component (36), and a fastening component (37). The third guide rail (34) is disposed on the third housing (35) along the axial direction of the third conduit (3). The third knob (33) is rotatably disposed on the third housing (35) and connected to the third internal thread component (32). The third external thread component (31) is slidably disposed on the third guide rail (34) and threadedly connected to the third internal thread component (32). The connecting component (36) is detachably connected to the third external thread component (31) through the fastening component (37). The proximal end of the third conduit (3) is connected to the connecting component (36).

6. The valve prosthesis delivery system according to claim 1, characterized in that, The fourth control unit (40) includes a fourth external thread component (41), a fourth internal thread component (42), a fourth knob (43), a fourth guide rail (44), a fourth housing (45), a mounting component (46), and a locking component (47). The mounting component (46) is disposed on the fourth housing (45). The proximal end of the conduit (4a) is connected to the mounting component (46). The locking component (47) fixes or releases the conduit (4a). The fourth guide rail (44) is disposed on the fourth housing (45) along the axial direction of the fourth conduit (4). The fourth knob (43) is rotatably disposed on the fourth housing (45) and connected to the fourth internal thread component (42). The fourth external thread component (41) is slidably disposed on the fourth guide rail (44) and threadedly connected to the fourth internal thread component (42). The proximal end of the rope (4b) is connected to the fourth external thread component (41).

7. The valve prosthesis delivery system according to claim 6, characterized in that, The fourth control unit (40) further includes a protective tube (48), the proximal end of which is connected to the mounting component (46), and the distal end is located outside the fourth housing (45). The locking component (47) acts on the distal end of the protective tube (48), and the proximal end of the conduit (4a) passes through the protective tube (48) and is fixed to the protective tube (48).

8. The valve prosthesis delivery system according to any one of claims 1 to 7, characterized in that, It also includes a catheter sheath assembly (200), the catheter sheath assembly (200) comprising: A fifth catheter (5) is provided for the first catheter (1) to pass through. A pull wire (5a) is provided on the fifth catheter (5), and the distal end of the pull wire (5a) is connected to the distal end of the fifth catheter (5). The fifth control unit (50) is connected to the proximal end of the pull wire (5a) and drives the pull wire (5a) to move along the axial direction of the fifth conduit (5); The sixth catheter (6) is inserted through the fifth catheter (5), and the distal end of the sixth catheter (6) is a tip (6a) with a gradually decreasing diameter; The sixth control unit (60) is connected to the proximal end of the sixth catheter (6) and drives the sixth catheter (6) to move axially within the fifth catheter (5).

9. The valve prosthesis delivery system according to claim 8, characterized in that, The fifth control unit (50) includes a fifth external thread component (51), a fifth internal thread component (52), a fifth knob (53), a fifth guide rail (54), a fifth housing (55), and a fixing component (56). The fixing component (56) is disposed on the fifth housing (55). The proximal end of the fifth conduit (5) is connected to the fixing component (56). The fifth guide rail (54) is disposed on the fifth housing (55) along the axial direction of the fifth conduit (5). The fifth knob (53) is rotatably disposed on the fifth housing (55) and connected to the fifth internal thread component (52). The fifth external thread component (51) is slidably disposed on the fifth guide rail (54) and threadedly connected to the fifth internal thread component (52). The proximal end of the pull wire (5a) is connected to the fifth external thread component (51).

10. The valve prosthesis delivery system according to claim 8, characterized in that, The sixth control unit (60) includes a sixth housing (61), which is detachably connected to the fifth control unit (50), and the proximal end of the sixth conduit (6) is connected to the sixth housing (61).

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