Tangential flow top layer clamp and tangential flow filtering device

Abstract

The utility model relates to the technical field of filtering, and discloses a tangential flow top layer clamp and a tangential flow filtering device.The tangential flow top layer clamp comprises a plate body, and a liquid inlet hole and a liquid outlet hole are formed in the plate body; the first gasket is arranged on the plate body, a filtering channel used for communicating the liquid inlet hole with the liquid outlet hole is formed in the first gasket, the filtering channel is a linear channel comprising a plurality of bent structures, and feed liquid circulates in the filtering channel; the tangential flow filtering device comprises the tangential flow top-layer clamp, a bottom-layer clamp is arranged on one side of the top-layer clamp, and a filter membrane is arranged between the bottom-layer clamp and the top-layer clamp. A filtrate cavity and a filtrate opening which are communicated with each other are formed in the bottom-layer clamp; and feed liquid passes through the filtrate cavity and the filtrate opening after penetrating through the membrane. The device has the technical effect of improving the filtering efficiency of the feed liquid.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the filter technical field, concretely relates to a tangential flow top layer clamp and tangential flow filter device. BACKGROUND

[0002] Life science technology is one of the mainstream directions of future science and technology development, in the life science technology field, usually involve the filtration operation of cell, protein and gene sample, realize separation, purification, concentration, sterilization or virus removal process treatment demand through filtration, in various separation and purification devices, tangential flow filter device is widely applied because of high efficiency, wide application range and other advantages.

[0003] In the related art, the tangential flow filter device includes a top clamp and a bottom clamp, and a membrane package for filtering the feed liquid is clamped between the top clamp and the bottom clamp. The top clamp is provided with a liquid inlet and a liquid outlet hole for sample flow, and a feed liquid channel is formed on the side of the top clamp close to the membrane package.

[0004] During filtration, the feed liquid to be filtered can be pumped into the liquid inlet by a peristaltic pump, and then the feed liquid flows into the feed liquid channel through the liquid inlet. In the feed liquid channel, the feed liquid flows at a high speed along the surface of the filter membrane of the membrane package in a direction parallel to the filter membrane. The feed liquid forms a tangential flow and generates a large transmembrane pressure. The transmembrane pressure promotes the components smaller than the pore size of the filter membrane in the feed liquid to pass through the filter membrane, while the components larger than the pore size of the filter membrane are retained on the surface of the filter membrane. At the same time, the tangential flow of the external liquid makes the retained components flow under the action of the tangential force, avoiding the deposition of the retained components on the surface of the filter membrane and blocking the membrane pores. To improve the filtration efficiency of the tangential flow filter device, the top clamp usually reduces the width and height of the feed liquid channel and increases the number of the feed liquid channel to increase the transmembrane pressure.

[0005] However, the effect of adjusting the width, height and number of the feed liquid channel to improve the filtration efficiency is limited, and the feed liquid filtration efficiency of the tangential flow filter device is not good. INVENTION CONTENTS

[0006] In order to solve the problems of the prior art, the utility model provides a tangential flow top clamp and tangential flow filter device. The linear channel formed by the plurality of bending structures in the filter channel of the top clamp makes the feed liquid form turbulent flow in the filter channel, enhances the shearing action of the feed liquid, and further improves the filtration efficiency of the feed liquid.

[0007] The technical effects achieved by the utility model are realized by the following technical aspects:

[0008] The utility model provides a tangential flow top layer clamp, including the board body, the board body is opened with the liquid inlet hole and the liquid outlet hole, and first gasket is set up on the board body, and the first gasket is opened with the filter channel for the intercommunication of liquid inlet hole and liquid outlet hole, the filter channel is the linear channel including a plurality of bending structure, and the feed liquid is circulated in the filter channel.

[0009] In some implementations, the inner wall of the filter channel is provided with a plurality of convex portions and a plurality of concave portions for forming turbulent flow of the feed liquid in the filter channel, and the convex portions and the concave portions are alternately arranged.

[0010] In some implementations, the surface of the board body in the filter channel is provided with convex points and / or grooves, and the convex points and the grooves are respectively provided with a plurality of convex points and / or grooves.

[0011] In some implementations, the filter channel is a zigzag linear channel.

[0012] In some implementations, the filter channel is an arc linear channel.

[0013] In some implementations, the board body is provided with a first embedding groove, the first gasket is provided with a first embedding portion, the first embedding portion protrudes outwardly from the first gasket, and the first embedding portion is embedded in the first embedding groove.

[0014] The utility model provides a tangential flow filter device, including above-mentioned tangential flow top layer clamp, one side of top layer clamp is provided with bottom layer clamp, and bottom layer clamp and top layer clamp between are provided with filter membrane, wherein, bottom layer clamp is opened with the filter liquid cavity and filter liquid mouth that communicate, and the feed liquid flows through filter liquid cavity and filter liquid mouth after the filter membrane.

[0015] In some implementations, the bottom layer clamp and the filter membrane are provided with a second gasket, and the second gasket is provided with an assembly opening.

[0016] In some implementations, the bottom layer clamp and the second gasket are provided with a support structure for supporting the filter membrane.

[0017] In some implementations, the support structure includes a plurality of support columns and a support sheet, the plurality of support columns are arrayed in the filter liquid cavity, the support sheet is disposed in the assembly opening, the support sheet is provided with a plurality of through holes for filter liquid to pass through, and the support sheet is placed on the support columns.

[0018] In summary, the utility model has at least the following advantages:

[0019] 1. The tangential flow top layer clamp provided by the utility model, when filtering, the feed liquid first enters the filter channel from the liquid inlet hole, the plurality of bending structures of the filter channel make the feed liquid form strong turbulent flow, the generation of the turbulent flow can enhance the shearing action of the feed liquid, thereby reducing the deposition of the filter medium in the feed liquid on the surface of the filter membrane, and the components intercepted by the filter membrane in the feed liquid flow out from the liquid outlet hole. Compared with the top layer clamp of the conventional membrane package, the tangential flow top layer clamp of the utility model can effectively improve the filtration efficiency of the feed liquid.

[0020] 2. The tangential flow filter device provided by the utility model, the top layer clamp and the bottom layer clamp cooperate to clamp the filter membrane, when filtering, the feed liquid is introduced into the liquid inlet hole, the feed liquid flows into the filter channel from the liquid inlet hole, and the feed liquid penetrates the filter membrane at the filter channel to perform filtering. The components smaller than the pore size of the filter membrane in the feed liquid penetrate the filter membrane, while the components larger than the pore size of the filter membrane are intercepted on the surface of the filter membrane, the components intercepted by the filter membrane in the feed liquid flow in the filter channel and form local turbulent flow, the shearing action of the liquid of the intercepted components in the feed liquid is enhanced, the filtration efficiency of the feed liquid is improved, and the filtered filtrate penetrates the filter membrane and flows into the filtrate cavity, and then flows out from the filtrate outlet, and the tangential flow filtration of the feed liquid is completed. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 It is a top view of a tangential flow top layer clamp of a specific embodiment of the utility model.

[0022] Figure 2 It is an explosion schematic view of a tangential flow device of a specific embodiment of the utility model.

[0023] Figure 3 It is a local structure schematic view of a tangential flow top layer clamp of a specific embodiment of the utility model.

[0024] Figure 4 It is a structure schematic view of a tangential flow top layer clamp of embodiment 2 of the utility model.

[0025] Figure 5 It is Figure 4 It is a test result view of each top layer clamp in the embodiment.

[0026] Figure 6 It is a structure schematic view of different curve type cavities in the top layer clamp of embodiment 3 of the utility model.

[0027] Figure 7 It is Figure 6 It is a test result view of each top layer clamp in the embodiment.

[0028] Figure 8 It is a structure schematic view of different cis wave type cavities in the top layer clamp of embodiment 3 of the utility model.

[0029] Figure 9 It is Figure 8The test result diagram of each top layer clamp.

[0030] Figure 10 The structure schematic diagram of the top layer clamp with different groove depths of the embodiment 4 of the utility model.

[0031] Figure 11 For Figure 10 The test result diagram of each top layer clamp.

[0032] Figure 12 The structure schematic diagram of the top layer clamp with different groove numbers of the embodiment 4 of the utility model.

[0033] Figure 13 For Figure 12 The test result diagram of each top layer clamp.

[0034] Figure 14 The structure schematic diagram of the top layer clamp with different arc line type channels of the embodiment 5 of the utility model.

[0035] Figure 15 For Figure 14 The test result diagram of each top layer clamp.

[0036] Figure 16 For Figure 2 The structure schematic diagram of another angle.

[0037] Figure 17 The structure schematic diagram of the bottom layer clamp, the second gasket and the support structure of the embodiment of the utility model.

[0038] Figure 18 For Figure 17 The structure schematic diagram of another angle.

[0039] Markings in the figure:

[0040] 1, plate body; 11, liquid inlet hole; 12, liquid outlet hole; 13, filter channel; 131, convex part; 132, concave part; 133, straight line type cavity; 134, curve type cavity; 14, groove; 141, first embedding slot; 15, first gasket; 151, first embedding part; 2, bottom layer clamp; 21, filtrate cavity; 22, filtrate port; 23, second gasket; 231, assembly port; 232, second embedding part; 24, second embedding slot; 3, filter membrane; 4, support structure; 41, support column; 42, support sheet; 421, through hole; 5, bolt; 51, nut. DETAILED DESCRIPTION

[0041] In order to make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme of the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. The described embodiments are part of the embodiments of the present application, but not all the embodiments.

[0042] Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed present application, but only represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of the present application.

[0043] Embodiment 1:

[0044] Please refer to the drawings Figure 1 and Figure 2 The tangential flow top layer clamp of the present application can cooperate with clamping the tangential flow filter membrane 3 package, improve the filtration efficiency of the tangential flow filtration under the condition of reducing the influence on the flow rate of the feed liquid, and make the tangential flow filter membrane 3 package obtain good filtration effect.

[0045] The tangential flow top layer clamp of the present application comprises a plate body 1, a liquid inlet hole 11 and a liquid outlet hole 12 are through-holed on the plate body 1, specifically, the hole diameter of the liquid inlet hole 11 can be 0.1-100mm, the diameter of the liquid outlet hole 12 can be 0.1-100mm, and the plate body 1 is provided with a joint at the liquid inlet hole 11 and the liquid outlet hole 12, wherein the liquid inlet hole 11 can be connected with a peristaltic pump through the joint, the peristaltic pump pumps the feed liquid to be filtered into the liquid inlet hole 11, and the liquid outlet hole 12 can be connected with a collecting device or a circulating device through the joint to collect or circulate filter liquid.

[0046] One side of the plate body 1 is provided with a first gasket 15, specifically, the first gasket 15 is preferably but not limited to a soft rubber gasket such as a silica gel gasket, the plate body 1 contacts the filter membrane of the membrane package through the first gasket 15, which is beneficial to protect the filter membrane and reduce the possibility of damaging the filter membrane.

[0047] A filter channel 13 for communicating the liquid inlet hole 11 and the liquid outlet hole 12 is formed on the first gasket 15, the first gasket 15 forms a channel for the flow of the feed liquid on the surface of the plate body 1 at the filter channel 13, the filter channel 13 is a linear channel comprising a plurality of bending structures, and the feed liquid flows through the liquid inlet hole 11, the filter channel 13 and the liquid outlet hole 12 in sequence during the filtration process.

[0048] In the preferred embodiment, the overall length L of the filtering channel 13 is 1-1000 cm, the overall width W is 1-1000 cm, and the depth D is 0.1-100 mm. The length, width, and depth of the filtering channel 13 can be adjusted according to the filtering condition of the feed liquid. The filtering channel 13 can form a local turbulent flow, which can improve the filtering efficiency of the feed liquid while reducing the impact on the flow speed of the feed liquid, and the feed liquid flows smoothly.

[0049] As shown in some specific embodiments, the first gasket 15 has an inner wall made of polyurethane, ABS, polyethylene terephthalate, polytetrafluoroethylene, polyvinyl chloride, polyacrylonitrile, polypropylene, polyethylene, polyvinylidene fluoride, cellulose, or silica gel.

[0050] The first gasket 15 is attached to the plate body 1, and the tangential flow top clamp can hold the filter membrane together with the bottom clamp 2. During filtering, the peristaltic pump pumps the feed liquid into the liquid inlet hole 11, and the feed liquid enters the filtering channel 13 through the liquid inlet hole 11. The multiple bending structures formed in the filtering channel 13 cause strong turbulent flow of the feed liquid when it flows through the filtering channel 13, which can enhance the shearing action on the feed liquid. The components in the feed liquid that are trapped by the membrane can flow to the liquid outlet hole 12 under the shearing action in a timely manner, reducing the possibility of deposition of the trapped components on the surface of the filter membrane of the membrane pack. The flowability of the feed liquid is enhanced, thereby improving the filtering efficiency of the feed liquid. The conventional feed liquid channel has limited effect on improving the filtering efficiency by adjusting the width, height, and number. The tangential flow top clamp of the present application can effectively improve the filtering rate of the feed liquid while reducing the impact on the flow speed of the feed liquid by optimizing the structure of the filtering channel 13.

[0051] Embodiment 2:

[0052] The difference between this embodiment and embodiment 1 is that, please refer to the attached Figure 3 In the preferred embodiment, the first plate body 1 is provided with a first embedding groove 141, and the first gasket 15 is provided with a first embedding part 151. The first embedding part 151 is adapted to the first embedding groove 141 and protrudes outwardly from the first gasket 15. When the first gasket 15 is attached to the plate body 1, the first embedding part 151 is embedded in the first embedding groove 141, and the filtering channel 13 is formed on the surface of the plate body 1. The first gasket 15 is detachably connected to the plate body 1 through the first embedding part 151, which can facilitate timely replacement of the first gasket 15 when it is damaged, thereby improving the flexibility of use.

[0053] Please refer to the attached Figure 4In a preferred embodiment, the filtering channel 13 is a zigzag channel comprising a plurality of bending structures, wherein a plurality of linear cavities 133 are formed in the filtering channel 13, and the plurality of linear cavities 133 are arranged in parallel. In some specific embodiments, the number of linear cavities 133 is 4. It can be understood that this is not a specific limitation on the number of linear cavities 133. In other specific embodiments, the number of linear cavities 133 can also be 6, 8, or 10, etc. Figure 4 Fig. 4b shows a top layer clamp with 8 linear cavities 133, Figure 4 Fig. 4c shows a top layer clamp with 6 linear cavities 133, Figure 4 Fig. 4d shows a top layer clamp with 4 linear cavities 133. Further, the width w of the linear cavity 133 is 0.1-30 mm, and the wall width a between the adjacent two linear cavities 133 is 0.1-50 mm. The filtering channel 13 has a reasonable structure layout, which is beneficial to improve the filtering efficiency of the feed liquid.

[0054] Further, Figure 4 Fig. 4a shows a top layer clamp with 4 linear cavities with branches, and the plate body 1 is provided with a branch in the linear cavity 133 of the filtering channel 13. The branch is specifically in the shape of a long strip. The branch can cause the feed liquid flowing in the linear cavity 133 to be branched, which is more beneficial to form a turbulent flow of the feed liquid in the filtering channel 13.

[0055] When a peristaltic pump with a rotation speed of 300 rpm and an ultrafiltration membrane with a molecular weight cut-off of 8 kDa are used for filtering test, please refer to the following Figure 5 Fig. 5a shows a test result diagram of the feed liquid flow rate at the liquid outlet hole 12 of the top layer clamp with 4, 6, 8 linear cavities 133 and the top layer clamp with branches, respectively. Fig. 5b shows a test result diagram of the liquid pressure at the liquid outlet hole 12 of the top layer clamp with 4, 6, 8 linear cavities 133 and the top layer clamp with branches, respectively. Fig. 5c shows a test result diagram of the permeation rate of the filter membrane 3 of the top layer clamp with 4, 6, 8 linear cavities 133 and the top layer clamp with branches, respectively. It can be seen that the different number of linear cavities 133 has little effect on the feed liquid flow rate. When the number of linear cavities 133 is 8, the feed liquid filtering rate of the top layer clamp is increased by 51.5%, and the filtrate filtering rate is proportional to the number of linear cavities 133.

[0056] Example 3:

[0057] The difference between this embodiment and Example 2 is that, please refer to Figure 6The inner wall of the filter channel 13 of the embodiment is provided with a plurality of protrusions 131 and a plurality of recesses 132, which are arranged alternately to form turbulent flow of the feed liquid in the filter channel 13. As shown in some specific embodiments, the protrusions 131 and the recesses 132 are arranged to form a plurality of curved cavities 134 in the filter channel 13, and the plurality of curved cavities 134 are arranged in parallel.

[0058] Specifically, the curved cavities 134 can be a mixed channel formed by one or more combinations of a cis wave cavity, a trans wave cavity, a cis zigzag cavity or a trans zigzag cavity, and the number of the curved cavities 134 can be 2-30, such as Figure 6 Fig. 6a shows a top layer clamp of the straight-line cavity 133, Figure 6 Fig. 6b shows a top layer clamp of the cis zigzag cavity, Figure 6 Fig. 6c shows a top layer clamp of the cis wave cavity, Figure 6 Fig. 6d shows a top layer clamp of the trans wave cavity.

[0059] When a peristaltic pump with a rotation speed of 300 rpm and an ultrafiltration membrane with a molecular weight cut-off of 8 kDa are used for the filtration test, please refer to the attached Figure 7 Fig. 7a shows the test results of the feed liquid flow rate at the outlet hole 12 of the top layer clamp of each shape cavity, Fig. 7b shows the test results of the liquid pressure at the outlet hole 12 of the top layer clamp of each shape cavity, and Fig. 7c shows the test results of the permeation rate at the filter membrane 3 of the top layer clamp of each shape cavity. It can be seen that, compared with the top layer clamp of the straight-line cavity 133, the top layer clamp of the cis zigzag cavity reduces the flow rate by 2% and increases the filtration efficiency by 50%; the top layer clamp of the trans wave cavity increases the filtration efficiency by 97%; and the top layer clamp of the cis wave cavity reduces the flow rate at the outlet hole 12 by 9% and increases the filtration efficiency by 20%. According to the above experimental results, the top layer clamp can improve the filtration efficiency of the feed liquid in the filter channel 13 by arranging the protrusions 131 and the recesses 132.

[0060] In a preferred embodiment, the amplitude between adjacent protrusions 131 and recesses 132 is 0.1-100 mm, wherein the adjacent protrusions 131 and recesses 132 can constitute a curved surface unit, and a plurality of curved surface units are arranged repeatedly to form the curved cavities 134 in the filter channel 13. Specifically, the number of repeated units of the curved surface unit is 1-100, such as 3, 6 or 9, etc. Please refer to Figure 8 Fig. 8a shows that the number of repeated units of the curved surface unit of the cis wave cavity is 9, Fig. 8b shows that the number of repeated units of the curved surface unit of the cis wave cavity is 6, and Fig. 8c shows that the number of repeated units of the curved surface unit of the cis wave cavity is 3.

[0061] When using a peristaltic pump with a rotation speed of 300 rpm and an ultrafiltration membrane with a molecular weight cut-off of 8 kDa for the filtration test, see Figure 9 , 9a is a diagram of the liquid flow rate test of the top layer of the cis wave-shaped cavity with different numbers of curved units at the liquid outlet hole 12, 9b is a diagram of the liquid pressure test of the top layer of the cis wave-shaped cavity with different numbers of curved units at the liquid outlet hole 12, and 9c is a diagram of the test of the permeation rate of the filter membrane of the top layer of the cis wave-shaped cavity with different numbers of curved units. It can be seen that the number of repeating units of the curved unit has no effect on the liquid flow rate, but has a greater effect on the filtration rate of the feed liquid. Compared with the linear cavity 133, the liquid flow rate in the cis wave-shaped cavity with 9 curved units does not change, and the filtration rate of the feed liquid is increased by 50%. The first gasket 15 can change the transmembrane pressure of the feed liquid in the filtration channel 13 by the arrangement of the convex part 131 and the concave part 132. The increase of the transmembrane pressure of the feed liquid can promote the permeation of the filtrate in the feed liquid through the filter membrane, thereby achieving the effect of improving the filtration rate of the feed liquid.

[0062] Example 4:

[0063] The difference between this embodiment and the above-mentioned embodiments is that, as shown in Figure 10 , the surface of the plate body 1 in the filtration channel 13 is provided with convex points and / or concave grooves 14. In this embodiment, the plate body 1 optimizes the structure of the filtration channel 13 by the arrangement of the concave grooves 14. In other specific embodiments, the plate body 1 can be provided with convex points alone or a mixture of concave grooves 14 and convex points.

[0064] In a preferred embodiment, the shape of the concave groove 14 can be circular, triangular, quadrilateral, pentagonal star, prismatic, hexagonal, octagonal, decagonal, dodecagonal, and the concave groove 14 can be a single shape or a mixture of multiple shapes. It can be understood that this is not a specific limitation on the shape of the concave groove 14, and those skilled in the relevant art can make substitutions on this basis. Specifically, the diameter of the circumscribed circle of the cross-sectional shape of the concave groove 14 is 0.1-100 mm, and the depth of the concave groove 14 is 0.1-100 mm. For example, Figure 10 the diameter of the concave groove 14 shown in 10a is 5 mm, and the depth is 1 mm; Figure 10 the diameter of the concave groove 14 shown in 10b is 5 mm, and the depth is 2 mm; Figure 10 the diameter of the concave groove 14 shown in 10c is 5 mm, and the depth is 3 mm.

[0065] When using a peristaltic pump with a rotation speed of 300 rpm and an ultrafiltration membrane with a molecular weight cut-off of 8 kDa for the filtration test, see Figure 11, 11a is the top layer clamp at the liquid outlet hole 12 of the feed liquid flow test results of each groove 14 depth, 11b is the top layer clamp at the liquid outlet hole 12 of the liquid pressure test results of each groove 14 depth, 11c is the top layer clamp of the filter membrane permeation rate test results of each groove 14 depth. It can be seen that the different groove 14 depths have little effect on the flow rate of the top layer clamp, and the filtration rate of the feed liquid at the filter membrane is increased by 9% to 40%.

[0066] As shown in some specific embodiments, the grooves 14 can be provided with a plurality of grooves 14, and the plurality of grooves 14 are arranged along the flow direction of the feed liquid in the filtration channel 13. The number of grooves 14 can be 1-100. As shown in the accompanying drawings, Figure 12 As shown in the accompanying drawings, the number of grooves 14 in each linear cavity 133 in 12a is 4, the number of grooves 14 in each linear cavity 133 in 12b is 3, and the number of grooves 14 in each linear cavity 133 in 12c is 2.

[0067] When using a peristaltic pump with a rotation speed of 300 rpm and an ultrafiltration membrane with a molecular weight cut-off of 8 kDa for filtration test, see Figure 13 , 13a is the top layer clamp at the liquid outlet hole of the feed liquid flow test results of each groove number, 13b is the top layer clamp at the liquid outlet hole of the liquid pressure test results of each groove number, 13c is the top layer clamp of the filter membrane permeation rate test results of each groove number. It can be seen that different groove 14 numbers have little effect on the flow rate of the feed liquid in the filtration channel 13, and have great effect on the filtration rate of the filtrate. Among them, the top layer clamp has the greatest effect on the filtration rate of the feed liquid when the number of grooves 14 is 3, and the filtration rate of the feed liquid is increased by 40%.

[0068] In a preferred embodiment, a plurality of convex points can be provided, and the plurality of convex points are arranged along the flow direction of the feed liquid in the filtration channel 13. The number of convex points can be 1-100.

[0069] As shown in some specific embodiments, the shape of the convex point can be circular, triangular, quadrilateral, pentagonal star, prismatic, hexagonal, octagonal, decagonal, dodecagonal, and the convex point can be single shape or multiple shapes. Further, the circumscribed circle diameter of the cross-sectional shape of the convex point can be 0.1-100 mm, and the recess depth of the groove 14 can be 0.1-100 mm.

[0070] According to Bernoulli's principle, the sum of the kinetic energy, potential energy and pressure potential energy of unit volume fluid at the cross section of ideal liquid flow pipe is a constant. The greater the flow rate, the smaller the pressure; the smaller the flow rate, the greater the pressure. The setting of the convex point and the groove 14 can reduce the flow rate of the feed liquid in the local area of the filtration channel 13 to increase the transmembrane pressure, thereby further improving the filtration efficiency of the feed liquid.

[0071] Example 5:

[0072] The difference between this embodiment and the above-mentioned embodiments is that, referring to Figure 14 , the filter channel 13 of this embodiment is an arc-shaped channel including multiple bending structures, as shown in some specific embodiments, such as Figure 14 , the filter channel 13 can be coiled on the first gasket 15, and the filter channel surrounds to form multiple ring-shaped cavities with increasing radii, or as shown in Figure 14 , the filter channel 13 can be folded back and forth to form multiple S-shaped cavities, and the multiple S-shaped cavities are connected in sequence. It can be understood that this is not a specific limitation on the bending mode of the filter channel 13, and those skilled in the related art can select according to the actual filtering situation. The arc-shaped channel with multiple bending structures can form turbulent flow of the feed liquid in the filter channel 13, thereby improving the filtration efficiency of the feed liquid.

[0073] When a peristaltic pump with a rotation speed of 300 rpm and an ultrafiltration membrane with a molecular weight cut-off of 8 kDa are used for filtration test, referring to Figure 15 , 15a is a feed liquid flow test result diagram of the top layer clamp containing each arc-shaped channel at the liquid outlet hole, 15b is a liquid pressure test result diagram of the top layer clamp containing each arc-shaped channel at the liquid outlet hole, and 15c is a filter membrane permeation rate test result diagram of the top layer clamp containing each arc-shaped channel. It can be seen that the arc-shaped cavities in the top layer clamp have little effect on the flow rate of the feed liquid and greatly improve the filtration efficiency. The filtration rate of the top layer clamp with ring-shaped cavities is increased by 53%, and the filtration rate of the top layer clamp with S-shaped cavities is increased by 33%.

[0074] Embodiment 6:

[0075] This embodiment is based on the above-mentioned embodiments and provides a tangential flow filtration device, referring to Figure 16 .

[0076] A tangential flow filtration device includes the above-mentioned tangential flow top layer clamp. The bottom layer clamp 2 is arranged on one side of the plate body 1 close to the first gasket 15. Specifically, the length of the bottom layer clamp 2 can be 1-2000 cm, the width can be 1-2000 cm, and the thickness can be 0.1-200 mm. The filter liquid cavity 21 is arranged on the side of the bottom layer clamp 2 close to the top layer clamp. The filter liquid cavity 21 can be a rectangular groove, and the length can be 1-1000 cm and the width can be 1-1000 cm. The filter liquid port 22 is arranged on the edge of the bottom layer clamp 2 and is in communication with the filter liquid cavity 21. Specifically, the pore size of the filter liquid port 22 can be 0.1-100 mm.

[0077] In the preferred embodiment, the top layer clamp and the bottom layer clamp 2 can be made of a clamp plate of polyurethane, ABS, polyethylene terephthalate, polytetrafluoroethylene, polyvinyl chloride, polyacrylonitrile, polypropylene, polyethylene, polyvinylidene fluoride, or cellulose, etc. Further, the first gasket 15 in the filter channel 13 is subjected to a hydrophilic modification treatment, and the first gasket 15 can be made of a modified component such as polyethylene glycol, sodium polyacrylate, sodium polypropane sulfonate, or polyacrylamide, which is subjected to a hydrophilic modification treatment by radiation, plasma treatment, etc. The clamp subjected to the hydrophilic modification treatment is known to those skilled in the art and can be realized, and is not described in detail in this embodiment.

[0078] The filter membrane 3 is arranged between the top layer clamp and the bottom layer clamp 2, and the type and pore size of the filter membrane 3 can be selected according to the composition of the feed liquid by those skilled in the related art.

[0079] During filtration, the top layer clamp is connected to the peristaltic pump at the joint of the liquid inlet hole 11, and the top layer clamp and the bottom layer clamp 2 cooperate to clamp the filter membrane 3. The peristaltic pump pumps the feed liquid into the liquid inlet hole 11, and the feed liquid flows into the filter channel 13 along the liquid inlet hole 11. The feed liquid flows tangentially in the filter channel 13, and the components in the feed liquid with a pore size smaller than that of the filter membrane 3 pass through the filter membrane 3 into the filtrate chamber 21. The filtrate collected in the filtrate chamber 21 flows out of the bottom layer clamp 2 through the filtrate hole, and the bottom layer clamp 2 can be externally connected to a filtrate collection device at the filtrate hole to uniformly collect the filtrate. The components in the feed liquid that are retained by the filter membrane 3 flow out through the liquid outlet hole 12, and the components retained by the filter membrane 3 form a local turbulent flow in the filter channel 13, which can enhance the shearing action and reduce the deposition of the retained components on the surface of the filter membrane 3, thereby improving the filtration efficiency and facilitating the operation.

[0080] Embodiment 7:

[0081] The difference between this embodiment and embodiment 8 is described in Figure 16 In this embodiment, the second gasket 23 is arranged between the bottom layer clamp 2 and the filter membrane 3, and the second gasket 23 is preferably but not limited to a soft rubber gasket such as a silica gel gasket. The second gasket 23 is provided with an assembly opening 231, and the filtrate passing through the filter membrane 3 enters the filtrate chamber 21 through the assembly opening 231. In some specific embodiments, the bottom layer clamp 2 is provided with a second embedding groove 24, which is annularly arranged on the outer side of the filtrate chamber 21. Further, the depth of the second embedding groove 24 can be 0.1-100 mm, and the width of the second embedding groove 24 can be 1-100 mm. The second embedding groove 24 can be a semicircular groove or a rectangular groove, etc.

[0082] Please refer to Figure 17 and 18The second gasket 23 is provided with a second fitting part 232 near one side of the bottom clamp 2. The second fitting part 232 protrudes from the second gasket 23. When the second gasket 23 is attached to the bottom clamp 2, the second fitting part 232 is fitted in the second fitting groove 24. The second gasket 23 is assembled with the bottom clamp 2.

[0083] See Figures 16-18 In the preferred embodiments, a support structure 4 is arranged between the bottom clamp 2 and the second gasket 23 to support the filter membrane 3. In some specific embodiments, the support structure 4 includes support columns 41, which can be cylindrical. The support columns 41 are arranged in an array in the filtrate cavity 21. Specifically, the diameter of the cross section of the support columns 41 is 0.1-100 mm. The height of the support columns 41 can be 0.1-100 mm. The distance between adjacent support columns 41 can be 0.1-100 mm. The support columns 41 are arranged at equal intervals.

[0084] In the preferred embodiments, the second gasket 23 is provided with a support sheet 42 at the assembly opening 231. Specifically, the support sheet 42 is adapted to the assembly opening 231. The support sheet 42 is provided with through holes 421 for the filtrate to pass through. During filtration, the filtrate passes through the filter membrane 3 and enters the filtrate cavity 21 through the through holes 421. When the top clamp and the bottom clamp 2 clamp the filter membrane 3, the support sheet 42 is placed on the support columns 41. The through holes 421 can be arranged in an array on the support sheet 42. Specifically, the through holes 421 can be circular through holes with a diameter of 0.1 nm-10 μm. The diameter of the through holes 421 is smaller than the diameter of the cross section of the support columns 41.

[0085] When the support sheet 42 is placed on the support columns 41, the sum of the thicknesses of the support columns 41 and the support sheet 42 can be 0.1-100 mm. The support sheet 42 can mechanically support the filter membrane 3, and the support columns 41 can mechanically support the support sheet 42.

[0086] In the preferred embodiments, screw holes are arranged on the top clamp and the bottom clamp. The number of the screw holes can be 4-100. Screws are arranged in the screw holes. The screws pass through the top clamp and the bottom clamp in sequence and are assembled by nuts. The top clamp and the bottom clamp are clamped and fixed by the screws. In some specific embodiments, the top clamp and the bottom clamp can be clamped and fixed by metal clamps such as stainless steel clamps.

[0087] In the utility model, unless another definite provision and limit, the terms "mount", "link", "connect", "fix" and so on should do the broad sense understanding, for example, can be fixed connection, also can be detachable connection, or be integrated;Can be mechanical connection, also can be electrical connection;Can be direct connection, also can indirectly connect through the intermediate medium, can be two element internal communication or two element mutual action relation.For the ordinary skilled person in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0088] In the description of the utility model, it needs to be explained that the orientation or position relation indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like is based on the orientation or position relation shown in the drawings, or the orientation or position relation commonly placed when the utility model product is used, which is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the indicated device or element must have a specific orientation, be constructed and operated in a specific orientation, so it cannot be understood as a limitation on the utility model.In addition, the terms "first", "second", "third" and the like are only used for differentiation in description, and cannot be understood as indicating or implying relative importance.

[0089] In addition, the terms "horizontal", "vertical", "overhang" and the like do not mean that the components must be absolutely horizontal or overhanging, but can be slightly inclined."Horizontal" only means that its direction is more horizontal relative to "vertical", and does not mean that the structure must be completely horizontal, but can be slightly inclined.

[0090] In the utility model, unless another definite provision and limit, the first feature above or below the second feature can include that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact through another feature between them.Furthermore, the first feature above, above and above the second feature includes that the first feature is directly above and obliquely above the second feature, or only indicates that the horizontal height of the first feature is higher than that of the second feature.The first feature below, below and below the second feature includes that the first feature is directly below and obliquely below the second feature, or only indicates that the horizontal height of the first feature is less than that of the second feature.

[0091] Although the description of the utility model is combined with the above specific embodiments, it is obvious that many substitutions, modifications and changes can be made by the person skilled in the art according to the above content.Therefore, all such alternatives, improvements and changes are included in the spirit and scope of the appended claims.

Claims

1. A tangential flow top layer clamp characterized by, The plate body (1) is provided with a liquid inlet hole (11) and a liquid outlet hole (12); and A first gasket (15) is arranged on the plate body (1), and a filtering channel (13) for communicating the liquid inlet hole (11) and the liquid outlet hole (12) is arranged on the first gasket (15). The filtering channel (13) is a linear channel comprising a plurality of bending structures, and the feed liquid flows in the filtering channel (13). A plurality of convex portions (131) and a plurality of concave portions (132) are arranged on the inner wall of the filtering channel (13) to form turbulent flow of the feed liquid in the filtering channel (13), and the convex portions (131) and the concave portions (132) are arranged alternately.

2. The tangential flow top layer clamp of claim 1, wherein, A plurality of convex points and / or concave grooves (14) are arranged on the surface of the plate body (1) in the filtering channel (13), and each of the convex points and the concave grooves (14) is provided with a plurality of convex points and / or concave grooves (14).

3. The tangential flow top layer clamp of claim 1, wherein, The filtering channel (13) is a zigzag linear channel.

4. The tangential flow top layer clamp of claim 1, wherein, The filtering channel (13) is an arcuate channel.

5. The tangential flow top layer clamp of claim 1, wherein, A first embedding groove (141) is arranged on the plate body (1), a first embedding portion (151) is arranged on the first gasket (15), the first embedding portion (151) protrudes outwardly from the first gasket (15), and the first embedding portion (151) is embedded in the first embedding groove (141).

6. The tangential flow top layer clamp of claim 1, wherein, The tangential flow top layer clamp comprises the tangential flow top layer clamp according to any one of claims 1-6, a bottom layer clamp (2) arranged on one side of the top layer clamp, and a filter membrane (3) arranged between the bottom layer clamp (2) and the top layer clamp.

7. A tangential flow filtration device characterized in that, The bottom layer clamp (2) is provided with a filter liquid cavity (21) and a filter liquid outlet (22) in communication, and the feed liquid flows through the filter liquid cavity (21) and the filter liquid outlet (22) after passing through the filter membrane (3). A second gasket (23) is arranged between the bottom layer clamp (2) and the filter membrane (3), and an assembly opening (231) is arranged on the second gasket (23).

8. The tangential flow filtration device of claim 7, wherein, A support structure (4) for supporting the filter membrane (3) is arranged between the bottom layer clamp (2) and the second gasket (23).

9. The tangential flow filtration device of claim 8, wherein, The support structure (4) comprises 10. The tangential flow filtration device of claim 9, wherein, A plurality of support columns (41) are arranged in an array in the filter liquid cavity (21); and A support sheet (42) is arranged in the assembly opening (231), and a permeation hole (421) for filter liquid permeation is arranged on the support sheet (42), and the support sheet (42) is placed on the support column (41). ​ ​

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