Micro-channel reactor for producing sitagliptin intermediate

Abstract

The utility model belongs to the technical field of medicine preparation, particularly relates to a micro-channel reactor for producing sitagliptin intermediates, and provides the following scheme aiming at the efficiency problem: the micro-channel reactor comprises a support frame, a first connecting plate is fixedly connected to the lower side of the outer surface of the supporting frame. A second connecting plate is fixedly connected to one side of the outer surface of the supporting frame. A first sliding groove is formed in the upper surface of the first connecting plate. A second sliding groove is formed in the outer surface of one side of the second connecting plate. A fixing frame is slidably mounted on the inner surface of the first sliding groove. A first sliding block is fixedly connected to the outer surface of one side of the fixing frame. A second sliding block is fixedly connected to the lower surface of the fixing frame. And a fixed rotating block is rotationally mounted on the inner surface of the first sliding block. And through the arrangement of the fixer, the connector can be quickly mounted and dismounted, and the efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to medicine preparation technical field especially, relates to a kind of microchannel reactor for sitagliptin intermediate production. BACKGROUND

[0002] Sitagliptin belongs to dipeptidyl peptidase-4 (DPP-4) inhibitor, can be applied alone, or with other oral hypoglycemic drugs compound drug treatment 2 type diabetes, its advantage is good safety, low incidence of adverse reactions such as hypoglycemia and weight gain;Sitagliptin intermediate needs to use microchannel reactor in production process.

[0003] The microchannel reactor has a high specific surface area due to its small channel structure, and has better mixing, mass transfer and heat transfer efficiency than a kettle-type reactor. By controlling process parameters such as mixing degree, temperature, pressure and residence time, the reaction can be precisely controlled, and the microchannel reactor has obvious advantages such as short reaction time, high conversion rate, high yield and small footprint.

[0004] However, the prior art still has some shortcomings. In the prior art, the microchannel reactor is not convenient to install, which reduces the efficiency, and the connector is not convenient to install.

[0005] Therefore, we propose a microchannel reactor for sitagliptin intermediate production to solve this problem. UTILITY MODEL CONTENT

[0006] The utility model aims at solving the problems raised in the background art and proposes a microchannel reactor for sitagliptin intermediate production.

[0007] To achieve the above-mentioned purpose, the utility model adopts the following technical solutions:

[0008] A microchannel reactor for sitagliptin intermediate production, comprising a support frame, a No. 1 connecting plate is fixed to the lower side of the outer surface of the support frame, a No. 2 connecting plate is fixed to one side of the outer surface of the support frame, a No. 1 sliding groove is provided on the upper surface of the No. 1 connecting plate, a No. 2 sliding groove is provided on one side of the outer surface of the No. 2 connecting plate, a fixed frame is slidably installed on the inner surface of the No. 1 sliding groove, a No. 1 sliding block is fixed to one side of the outer surface of the fixed frame, a No. 2 sliding block is fixed to the lower surface of the fixed frame, a fixed rotating block is rotatably installed on the inner surface of the No. 1 sliding block, a microchannel reactor body is fixed to the inner surface of the fixed frame, a connecting screw is fixed to the outer surface of the microchannel reactor body, a limiting rotating block is rotatably installed on the outer cylindrical surface of the connecting screw, a fixing mechanism is fixed to one side of the outer surface of the microchannel reactor body, and a connector is fixed to one side of the outer surface of the microchannel reactor body.

[0009] Preferably, the fixing mechanism includes a mounting block fixed to one outer surface of the microchannel reactor body; a third sliding groove is provided on one outer surface of the mounting block; a fixing block is slidably installed on the inner surface of the third sliding groove; a connecting rod is fixed to one outer surface of the fixing block; a spring is sleeved on the outer circular surface of the connecting rod; and a pull block is fixed to one end of the connecting rod.

[0010] Preferably, one end of the spring is fixed to the outer surface of one side of the fixed block; the other end of the spring is fixed to the inner surface of the third sliding groove.

[0011] Preferably, the connector includes a connecting block fixed to one outer surface of the microchannel reactor body; a connecting pipe is fixed to one outer surface of the connecting block; fixing grooves are provided on both outer surfaces of the connecting block; a sealing ring is fixed to the inner surface of the connecting block; and the connecting block is fixed to one outer surface of the microchannel reactor body by a fixing block.

[0012] Preferably, the first slider is slidably mounted on the inner surface of the second slide groove; the second slider is slidably mounted on the inner surface of the first slide groove.

[0013] In this invention, a microchannel reactor for the production of sitagliptin intermediates is described. Through the arrangement of a support frame, a first connecting plate, a first chute, a second connecting plate, a second chute, a fixed frame, a first slider, a second slider, a fixed rotating block, a microchannel reactor body, a connecting screw, and a limiting rotating block, the microchannel reactor body is installed by placing the fixed frame on the first connecting plate, rotating the fixed rotating block to fix the fixed frame to the outer surface of the first connecting plate, placing the microchannel reactor body on the fixed frame, and then installing the limiting rotating block onto the outer surface of the connecting screw. The microchannel reactor body is installed by clamping the limiting rotating block with the fixed frame, achieving rapid installation of the microchannel reactor body and rapid adjustment of the fixed frame, thus improving efficiency.

[0014] In this invention, a microchannel reactor for the production of sitagliptin intermediates is described. Through the arrangement of an installation block, a third-order chute, a fixing block, a connecting rod, a spring, a pull block, a connecting tube, a fixing groove, and a sealing ring, the connector is installed by pushing the connecting block. The movement of the connecting block moves the fixing block, which in turn moves the fixing groove. The movement of the fixing block compresses the spring. When the fixing groove moves to one side of the fixing block, the fixing block enters the fixing groove under the spring's rebound, thus fixing the connector. To disassemble the connector, pulling the pull block moves the fixing block via the connecting rod, causing the fixing block to leave the fixing groove, allowing the connector to be removed from the microchannel reactor body. This enables rapid installation and disassembly of the connector, improving efficiency.

[0015] This utility model has a reasonable structural design, is simple to operate, and has high reliability. Attached Figure Description

[0016] Figure 1 This is a front-view three-dimensional structural diagram of a microchannel reactor for the production of sitagliptin intermediates proposed in this utility model;

[0017] Figure 2 This is a rear-view three-dimensional structural diagram of a microchannel reactor for the production of sitagliptin intermediates proposed in this utility model.

[0018] Figure 3 This is a three-dimensional structural diagram of the fixing frame in this utility model;

[0019] Figure 4 This is a cross-sectional schematic diagram of a microchannel reactor for the production of sitagliptin intermediates proposed in this utility model.

[0020] In the diagram: 1. Support frame; 2. Connecting plate 1; 21. Slide 1; 3. Connecting plate 2; 31. Slide 2; 4. Fixing frame; 41. Slider 1; 42. Slider 2; 43. Fixing rotating block; 5. Microchannel reactor body; 51. Connecting screw; 6. Fixing mechanism; 61. Mounting block; 62. Slide 3; 63. Fixing block; 64. Connecting rod; 65. Spring; 66. Pull block; 7. Connector; 71. Connecting block; 72. Connecting pipe; 73. Fixing groove; 74. Sealing ring; 8. Restricting rotating block. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0022] Reference Figures 1-4A microchannel reactor for the production of sitagliptin intermediates includes a support frame 1; a first connecting plate 2 is fixedly connected to the lower side of the outer surface of the support frame 1; a second connecting plate 3 is fixedly connected to one side of the outer surface of the support frame 1; a first sliding groove 21 is provided on the upper surface of the first connecting plate 2; a second sliding groove 31 is provided on one side of the outer surface of the second connecting plate 3; a fixing frame 4 is slidably installed on the inner surface of the first sliding groove 21; a first slider 41 is fixedly connected to one side of the outer surface of the fixing frame 4; a second slider 42 is fixedly connected to the lower surface of the fixing frame 4; a fixing block 43 is rotatably installed on the inner surface of the first slider 41; a microchannel reactor body 5 is fixedly connected to the inner surface of the fixing frame 4; a connecting screw 51 is fixedly connected to the outer surface of the microchannel reactor body 5; a limiting block 8 is rotatably installed on the outer circular surface of the connecting screw 51; a fixing mechanism 6 is fixedly connected to one side of the outer surface of the microchannel reactor body 5; and a connector 7 is fixedly connected to one side of the outer surface of the microchannel reactor body 5.

[0023] Furthermore, the fixing mechanism 6 includes a mounting block 61 fixed to one side of the outer surface of the microchannel reactor body 5; a third sliding groove 62 is provided on one side of the outer surface of the mounting block 61; a fixing block 63 is slidably mounted on the inner surface of the third sliding groove 62; a connecting rod 64 is fixed to one side of the outer surface of the fixing block 63; a spring 65 is sleeved on the outer circular surface of the connecting rod 64; and a pull block 66 is fixed to one end of the connecting rod 64.

[0024] Furthermore, one end of the spring 65 is fixed to the outer surface of one side of the fixed block 63; the other end of the spring 65 is fixed to the inner surface of the third slide groove 62.

[0025] Furthermore, the connector 7 includes a connecting block 71 fixed to one outer surface of the microchannel reactor body 5; a connecting pipe 72 is fixed to one outer surface of the connecting block 71; a fixing groove 73 is provided on both outer surfaces of the connecting block 71; a sealing ring 74 is fixed to the inner surface of the connecting block 71; and the connecting block 71 is fixed to one outer surface of the microchannel reactor body 5 by a fixing block 63.

[0026] Furthermore, slider 41 is slidably mounted on the inner surface of slide groove 31; slider 42 is slidably mounted on the inner surface of slide groove 21.

[0027] In this invention, during use, when installing the microchannel reactor body 5, the fixing frame 4 is placed on the first connecting plate 2, and the fixing block 43 is rotated to fix the fixing frame 4 to the outer surface of the second connecting plate 3. Then, the microchannel reactor body 5 is placed on the fixing frame 4, and the limiting rotating block 8 is installed on the outer circular surface of the connecting screw 51. By clamping the limiting rotating block 8 with the fixing frame 4, the microchannel reactor body 5 is installed, achieving rapid installation of the microchannel reactor body 5 and rapid adjustment of the fixing frame 4, thus improving efficiency. When installing the connector 7, the connecting block 71 is pushed, and the connecting block 71... The movement of the connecting block 71 will push the fixed block 63 to move, and the movement of the connecting block 71 will drive the fixed groove 73 to move. The movement of the fixed block 63 will compress the spring 65. When the fixed groove 73 moves to one side of the fixed block 63, the fixed block 63 will enter the fixed groove 73 under the action of the spring 65 to fix the connecting block 71. When disassembling the connector 7, pull the pull block 66. The movement of the pull block 66 will drive the fixed block 63 to move through the connecting rod 64, so that the fixed block 63 leaves the fixed groove 73. Then the connecting block 71 can be taken out from the microchannel reactor body 5, which realizes the quick installation and disassembly of the connector 7 and improves efficiency.

[0028] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0029] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0030] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A microchannel reactor for the production of sitagliptin intermediates, characterized in that, The system includes a support frame (1); a first connecting plate (2) is fixedly connected to the lower side of the outer surface of the support frame (1); a second connecting plate (3) is fixedly connected to one side of the outer surface of the support frame (1); a first sliding groove (21) is provided on the upper surface of the first connecting plate (2); a second sliding groove (31) is provided on one side of the outer surface of the second connecting plate (3); a fixing frame (4) is slidably installed on the inner surface of the first sliding groove (21); a first slider (41) is fixedly connected to one side of the outer surface of the fixing frame (4); and a first connecting plate (41) is fixedly connected to the lower surface of the fixing frame (4). There is a second slider (42); a fixed rotating block (43) is rotatably installed on the inner surface of the first slider (41); the inner surface of the fixed frame (4) is fixedly connected to the microchannel reactor body (5); the outer surface of the microchannel reactor body (5) is fixedly connected to the connecting screw (51); the outer circular surface of the connecting screw (51) is rotatably installed with a limiting rotating block (8); a fixing mechanism (6) is fixedly connected to one side of the outer surface of the microchannel reactor body (5); a connector (7) is fixedly connected to one side of the outer surface of the microchannel reactor body (5).

2. A microchannel reactor for the production of sitagliptin intermediates according to claim 1, characterized in that, The fixing mechanism (6) includes a mounting block (61) fixed to one side of the outer surface of the microchannel reactor body (5); a third sliding groove (62) is provided on one side of the outer surface of the mounting block (61); a fixing block (63) is slidably installed on the inner surface of the third sliding groove (62); a connecting rod (64) is fixed to one side of the outer surface of the fixing block (63); a spring (65) is sleeved on the outer circular surface of the connecting rod (64); and a pull block (66) is fixed to one end of the connecting rod (64).

3. A microchannel reactor for the production of sitagliptin intermediates according to claim 2, characterized in that, One end of the spring (65) is fixed to the outer surface of one side of the fixed block (63); the other end of the spring (65) is fixed to the inner surface of the third slide groove (62).

4. A microchannel reactor for the production of sitagliptin intermediates according to claim 1, characterized in that, The connector (7) includes a connecting block (71) fixed to one side of the outer surface of the microchannel reactor body (5); a connecting pipe (72) is fixed to one side of the outer surface of the connecting block (71); a fixing groove (73) is provided on both sides of the outer surface of the connecting block (71); a sealing ring (74) is fixed to the inner surface of the connecting block (71); the connecting block (71) is fixed to one side of the outer surface of the microchannel reactor body (5) by a fixing block (63).

5. A microchannel reactor for the production of sitagliptin intermediates according to claim 1, characterized in that, The first slider (41) is slidably mounted on the inner surface of the second slide groove (31); the second slider (42) is slidably mounted on the inner surface of the first slide groove (21).

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