Dry blood spot preparation device

Abstract

The utility model discloses a dried blood spot preparation device which comprises a sealing box, a cover body and a lining, a sample bin and a drying bin which are independent are arranged on the lining, a plurality of clamping grooves are formed in the sample bin and used for containing dried blood spot test paper, and a drying agent is arranged in the drying bin; a containing space is formed between the lining and the inner periphery of the sealing box, the containing space is communicated with the sample bin and the drying bin, and an air making system is arranged in the containing space. The dried blood spot preparation device can effectively promote quick drying of dried blood spots, so that water residues are reduced, the integrity of to-be-detected substances in the dried blood spots is guaranteed to the maximum extent, the stability of dried blood spot samples is remarkably improved, and a more reliable basis is provided for subsequent detection and analysis.

Description

TECHNICAL FIELD

[0001] The utility model relates to scientific research and medical detection appliance technical field, concretely relates to a dry blood spot preparation device. BACKGROUND

[0002] Dry blood spot technology, also known as trace blood collection, drying and storage biological sampling technology, since it was first introduced in 1962 in Robert Guthrie's method of screening for phenylketonuria in newborns, it has made remarkable achievements in the fields of medical diagnosis and forensic identification. This technology mainly relies on 903 and FTA patented blood collection filter paper, so that dry blood spot samples can be applied to time-resolved immunofluorescence (TRFIA), tandem mass spectrometry (LC-MS / MS), enzyme chemistry, fluorescence chemistry and other analysis methods, becoming a key tool for screening and research of genetic metabolic diseases in newborns. With the continuous progress of technology, the application range of dry blood spots has not been limited to the field of DNA and protein analysis. For example, at the Beijing Winter Olympics, dry blood spot technology was first used for doping detection. In addition, dry blood spot technology is also widely used in home health detection projects, including allergen detection, food intolerance detection, vitamin D detection, NAD+ detection, etc. Compared with traditional venous blood collection, dry blood spot sampling does not require venipuncture and can be completed with only a small amount of finger blood, and the dry blood spot sample is relatively stable and easy to transport.

[0003] However, as the application of dry blood spot technology in multiple fields becomes increasingly widespread, the limitations in its production process have gradually become apparent. Ensuring that the dry blood spot sample is fully dried is a crucial step. Currently, commercially available dry blood spot production usually requires 2-4 hours of air drying in a naturally ventilated environment. If the drying process is not complete, the blood sample may be contaminated with other objects, resulting in blood sample loss. In addition, during the drying process, the blood sample is exposed to an open environment, which is easily contaminated and poses a risk of disease transmission through blood. The production environment of dry blood spots can also affect test results, especially when testing for vitamins, NAD+, etc. The stability of the analyte is poor. Higher environmental humidity will prolong the drying time of the blood spot and may cause excessive water to remain, promoting the degradation of the analyte in the dry blood spot and causing a large deviation between the quantitative test result and the actual value. Placing the dry blood spot in a sealed bag with desiccant can ensure the final sample drying of the dry blood spot, but due to the lack of air circulation in the sealed bag, the drying speed is slowed down and the time is extended, and the degradation loss of the analyte during the drying process cannot be recovered. To reduce the deviation of the dry blood spot test result, it is crucial to maintain a well-ventilated drying environment during the drying process. SUMMARY

[0004] The utility model aims at the prior art existing problem, provides a dry blood spot preparation device.

[0005] To achieve the above object, the utility model adopts the technical scheme of:

[0006] A dry blood spot preparation device, comprising a sealed box, the sealed box is equipped with openable cover, the sealed box is equipped with inner lining, the inner lining is equipped with independent sample bin and dry bin, the sample bin is equipped with a plurality of clamping grooves for placing dry blood spot test paper, the dry bin is equipped with drying agent, the inner lining and the inner circumference of the sealed box are equipped with containing space, the containing space is communicated with the sample bin and the dry bin, the containing space is equipped with air making system.

[0007] The dry blood spot preparation device is equipped with drying agent and air making system in the sealed box, which can ensure that the environment of dry blood spot test paper is always dark, dry and ventilated during the formation of dry blood spot, which can effectively promote the rapid drying of dry blood spot and reduce the residual moisture, and the environmental control measures can maximize the integrity of the measured substance in the dry blood spot, and the measured substance sensitive to light can be protected to the maximum extent, so that the stability of the dry blood spot sample is significantly improved, and a more reliable basis is provided for subsequent detection and analysis.

[0008] The sealed box and the cover can form a relatively sealed and dark environment, which can reduce the air exchange between the inside and the outside environment, so as to prevent the influence of the high air humidity (relatively dry) outside on the drying speed of dry blood spot, and can store or transport the dry blood spot without waiting for the complete drying of the dry blood spot during actual use, which greatly improves the efficiency of sample processing and ensures that the sample is away from dust and other objects that may cause pollution during storage and transportation, thereby effectively preventing sample pollution and reducing the risk of disease transmission during dry blood spot drying, thereby providing safer protection measures for sampling personnel.

[0009] The dry blood spot preparation device can clamp a plurality of dry blood spot test papers at the same time through the plurality of clamping grooves, so as to prepare a plurality of dry blood spot samples at the same time, which significantly improves the efficiency of dry blood spot sampling. This advantage makes the dry blood spot sampling process more convenient, stable and safe, and sampling personnel can complete more sample collection work in a short time, reduce the operation time and improve the overall work efficiency. At the same time, due to the simplification and optimization of sample processing process, the uncertainty in the sampling process is effectively controlled, which further ensures the stability and safety of the sampling process.

[0010] Further, the air making system comprises a fan, a power supply and a switch connected with the fan, the fan is installed on the inner wall of the sealed box through a mounting seat, and the switch is arranged on the inner liner, so that the use is more simple and convenient.

[0011] Further, the power supply is a battery or an external power supply, the battery is installed in the accommodating space through a battery seat, and mounting holes are arranged on the inner liner, and the switch is installed at the mounting holes.

[0012] Further, a plurality of ventilation holes are arranged on the wall of the drying bin. The ventilation holes are arranged to ensure that the airflow generated by the air making system can flow freely in the whole sealed box, the air circulation can quickly remove the saturated moisture accumulated on the surface of the test paper, avoids the moisture from being recondensed on the surface of the test paper, and thus accelerates the drying process.

[0013] Further, the clamping grooves are arranged on a pair of opposite bin walls of the sample bin, and the clamping grooves are arranged at equal intervals adjacent to each other; and the other pair of bin walls of the sample bin is also provided with ventilation holes.

[0014] Further, the vertical height of the dried blood spot test paper is lower than the height of the clamping groove, so that there is a gas flow space above the dried blood spot test paper.

[0015] Further, the sealed box is a non-light-transmitting box body, and the cover body is a non-light-transmitting cover body, so that a dark environment without light can be formed.

[0016] Further, the cover body is a flip cover structure, the side edge of the cover body is provided with a folding edge, and the folding edge is overlapped on the outer side wall of the sealed box, so that the opening and closing of the cover body is facilitated.

[0017] Compared with the prior art, the dry blood spot preparation device has the following beneficial effects: 1. The dry blood spot preparation device is provided with the desiccant and the air making system in the sealed box body, so that the environment of the dry blood spot test paper can be kept in a dark, dry and ventilated state during the formation of the dry blood spot, and the dry blood spot can be effectively and rapidly dried in this way, thereby reducing the residual moisture, and the environmental control measure maximally ensures the integrity of the to-be-tested substance in the dry blood spot, that is, the to-be-tested substance sensitive to light can be maximally protected, so that the stability of the dry blood spot sample is significantly improved, thereby providing a more reliable basis for subsequent detection and analysis; 2. The dry blood spot preparation device is provided with the sample bin and the drying bin on the inner lining of the sealed box, and the flowing air flow among the sample bin, the containing space and the drying bin is formed by the air making system in the inner lining, so that the moisture evaporation and drying of the dry blood spot are accelerated under the action of the air flow and the wind, and the desiccant can well adsorb the moisture in the air, which is beneficial to the drying of the dry blood spot in the sealed box; 3. The sealed box and the cover body are provided, so that a relatively sealed and dark environment can be formed, and such a setting can reduce the air exchange between the inside and the outside of the environment, so as to prevent the high air humidity outside from affecting the drying speed of the dry blood spot; on the other hand, the blood spot can be stored or transported without waiting for the blood spot to be completely dried in the actual use process, and this feature greatly improves the sample processing efficiency, and also ensures that the sample is far away from dust and other objects that can cause pollution during storage and transportation, so that the sample pollution is effectively prevented, and the disease transmission risk in the dry blood spot drying process is reduced, thereby providing safer protection measures for the sampling personnel; 4. The dry blood spot preparation device can clamp a plurality of dry blood spot test papers at the same time through the plurality of clamping grooves, so that a plurality of dry blood spot samples can be prepared at the same time, the efficiency of dry blood spot sampling is significantly improved, the dry blood spot sampling process becomes more convenient, stable and safe, the sampling personnel can complete more sample collection work in a short time, the operation time is reduced, and the overall work efficiency is improved; at the same time, due to the simplification and optimization of the sample processing process, the uncertain factors in the sampling process are effectively controlled, and the stability and safety of the sampling process are further ensured. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is an overall structure schematic view of the dry blood spot preparation device of the utility model;

[0019] Figure 2 It is an explosion structure schematic view of the dry blood spot preparation device of the utility model;

[0020] In the figure: 1, sealed box; 2, cover; 3, inner liner; 4, sample bin; 5, card slot; 6, dry blood spot test paper; 7, drying bin; 8, desiccant; 9, ventilation hole; 10, fan; 11, battery; 12, switch; 13, mounting hole; 14, folding edge. DETAILED DESCRIPTION

[0021] The technical scheme of the utility model will be described below in connection with the drawings in the utility model, obviously, the described embodiment is only a part of the embodiment of the utility model, not all the embodiment. Based on the embodiment in the utility model, all other embodiments obtained by the ordinary skill in the art without creative labor belong to the scope of protection of the utility model.

[0022] In the description of the utility model, it is necessary to explain that the orientation or position relation indicated by the terms "intermediate", "upper", "lower", "left", "right", "inner", "outer" and the like is the orientation or position relation shown based on the drawing, only for the convenience of describing the utility model and simplifying the description, and cannot be understood as indicating or implying that the indicated device or element must have a specific orientation, be constructed and operated in a specific orientation, therefore, cannot be understood as limiting the utility model. In addition, the terms "first", "second" and the like are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0023] As shown in Figure 1 and Figure 2 A dry blood spot preparation device, including a sealed box 1, the sealed box 1 is equipped with openable and closable cover 2, the sealed box 1 is equipped with inner liner 3, the inner liner 3 is equipped with independent sample bin 4 and drying bin 7, the sample bin 4 is equipped with several card slots 5, for placing dry blood spot test paper 6, namely the test paper with blood, the drying bin 7 is equipped with desiccant 8, the inner liner 3 and the inner circumference of the sealed box 1 are equipped with containing space, the containing space is communicated with the sample bin 4 and the drying bin 7 through the air hole, the containing space is equipped with air making system.

[0024] The dry blood spot preparation device is equipped with the desiccant and air making system in the sealed box body, can ensure that the environment where the dry blood spot test paper is kept in the dark, dry and ventilated state during the process of dry blood spot formation, through this mode, can effectively promote the rapid drying of dry blood spot, thereby reducing the residual moisture, this environmental control measure maximizes the integrity of the measured substance in the dry blood spot, even the measured substance sensitive to light can be protected to the maximum extent, therefore, the stability of dry blood spot sample is significantly improved, thereby providing a more reliable basis for subsequent detection and analysis. Moreover, the dry blood spot preparation device is simple in structure, easy to carry and use, and convenient to manufacture, and low in production cost.

[0025] The dry blood spot preparation device is provided with the sample bin 4 and the drying bin 7 on the inner liner 3 of the sealed box 1, and a flow of air is formed between the sample bin, the containing space and the drying bin by using the air making system in the inner liner, so that the moisture evaporation and drying of the dry blood spot are accelerated under the action of the flow of air and the wind. Since the desiccant is provided, the moisture in the air can be well adsorbed, which is beneficial to the drying of the dry blood spot in the sealed box.

[0026] The sealed box 1 and the cover 2 are provided to form a relatively sealed and dark environment. On the one hand, this arrangement reduces the air exchange between the inside and the outside environment, so as to prevent the high air humidity (compared with dryness) outside from affecting the drying speed of the dry blood spot. On the other hand, in actual use, the dry blood spot can be stored or transported without waiting for it to be completely dried. This feature greatly improves the efficiency of sample processing, and also ensures that the sample is away from dust and other objects that may cause pollution during storage and transportation. In this way, sample pollution is effectively prevented, and the risk of disease transmission during the drying process of the dry blood spot is reduced, thereby providing safer protection measures for the sampling personnel.

[0027] The dry blood spot preparation device can clamp multiple dry blood spot test papers 6 at the same time through the provision of the plurality of clamping grooves 5, so that multiple dry blood spot samples can be prepared at the same time, thereby significantly improving the efficiency of dry blood spot sampling. This advantage makes the dry blood spot sampling process more convenient, stable and safe. The sampling personnel can complete more sample collection work in a shorter period of time, reducing the operation time and improving the overall work efficiency. At the same time, due to the simplification and optimization of the sample processing process, the uncertainty factors in the sampling process are effectively controlled, further ensuring the stability and safety of the sampling process.

[0028] Further, the air making system comprises a fan 10, and a power supply and a switch 12 connected with the fan 10. The fan 10 is installed on the inner wall of the sealed box 1 through a mounting seat, and the switch 12 is arranged on the inner liner 3.

[0029] The fan 10, the power supply and the switch 12 are connected with each other through wires, so that the operation of the switch can control the operation of the fan. The switch 12 is arranged at the upper surface of the inner liner, so that it is more simple and convenient to use.

[0030] Further, the power supply is a battery 11, such as a dry battery or a rechargeable lithium battery, which can also be in the form of an external power supply. The battery 11 is installed in the containing space through a battery seat. The inner liner 3 is provided with a mounting hole 13, and the switch 12 is installed at the mounting hole 13. The operation button of the switch 12 is exposed from the mounting hole 13 for use.

[0031] Further, the dry tank 7 is provided with a plurality of ventilation holes 9 around the tank wall, and a pair of ventilation holes 9 are also provided on the tank wall of the sample tank 4. The fan 10 is arranged towards the ventilation holes on the sample tank 4.

[0032] The sample tank 4 and the dry tank 7 are both provided with ventilation holes 9 to ensure that the airflow generated by the air making system can freely circulate in the entire sealed box. The circulation of air can quickly remove the saturated moisture accumulated on the surface of the test paper, avoid the moisture from recondensing on the surface of the test paper, and thus accelerate the drying process.

[0033] The desiccant 8 is placed in the dry tank 7, which functions to absorb the moisture in the sealed box and reduce the relative humidity in the device, thereby accelerating the drying speed of the dried blood spot.

[0034] Further, the card slot 5 is arranged on a pair of opposite tank walls of the sample tank 4, and the adjacent card slots 5 are arranged at equal intervals. The vertical height of the dried blood spot test paper 6 inserted therein is lower than the height of the card slot 5. Through such arrangement, when the cover is closed, there is a space for air flow above the dried blood spot test paper, which can allow the air to flow from one side to the other side of the sample tank.

[0035] Further, the sealed box 1 is a non-light-transmitting box body, and the cover 2 is a non-light-transmitting cover. The use of light-proof materials ensures that there is no light during the preparation of the dried blood spot.

[0036] Further, the cover 2 is a flip cover structure, and the side edge of the cover 2 is provided with a folded edge 14 which is overlapped on the outer side wall of the sealed box 1.

[0037] The cover 2 can be used to cover the sealed box 1 by flipping, and the inner liner is arranged slightly lower than the upper end surface of the sealed box, so that the cover can be better covered on the sealed box when the cover is closed, forming a relatively sealed environment.

[0038] In some embodiments, a locking device such as a buckle, a lock or a magnetic buckle is arranged between the folded edge 14 and the outer side wall of the sealed box 1, so as to fix the cover when it is closed.

[0039] When using the dried blood spot preparation device, the blood is simply dropped on the dried blood spot test paper 6, the dried blood spot test paper 6 is fixed in the card slot 5 of the sample tank 4, and then the switch 12 of the air making system is turned on and the sealed box 1 is closed. After such operation, the dried blood spot sample will be completely dried within one hour, which significantly shortens the preparation time and reduces the residual moisture, thereby maximizing the integrity of the test substance.

[0040] Although the embodiments of the present application have been shown and described, it is to be understood that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A dried blood spot preparation device, characterized in that, The sealed box is provided with a cover which can be opened and closed, and the sealed box is provided with an inner liner, and the inner liner is provided with independent sample bin and dry bin, and the sample bin is provided with a plurality of clamping grooves for placing dried blood spot test paper, and the dry bin is provided with a drying agent; the inner liner and the inner wall of the sealed box are provided with a containing space, the containing space is communicated with the sample bin and the dry bin, and the containing space is provided with a wind making system.

2. The dried blood spot preparation device of claim 1, wherein, The wind making system comprises a fan, a power supply and a switch connected with the fan, the fan is installed on the inner wall of the sealed box through a mounting seat, and the switch is arranged on the inner liner.

3. The dried blood spot preparation device of claim 2, wherein, The power supply is a battery or an external power supply, the battery is installed in the containing space through a battery holder, and the inner liner is provided with a mounting hole, and the switch is installed at the mounting hole.

4. The dried blood spot preparation device of claim 1, wherein, The bin wall of the dry bin is provided with a plurality of ventilation holes.

5. The dried blood spot preparation device of claim 1, wherein, The clamping grooves are arranged on a pair of opposite bin walls of the sample bin, and the adjacent clamping grooves are arranged at equal intervals; the other pair of bin walls of the sample bin is provided with ventilation holes.

6. The dried blood spot preparation device of claim 1, wherein, The vertical height of the dried blood spot test paper is lower than the height of the clamping groove.

7. The dried blood spot preparation device of claim 1, wherein, The sealed box is a non-light-transmitting box body, and the cover is a non-light-transmitting cover.

8. The dried blood spot preparation device of claim 1, wherein, The cover is a flip cover structure, the side edge of the cover is provided with a folding edge, and the folding edge is overlapped on the outer side wall of the sealed box.

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