Mouse airway administration device
By designing a mouse airway drug delivery device, which uses a conical seal to block the airway and provide oxygen through the air inlet, the problems of drug blockage and suffocation were solved, achieving precise drug delivery and reducing mortality.
Patent Information
- Application Number
- CN202421911963.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-07
- Publication Date
- 2025-12-02
- Estimated Expiration
- 2034-08-07
AI Technical Summary
When drugs are administered via the airway in mice, the drugs enter the trachea directly, obstructing the airway and making it difficult for air to enter, which can easily lead to suffocation. In addition, conventional administration methods can cause drug reflux, inaccurate dosage, and increase the risk of death.
A mouse airway drug delivery device was designed, comprising a main body, a conical sealing body, an air delivery tube, and an air inlet. The conical sealing body blocks the airway to prevent drug reflux, the air inlet is connected to an animal ventilator to provide oxygen, and a metering tube controls the drug dosage to avoid suffocation and drug waste.
It effectively prevents drug reflux and suffocation, improves the success rate of drug administration, reduces the mortality rate of mice, ensures accurate drug dosage, and reduces coughing reactions.
Smart Images
Figure CN223614968U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the technical field of airway drug delivery devices for mice, specifically an airway drug delivery device for mice. Background Technology
[0002] Mouse lung disease models typically involve direct airway drug administration. However, due to the narrow airways of mice and the small diameter of the intubation tubes used, it is difficult to inflate the tubes with a cuff, resulting in ineffective fixation. Conventional endotracheal intubation drug delivery or the use of handheld animal lung spray systems inevitably leads to coughing in mice, causing drug reflux from the airway into the mouth, resulting in inaccurate dosage. Furthermore, because the drug enters directly through the trachea, it obstructs the airway, hindering air intake and easily inducing asphyxiation and death in mice. Therefore, improvements to current technologies are necessary. Utility Model Content
[0003] To address the shortcomings of existing technologies, this invention provides a mouse airway drug delivery device, which solves the problem that when drugs enter directly through the trachea, they can block the airway, hindering air intake and easily causing suffocation and death in mice.
[0004] To achieve the above objectives, this utility model provides the following technical solution: a mouse airway drug delivery device. It includes a main body, a conical sealing body fitted around the lower part of the main body, an air guide tube fixed to the side of the main body, an air inlet fixedly connected to the top of the air guide tube, and a drug inlet fixedly connected to the top of the main body.
[0005] Preferably, the main body is hollow inside, and the conical sealing body surrounds the bottom of the main body.
[0006] Preferably, an animal ventilator is externally connected to the air inlet.
[0007] Preferably, a metering tube is fixedly connected to the top of the drug inlet, the top of the metering tube has a hole and a piston is slidably connected inside, an infusion tube is fixedly connected to the side of the metering tube, a first ball valve is rotatably connected inside the infusion tube, and a second ball valve is fixedly provided between the drug inlet and the metering tube.
[0008] Preferably, the surface of the metering tube is provided with graduations.
[0009] This invention provides a mouse airway drug delivery device. Compared with the prior art, it has the following advantages:
[0010] 1. A mouse airway drug delivery device, wherein the inlet is connected to a top metering tube for direct drug injection, the air inlet can be connected to an animal ventilator to continuously provide oxygen to the mouse and prevent suffocation, and the conical seal can be embedded in the airway through positive pressure to block and seal the mouse trachea, prevent drug reflux, prevent drug loss caused by coughing after airway drug administration and respiratory suffocation caused by airway drug administration, reduce mouse mortality, and increase the success rate of airway drug administration in mice.
[0011] 2. A mouse airway drug delivery device, comprising a metering tube at the top of the drug inlet, an infusion tube on the side of the metering tube that can be connected to the drug, and graduations on the surface of the metering tube to control the dosage of the drug in the mouse. When the piston rises inside the metering tube, the drug solution enters the inside of the metering tube from the infusion tube due to air pressure. After a specific amount has been reached, the ball valve is closed, which can directly push the metered amount of drug into the mouse's trachea through the main tube, avoiding the death of the mouse and waste of the drug due to improper drug dosage control. Attached Figure Description
[0012] Figure 1 This is a schematic diagram of the overall structure of this utility model;
[0013] Figure 2 This is a schematic diagram of the tube body assembly structure of this utility model;
[0014] Figure 3 This is a schematic diagram of the quantitative component structure of this utility model.
[0015] In the diagram: 1. Main tube; 2. Drug inlet; 3. Gas inlet tube; 4. Air inlet; 5. Conical seal; 6. Metering tube; 7. Piston; 8. Infusion tube; 9. First ball valve. Detailed Implementation
[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0017] Please see Figure 1-3This utility model provides a technical solution: a mouse airway drug delivery device. It includes a main body 1, with a conical sealing body 5 fitted around its lower part. The conical sealing body 5 can be embedded in the airway through positive pressure, blocking and sealing the mouse's trachea to prevent drug reflux. A duct 3 is fixed to the side of the main body 1, and an air inlet 4 is fixedly connected to the top of the duct 3. The air inlet 4 can be connected to an animal ventilator to continuously provide oxygen to the mouse and prevent suffocation. A drug inlet 2 is fixedly connected to the top of the main body 1. The main body 1 is hollow inside, with the conical sealing body 5 surrounding its lower part. The portion below the connection between the main body 1 and the conical sealing body 5 is made of silicone to avoid scratching the mouse's tracheal wall when the device is inserted into the mouse's trachea. A metering tube 6, made of plastic, is fixedly connected to the top of the drug inlet 2. Common materials include polypropylene and polycarbonate. Both materials have good transparency, strength, and chemical resistance, and can be autoclaved. The top of the metering tube 6 has a hole and a piston 7 is slidably connected inside. An infusion tube 8 is fixedly connected to the side of the metering tube 6. A first ball valve 9 is rotatably connected inside the infusion tube 8. The first ball valve 9 is hemispherical and fits inside the infusion tube 8. When the first ball valve 9 is opened, the drug can enter the inside of the metering tube 6 through the infusion tube 8. When the amount of drug entering is sufficient, the first ball valve 9 is rotated, so that the ball at the bottom of the first ball valve 9 blocks the inside of the infusion tube 8, preventing the drug from entering the inside of the metering tube 6. The surface of the metering tube 6 is marked with graduations, which can control the opening and closing of the first ball valve 9 according to the amount of drug entering.
[0018] In a preferred embodiment, a metering tube 6 is fixedly connected to the top of the inlet 2, and a second ball valve is fixedly provided between the inlet 2 and the metering tube 6. When the drug is drawn from the infusion tube 8, the valve closes the channel between the inlet 2 and the metering tube 6, so that the piston 7 slides inside the metering tube 6 to affect the air pressure of the inlet 2, thereby effectively drawing the drug from the infusion tube 8.
[0019] In use, first install the metering tube 6 on top of the inlet 2, and connect the air inlet 4 to the animal ventilator. Let the piston 7 slide inside the metering tube 6 to draw the drug from the infusion tube 8. After a sufficient amount of drug has entered the metering tube 6, turn the first ball valve 9 to prevent the drug from entering the metering tube 6. Insert the bottom of the main tube 1 into the mouse's trachea. The silicone structure at the bottom of the main tube 1 avoids damage to the mouse's tracheal wall during insertion. Since the air inlet 4 can be connected to the animal ventilator, it continuously provides oxygen to the mouse and prevents the mouse from suffocating. The conical seal 5 can be embedded in the airway through positive pressure to block and seal the mouse's trachea, prevent drug backflow, prevent drug loss caused by coughing after airway administration, and prevent respiratory suffocation caused by airway administration, reduce mouse mortality, and increase the success rate of airway administration in mice.
[0020] In this embodiment, a mouse airway drug delivery device is described. The structural features and working principle of the above-mentioned components are based on existing technologies and will not be described in detail here.
[0021] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.
[0022] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
[0023] The above description is only a preferred embodiment of the present utility model and does not limit the implementation method and protection scope of the present utility model. Those skilled in the art should realize that all solutions obtained by equivalent substitutions and obvious changes made based on the description and illustrations of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A mouse airway drug delivery device, comprising a main body (1), characterized in that: A conical sealing body (5) is fitted below the main body (1), a gas guide tube (3) is fixed on the side of the main body (1), an air inlet (4) is fixedly connected to the top of the gas guide tube (3), and a drug inlet (2) is fixedly connected to the top of the main body (1).
2. The mouse airway drug delivery device according to claim 1, characterized in that: The main body (1) is hollow inside, and the conical sealing body (5) surrounds the bottom of the main body (1).
3. The mouse airway drug delivery device according to claim 1, characterized in that: An animal ventilator is externally connected to the air inlet (4).
4. The mouse airway drug delivery device according to claim 1, characterized in that: A metering tube (6) is fixedly connected to the top of the inlet (2). The top of the metering tube (6) has a hole and a piston (7) is slidably connected inside. An infusion tube (8) is fixedly connected to the side of the metering tube (6). A first ball valve (9) is rotatably connected inside the infusion tube (8). A second ball valve is fixedly provided between the inlet (2) and the metering tube (6).
5. The mouse airway drug delivery device according to claim 4, characterized in that: The surface of the quantitative tube (6) is provided with graduations.