Drug reservoir for intraocular lens, and intraocular lens comprising such drug reservoir
By setting a drug reservoir gap on the loop of the intraocular lens and utilizing shape fit and interference fit, the problem of easy drug reservoir detachment was solved, and stable attachment of the drug reservoir to the intraocular lens and reliable drug delivery were achieved.
Patent Information
- Application Number
- CN202390000361.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Priority Date
- 2022-05-20
- Filing Date
- 2023-05-12
- Publication Date
- 2025-12-05
- Estimated Expiration
- 2033-05-12
AI Technical Summary
In the prior art, the drug reservoir is prone to release from the intraocular lens, leading to unstable drug delivery.
A drug reservoir is designed by setting a first and second drug reservoir gap on a loop arm, using form fit and interference fit to firmly attach the drug reservoir to the loop arm, the longitudinal end of the loop arm is set in a through hole, and displacement and pivoting movements ensure that the drug reservoir does not release from the intraocular lens.
This achieves stable attachment between the drug reservoir and the intraocular lens, preventing drug detachment during insertion and ensuring the reliability and stability of drug delivery.
Smart Images
Figure CN223627646U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present invention relates to a drug reservoir for an intraocular lens, and to an intraocular lens having such a drug reservoir. BACKGROUND
[0002] In the treatment of cataracts of the eye, the natural lens is replaced by an artificial intraocular lens. For this purpose, usually only a small incision is made in the cornea of the eye, which is large enough to allow the tip of an injector to be introduced into the eye through the incision. After the incision has been made in the cornea, the natural lens of the eye is usually pulverized by phacoemulsification and then suctioned out of the capsular bag of the eye. Thereafter, the intraocular lens is inserted into the eye by means of the injector.
[0003] After the treatment of cataracts, a drug, for example an antibiotic and / or an anti-inflammatory agent, is usually delivered into the eye. A drug reservoir which is introduced into the eye together with the intraocular lens can be attached to the intraocular lens, for example. If the intraocular lens is inserted into the eye via the tip, the drug reservoir should not be released from the intraocular lens. US 2021 / 0267751 Al discloses an intraocular drug delivery platform. US 2014 / 0148900 Al discloses an intraocular device to which a drug delivery structure is attached. SUMMARY
[0004] It is therefore an object of the present invention to provide a drug reservoir and an intraocular lens having a drug reservoir, wherein the drug reservoir is not released from the intraocular lens when the drug reservoir is attached to the intraocular lens.
[0005] The drug reservoir for an intraocular lens according to the application has a drug, a through-hole, a first drug reservoir gap which communicates with the through-hole, a first web which delimits the first drug reservoir gap, a first end face which delimits the through-hole, and a second end face which is arranged facing away from the first end face and delimits the through-hole, wherein the through-hole has a first longitudinal end in the region of the first end face and a second longitudinal end in the region of the second end face, wherein the drug reservoir has a displacement direction which is oriented from the first longitudinal end to the second longitudinal end, wherein the first drug reservoir gap is formed in such a way that the through-hole can be entered from the outside of the drug reservoir in a drug reservoir radial direction in terms of the displacement direction through the first drug reservoir gap. The drug reservoir can be coupled to a haptic arm of the intraocular lens, since a longitudinal end of the haptic arm is arranged in the through-hole, which longitudinal end of the haptic arm is arranged facing away from an optical body of the intraocular lens, and the drug reservoir is subsequently displaced in the displacement direction and closer to the optical body. The drug reservoir can be attached particularly firmly to the haptic arm, since a portion of the haptic arm is subsequently introduced into the first drug reservoir gap, for example since the haptic arm has a protrusion which is designated to engage in the first drug reservoir gap. The drug reservoir will therefore be less likely to be released from the intraocular lens, in particular if the intraocular lens is inserted into the capsular bag of the eye by means of a tip of an injector.
[0006] The displacement direction is preferably arranged parallel to a normal to the first end face and / or parallel to a normal to the second end face.
[0007] It is preferred that the first web forms a portion of the first end face. It is particularly preferred that the first web delimits the first drug reservoir gap in a direction which is oriented opposite to the displacement direction.
[0008] It is preferred that the second end face does not form in the region of the first drug reservoir gap, so that the first drug reservoir gap is enterable from the outside of the drug reservoir in the displacement direction. This makes it possible for the haptic arm to be introduced into the first drug reservoir gap by means of a pivoting movement of the drug reservoir when the haptic arm is arranged in the through-hole.
[0009] The drug reservoir preferably has a second drug reservoir gap which communicates with the through-hole, and a second web which delimits the second drug reservoir gap, wherein the second drug reservoir gap is formed in such a way that the through-hole can be entered from the outside of the drug reservoir in a further drug reservoir radial direction in terms of the displacement direction through the second drug reservoir gap. The drug reservoir can be attached more firmly to the haptic arm, since the haptic arm is arranged in the second drug reservoir gap, in particular since a further protrusion of the haptic arm engages in the second drug reservoir gap.
[0010] The first drug reservoir gap and the second drug reservoir gap are preferably spaced apart from one another.
[0011] The second connecting plate preferably forms a part of the second end face. It is particularly preferred that the second connecting plate bounds the second drug reservoir gap in the displacement direction.
[0012] It is preferred that the first end face is not formed in the region of the second drug reservoir gap, such that the second drug reservoir gap is accessible from the outside of the drug reservoir counter to the displacement direction. This advantageously makes it possible to introduce the haptic arm into the first drug reservoir gap and the second drug reservoir gap simultaneously by means of a pivoting movement.
[0013] It is preferred that the drug reservoir is designated to dispense the drug continuously. In particular, the drug reservoir can be designated to be biodegradable. To this end, the drug reservoir can have a matrix into which the drug can be introduced, the matrix comprising a copolymer formed from a first monomer and a second monomer. The first monomer can be caprolactone, and the second monomer can be selected from the group comprising lactide, glycolide and / or trimethylene carbonate. An example of a matrix into which the drug can be introduced and which is not biodegradable is polymeric hydroxyethyl methacrylate.
[0014] The drug can comprise, for example, an antibiotic (such as moxifloxacin), and / or a steroidal anti-inflammatory (e.g. dexamethasone), and / or a non-steroidal anti-inflammatory (e.g. a non-steroidal anti-rheumatic, such as diclofenac). For example, the drug can additionally or alternatively comprise a diagnostic substance, such as a contrast agent.
[0015] The drug reservoir can comprise, for example, a single material, the single material comprising a matrix into which the drug is introduced, or the single material consisting of a matrix into which the drug is introduced.
[0016] The drug reservoir preferably comprises a first material, the first material comprising a matrix into which the drug is introduced, and a second material, the second material being different from the first material and forming the first connecting plate, in particular forming the second connecting plate. The second material is preferably not biodegradable. To this end, the second material can be selected from the group comprising polymethyl methacrylate, polymeric hydroxyethyl methacrylate, polypropylene, silicone, acrylate copolymer.
[0017] The drug reservoir preferably has a first cover plate, the first cover plate being formed from the second material and forming the first end face. Furthermore, the drug reservoir can have a second cover plate, the second cover plate being formed from the second material and forming the second end face.
[0018] The intraocular lens according to the application has an optical body, a haptic arm fastened to the optical body, and a drug reservoir according to the application or according to a preferred embodiment of the drug reservoir according to the application, wherein the haptic arm is arranged in the through-hole and in the first drug reservoir gap.
[0019] It is preferred that the haptic arm is of a curved design. The haptic arm is particularly preferably designed in the shape of a C or a J.
[0020] The drug reservoir is preferably secured to the loop arm by a form fit and / or interference fit. As a result, the drug reservoir is particularly securely mounted on the loop arm. Attached Figure Description
[0021] The invention will now be explained in more detail with reference to the accompanying drawings. In the drawings:
[0022] Figure 1 A top view of an intraocular lens according to the invention is shown, which is depicted as being disposed in a capsular bag;
[0023] Figure 2 A perspective view of a drug reservoir unrelated to the present invention is shown;
[0024] Figure 3 A perspective view of the first drug reservoir according to the present invention is shown;
[0025] Figure 4 A perspective view of the second drug reservoir according to the present invention is shown;
[0026] Figure 5 A side view of the intraocular lens according to the present invention is shown;
[0027] Figure 6 A loop arm and a drug reservoir according to the invention are shown, the drug reservoir being arranged spaced apart from the loop arm;
[0028] Figure 7 It shows Figure 6 The loop arm and the drug reservoir, wherein the drug reservoir is displaced onto the loop arm; and
[0029] Figure 8 It shows Figure 6 and Figure 7 The loop arm and the drug reservoir are drawn to be disposed in the pouch, wherein a first connecting plate of the loop arm is disposed in a first axial gap of the loop arm, and a second connecting plate of the loop arm is disposed in a second axial gap of the loop arm. Detailed Implementation
[0030] As from Figure 3 and Figure 4As can be seen, the drug reservoir 4 for an intraocular lens 1 according to the present invention has a drug, a through hole 8, a first drug reservoir gap 23 communicating with the through hole 8, a first connecting plate 25 defining the first drug reservoir gap 23, a first end face 31 defining the through hole 8, and a second end face 32 disposed opposite to the first end face 31 and defining the through hole 8. The through hole 8 has a first longitudinal end 34 in the region of the first end face 31 and a second longitudinal end 35 in the region of the second end face 32. The drug reservoir 4 has a displacement direction 15 oriented from the first longitudinal end 34 to the second longitudinal end 35. The first drug reservoir gap 23 is formed such that the through hole 8 can enter from the outside of the drug reservoir 4 through the first drug reservoir gap 23 in the drug reservoir radial direction 16 with respect to the displacement direction 15. The drug reservoir 4 according to the present invention and Figure 2 The difference between the drug reservoir 4 and the drug storage device 4 is that... Figure 2 The first drug storage gap 23 is not provided in the drug storage 4.
[0031] The drug reservoir 4 may have a circumferential surface 33 on its outer side, which is disposed between the first end face 31 and the second end face 32, specifically, it may be directly adjacent to the first end face 31 and the second end face 32.
[0032] As from Figure 1 , Figure 5 and Figure 8 As can be seen, the intraocular lens 1 according to the present invention has an optical body 2 (see...). Figure 1 and Figure 5 The loop arm 3, which is fastened to the optical body 2, and the drug reservoir 4, wherein the loop arm 3 is disposed in the through hole 8 and in the first drug reservoir gap 23.
[0033] The loop arm 3 can be a curved design, specifically designed as a C-shape (see [reference]). Figure 1 () or J-shaped.
[0034] The drug reservoir 4 can be fastened to the loop arm 3 by, for example, shape fit and / or interference fit.
[0035] Figure 1 and Figure 5 The optical body 2 is shown to include an optical axis 11. The loop arm 3 may have a radial gap 6 (see...). Figure 1 and Figure 6 to Figure 8 The drug reservoir 4 is disposed within the radial gap, which is coupled to one side of the loop arm 3, which is located externally in the radial direction 13 with respect to the optical axis 11. Because the drug reservoir 4 is disposed within the radial gap 6, it is particularly securely mounted to the loop arm 3. Therefore, the possibility of the drug reservoir 4 detaching from the loop arm 3 is extremely low, especially if the intraocular lens 1 is injected into the eye's capsular bag 5 via the tip of the injector (see...).Figure 1 and Figure 8 ). Since the radial gap 6 is incorporated in the outer side of the haptic arm 3 in the radial direction 13, the drug reservoir 4 does not protrude or only slightly protrudes outward from the haptic arm 3 in the radial orientation 13. Because the outer side of the haptic arm 3 contacts the capsular bag 5 in the radial direction 13, the decentration of the optical body 2 of the intraocular lens 1 in the eye caused by the drug reservoir 4 can be reduced or even avoided.
[0036] Figure 1 and Figure 8 It is shown how the drug reservoir 4 can be recessed into the radial gap 6. This has the effect that the drug reservoir 4 does not cause the capsular bag 5 to bulge outward, i. e. away from the optical body 2, when the intraocular lens 1 is introduced into the capsular bag 5 of the eye, see Figure 1 and Figure 8 .
[0037] Figure 6 It is shown that the radial gap 6 can be delimited by a first side 41 which delimits the displacement of the drug reservoir 4 opposite the radial direction 13, i. e. towards the optical axis 11. Furthermore, the radial gap 6 can be delimited by a second side 42 which delimits the displacement of the drug reservoir 4 in the circumferential direction 14 with respect to the optical axis 11. Furthermore, the radial gap 6 can be delimited by a third side 43 which delimits the displacement of the drug reservoir 4 in a direction which is oriented opposite the circumferential direction 14.
[0038] Figure 3 and Figure 4 It is shown that the first connecting plate 25 can form a part of the first end face 31. Figure 6 to Figure 8 It is shown that the haptic arm 3 can have a first axial gap 7a in which the first connecting plate 25 is arranged and which is incorporated in a first side of the haptic arm 3 which is arranged externally in the axial direction 12 with respect to the optical axis 11. The second end face 32 can not be formed in the region of the first drug reservoir gap 23, see Figure 3 and Figure 4 so that the first drug reservoir gap 23 is accessible from the outside of the drug reservoir 4 in the displacement direction 15. The first connecting plate 25 can delimit the first drug reservoir gap 23 in a direction which is oriented opposite the displacement direction 15.
[0039] Figure 6 It is shown that the first axial gap 7a can be delimited by a first side 44 which delimits the displacement of the drug reservoir 4 opposite the axial direction 12. Furthermore, the first axial gap 7a can be delimited by a second side 45 which delimits the displacement of the drug reservoir 4 opposite the circumferential direction 14. Furthermore, the first axial gap 7a can be delimited by a third side 46 which delimits the displacement of the drug reservoir 4 in the circumferential direction 14.
[0040] The first side 41 of the radial gap 6 and the first side 44 of the first axial gap 7a can for example enclose an angle of 60° to 120°, in particular 80° to 100° or essentially 90°.
[0041] Figure 3 and Figure 4 It is further shown that the drug reservoir 4 can have a second drug reservoir gap 24 which is in communication with the through-hole 8, and a second web 26 which bounds the second drug reservoir gap 24, wherein the second drug reservoir gap 24 is formed such that the through-hole 8 is accessible from the outside of the drug reservoir 4 in a further drug reservoir radial direction 16 of the displacement direction 15. The first drug reservoir gap 23 and the second drug reservoir gap 24 can be spaced apart from each other. In particular, the first drug reservoir gap 23 and the second drug reservoir gap 24 can be arranged such that they follow the curvature of the loop arm 3 and thus do not cause any deformation of the loop arm 3 when the drug reservoir 4 is attached to the loop arm 3.
[0042] The second web 26 can form a part of the second end face 32. Further, it can be seen from Figure 6 to Figure 8 It can be seen from Fig. 2 that the loop arm 3 can have a second axial gap 7b in which the second web 26 is arranged and which is offset from the first axial gap 7a in a circumferential direction 14 of the optical axis 11 and is incorporated in a second side of the loop arm 3 which is arranged externally opposite to the axial direction 12 and is arranged to face away from the first side. The first end face 31 can not be formed in the region of the second drug reservoir gap 24 such that the second drug reservoir gap 24 is accessible from the outside of the drug reservoir 4 opposite to the displacement direction 15. The second web 26 can bound the second drug reservoir gap 24 in the displacement direction 15.
[0043] Figure 6 It is shown that the second axial gap 7b can be bounded by a first side 47 which bounds the displacement of the drug reservoir 4 in the axial direction 12. Further, the second axial gap 7b can be bounded by a second side 48 which bounds the displacement of the drug reservoir 4 opposite to the circumferential direction 14. Further, the second axial gap 7b can be bounded by a third side 49 which bounds the displacement of the drug reservoir 4 in the circumferential direction 14.
[0044] The first side 41 of the radial gap 6 and the first side 47 of the second axial gap 7b can for example enclose an angle of 60° to 120°, in particular 80° to 100° or essentially 90°.
[0045] The first axial gap 7a can directly adjoin the radial gap 6 and / or the second axial gap 7b can directly adjoin the radial gap 6 (see Fig. 2). Figure 6 to Figure 8). The second axial gap 7b can be arranged spaced apart in the circumferential direction 14 from the first axial gap 7a. Figure 1 and Figure 6 to Figure 8 It is shown that the intraocular lens 1 can have a radial protrusion 10 which protrudes inward in the radial direction 13 from the rest of the haptic arm 3 and which is arranged in the same region as the radial gap 6 in the circumferential direction 14 relative to the optical axis 11.
[0046] The first connecting plate 25 can be recessed into the first axial gap 7a such that the drug reservoir 4 can be arranged in the region of the first side in order to be flush with the haptic arm 3 when viewed in the radial direction 13 (see Figure 5 ). The second connecting plate 26 can be recessed into the second axial gap 7b such that the drug reservoir 4 can be arranged in the region of the second side in order to be flush with the haptic arm 3 when viewed in the radial direction 13 (see Figure 5 ). Due to this fact, it can be particularly reliably avoided that the drug reservoir 4 is released from the haptic arm 3 upon injection of the intraocular lens 1. When folding the intraocular lens 1 before injection of the intraocular lens 1, it can also be easily possible to transfer the haptic arm 3 onto the optical body 2 and to fold the optical body 2 around the haptic arm 3.
[0047] The displacement direction 15 can be oriented in the direction in which the drug reservoir 4 is to be displaced in order to displace the drug reservoir 4 into the radial gap 6. It can be conceivable that the displacement direction 15 is arranged parallel to the normal of the first end face 31 and / or parallel to the normal of the second end face 32. The first end face 31 can form a longitudinal end of the drug reservoir 4 which lies in the displacement direction 15, and the second end face 21 can form a longitudinal end of the drug reservoir 4 which lies in a direction which is oriented opposite to the displacement direction 15.
[0048] Figure 6 to Figure 8 It is shown how the drug reservoir 4 can be attached to the haptic arm 3. First, the drug reservoir 4 is arranged spaced apart from the haptic arm 3. Subsequently, the longitudinal end 9 of the haptic arm 3 which is arranged facing away from the optical body 2 can first be arranged in the through-hole 8. By displacing the drug reservoir 4 in the displacement direction 15, the drug reservoir 4 can be displaced until the drug reservoir 4 reaches the radial gap 6 (see Figure 7 ). In the first embodiment of the drug reservoir 4, the displacement is completed here, and for example the arrangement shown in Figure 1 is obtained. In the second and third embodiments of the drug reservoir 4, a pivoting of the drug reservoir 4 is still required such that the first connecting plate 25 reaches the first axial gap 7a and the second connecting plate 26 reaches the second axial gap 7b (see Figure 8 ). It can be conceivable here that the displacement direction 15 is arranged parallel to the optical axis 11, see Figure 8 .
[0049] The drug reservoir 4 can comprise only a single material comprising the drug, as is the case in the first embodiment according to the application in the drug reservoir 4 according to Figure 3
[0050] Alternatively, it is conceivable that the drug reservoir 4 comprises a first material comprising the drug and a second material different from the first material and forming the first connection plate 25, as is the case in the second embodiment according to the application in the drug reservoir 4 according to Figure 4
[0051] The first cover plate 21 and / or the second cover plate 22 can be porous. This allows a faster release of the drug.
[0052] The drug reservoir 4 can have a post extending through the first material and connecting the first cover plate 21 and the second cover plate 22 to each other. For example, the post can comprise and / or consist of the second material. It is also conceivable that a plurality of posts is provided, which in particular all connect the first cover plate 21 and the second cover plate 22 to each other.
[0053] List of reference signs
[0054] 1 intraocular lens
[0055] 2 optical body
[0056] 3 haptic arm
[0057] 4 drug reservoir
[0058] 5 capsule bag
[0059] 6 radial gap
[0060] 7a first axial gap
[0061] 7b second axial gap
[0062] 8 through-hole
[0063] 9 longitudinal end
[0064] 10 radial protrusion
[0065] 11 optical axis
[0066] 12 axial direction
[0067] 13 radial direction
[0068] 14 circumferential direction
[0069] 15 displacement direction
[0070] 16 drug reservoir radial direction
[0071] 17 drug reservoir circumferential direction
[0072] 20 central portion
[0073] 21 first cover plate
[0074] 22 second cover plate
[0075] 23 first drug reservoir gap
[0076] 24 second drug reservoir gap
[0077] 25 first connecting plate
[0078] 26 second connecting plate
[0079] 31 first end face
[0080] 32 second end face
[0081] 33 circumferential surface
[0082] 34 first longitudinal end
[0083] 35 second longitudinal end
[0084] 41 first side of radial gap
[0085] 42 second side of radial gap
[0086] 43 third side of radial gap
[0087] 44 first side of first axial gap
[0088] 45 second side of first axial gap
[0089] 46 third side of first axial gap
[0090] 47 first side of second axial gap
[0091] 48 second side of second axial gap
[0092] 49 third side of third axial gap
Claims
1. A drug reservoir for an intraocular lens (1), the drug reservoir having a drug, a through-hole (8), a first drug reservoir gap (23) in communication with the through-hole (8), a first web (25) delimiting the first drug reservoir gap (23), a first end face (31) delimiting the through-hole (8), and a second end face (32) arranged to face away from the first end face (31) and delimiting the through-hole (8), wherein, The through-hole (8) has a first longitudinal end (34) in the region of the first end face (31) and a second longitudinal end (35) in the region of the second end face (32), wherein the drug reservoir (4) has a displacement direction (15) oriented from the first longitudinal end (34) to the second longitudinal end (35), wherein the first drug reservoir gap (23) is formed such that the through-hole (8) is accessible from outside the drug reservoir (4) through the first drug reservoir gap (23) in a drug reservoir radial direction (16) with respect to the displacement direction (15).
2. The drug reservoir of claim 1, wherein, The first connection plate (25) forms a portion of the first end face (31).
3. The drug reservoir of claim 1 or 2, wherein, The second end face (32) is not formed in the region of the first drug reservoir gap (23) such that the first drug reservoir gap (23) is accessible from outside the drug reservoir (4) in the displacement direction (15).
4. The drug reservoir of claim 1 or 2, wherein, The drug reservoir (4) has a second drug reservoir gap (24) which communicates with the through-hole (8) and a second connection plate (26) which delimits the second drug reservoir gap (24), wherein the second drug reservoir gap (24) is formed such that the through-hole (8) is accessible from outside the drug reservoir (4) through the second drug reservoir gap (24) in a further drug reservoir radial direction (16) with respect to the displacement direction (15).
5. The drug reservoir of claim 4, wherein, The second connection plate (26) forms a portion of the second end face (32).
6. The drug reservoir of claim 4, wherein, The first end face (31) is not formed in the region of the second drug reservoir gap (24) such that the second drug reservoir gap (24) is accessible from outside the drug reservoir (4) counter to the displacement direction (15).
7. The drug reservoir of claim 5, wherein, The first end face (31) is not formed in the region of the second drug reservoir gap (24) such that the second drug reservoir gap (24) is accessible from outside the drug reservoir (4) counter to the displacement direction (15).
8. The drug reservoir of claim 1 or 2, wherein, The drug reservoir (4) comprises only a single material, the single material comprising a matrix having the drug introduced therein.
9. The drug reservoir of claim 1 or 2, wherein, The drug reservoir (4) comprises a first material and a second material, the first material comprising a matrix having the drug introduced therein, the second material being different from the first material and forming the first connection plate (25).
10. The drug reservoir of claim 9, wherein, The drug reservoir (4) has a first cover plate (21) which is formed from the second material and forms the first end face (31).
11. An intraocular lens having an optical body (2), a haptic arm (3) fastened to the optical body (2), and a drug reservoir (4) as claimed in one of claims 1 to 10, wherein The loop arm (3) is arranged in the through-hole (8) and in the first drug reservoir gap (23).
Citation Information
Patent Citations
Device and method for intraocular drug delivery
US20140148900A1
Intraocular drug delivery platform
US20210267751A1