Hair treatment device
By combining a multi-layered test tube structure with grinding beads, the complexity and inaccuracy of hair drug detection have been solved, achieving efficient and stable hair drug detection, simplifying the operation process and reducing the risk of environmental pollution.
Patent Information
- Application Number
- CN202422192875.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-09
- Publication Date
- 2025-12-09
- Estimated Expiration
- 2034-09-09
AI Technical Summary
Existing hair drug testing methods suffer from problems such as high false positive/negative probability, narrow detection range, low sensitivity, long processing time, complex operation, high cost, and environmental pollution. In particular, laboratory testing procedures are cumbersome and require professional personnel to operate, making it difficult to guarantee the accuracy of the results.
A hair processing device is provided, comprising a multi-layer test tube structure, which achieves hair cleaning, drying, grinding, and extraction filtration through a combination of conical holes, filter membranes, and grinding beads, simplifying the operation process and improving detection efficiency and accuracy.
It achieves highly stable and efficient hair drug detection, reduces the complexity of manual operation and the risk of environmental pollution, and improves the reliability and sensitivity of test results.
Smart Images
Figure CN223650259U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of chemical detection, and in particular to a hair treatment device. Background Technology
[0002] Currently, the routine detection methods for drugs in hair samples are mainly as follows:
[0003] 1. On-site rapid screening mainly uses colloidal gold, quantum dot fluorescence, Raman spectroscopy, etc. Its main drawback is:
[0004] It suffers from drawbacks such as a high probability of false positives / negatives, a narrow detection range (one or several types), and low sensitivity. In actual testing, it requires repeated manual operation and judgment, which reduces the reliability of the results.
[0005] 2. Laboratory testing mainly uses acid hydrolysis, alkaline hydrolysis, solvent ultrasonication, and dry grinding; the main drawback of this method is:
[0006] The current method suffers from drawbacks such as long processing time, severe static electricity, environmental pollution and health risks from organic reagents, high testing costs, and complex operation. For example, the Ministry of Justice standard SF / Z JD0107025-2018, "Liquid Chromatography-Tandem Mass Spectrometry Method for Detection of 15 Narcotic Drugs and Their Metabolites in Hair," specifies a hair sample processing procedure involving washing, drying, cutting, weighing, freeze-grinding, sonication in an ice bath, centrifugation, followed by taking the supernatant, drying, reconstitution, and mass spectrometry detection. This method is cumbersome, time-consuming, and labor-intensive. Furthermore, it requires professional personnel to operate the mass spectrometer and assess and adjust its condition; otherwise, the accuracy of the results cannot be guaranteed. Therefore, there is an urgent need for a stable and efficient detection method. Summary of the Invention
[0007] To address the aforementioned problems, this application provides a grinding instrument.
[0008] This application provides a hair treatment device, including:
[0009] A first test tube having a through hole in its side wall; a second test tube with a sealing cap, the diameter of which is larger than that of the first test tube; a third test tube having a filter membrane disposed on at least its bottom wall, the diameter of which is larger than that of the first test tube; and a fourth test tube having a diameter larger than that of the third test tube, and a length greater than that of the third test tube.
[0010] In one embodiment, the through hole is a tapered hole, and the opening diameter of the tapered hole facing the inner wall of the first test tube is larger than the opening diameter of the tapered hole facing the outer wall of the first test tube.
[0011] In one embodiment, the diameter of the opening of the tapered hole toward the inner wall of the first test tube is smaller than the diameter of the grinding bead.
[0012] In one embodiment, the diameter of the through hole is less than 2 mm, and the wall thickness of the first test tube is no more than 1 mm.
[0013] In one embodiment, the filter membrane is disposed on the sidewall of the third test tube.
[0014] In one embodiment, after the third test tube is inserted into the fourth test tube, the fourth test tube is capable of holding at least 1 ml of extract.
[0015] In one embodiment, a concave-convex fit is provided between the third test tube and the fourth test tube to restrict the rotation of the third test tube after it is inserted into the fourth test tube.
[0016] A hair treatment method, characterized in that it utilizes the aforementioned hair treatment apparatus, the method comprising:
[0017] The hair is placed in the first test tube, and the first mass of the hair and the first test tube is obtained;
[0018] Place the first test tube into the second test tube, and add cleaning solution to the second test tube to clean the hair;
[0019] Remove the first test tube from the second test tube and dry it to obtain the second mass of the hair and the first test tube;
[0020] Place the first test tube into the third test tube, and then place the third test tube into the fourth test tube. Place grinding beads and extract into the first test tube and the third test tube.
[0021] After grinding and extracting the hair, the extract is obtained in the fourth test tube.
[0022] In some embodiments, the extract is obtained by pressure or centrifugation.
[0023] In some embodiments, the cleaning solution is a water-acetone cleaning solution.
[0024] This application provides a hair treatment device, comprising a first test tube, a second test tube, a third test tube, and a fourth test tube. The first test tube has through holes in its sidewall. That is, the first test tube can be a perforated structure. The first test tube can be used to hold a sample, such as hair. The first test tube can be made of metal mesh, including multiple mesh openings. The second test tube has a sealing cap, and the diameter of the second test tube is larger than the diameter of the first test tube. Therefore, the first test tube can be placed inside the second test tube. The second test tube can be used to hold a cleaning solution. After the first test tube is placed inside the second test tube, the hair can be cleaned. When the first test tube is placed inside the second test tube, the sealing cap seals the second test tube, so the cleaning solution and sample will not splash out when the second test tube is shaken. The third test tube has at least a filter membrane on its bottom wall; the diameter of the third test tube is larger than the diameter of the first test tube. Therefore, the first test tube can be placed inside the third test tube. After the hair in the first test tube is cleaned and dried, it can be placed into the third test tube. The third test tube may contain an extraction solution. The extraction solution can be used to extract components from the hair in the first test tube to analyze for the presence of drug components. The diameter of the fourth test tube is larger than that of the third test tube, and the length of the fourth test tube is larger than that of the third test tube. In other words, the third test tube can be placed inside the fourth test tube.
[0025] The extraction of hair components can be performed in the fourth test tube. Specifically, the first test tube containing the hair is first placed into the third test tube. Then, the third test tube is placed into the fourth test tube. After injecting the extraction solution into the third test tube, the solution can enter the first test tube through the through-hole to soak the hair and extract its components. After a period of time, the fourth test tube can be centrifuged or pressurized to filter the extraction solution through the filter membrane provided in the third test tube into the fourth test tube. Since the filter membrane prevents hair from entering the fourth test tube, the extraction solution in the fourth test tube can be analyzed to determine whether drug components are present in the hair. Therefore, the hair treatment device provided in this application embodiment has good stability and high processing efficiency. Attached Figure Description
[0026] Figure 1 A schematic diagram provided for an embodiment of this application;
[0027] Figure 2 This is a schematic diagram illustrating the method of using the hair treatment device provided in the embodiments of this application;
[0028] Figure 3 This is a schematic diagram illustrating the method of using the hair treatment device provided in the embodiments of this application;
[0029] Figure 4 This is a schematic diagram illustrating the method of using the hair treatment device provided in the embodiments of this application;
[0030] Figure 5 This is a schematic diagram illustrating the method of using the hair treatment device provided in the embodiments of this application;
[0031] Figure 6 This is a schematic diagram illustrating the method of using the hair treatment device provided in the embodiments of this application;
[0032] Figure 7 This is a schematic diagram illustrating the method of using the hair treatment device provided in the embodiments of this application.
[0033] Figure label:
[0034] Hair treatment device 10
[0035] First test tube 110
[0036] Through hole 111
[0037] Second test tube 120
[0038] Sealing cap 121
[0039] Third test tube 130
[0040] Filter membrane 131
[0041] Fourth test tube 140
[0042] 150 hairs
[0043] Extract 142 Detailed Implementation
[0044] To make the objectives, technical solutions, and advantages of this application clearer, the grinding apparatus of this application will be further described in detail below through embodiments and in conjunction with the accompanying drawings. It should be understood that the specific embodiments described herein are only for explaining this application and are not intended to limit this application.
[0045] The serial numbers assigned to components in this document, such as "first" and "second," are used solely to distinguish the described objects and have no sequential or technical meaning. The terms "connection" and "linkage" used in this application, unless otherwise specified, include both direct and indirect connections (linkages). It should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings and are used solely for the convenience of describing this application and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.
[0046] In this application, unless otherwise expressly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.
[0047] Please see Figure 1This application provides a hair 150 processing device 10, which includes a first test tube 110, a second test tube 120, a third test tube 130, and a fourth test tube 140. The first test tube 110 has a through hole 111 in its sidewall. That is, the first test tube 110 can be a hollow structure. The first test tube 110 can be used to hold a sample, such as hair 150. The first test tube 110 can be made of metal wire mesh, including multiple mesh openings. The second test tube 120 has a sealing cap 121, and the diameter of the second test tube 120 is larger than the diameter of the first test tube 110. Therefore, the first test tube 110 can be placed inside the second test tube 120. The second test tube 120 can be used to hold the cleaning solution. After the first test tube 110 is placed into the second test tube 120, the hair 150 can be cleaned. When the first test tube 110 is placed in the second test tube 120, the second test tube 120 is sealed by the sealing cap 121, so the second test tube 120 can be shaken without the cleaning solution and sample splashing out. The third test tube 130 has a filter membrane 131 at least on its bottom wall; that is, a filter membrane 131 can also be placed in other locations within the third test tube 130, which is not limited here. The diameter of the third test tube 130 is larger than the diameter of the first test tube 110. Therefore, the first test tube 110 can be placed inside the third test tube 130. After the hair in the first test tube 110 is cleaned, it is dried. After drying, the first test tube 110 can be placed inside the third test tube 130. The third test tube 130 may contain an extract 142. The hair 150 in the first test tube 110 can be extracted using extraction solution 142 to analyze the presence of drug components. The diameter of the fourth test tube 140 is larger than that of the third test tube 130, and the length of the fourth test tube 140 is larger than that of the third test tube 130. That is, the third test tube 130 can be placed inside the fourth test tube 140.
[0048] The extraction of components from the hair 150 can be performed in the fourth test tube 140. Specifically, the first test tube 110 containing the hair 150 is first placed into the third test tube 130. Then, the third test tube 130 is placed into the fourth test tube 140. After injecting the extraction solution 142 into the third test tube 130, the extraction solution 142 can enter the first test tube 110 through the through-hole 111 to soak and extract components from the hair 150. After a period of time, the fourth test tube 140 can be centrifuged or pressurized to filter the extraction solution 142 through the filter membrane 131 provided in the third test tube 130 into the fourth test tube 140. Since the filter membrane 131 can prevent the hair 150 from entering the fourth test tube 140, the extraction solution 142 in the fourth test tube 140 can be analyzed to determine whether drug components are present in the hair 150. Therefore, the hair processing device 10 provided in this application embodiment has good stability and high processing efficiency.
[0049] In some embodiments, after placing the hair 150 into the first test tube 110, the first test tube 110 and the hair 150 can be weighed to obtain a first weight; after washing and drying the hair 150, the hair 150 and the first test tube 110 are weighed again to obtain a second weight. The second weight minus the first weight yields the weight of the relatively pure hair 150. The weight of the hair and the drug components extracted from the final extract can be used to analyze the drug content per unit weight.
[0050] In some embodiments, the through hole 111 is a tapered hole. The opening diameter of the tapered hole facing the inner wall of the first test tube 110 is larger than the opening diameter of the tapered hole facing the outer wall of the first test tube 110. That is, the diameter of the tapered hole gradually decreases from the inside of the first test tube 110 to the outside of the first test tube 110. Therefore, it can prevent hair 150 from leaking out of the first test tube 110, while maximizing the volume of the first test tube 110.
[0051] In some embodiments, the diameter of the opening of the tapered orifice facing the inner wall of the first test tube 110 is smaller than the diameter of the grinding beads. When extracting components from the hair 150, grinding beads can be placed in the first test tube 110 to facilitate grinding of the hair 150. The smaller diameter of the opening of the tapered orifice facing the inner wall of the first test tube 110 prevents the grinding beads from entering the through hole 111 and causing blockage.
[0052] In some embodiments, the diameter of the through hole 111 is less than 2 mm. This prevents hair 150 from remaining in the hole and being unable to be ground.
[0053] In some embodiments, the wall thickness of the first test tube 110 is no more than 1 mm. Therefore, it is possible to prevent hair 150 from remaining in the hole, that is, even if hair 150 enters the through hole 111, at least part of it will be exposed.
[0054] In some embodiments, the through hole 111 is a tapered hole, and the opening diameter of the tapered hole toward the inner wall of the first test tube 110 is larger than the opening diameter of the tapered hole toward the outer wall of the first test tube 110.
[0055] In some embodiments, the filter membrane 131 is disposed on the sidewall of the third test tube 130. Therefore, the passing area of the extract 142 can be increased, thereby improving the extraction efficiency.
[0056] In some embodiments, after the third test tube 130 is inserted into the fourth test tube 140, the fourth test tube 140 is capable of holding at least 1 ml of extract 142. That is, the space in the fourth test tube 140 is at least 1 ml larger than the space in the third test tube 130, thus enabling the collection of extract 142.
[0057] In some embodiments, a convex-concave fit is provided between the third test tube 130 and the fourth test tube 140 to restrict the rotation of the third test tube 130 after it is inserted into the fourth test tube 140. That is, the fourth test tube 140 may have a mechanism to limit the third test tube 130, preventing it from rotating relative to the fourth test tube 140 during operations such as centrifugation. Similarly, a convex-concave fit can be provided between the first test tube 110 and the second test tube 120, and also between the first test tube 110 and the third test tube 130.
[0058] In some embodiments, the opening edge of the first test tube 110 is provided with an outwardly flared edge, and the openings of the second test tube 120 and the third test tube 130 may also be provided with outwardly flared edges. The outer diameters of these three tubes may be the same. The outer wall height of the first test tube 110 may be the same as the inner wall height of the second test tube 120 and the third test tube 130, so that the first test tube 110 can be placed inside the second test tube 120 and the third test tube 130. Alternatively, the outer wall height of the first test tube 110 may be less than the inner wall height of the second test tube 120, to facilitate the accommodation of the first test tube 110.
[0059] Please continue reading Figure 2-7 This application also provides a hair treatment method, which can be applied to the hair treatment device 10 described above. The method includes:
[0060] Please see Figure 2S10, place hair 150 into the first test tube 110 and obtain the first mass of hair 150 and the first test tube 110; the hair 150 may be about 20mg.
[0061] Please see Figure 3-4 S20, the first test tube 110 is placed into the second test tube 120, and cleaning solution is added to the second test tube 120 to clean the hair 150.
[0062] In this embodiment, the cleaning solution after washing the hair 150 can remain in the second test tube 120.
[0063] In some embodiments, the cleaning solution is a water-acetone cleaning solution. Since hair 150 grows on the body surface, the drugs in hair 150 may enter the hair 150 not only through metabolism from the blood, but also through soaking in sweat, sebaceous glands, or through external environmental pollution. Cleaning has two main purposes: first, to remove hair care products, sweat, sebum, or surface substances that may interfere with analysis or reduce extraction recovery rates; second, to remove potential external drug contamination from the environment. Currently reported cleaning methods include: dichloromethane-water, methanol, dichloromethane-deionized water-methanol, dichloromethane, dichloromethane-methanol, methanol-water, acetone-water, sodium dodecyl sulfate solution-detergent solution-water-acetone, and many others. Blank hair samples (150) from the same batch were cleaned and ground using three different methods: water-methanol, water-acetone, and 0.5% SDS-water-acetone. After cleaning, a matrix extract (142) of the blank hair sample (150) was prepared. Methamphetamine standard was added, and the matrix effect of the hair sample under the three different cleaning conditions was calculated to be 80.1%, 80.7%, and 77.5%, respectively. The matrix effect of the three cleaning methods on methamphetamine detection was not significantly different. Since methanol can extract more components from the hair sample (150), the water-acetone cleaning method was used.
[0064] Please see Figure 5 S30, the first test tube 110 is removed from the second test tube 120 and dried to obtain the second mass of the hair 150 and the first test tube 110;
[0065] In this embodiment, the first test tube 110 containing the hair 150 can be air-dried or blow-dried.
[0066] Please see Figure 6 S40, the first test tube 110 is placed into the third test tube 130, and the third test tube 130 is placed into the fourth test tube 140. Grinding beads and extract 142 are placed in the first test tube 110 and the third test tube 130.
[0067] In some embodiments, the extract 142 may be methanol.
[0068] Please see Figure 7 S50, after grinding and extracting the hair 150, the extract 142 is obtained in the fourth test tube 140. It can be understood that during the extraction process, the extract 142 enters the third test tube 130 through the through-hole 111 in the first test tube 110, and then enters the fourth test tube 140 through the filter membrane 131 of the third test tube 130. The hair 150 is retained on the filter membrane 131.
[0069] In some embodiments, the extract 142 is obtained by pressure or centrifugation.
[0070] In some embodiments, the outer diameter of the third test tube 130 is the same as or larger than the diameter of the fourth test tube 140, so as to prevent the third test tube 130 from falling into the fourth test tube 140 during centrifugation.
[0071] In some embodiments, to prevent excessive hair 150 from clogging the filter membrane 131 at the bottom of the third test tube 130 and preventing liquid from flowing out, the filter membrane 131 can also be provided in the lower part of the wall of the third tube to increase the area for liquid flow. The diameter of the lower part of the third test tube 130 can gradually decrease to facilitate the flow of the extract 142 into the fourth test tube 140. The portion of the third test tube 130 with the filter membrane 131 can also be square to facilitate the outflow of the extract 142.
[0072] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
[0073] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of this patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.
Claims
1. A hair treatment device, characterized in that, include: The first test tube has a through hole in its side wall; The second test tube has a sealed cap and its diameter is larger than that of the first test tube. A third test tube, wherein at least the bottom wall of the third test tube is provided with a filter membrane; the diameter of the third test tube is larger than the diameter of the first test tube; as well as The fourth test tube has a larger diameter than the third test tube and a longer length than the third test tube.
2. The hair treatment device as described in claim 1, characterized in that, The through hole is a tapered hole, and the diameter of the opening of the tapered hole toward the inner wall of the first test tube is smaller than the diameter of the grinding bead.
3. The hair treatment apparatus according to any one of claims 1-2, characterized in that, The filter membrane is provided on the side wall of the third test tube.
4. The hair treatment apparatus according to any one of claims 1-2, characterized in that, After the third test tube is inserted into the fourth test tube, the remaining space in the fourth test tube should be able to hold at least 1 ml of extract.
5. The hair treatment apparatus according to any one of claims 1-2, characterized in that, The third test tube and the fourth test tube are provided with a concave-convex fit to restrict the rotation of the third test tube after it is inserted into the fourth test tube.
6. The hair treatment apparatus as claimed in claim 1, characterized in that, The through hole is a tapered hole, and the opening diameter of the tapered hole facing the inner wall of the first test tube is larger than the opening diameter of the tapered hole facing the outer wall of the first test tube.