Mounting structure of electrospray structure of liquid chromatogram tandem mass spectrometer

Abstract

The utility model relates to the technical field of liquid chromatogram mass spectrometers, and discloses a mounting structure of an electrospray structure of a liquid chromatogram tandem mass spectrometer, which comprises a mounting seat, a sleeve is connected to the mounting seat in a penetrating manner, a sliding sleeve is slidably connected in the sleeve, an electrospray needle is arranged in the sliding sleeve, one end, far away from the mounting seat, of the sliding sleeve is rotatably sleeved with the sliding sleeve, and the other end of the sliding sleeve is rotatably sleeved with the sliding sleeve. A plurality of clamping arms are arranged between the rotating ring and the sliding sleeve, a first sinking groove is formed in the rotating ring, one end of each clamping arm is rotationally connected into the first sinking groove, a sliding groove is formed in the clamping arm in the length direction of the clamping arm, a shifting rod sliding along the sliding groove is arranged on the outer side wall of the sliding sleeve, and when the rotating ring rotates, the shifting rod drives the clamping arms to rotate. And the clamping arm is abutted against or separated from the outer side wall of the electrospray needle. The electrospray needle is fixed through the multiple clamping arms, and the adjustable space for containing the electrospray needle is formed among the multiple clamping arms, so that the mounting structure is adaptive to the electrospray needles of different sizes, and the application range of the mounting structure is widened.

Description

Technical Field

[0001] This application relates to the field of liquid chromatography-mass spectrometry (LC-MS) technology, and in particular to an installation structure for an electrospray structure of a liquid chromatography-tandem mass spectrometer. Background Technology

[0002] Electrospray ionization (ESI) typically refers to the interface device used in liquid chromatography-mass spectrometry (LC-MS). The solvent carries ionic or polar sample molecules through a capillary. A high-voltage electric field is applied at the capillary outlet, and under the influence of Coulomb force, the sample molecules are atomized into tiny charged droplets at the capillary outlet.

[0003] The electro-spray structure includes a housing and an electro-spray needle mounted on the housing. Currently, the installation of the electro-spray needle requires a suitable mounting structure on the housing, and only electro-spray needles of specific sizes can be installed. The design cannot be adjusted according to the size of the electro-spray needle, resulting in poor adaptability of the mounting structure. Utility Model Content

[0004] To address the issue that existing electrospray needle mounting structures can only accommodate electrospray needles of specific sizes, resulting in poor applicability, this application provides a mounting structure for an electrospray system in a liquid chromatography-tandem mass spectrometer.

[0005] This application provides an installation structure for the electrospray ionization (ESI) mechanism of a liquid chromatography-tandem mass spectrometer, employing the following technical solution:

[0006] An installation structure for an electrospray ionization (ESI) structure of a liquid chromatography-tandem mass spectrometer includes a mounting base, a sleeve extending through the mounting base, a sliding sleeve slidably connected within the sleeve, an electrospray needle disposed within the sliding sleeve, and a sliding sleeve rotatably fitted onto the end of the sliding sleeve furthest from the mounting base. Multiple clamping arms are disposed between a rotating ring and the sliding sleeve. The rotating ring has a first groove, and one end of each clamping arm is rotatably connected to the first groove. A groove is formed along the length of each clamping arm. A lever is provided on the outer wall of the sliding sleeve, sliding along the groove. A clearance opening is provided on the sliding sleeve for the clamping arms to rotate. When the rotating ring rotates, the lever drives the clamping arms to rotate, causing the end of the clamping arm furthest from the rotating ring to abut or separate from the outer wall of the electrospray needle. A locking structure is provided between the rotating ring and the sliding sleeve to restrict the rotation of the rotating ring.

[0007] By adopting the above technical solution, rotating the rotating ring causes the lever to slide along the slide groove, thereby rotating the clamping arm. This allows the end of the clamping arm away from the rotating ring to abut or separate from the outer wall of the electro-spray needle. Multiple clamping arms form an adjustable space to accommodate the electro-spray needle, thus adapting the installation structure to electro-spray needles of different sizes and increasing the applicability of the installation structure. At the same time, the locking structure restricts the rotation of the rotating ring, ensuring that the clamping arm abuts against the electro-spray needle and fixes the electro-spray needle. The sliding sleeve is slidably connected inside the sleeve, facilitating the adjustment of the installation height of the electro-spray needle.

[0008] Optionally, the locking structure includes locking teeth disposed on the outer peripheral wall of the sliding sleeve, and a locking member cooperating with the locking teeth. The rotating ring is provided with a second recess, and the middle part of the locking member is rotatably connected in the second recess. One end of the locking member abuts against the locking teeth, and the other end of the locking member is provided with a tension spring between it and the inner sidewall of the rotating ring. The sidewall of the rotating ring has a through hole, and a button is disposed in the through hole. The button passes through and slides in the through hole. One end of the button extends outside the rotating ring, and the other end of the button is placed inside the rotating ring and abuts against the end of the locking member away from the locking teeth.

[0009] By adopting the above technical solution, under the action of the tension spring, the locking part abuts against the locking teeth. When fixing the electro-spray needle, the rotation of the rotating ring is restricted, ensuring that the clamping arm abuts against the electro-spray needle. When disassembling the electro-spray needle, the lever principle is used. By pressing the button, the locking part is rotated, causing the locking part to separate from the locking teeth. The rotating ring is in the unlocked state. By rotating the rotating ring in the opposite direction, the clamping arm separates from the electro-spray needle.

[0010] Optionally, the mounting base includes a fixed plate, an adjusting plate one, and an adjusting plate two that are slidably connected in sequence. The upper surface of the fixed plate is provided with first guide rails on both sides. The lower surface of the adjusting plate one is provided with a first guide groove that mates with the first guide rails. The upper surface of the adjusting plate one is provided with second guide rails on both sides. The first and second guide rails are perpendicular to each other. The lower surface of the adjusting plate two is provided with a second guide groove that mates with the second guide rails. An adjusting element is provided between the fixed plate and the adjusting plate one, and between the adjusting plate one and the adjusting plate two.

[0011] By adopting the above technical solution, through the cooperation of the first guide rail and the first guide groove, and the cooperation of the second guide rail and the second guide groove, and with the first guide rail and the second guide rail being perpendicular to each other, the horizontal displacement of the electro-spray needle is achieved. By setting the adjustment component, the displacement of the adjustment plate one or the adjustment plate two can be precisely adjusted, which is conducive to accurately adjusting the position of the electro-spray needle.

[0012] Optionally, the adjusting member is rotatably connected to the side wall of adjusting plate one or adjusting plate two, one end of the adjusting member is provided with a knob, the other end of the adjusting member is provided with a gear, and one side of the fixing plate or adjusting plate one is provided with a rack that meshes with the gear.

[0013] By adopting the above technical solution, the torque is increased by setting a knob, which facilitates the rotation of the adjustment component; when the knob is rotated, the gear is driven to rotate, and through the cooperation of the gear and rack, the adjustment plate one or adjustment plate two is moved.

[0014] Optionally, the fixing plate, adjusting plate one, and adjusting plate two are all provided with receiving holes through which the power supply spray needle can pass.

[0015] By adopting the above technical solution and setting the receiving hole, on the one hand, it is used for the electro-spray to pass through, and on the other hand, it allows the electro-spray needle to have a certain displacement space when adjusting the position of the electro-spray needle, so as to facilitate the adjustment of the position of the electro-spray needle.

[0016] Optionally, a sealing ring is provided between the fixed plate and the first adjusting plate, and between the first adjusting plate and the second adjusting plate.

[0017] By adopting the above technical solution and setting a sealing ring, leakage of the atomized gas generated by the electro-spray needle during operation is prevented.

[0018] Optionally, the sliding sleeve is provided with a guide plate, the sleeve is provided with a guide groove for the guide plate to slide, the guide plate is provided with a fixing rod, and the side walls on both sides of the guide groove are provided with oval holes. The two ends of the fixing rod are respectively inserted into the oval holes on both sides. One end of the fixing rod is provided with a protrusion, the inner side of the protrusion abuts against the inner wall of the guide groove, and the other end of the fixing rod is threaded with an end cap, wherein the end cap abuts against the side wall of the guide groove by rotating the end cap.

[0019] By adopting the above technical solution, the guide plate slides along the guide groove and is fixed by the fixing rod, limiting the sliding distance of the sliding sleeve, thereby realizing the adjustment of the height of the electro-spray needle.

[0020] In summary, this application includes at least one of the following beneficial technical effects: by having multiple clamping arms abut against the side wall of the electro-spray needle and fix the electro-spray needle, an adjustable space for accommodating the electro-spray needle is formed between the multiple clamping arms, thereby enabling the installation structure to adapt to electro-spray needles of different sizes and increasing the applicability of the installation structure. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the installation structure of the electrospray structure of the liquid chromatography-tandem mass spectrometer of this application.

[0022] Figure 2This is an exploded view of the installation structure of the electrospray structure of the liquid chromatography-tandem mass spectrometer of this application.

[0023] Figure 3 This is a front view of the mounting structure of the electrospray structure of the liquid chromatography-tandem mass spectrometer of this application.

[0024] Figure 4 yes Figure 3 Cross-sectional view of AA.

[0025] Figure 5 yes Figure 4 Enlarged view of section C.

[0026] Figure 6 yes Figure 3 Cross-sectional view of BB.

[0027] Reference numerals: 1. Mounting base; 11. Fixing plate; 111. First guide rail; 12. Adjusting plate one; 121. First guide groove; 122. Second guide rail; 13. Adjusting plate two; 131. Second guide groove; 14. Receiving hole; 15. Rack; 2. Sleeve; 21. Guide groove; 22. Oval hole; 3. Sliding sleeve; 31. Lever; 32. Clearance opening; 33. Locking tooth; 34. Guide plate; 4. Rotating ring; 41. First recessed groove; 42. Second recessed groove; 43. Button; 44. Locking element; 45. Tension spring; 5. Clamping arm; 51. Sliding groove; 6. Adjusting element; 61. Knob; 62. Gear; 7. Sealing ring; 8. Fixing rod; 81. Protrusion; 82. End cap; 9. Electrospray needle. Detailed Implementation

[0028] The embodiments of this application are described in detail below, and examples of the embodiments are shown in the accompanying drawings.

[0029] In the description of this specification, the references to "certain embodiments," "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples" refer to specific features, structures, materials, or characteristics described in connection with the described embodiment or example, which are included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0030] This application discloses an installation structure for the electrospray structure of a liquid chromatography-tandem mass spectrometer, referring to... Figures 1 to 6The system includes a mounting base 1, a sleeve 2 that is hollow inside the mounting base 1, a sliding sleeve 3 that is slidably connected inside the sleeve 2, an electro-spray needle 9 that is disposed inside the sliding sleeve 3, and a sliding sleeve 3 that is rotatably fitted at the end of the sliding sleeve 3 away from the mounting base 1. Multiple clamping arms 5 are disposed between a rotating ring 4 and the sliding sleeve 3, and are evenly spaced along the circumference of the rotating ring 4. A first recess 41 is provided on the rotating ring 4, and one end of each clamping arm 5 is rotatably connected to the first recess 41. Inside the sleeve 3, a groove 51 is provided along the length of the clamping arm 5. A lever 31 that slides along the groove 51 is fixed on the outer wall of the sleeve 3. A clearance opening 32 is provided on the sleeve 3 to allow the clamping arm 5 to rotate. When the rotating ring 4 rotates, the lever 31 drives the clamping arm 5 to rotate, so that the end of the clamping arm 5 away from the rotating ring 4 abuts or separates from the outer wall of the electrospray needle 9. A locking structure is provided between the rotating ring 4 and the sleeve 3 to limit the rotation of the rotating ring 4.

[0031] Reference Figure 4 and Figure 5 The locking structure includes locking teeth 33 on the outer peripheral wall of the sliding sleeve 3, and a locking member 44 that cooperates with the locking teeth 33. A second recess 42 is provided on the rotating ring 4. The middle part of the locking member 44 is rotatably connected in the second recess 42. One end of the locking member 44 abuts against the locking teeth 33. A tension spring 45 is provided between the other end of the locking member 44 and the inner side wall of the rotating ring 4. One end of the tension spring 45 is fixed to the locking member 44, and the other end of the tension spring 45 is fixed to the inner wall of the rotating ring 4. A through hole is provided on the side wall of the rotating ring 4. A button 43 is installed in the through hole. The button 43 passes through and slides in the through hole. One end of the button 43 extends to the outside of the rotating ring 4, and the other end of the button 43 is placed inside the rotating ring 4 and abuts against the end of the locking member 44 away from the locking teeth 33.

[0032] Reference Figure 2 The mounting base 1 includes a fixed plate 11, an adjusting plate 12, and an adjusting plate 13 that are slidably connected in sequence. The fixed plate 11 has first guide rails 111 on both sides of its upper surface. The adjusting plate 12 has a first guide groove 121 on its lower surface that mates with the first guide rails 111. The adjusting plate 12 has second guide rails 122 on both sides of its upper surface. The first guide rails 111 and 122 are perpendicular to each other. The adjusting plate 13 has a second guide groove 131 on its lower surface that mates with the second guide rails 122. The cross-sections of the first guide rails 111 and 122 are inverted trapezoidal structures, serving a guiding function and, through the engagement of the first guide rail 111 with the first guide groove 121 and the second guide rail 122 with the second guide groove 131, facilitating the fixing of the adjusting plate 12 and the adjusting plate 13. An adjusting element 6 is provided between the fixed plate 11 and the adjusting plate 12, and between the adjusting plate 12 and the adjusting plate 13.

[0033] The adjusting component 6 is rotatably connected to the side wall of adjusting plate 12 or adjusting plate 13. One end of the adjusting component 6 is fixedly connected to a knob 61. By setting the knob 61, the torque is increased, making it easier to rotate the adjusting component 6. The other end of the adjusting component 6 is fixed with a gear 62. A rack 15 that meshes with the gear 62 is provided on one side of the fixing plate 11 or adjusting plate 12. When the knob 61 is rotated, the gear 62 is driven to rotate. Through the meshing of the gear 62 and the rack 15, the adjusting plate 12 or adjusting plate 13 is moved.

[0034] The fixed plate 11, the first adjusting plate 12, and the second adjusting plate 13 are all provided with receiving holes 14 through which the electric spray needle 9 can pass. By providing receiving holes 14, the electric spray needle 9 is allowed to pass through, and at the same time, the electric spray needle 9 has a certain displacement space when its position is adjusted, so as to facilitate the adjustment of the position of the electric spray needle 9.

[0035] Sealing rings 7 are provided between the fixed plate 11 and the adjusting plate 12, and between the adjusting plate 12 and the adjusting plate 13. By providing sealing rings 7, leakage of atomized gas generated by the electro-spray needle 9 during operation is prevented.

[0036] The sliding sleeve 3 is provided with a guide plate 34, and the sleeve 2 is provided with a guide groove 21 for the guide plate 34 to slide. The guide plate 34 is provided with a fixing rod 8. The side walls on both sides of the guide groove 21 are provided with oval holes 22. The two ends of the fixing rod 8 are respectively inserted into the oval holes 22 on both sides. One end of the fixing rod 8 is provided with a protrusion 81, and the inner side of the protrusion 81 abuts against the inner wall of the guide groove 21. The other end of the fixing rod 8 is threadedly connected with an end cap 82. By rotating the end cap 82, the end cap 82 abuts against the side wall of the guide groove 21.

[0037] The implementation principle of the electrospray structure of a liquid chromatography-tandem mass spectrometer according to an embodiment of this application is as follows: During installation, the electrospray needle 9 is placed inside the microphone sliding sleeve 3. By rotating the rotating ring 4, the lever 31 slides along the sliding groove 51, thereby rotating the clamping arm 5. The end of the clamping arm 5 away from the rotating ring 4 abuts against the outer wall of the electrospray needle 9, fixing the electrospray needle 9. An adjustable space for accommodating the electrospray needle 9 is formed between the multiple clamping arms 5, so that the installation structure can be adapted to electrospray needles 9 of different sizes, increasing the applicability of the installation structure. At the same time, under the action of the tension spring 45, the locking member 44 abuts against the locking tooth 33, restricting the rotation of the rotating ring 4 and ensuring that the clamping arm 5 abuts against the electrospray needle 9.

[0038] When disassembling the electro-spray needle 9, pressing the button 43 causes the locking member 44 to rotate, separating the locking member 44 from the locking tooth 33. The rotating ring 4 is in the unlocked state. By rotating the rotating ring 4 in the opposite direction, the lever 31 slides in the opposite direction along the slide groove 51, thereby causing the clamping arm 5 to rotate in the opposite direction, separating the clamping arm 5 from the electro-spray needle 9.

[0039] When adjusting the position of the electro-spray needle 9, the first guide rail 111 and the first guide groove 121 cooperate, and the second guide rail 122 and the second guide groove 131 cooperate with each other. The first guide rail 111 and the second guide rail 122 are perpendicular to each other. By rotating the adjusting member 6, the displacement of the adjusting plate 12 and the adjusting plate 13 is adjusted, thereby realizing the horizontal displacement of the electro-spray needle 9. The guide plate 34 slides along the guide groove 21, and the guide plate 34 is fixed by the fixing rod 8, limiting the sliding distance of the sliding sleeve 3, thereby realizing the adjustment of the height of the electro-spray needle 9.

[0040] Although embodiments of this application have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting this application. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of this application.

Claims

1. A mounting structure for the electrospray ionization structure of a liquid chromatography-tandem mass spectrometer, characterized in that, The device includes a mounting base (1), a sleeve (2) is connected through the mounting base (1), a sliding sleeve (3) is slidably connected inside the sleeve (2), an electrospray needle (9) is disposed inside the sliding sleeve (3), the end of the sliding sleeve (3) away from the mounting base (1) is rotatably fitted with the sliding sleeve (3), a rotating ring (4) is provided between the sleeve (2) and the sliding sleeve (3), a plurality of clamping arms (5) are provided between the rotating ring (4) and the sliding sleeve (3), a first recess (41) is provided on the rotating ring (4), and one end of the clamping arm (5) is rotatably connected to the first recess (41). The clamping arm (5) has a groove (51) extending along its length. The outer wall of the sliding sleeve (3) is provided with a lever (31) that slides along the groove (51). The sliding sleeve (3) has a clearance opening (32) for the clamping arm (5) to rotate. When the rotating ring (4) rotates, the lever (31) drives the clamping arm (5) to rotate, so that the end of the clamping arm (5) away from the rotating ring (4) abuts or separates from the outer wall of the electrospray needle (9). A locking structure is provided between the rotating ring (4) and the sliding sleeve (3) to restrict the rotation of the rotating ring (4).

2. The mounting structure of the electrospray structure of the liquid chromatography-tandem mass spectrometer according to claim 1, characterized in that, The locking structure includes locking teeth (33) on the outer peripheral wall of the sliding sleeve (3) and a locking member (44) that cooperates with the locking teeth (33). The rotating ring (4) is provided with a second recess (42). The middle part of the locking member (44) is rotatably connected in the second recess (42). One end of the locking member (44) abuts against the locking teeth (33). The other end of the locking member (44) is provided with a tension spring (45) between it and the inner side wall of the rotating ring (4). The side wall of the rotating ring (4) is provided with a through hole. A button (43) is provided in the through hole. The button (43) passes through and slides in the through hole. One end of the button (43) extends to the outside of the rotating ring (4). The other end of the button (43) is placed in the rotating ring (4) and abuts against the end of the locking member (44) away from the locking teeth (33).

3. The mounting structure of the electrospray structure for a liquid chromatography-tandem mass spectrometer according to claim 1, characterized in that, The mounting base (1) includes a fixed plate (11), an adjusting plate one (12), and an adjusting plate two (13) that are slidably connected in sequence. The fixed plate (11) has a first guide rail (111) on both sides of its upper surface. The adjusting plate one (12) has a first guide groove (121) that cooperates with the first guide rail (111) on its lower surface. The adjusting plate one (12) has a second guide rail (122) on both sides of its upper surface. The first guide rail (111) and the second guide rail (122) are perpendicular to each other. The adjusting plate two (13) has a second guide groove (131) that cooperates with the second guide rail (122) on its lower surface. An adjusting member (6) is provided between the fixed plate (11) and the adjusting plate one (12), and between the adjusting plate one (12) and the adjusting plate two (13).

4. The mounting structure of the electrospray structure of the liquid chromatography-tandem mass spectrometer according to claim 3, characterized in that, The adjusting member (6) is rotatably connected to the side wall of the adjusting plate one (12) or the adjusting plate two (13). One end of the adjusting member (6) is provided with a knob (61), and the other end of the adjusting member (6) is provided with a gear (62). One side of the fixing plate (11) or the adjusting plate one (12) is provided with a rack (15) that meshes with the gear (62).

5. The mounting structure of the electrospray structure for a liquid chromatography-tandem mass spectrometer according to claim 3, characterized in that, The fixed plate (11), the first adjusting plate (12) and the second adjusting plate (13) are all provided with receiving holes (14) through which the power-powered spray needle (9) can pass.

6. The mounting structure of the electrospray structure of the liquid chromatography-tandem mass spectrometer according to claim 3, characterized in that, A sealing ring (7) is provided between the fixed plate (11) and the first adjusting plate (12), and between the first adjusting plate (12) and the second adjusting plate (13).

7. The mounting structure of the electrospray structure of the liquid chromatography-tandem mass spectrometer according to claim 1, characterized in that, The sliding sleeve (3) is provided with a guide plate (34), and the sleeve (2) is provided with a guide groove (21) for the guide plate (34) to slide. The guide plate (34) is provided with a fixing rod (8). The side walls on both sides of the guide groove (21) are provided with oval holes (22). The two ends of the fixing rod (8) are respectively inserted into the oval holes (22) on both sides. One end of the fixing rod (8) is provided with a protrusion (81). The inner side of the protrusion (81) abuts against the inner wall of the guide groove (21). The other end of the fixing rod (8) is threadedly connected with an end cap (82). By rotating the end cap (82), the end cap (82) abuts against the side wall of the guide groove (21).

Images