Tumor electric field treatment device and treatment system

Abstract

The utility model discloses a tumor electric field treatment device and a treatment system, the tumor electric field treatment device is provided with a frame body and a pole piece module, the frame body forms a skeleton structure of the treatment device, the pole piece module is attached to the frame body, the pole piece module is provided with a plurality of electrode contacts, and each electrode contact can form an active contact or a passive contact. The active contact and the radio frequency generation module can form a loop; after the treatment device is implanted into a tumor excision part, all the electrode contacts form active contacts, and all the electrode contacts and the radio frequency generation module form a loop to distinguish normal tissues from pathological tissues; after the normal tissue and the lesion tissue are distinguished, the electrode contacts in the normal tissue area form passive contacts, and the electrode contacts in the lesion tissue area form active contacts, so that targeted treatment of the lesion tissue is realized, and side effects generated by electric field treatment are reduced.

Description

Technical Field

[0001] This utility model relates to the field of medical equipment technology, specifically to a tumor electric field therapy device and treatment system. Background Technology

[0002] Currently, malignant tumor treatments only involve removing the proliferating tissue through surgery and radiotherapy, which does not effectively alleviate the patient's condition. Tumor electric field therapy (TTF) devices, by applying an alternating electric field to the tumor site, can inhibit the proliferation of malignant tumors to a certain extent, greatly increasing the patient's survival time and providing a new approach to the treatment of malignant tumors.

[0003] Tumor electric field therapy (TTF), as an emerging treatment method, has shown positive effects in some tumor types, especially in the treatment of gliomas. For example, the tumor electric field therapy system disclosed in patent document CN216653129U involves a radio frequency generation module and an electrode patch assembly electrically connected to the radio frequency generation module. The electrode patch is attached to the body surface corresponding to the tumor site through a backing, and an alternating electric field is applied to the tumor site through the electrode functional components to interfere with or inhibit the mitosis of tumor cells, thereby achieving the purpose of treating the tumor.

[0004] Although existing tumor electric field therapy (TTF) has brought some positive effects to the treatment of tumors, TTF applies an electric field to the entire head by attaching large electrodes to the scalp to inhibit malignant tumors. It does not apply targeted, small-scale electric field treatment to the lesion area. When the human body is exposed to the electric field for a long time, it may cause a series of side effects, such as contact dermatitis and neurological dysfunction. Utility Model Content

[0005] The purpose of this invention is to overcome the above-mentioned technical deficiencies and propose a tumor electric field therapy device and treatment system to solve the technical problem that existing tumor electric field therapy is difficult to target the lesion area.

[0006] To achieve the above-mentioned technical objectives, the present invention adopts the following technical solution:

[0007] In a first aspect, this utility model provides a tumor electric field therapy device, comprising:

[0008] Frame, for implantation at the tumor resection site; and

[0009] The pole piece module is attached to the frame body, and the pole piece module is provided with a plurality of electrode contacts. Each electrode contact forms an active contact or a passive contact by connecting or not connecting a radio frequency generating module. The active contact is used to form a loop with the radio frequency generating module and form an electric current at the tumor resection site to ablate cancer cells.

[0010] In some embodiments, the frame body is an inflatable or contractible capsule structure. The frame body can be implanted at the tumor resection site by contraction of the capsule structure. The pole piece module is a flexible electrode. The pole piece module can be attached to the tumor resection site by inflation of the capsule structure.

[0011] In some embodiments, the frame body includes a plurality of elastic bodies. Each elastic body is sequentially connected and enclosed to form the capsule structure. The frame body can expand or contract the capsule structure by deformation of each elastic body.

[0012] In some embodiments, the inner side of the frame body forms a fluid accumulation chamber. A liquid passing gap is formed between each elastic body and is in communication with the fluid accumulation chamber.

[0013] In some embodiments, the pole piece module includes a plurality of flexible electrodes. Each flexible electrode is attached to each elastic body. Each electrode contact is provided on each flexible electrode.

[0014] In some embodiments, the pole piece module further includes a connecting portion connecting each flexible electrode.

[0015] In a second aspect, the utility model also provides a tumor electric field treatment system, comprising:

[0016] The tumor electric field treatment device;

[0017] A circuit board is connected to the pole piece module.

[0018] An electric field generating module is provided on the circuit board and is used to power the pole piece module to form an electric field through each electrode contact.

[0019] A radio frequency generating module is provided on the circuit board and is used to power the pole piece module to form an electric current between each electrode contact with an active contact.

[0020] In some embodiments, the circuit board is provided with a CMOS semiconductor. The CMOS semiconductor is connected to the pole piece module through a microstrip line.

[0021] In some embodiments, the tumor electric field treatment system further includes a liquid extraction microflow tube. The liquid extraction microflow tube is fixed to the frame body and extends to the fluid accumulation chamber to extract the cerebrospinal fluid in the fluid accumulation chamber.

[0022] In some embodiments, the tumor electric field treatment system further comprises a drug microflow tube fixed to the frame and extending to the lesion area for drug administration to the lesion area.

[0023] Compared with the prior art, the tumor electric field treatment device provided by the utility model realizes the implantation to the tumor resection site, provides support for the treatment device, the electrode module is attached to the frame, the electrode module is provided with a plurality of electrode contacts, and each electrode contact can form an active contact or a passive contact, the active contact can form a loop with the radio frequency generating module, when the treatment device is implanted in the tumor resection site, all the electrode contacts form active contacts, each electrode contact forms a loop with the electric field generating module, and the tumor resection site is continuously provided with an electric field under the power supply of the electric field generating module, so that the growth of cancer cells in the tumor resection site is inhibited, because the impedance value of cancer cells in tumor tissue is generally greater than that of normal tissue cells, the current value formed between the active contacts in the diseased tissue region is relatively small, and normal tissue and diseased tissue can be distinguished, after the normal tissue and the diseased tissue are distinguished, the electrode contacts in the normal tissue region form passive contacts, the electrode contacts in the diseased tissue region form active contacts, a radio frequency current can be separately formed in the diseased tissue region, the diseased tissue can be treated with the radio frequency current, the cancer cells in the diseased tissue region are ablated, the tumor electric field treatment system realizes the targeted radio frequency current treatment of the diseased tissue by the radio frequency generating module, realizes the ablation of the cancer cells in the diseased tissue, and thus the side effects caused by the electric field treatment are reduced. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 is a structural schematic view of the tumor electric field treatment device provided by the utility model embodiment;

[0025] Figure 2 is a structural schematic view of the frame of the tumor electric field treatment device provided by the utility model embodiment;

[0026] Figure 3 is a structural schematic view of the electrode module of the tumor electric field treatment device provided by the utility model embodiment;

[0027] Figure 4 is a structural schematic view of the electrode module of the tumor electric field treatment device provided by another utility model embodiment;

[0028] Figure 5 is a distribution diagram of the electrode contacts of the flexible electrode of the tumor electric field treatment device provided by the utility model embodiment;

[0029] Figure 6is the electrode contact diagram of the flexible electrode of the tumor electric field treatment device provided by another embodiment of the utility model;

[0030] Figure 7 is the principle diagram of the forming process (a) step of the electrode module of the tumor electric field treatment device provided by the embodiment of the utility model;

[0031] Figure 8 is the principle diagram of the forming process (b) step of the electrode module of the tumor electric field treatment device provided by the embodiment of the utility model;

[0032] Figure 9 is the principle diagram of the forming process (c) step of the electrode module of the tumor electric field treatment device provided by the embodiment of the utility model;

[0033] Figure 10 is the principle diagram of the forming process (d) step of the electrode module of the tumor electric field treatment device provided by the embodiment of the utility model;

[0034] Figure 11 is the principle diagram of the forming process (e) step of the electrode module of the tumor electric field treatment device provided by the embodiment of the utility model;

[0035] Figure 12 is the principle diagram of the forming process (f) step of the electrode module of the tumor electric field treatment device provided by the embodiment of the utility model;

[0036] Figure 13 is the principle diagram of the forming process (g) step of the electrode module of the tumor electric field treatment device provided by the embodiment of the utility model;

[0037] Figure 14 is the structure schematic diagram of the tumor electric field treatment system provided by the embodiment of the utility model. DETAILED DESCRIPTION

[0038] In order to make the utility model's purpose, technical scheme and advantage more clearly, the following is combined with the embodiment, and the utility model is further detailedly explained.It should be understood that the specific embodiment described here is only used to explain the utility model, and is not used to limit the utility model.

[0039] The existing tumor electric field treatment (TTF) realizes inhibition of malignant tumors by applying an electric field to the whole head through large electrodes attached to the scalp, and does not apply a targeted and small-range electric field treatment to the lesion area, resulting in that the tumor electric field treatment is prone to cause a series of side effects, in order to solve the technical problem that the tumor electric field treatment in the prior art is difficult to perform targeted treatment on the lesion area, the tumor electric field treatment device is provided, and the tumor electric field treatment device can perform targeted electric field treatment on the lesion tumor tissue area, so that the side effects of the tumor electric field treatment are reduced.

[0040] It should be noted that the tumor electric field treatment device is used for, but not limited to, brain tumor tissue treatment, in order to facilitate the description, in the utility model, only the tumor electric field treatment device applied to brain tumor tissue treatment is taken as an example for description, and the principle of the tumor electric field treatment device applied to other types of equipment is substantially the same as that applied to brain tumor tissue treatment, which is not described here.

[0041] The tumor electric field treatment device provided in the utility model embodiment, as shown in Figure 1 The tumor electric field treatment device provided in the utility model embodiment, as shown in

[0042] Specifically, the tumor electric field treatment device is provided with the frame body 10 and the polar sheet module 20, the frame body 10 forms the framework structure of the treatment device, realizes implantation to the tumor resection site, provides support for the treatment device, the polar sheet module 20 is attached to the frame body 10, the polar sheet module 20 is provided with a plurality of electrode contacts 21, and each electrode contact 21 can form an active contact 211 or a passive contact 212, and the active contact 211 can form a loop with the radio frequency generating module; after the treatment device is implanted in the tumor resection site, each electrode contact 21 is connected with the radio frequency generating module, and an electric field is continuously formed under the power supply of the electric field generating module, so as to inhibit the growth of cancer cells in the tumor resection site, and since the impedance value of the cancer cells of the tumor tissue is usually greater than that of the normal tissue cells, the current value formed between the active contacts 211 of the lesion tissue area 10a is relatively small, as shown in Figures 5-6 After the normal tissue area and the lesion tissue area 10a are distinguished, the electrode contacts 21 in the normal tissue area form passive contacts 212, as shown in Figures 5-6As shown, the electrode contact 21 of the lesion tissue region 10a forms an active contact 211, and the active contact 211 of the lesion tissue region 10a forms an alternating current through the loop formed by the radio frequency generating module, while the passive contact 212 of the normal tissue region does not form a current or forms a low voltage current according to the disease condition, so as to additionally and separately pass an alternating current to the lesion tissue region 10a, so as to ablate the tumor tissue cells of the lesion, realize the targeted treatment of the tumor tissue of the lesion, effectively reduce the side effects caused by the electric field treatment, and reduce the damage caused by the electric field treatment to the human body.

[0043] In the embodiment, as shown in Figures 5-6 The active contact 211 includes a positive electrode contact and a negative electrode contact, the positive electrode contact is connected to the output terminal of the radio frequency generating module and receives a radio frequency current, and the negative electrode contact is connected to the ground terminal of the radio frequency generating module and forms a loop with the positive electrode contact.

[0044] In the targeted treatment of the lesion tissue region 10a, for the proliferative tumor tissue of the lesion, the radio frequency generating module adjusts the amplitude, phase, current and power of the radio frequency signal according to the size, shape, positive electrode contact and negative electrode contact distance of the lesion region, so that the lesion tissue moves at a high speed and oscillates at the same frequency as the radio frequency current to generate friction heat, so that the inside of the tumor tissue is heated and the lesion tissue in the proliferative region is ablated.

[0045] For the tissue without proliferation, the active contact 211 located at the center can be grounded as a negative electrode contact, and the other active contacts 211 around it are connected to the positive electrode of the electric field generating module as positive electrode contacts to form an electric field with an electric field strength of 1-3V / cm and an alternating frequency of 100K-300KHz, so as to interfere with the mitosis process of cancer cells, so as to achieve the effect of inhibiting the proliferation of tumor cells at the lesion site and inducing the death of cancer cells.

[0046] It can be understood that the frame body 10 can be a plate body, a rod body or any structure capable of being implanted in the tumor resection site and attached to the electrode module.

[0047] It can be understood that the polar sheet module 20 can be a polar sheet structure of any material and shape, as long as it can be attached to the surface of the frame body 10.

[0048] In one of the embodiments, as shown in Figures 1-2 and 14, the frame body 10 is a balloon structure that can be expanded or contracted, the frame body 10 can be implanted in the tumor resection site by contraction of the balloon structure, and the polar sheet module 20 is a flexible electrode 22, and the polar sheet module 20 can be attached to the tumor resection site by expansion of the balloon structure.

[0049] Specifically, by configuring the frame 10 as an expandable or contractible sac structure, when the treatment device is implanted, the frame 10 contracts to form a strip structure, thereby reducing its volume, facilitating implantation, and minimizing implantation trauma. After implantation, the treatment device can expand according to the size of the tumor resection site, allowing each electrode contact 21 to fit well with the tissue. During tissue recovery, the frame 10 can be compressed to contract, reducing its volume and avoiding obstruction to tissue growth and recovery. By configuring the electrode module 20 as a flexible electrode 22, it can adapt well to the expansion and contraction of the frame 10, ensuring stable contact with the frame 10 during expansion and contraction. This ensures that even when the frame 10 expands and contracts, the electrode contacts 21 at the lesion site on the electrode module 20 remain above the lesion site, preventing the expansion and contraction of the frame 10 from affecting the treatment of the lesion area.

[0050] Understandably, the frame 10 can be a sealed air bladder or liquid bladder structure, which expands by inflating the frame 10 with air or liquid and contracts by venting or draining the liquid.

[0051] In one embodiment, such as Figures 1-2 As shown in Figure 14, the frame 10 includes a plurality of elastic bodies 11, which are sequentially connected and enclosed to form the capsule structure. The frame 10 can expand or contract the capsule structure through the deformation of each elastic body 11.

[0052] Specifically, the scaffold 10 expands or contracts through the elasticity of each elastomer 11, thus adaptively expanding and contracting according to the size of the tumor resection site. This adaptively adjusts the adhesion between the electrode module 20 and the tissue site, facilitating tissue growth and the acquisition of the lesion area. Furthermore, the expansion and contraction of the scaffold 10 itself eliminates the need for a sealed cystic structure, making it easier for the scaffold 10 to form a non-sealed cystic structure. This non-sealed cystic structure allows interstitial fluids to pass through the scaffold 10 without hindering the flow and exchange of interstitial fluids.

[0053] In this embodiment, the frame 10 expands or contracts by the deformation of the middle part of each elastic body 11. Extreme contraction can form a strip structure, and extreme expansion can form a spherical capsule structure.

[0054] Understandably, elastomer 11 may include, but is not limited to, biocompatible elastic materials such as nickel-titanium alloys, cobalt alloys, and magnesium alloys.

[0055] In one embodiment, such as Figures 1-2As shown in Figs. 4 and 14, the inner side of the frame body 10 forms the effusion cavity 12, and the liquid-passing gap 13 is formed between each elastic body 11, and the liquid-passing gap 13 is communicated with the effusion cavity 12. Specifically, the effusion cavity 12 is formed through the inner side of the frame body 10, and the liquid-passing gap 13 is formed between each elastic body 11, so that the brain effusion formed by the diseased tissue can pass through the liquid-passing gap 13 into the effusion cavity 12, thereby facilitating the discharge of the brain and accelerating the treatment of the effusion in the diseased area.

[0056] In this embodiment, since the tissue part is attached to the frame body 10, the brain effusion in the effusion cavity 12 can be prevented from flowing out of the liquid-passing gap 13 by the blockage of the tissue part.

[0057] In this embodiment, the frame body 10 can be prepared by a pipe body with a diameter of 0.5 cm, 1 cm, 2 cm, 3 cm, etc., and made of materials such as nickel-titanium alloy, cobalt alloy, and magnesium alloy. During preparation, the pipe surface is first cut and processed by a laser cutting process to form a semi-finished frame body 10 with a balloon structure. The semi-finished frame body 10 is then post-processed, which includes but is not limited to heat treatment, pickling, sandblasting, polishing, etc. The post-processing increases the smoothness of the surface of the balloon frame body 10 to prevent friction and cutting injury caused by the rough surface of the balloon frame body 10 after implantation.

[0058] In one of the embodiments, to adapt to the deformation of each elastic body 11, as shown in Figs. 5 and 15, Figure 1 、 3 As shown in Figs. 4 and 14, the pole piece module 20 includes a plurality of flexible electrodes 22, each flexible electrode 22 is attached to each elastic body 11, and each electrode contact 21 is arranged on each flexible electrode 22. Specifically, during the deformation of each elastic body 11, each flexible electrode 22 attached thereto is deformed synchronously,

[0059] It can be understood that the number of flexible electrodes 22 matches the number of elastic bodies 11, and the size can be adaptively set according to the size of the tumor resection site. The number of electrode contacts 21 on each flexible electrode 22 can be 22, 44, or 86, etc. The electrode contacts 21 are arranged in an array and distributed at both ends of the flexible electrode 22 to realize the functions of accurate collection and ablation of the lesion area.

[0060] It can be understood that the formation of the active contact 211 and the passive contact 212 of each electrode contact 21 can be formed by surgery or a contact control module. The positive electrode contact of the active contact 211 is formed by connecting the output terminal of the radio frequency generating module, and the negative electrode contact of the active contact 211 is connected to the ground terminal of the radio frequency generating module.

[0061] In one of the embodiments, as shown in Figs. 6 and 16, Figure 1 、 3As shown in Figs. 4 and 14, the pole piece module 20 is further provided with a connecting portion 23 connecting the flexible electrodes 22. Specifically, the connecting portion 23 can realize the series connection of the flexible electrodes 22, so that the circuit board only needs to be connected with the connecting portion 23, thereby facilitating the connection of the flexible electrodes 22 with the circuit board.

[0062] In the embodiment, the connecting belt 23 is provided with a microstrip line, the microstrip line is flip-chip connected with a CMOS (Complementary Metal Oxide Semiconductor), and the control of the high-channel electrode and the signal collection are realized.

[0063] As shown in Figs. 4 and 14, the connecting belt 23 is provided with a connecting portion 23 connecting the flexible electrodes 22. Specifically, the connecting portion 23 can realize the series connection of the flexible electrodes 22, so that the circuit board only needs to be connected with the connecting portion 23, thereby facilitating the connection of the flexible electrodes 22 with the circuit board. Figure 1 and 3 As shown in Figs. 4 and 14, the connecting belt 23 is provided with a connecting portion 23 connecting the flexible electrodes 22. Specifically, the connecting portion 23 can realize the series connection of the flexible electrodes 22, so that the circuit board only needs to be connected with the connecting portion 23, thereby facilitating the connection of the flexible electrodes 22 with the circuit board.

[0064] In the embodiment, the pole piece module 20 and the microstrip line are based on a MEMS (Micro-Electro-Mechanical System) process to prepare the high-channel electrode on the PI flexible electrode 22, so as to realize the detection, electric field suppression and ablation of the treatment device.

[0065] In the embodiment, the high-channel electrode is prepared on the PI flexible substrate based on the MEMS process, so as to realize the detection, electric field suppression and ablation of the electrode module. The specific MEMS process flow of the electrode module is as follows:

[0066] (a) As shown in Fig. 3, a substrate 301 is prepared, and the substrate material includes but is not limited to a silicon wafer, a quartz wafer, silicon carbide, etc. An oxide layer 302 is prepared on the surface of the silicon wafer as a dielectric layer; Figure 7 (b) As shown in Fig. 4, a first layer of flexible substrate material 303 is prepared on the surface of the wafer substrate 301. The substrate material 303 can include but is not limited to PI, PDMS, silicone resin, etc. The substrate material 303 is subjected to uniform coating, photolithography, development and other steps to prepare the electrode module substrate shape;

[0067] Figure 8 (c) As shown in Fig. 5, metal is deposited on the surface of the substrate material 303 to prepare a metal electrode and metal wiring 304. The deposited metal can be any one or a combination of gold, platinum, iridium, tungsten, magnesium, molybdenum, platinum-iridium alloy, titanium alloy, graphite, carbon nanotube, etc. The deposited metal is patterned.

[0068] (d) As shown in Fig. 6, a metal electrode surface modification material 305 is deposited, and the deposited modification material 305 is patterned. The modification material 305 includes but is not limited to one or more of platinum, titanium nitride, iridium oxide, etc. Figure 9

[0069] Figure 10

[0070] ​​​​(e) such as Figure 11 As shown, an insulating layer 306 is spin-coated. The insulating layer 306 may include, but is not limited to, PI, PDMS, silicone resin, etc. The insulating layer is then homogenized, photolithographically etched, and developed, and the cavity is prepared by RIE etching.

[0071] (f) such as Figure 12 As shown, indium metal is deposited, and the metal surface is uniformly coated, photolithographically etched, and developed. The indium metal is patterned using a dry etching method to form a CMOS flip-chip array 307.

[0072] (g) such as Figure 13 As shown, the substrate material 303 is released from the substrate 301. The release process can be carried out by any one or a combination of mechanical, physical or chemical methods to complete the fabrication of the flexible electrode 22 module.

[0073] Through the above preparation process, while realizing the preparation of the flexible electrode 22 module, the number of electrode contacts can be guaranteed.

[0074] In this embodiment, after the flexible module is prepared, the treatment device is then formed. During the forming process, the finished frame 10 is flattened on the mold, and a biocompatible adhesive is evenly applied to the frame 10. The prepared flexible electrode module 20 is then attached to the frame 10 and cured. The biocompatible adhesive may include, but is not limited to, UV-curable adhesive, biocompatible epoxy resin cyanoacrylate, etc. After curing, the balloon frame 10 is released from the mold by physical or chemical means, and the surface of the frame 10 is cleaned.

[0075] This utility model embodiment also provides a tumor electric field therapy system, including a circuit board 30, an electric field generating module, a radio frequency generating module, and the tumor electric field therapy device. The circuit board 30 is connected to the electrode module 20 of the tumor electric field therapy device. The radio frequency generating module is disposed on the circuit board and is used to energize the electrode module so that the electrode module forms an electric field through each electrode contact. The radio frequency generating module is disposed on the circuit board 30 and is used to energize the electrode module 20 so that a current is formed between each electrode contact 21 forming an active contact 211.

[0076] Specifically, when the treatment device is implanted in the tumor resection site, each electrode contact 21 forms a loop with the radio frequency generating module. The electric field generating module supplies power to each electrode contact 21, so that an electric field is formed between each electrode contact 21. Since the impedance value of cancer cells in tumor tissue is generally greater than that of normal tissue cells, the current value between the active contacts 211 in the diseased tissue region 10a is relatively small, so that normal tissue and diseased tissue can be distinguished. After distinguishing normal tissue and diseased tissue, the electrode contacts 21 in the normal tissue region form passive contacts 212, and the electrode contacts 21 in the diseased tissue region 10a form active contacts 211. The active contacts 211 in the diseased tissue region 10a can form a current through the loop formed with the radio frequency generating module, while the passive contacts 212 in the normal tissue region cannot form a current, thereby realizing separate energization of the diseased tissue region 10a, realizing targeted treatment of diseased tumor tissue, effectively reducing the side effects of electric field treatment, and reducing the damage caused by electric field treatment to the human body.

[0077] In the embodiment, the circuit board 30 is also provided with a charging circuit, a data processing circuit, a wireless communication circuit, a power management circuit, a pulse generating circuit, and a flip chip contact array. The electrode acquisition signal transmitted by the microstrip line 32 is processed by the data processing module in the PCB circuit. The wireless communication module is used to realize real-time, rapid and accurate extraction of neural signals, so as to minimize transmission loss and noise signals. The power management circuit can control the on-off of each module according to the working mode. The pulse generating circuit applies a high-frequency pulse signal to the implanted electrode module, realizing the inhibition and ablation function of the tumor.

[0078] In the embodiment, the circuit board 30 is also provided with a contact control module, which is used to control each electrode contact 21 to form an active contact 211 or a passive contact 212.

[0079] In one of the embodiments, the circuit board 30 is provided with a CMOS semiconductor 31, and the CMOS semiconductor 31 is connected to the connection strip 23 through the microstrip line 32. Specifically, the electrode module can realize control and signal acquisition of the high-channel electrode module by connecting the CMOS semiconductor 31.

[0080] In the embodiment, the CMOS semiconductor 31 is fixed to the flip chip contact array of the circuit board 30 through the flip chip bonding process.

[0081] In the embodiment, the tumor electric field treatment system further comprises a power supply device 40, which is connected to the circuit board 30 and used to supply power to the circuit board 30.

[0082] In one of the embodiments, the tumor electric field treatment system further comprises a liquid suction micro-pipe 50 fixed to the frame 10 and extending to the hydrocephalus cavity 12 for suction of the cerebrospinal fluid in the hydrocephalus cavity 12. Specifically, the liquid suction micro-pipe 50 can prevent the increase of the intracranial pressure due to the cerebrospinal fluid after the tumor surgery by suction of the cerebrospinal fluid in the hydrocephalus cavity 12, and reduce the complications caused by the increase of the intracranial pressure after the tumor surgery.

[0083] In one of the embodiments, the tumor electric field treatment system further comprises a drug delivery micro-pipe 60 fixed to the frame 10 and extending to the lesion area for drug delivery to the lesion area. Specifically, the drug delivery micro-pipe 60 can realize accurate drug delivery to the lesion area, and reduce the side effects caused by taking the chemotherapy drugs by accurate drug delivery to the lesion area.

[0084] In one of the embodiments, the tumor electric field treatment system further comprises a pumping device 70 connected to the liquid suction micro-pipe and the drug delivery micro-pipe 60 to realize the suction of the cerebrospinal fluid and the drug delivery to the lesion area.

[0085] In the embodiment, after the molding of the electric field treatment device is completed, the indium column solder joints of the wires of the flexible electrode 22 are soldered with the CMOS using the flip-chip soldering process, and then the liquid suction micro-pipe 50 and the drug delivery micro-pipe 60 are fixed to the frame 10.

[0086] In order to better understand the present application, the technical scheme of the present application will be described in detail below with reference to the accompanying drawings. Figures 1-6 and 14: In the treatment process of the tumor tissue, first, the tumor tissue is removed by the conventional tumor resection surgery, the contracted treatment device is implanted into the tumor resection site through the surgical wound, the treatment device is inflated and expanded into a balloon shape, and the electrode module is attached to the tissue after the tumor resection. The tumor tissue needs a large amount of free water to promote division due to the unlimited reproduction and close arrangement of the cancer cells, and thus the impedance value thereof is usually greater than that of the normal tissue. The impedance value of the tumor resection site at different frequencies is measured by the power supply of the electric field generating module to each electrode contact, the normal tissue and the lesion tissue are distinguished, and the size, shape and state of the tumor growth in the tumor resection site are determined. The contact point control module controls the electrode contact 21 of the lesion tissue to be an active contact 211, and controls the electrode contact 21 of the normal tissue to be a passive contact 212. The positive electrode contact of the active contact 211 is connected to the output terminal of the radio frequency generating module, and receives the radio frequency ablation current of the radio frequency generating module. The negative electrode contact of the active contact 211 is connected to the ground terminal of the radio frequency generating module, and forms a loop with the positive electrode contact. The radio frequency signal amplitude, phase, current and power are adjusted by the radio frequency generating module device according to the size, shape, distance between the positive electrode contact and the negative electrode contact of the lesion area, so that the lesion tissue moves at a high speed at the same frequency as the radio frequency current to generate friction heat, the internal temperature of the tumor tissue is raised, and the lesion tissue in the growth area is ablated.

[0087] The tumor electric field treatment system also extracts the cerebrospinal fluid at the tumor resection site through the set liquid extraction micro flow pipe 50, prevents the intracranial pressure increase caused by the cerebrospinal fluid after the tumor operation, and reduces the complications caused by the intracranial pressure increase after the tumor operation. At the same time, for the postoperative tissue without hyperplasia, the drug micro flow pipe 60 accurately gives medicine in the postoperative lesion area while the tumor inhibition electric field is applied, and reduces the systemic side effects caused by taking chemotherapy drugs.

[0088] The specific implementation manner of the utility model above does not constitute the limitation of the protection scope of the utility model. Any various other corresponding changes and variations made according to the technical concept of the utility model should be included in the protection scope of the utility model claim.

Claims

1. A tumor electric field treatment device, characterized by, include: The frame is used for implantation at the tumor resection site; and An electrode module is attached to the frame. The electrode module is provided with a number of electrode contacts. Each electrode contact is connected to or not connected to the radio frequency generation module to form an active contact or a passive contact. The active contact is used to form a circuit with the radio frequency generation module and generate current at the tumor resection site to ablate cancer cells.

2. The tumor electric field treatment device of claim 1, wherein, The frame is an expandable or contractible cystic structure. The frame can be implanted into the tumor resection site through the contraction of the cystic structure. The electrode module is a flexible electrode. The electrode module can be attached to the tumor resection site through the expansion of the cystic structure.

3. The tumor electric field treatment device of claim 2, wherein, The frame includes a plurality of elastic bodies, which are sequentially connected and enclosed to form the capsule structure. The frame can expand or contract the capsule structure by deforming each of the elastic bodies.

4. The tumor electric field treatment device of claim 3, wherein, A liquid accumulation cavity is formed on the inner side of the frame, and a liquid passage gap is formed between each of the elastic bodies, the liquid passage gap being in communication with the liquid accumulation cavity.

5. The tumor electric field treatment device of claim 3, wherein, The electrode module includes a plurality of flexible electrodes, each of which is attached to a specific elastic body, and each of which has an electrode contact disposed on a specific flexible electrode.

6. The tumor electric field treatment device of claim 5, wherein, The electrode module is also provided with a connecting part, which connects to each of the flexible electrodes.

7. A tumor electric field treatment system, comprising: include: The tumor electric field therapy device according to any one of claims 1-6; Circuit board, connected to the electrode module; An electric field generating module is disposed on the circuit board and is used to energize the electrode module so that the electrode module generates an electric field through each electrode contact. A radio frequency generation module, disposed on the circuit board, is used to energize the electrode module so that current is formed between the electrode contacts that form active contacts.

8. The tumor electric field treatment system of claim 7, wherein, The circuit board is equipped with a CMOS semiconductor, which is connected to the electrode module via microstrip lines.

9. The tumor electric field treatment system of claim 7, wherein, The tumor electric field therapy system also includes a fluid aspiration microfluidic tube, which is fixed to the frame and extends to the effusion cavity for aspirating cerebrospinal fluid from the effusion cavity.

10. The tumor electric field treatment system of claim 7, wherein, The tumor electric field therapy system also includes a drug delivery microfluidic tube, which is fixed to the frame and extends to the lesion area for drug delivery to the lesion area.

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