Interventional material dissociation component analysis sample collection device

Abstract

The utility model belongs to the technical field of polymer medical instrument experiments, and particularly relates to a sample collecting device for dissociation component analysis of an implant material. The device comprises a circulation pipeline; a sample loading cavity, heating equipment and liquid driving equipment which are communicated with one another are arranged on the circulating pipeline, and the sample loading cavity, the heating equipment and the liquid driving equipment form a closed circulating experiment pipeline through the circulating pipeline; the closed circulation experiment pipeline is filled with an experiment medium; a fixing assembly is arranged on the sample loading cavity, and the fixing assembly is used for loading a polymer medical device to be experimented in the sample loading cavity; any section of circulating pipeline is provided with a first branch, the first branch is communicated with a three-way switch used for sample / medicine injection and sample collection, and the three-way switch is communicated with the first branch, an external sampling device and a medicine injector. In-vitro human body circulation simulation can be achieved, and medical instrument degradation products are dynamically collected.

Description

TECHNICAL FIELD

[0001] The utility model belongs to polymer medical instrument experimental technical field, concretely relates to a kind of implant interventional material dissociation component analysis sample collection device. BACKGROUND

[0002] High-performance polymer materials have been widely used in medical device products. Since it needs to be in direct contact with the drug solution and the human body, medical polymers are also more strictly regulated in the risk control of regulatory authorities. In vitro degradation research of polymer medical devices has become an important part of product safety evaluation. According to GB / T16886.1-2022, collecting physical or chemical information of medical devices or components is the first crucial step in the biological evaluation process and related material characterization. For example, the degradation rate of new drug coating materials such as polylactic acid and polyhydroxyalkanoate (PLGA) is directly related to drug release capacity, safety and effectiveness, and also affects the final treatment effect. In addition, clinical patients taking some drugs will also affect the surface properties of in-vivo medical devices, the surrounding microenvironment, and the degradation rate. Therefore, it is crucial to study the degradation performance of the material and the effect of the drug on it before clinical trials.

[0003] However, there is currently a lack of dynamic collection devices for medical device degradation products, which cannot monitor the degradation process of medical devices, cannot dynamically collect medical device degradation products, and cannot meet the research needs of the effect of in-vitro drug on the degradation process of medical devices. UTILITY MODEL CONTENT

[0004] The utility model aims to provide a kind of implant interventional material dissociation component analysis sample collection device, to solve the problem that cannot monitor the degradation process of medical devices, cannot dynamically collect medical device degradation products in prior art, and cannot meet the research needs of the effect of in-vitro drug on the degradation process of medical devices.

[0005] To achieve the above purpose, the utility model adopts the following technical solutions:

[0006] A kind of implant interventional material dissociation component analysis sample collection device, comprising:

[0007] Circulating pipeline;

[0008] The circulating pipeline is provided with a sample loading cavity, a heating device and a liquid driving device in communication, and the sample loading cavity, the heating device and the liquid driving device constitute a closed circulating experimental pipeline through the circulating pipeline; the heating device is provided with a heating device control panel, which is used for controlling the heating device and displaying heating related parameters; the liquid driving device is provided with a liquid driving device control panel, which is used for setting control parameters of the liquid driving device and displaying flow rate and pressure data of the circulating pipeline;

[0009] The closed circulating experimental pipeline is filled with experimental medium;

[0010] The sample loading cavity is provided with a fixing assembly, which is used for loading a polymer medical instrument to be experimented in the sample loading cavity;

[0011] A first branch is arranged on any section of the circulating pipeline, and a three-way switch for drug / sample injection and sample collection is communicated with the first branch, and the three-way switch is communicated with the first branch, an external sampling device and a drug injector.

[0012] Further, a second branch is arranged on any section of the circulating pipeline, and the second branch is communicated with the circulating pipeline and an external liquid storage bottle, and a pressure sensing switch is arranged on the second branch.

[0013] Further, the fixing assembly comprises a distance adjusting member and a contact mounting member; the distance adjusting member is mounted on the sample loading cavity, and the contact mounting member is arranged in the sample loading cavity and connected with the distance adjusting member and capable of moving under the adjustment of the distance adjusting member.

[0014] Further, the distance adjusting member is a bolt, and the contact mounting member is an extrusion plate;

[0015] The bolt is rotationally connected on the sample loading cavity, and a first end of the bolt is located in the sample loading cavity and mounted with the extrusion plate.

[0016] Further, the distance adjusting member can also be a bolt, and the contact mounting member is a spring clamp;

[0017] The bolt is rotationally connected on the sample loading cavity, and a first end of the bolt is located in the sample loading cavity and mounted with the spring clamp.

[0018] Further, the fixing assembly comprises at least two pairs, and each pair of fixing assemblies is oppositely arranged.

[0019] Further, a knob is arranged on a second end of the bolt.

[0020] Further, a sealing member is arranged at the position where the bolt is connected with the sample loading cavity.

[0021] Further, the sample loading cavity is a cylindrical sealing structure, and an operation port is arranged on the cylindrical sealing structure, and a sealing door is arranged at the operation port.

[0022] Compared with the prior art, the utility model has the advantages of the following:

[0023] The utility model provides a kind of implant interventional material dissociation component analysis sample collection device, comprising: circulation pipeline;Connected communication sample loading cavity, heating equipment and liquid driving equipment are arranged on the circulation pipeline, and the sample loading cavity, heating equipment and liquid driving equipment are connected by circulation pipeline and constitute closed circulation experimental pipeline;Experimental medium is filled in the closed circulation experimental pipeline;Fixed assembly is arranged on the sample loading cavity, and the fixed assembly is used to load the polymer medical instrument to be experimented in the sample loading cavity;First branch is arranged on any section of the circulation pipeline, and the first branch is communicated with the three-way switch for drug / sample injection and sample collection, and the three-way switch is communicated with first branch, external sampling device and medicine injector.It can realize in-vitro simulation human circulation, and dynamically collect medical instrument degradation product.For subsequent analysis of dissociation component of degradable material, drug release rate and duration of drug eluting stent and evaluation of coupling technology provide the convenience.

[0024] The utility model discloses the three-way switch for drug / sample injection and sample collection, can realize the dynamic addition of drug, and it is favorable to explore the influence of drug on medical instrument degradation process.

[0025] The utility model sets up pressure sensor switch, and in real time monitoring circulation pipeline pressure is cooperated with liquid storage bottle, and the experimental medium missing due to sample collection can be dynamically supplemented, and the expected circulation volume and pressure of experiment are maintained.

[0026] The utility model sets different forms of fixed assembly and corresponding sample loading element, and can satisfy the experimental object of different shape characteristics, and is convenient to fix, observe and assemble. BRIEF DESCRIPTION OF DRAWINGS

[0027] The drawings accompanying the specification provide further understanding of the utility model, and the illustrative embodiment of the utility model and its explanation are used to explain the utility model, and do not constitute improper limitation to the utility model.In the drawings:

[0028] Figure 1 It is the general connection diagram of the utility model embodiment a kind of implant interventional material dissociation component analysis sample collection device.

[0029] Figure 2 is the sample loading cavity of the fixed tubular experimental object in the embodiment of the utility model.

[0030] Figure 3 is the sample loading cavity of the fixed tubular experimental object in the embodiment of the utility model.

[0031] Figure 4 is the sample loading cavity of the fixed sheet experimental object in the embodiment of the utility model.

[0032] Figure 5 is the sample loading cavity of the fixed sheet experimental object in the embodiment of the utility model.

[0033] In the figure: 1, sample loading cavity; 2, circulating pipeline; 3, three-way switch; 4, heating equipment; 5, heating equipment control panel; 6, liquid driving equipment; 7, liquid driving equipment control panel; 8, pressure sensing switch; 9, liquid storage bottle; 10, bolt; 11, extrusion plate; 12, spring clamp. DETAILED DESCRIPTION

[0034] The utility model will be described below in detail with reference to the drawings and in combination with the embodiments. It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0035] The following detailed description is exemplary description, which aims to provide further detailed description of the utility model. Unless otherwise specified, all technical terms used in the utility model are the same as the meanings generally understood by the general technical personnel in the field to which the present application belongs. The terms used in the utility model are only for describing the specific embodiments, and are not intended to limit the exemplary embodiments according to the utility model.

[0036] In the description of the utility model, it should be understood that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like is based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the utility model and simplifying the description, and is not intended to indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, therefore it cannot be understood as a limitation on the utility model.

[0037] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more. It should be noted in the description of this utility model that, unless otherwise explicitly specified and limited, the terms "installed," "connected," and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0038] Example 1

[0039] like Figures 1-5 As shown, Embodiment 1 of this utility model provides a sample collection device for analyzing the dissociation components of implantable materials. Under simulated in vivo circulation conditions, it can dynamically collect degradation substances of medical devices and study the effects of drugs on medical devices.

[0040] The device comprises the following components:

[0041] Circulation pipe 2;

[0042] The circulation pipeline 2 is equipped with a connected sample loading chamber 1, a heating device 4, and a liquid driving device 6. The sample loading chamber 1, the heating device 4, and the liquid driving device 6 are connected by the circulation pipeline 2 to form a closed circulation experimental pipeline.

[0043] The closed-loop experimental pipeline is filled with an experimental medium.

[0044] The sample loading cavity 1 is provided with a fixing component, which is used to load the polymer medical device to be tested into the sample loading cavity 1.

[0045] A first branch 21 is provided on any section of the circulation pipeline 2. The first branch 21 is connected to a three-way switch 3 for drug / sample injection and sample collection. The three-way switch 3 is connected to the first branch 21, an external sampling device, and a drug injector.

[0046] The solution provided in the above embodiments, by setting up a sample loading chamber 1, a heating device 4 and a liquid driving device 6, and forming a closed-loop experimental pipeline through a circulation pipeline 2, injects an experimental medium into the closed-loop experimental pipeline, which can simulate extracorporeal circulation and dynamically collect medical device degradation products.

[0047] The three-way switch 3 can switch the pipeline flow direction by rotating the valve, realize the injection of experimental medium or drug and the dynamic collection of sample. The drug can be dynamically added through the three-way switch 3 to explore the influence of the drug on the degradable material and the drug coating material.

[0048] The applicant needs to explain that the connection order of the sample loading cavity 1, the heating device 4 and the liquid driving device 6 in the embodiment is not limited, which can be that the sample loading cavity 1, the heating device 4 and the liquid driving device 6 are connected in sequence, or the heating device 4, the sample loading cavity 1 and the liquid driving device 6 are connected in sequence, or the heating device 4, the liquid driving device 6 and the sample loading cavity 1 are connected in sequence, etc. The communication mode will not affect the technical effect of the scheme.

[0049] In a specific embodiment, a second branch 22 is arranged on any section of the circulating pipeline 2, the second branch 22 is communicated with the circulating pipeline 2 and an external liquid storage bottle 9, and a pressure sensitive switch 8 is arranged on the second branch 22.

[0050] The pressure sensitive switch 8 is used for monitoring the real-time pressure of the circulating pipeline, and the liquid storage bottle 9 is used for storing experimental medium.

[0051] In the scheme, the second branch 22, the liquid storage bottle 9 and the corresponding pressure sensitive switch 8 are arranged, the experimental medium is stored in the liquid storage bottle 9, the pressure in the circulating pipeline 2 can be sensed, the pressure sensitive switch 8 is automatically opened by the preset pressure level, the experimental medium in the liquid storage bottle 9 is extracted, and the experimental medium in the circulating pipeline 2 is supplemented after sampling.

[0052] Specifically, when the actual pressure of the circulating pipeline is detected to be lower than the set pressure value, the pressure sensitive switch 8 is in an open state, the liquid storage bottle 9 is sucked into the circulating pipeline for supplement, and the circulating volume and the set pressure are maintained. When the actual pressure of the circulating pipeline returns to the set pressure value, the pressure sensitive switch 8 is automatically closed. The experimental medium can be automatically supplemented to maintain the circulating volume required by the experiment.

[0053] In a specific embodiment, the fixing assembly includes a distance adjusting piece and a contact mounting piece; the distance adjusting piece is installed on the sample loading cavity 1, the contact mounting piece is arranged in the sample loading cavity 1, and the contact mounting piece is connected with the distance adjusting piece and can move under the adjustment of the distance adjusting piece.

[0054] In the scheme, the distance adjusting piece is arranged, the position of the contact mounting piece in the sample loading cavity 1 is adjusted by the distance adjusting piece, and then various sizes of polymer medical devices are adapted.

[0055] In an optional embodiment, the distance adjusting member is a bolt 10, and the contact mounting member is an extrusion plate 11; the bolt 10 is rotationally connected to the sample loading cavity 1; and the first end of the bolt 10 is located in the sample loading cavity 1 and is provided with the extrusion plate 11.

[0056] In this scheme, the extrusion plate 11 can be used to fix the polymer medical device with a three-dimensional spatial structure, such as a tubular experimental object, such as an artificial blood vessel.

[0057] In an optional embodiment, the distance adjusting member is also a bolt 10, and the contact mounting member is a spring clamp 12; the bolt 10 is rotationally connected to the sample loading cavity 1; and the first end of the bolt 10 is located in the sample loading cavity 1 and is provided with the spring clamp 12.

[0058] In this scheme, the spring clamp 12 can be used to clamp and fix the experimental object in the form of a sheet, such as a heart valve.

[0059] In a preferred embodiment, the fixing assembly includes at least two pairs, and each pair of fixing assemblies is oppositely arranged.

[0060] Specifically, the fixing assemblies are oppositely arranged in pairs, and at least four fixing assemblies are provided, and the four fixing assemblies collectively fix the experimental object.

[0061] In an optional embodiment, more fixing assemblies can be designed according to actual needs to improve the fixing effect.

[0062] In an optional embodiment, the second end of the bolt 10 is provided with a knob for easy operation.

[0063] In a preferred embodiment, the position where the bolt 10 meets the sample loading cavity 1 is provided with a sealing member. The sealing member is used to improve the sealing performance and prevent the experimental medium from leaking out.

[0064] As a specific example, the sample loading cavity 1 is preferably a cylindrical sealing structure, and an operation port is provided on the cylindrical sealing structure, and a sealing door is provided at the operation port.

[0065] More specifically, the sample loading cavity 1 is a hard transparent tube, and both ends are sealed, and it is used to load and fix the experimental object.

[0066] The two ends of the sample loading cavity 1 are respectively detachably connected to the circulation pipeline 2. When preventing the experimental object, the sealing door is opened, the position of the fixing assembly is adjusted according to the size of the experimental object, and then the experimental object is limited between the oppositely arranged fixing assemblies.

[0067] According to the shape characteristics of the experimental object, different sample loading cavities 1 can be selected for fixation. For example, a tubular experimental object such as an artificial blood vessel can be fixed by using the sample loading cavity shown in FIGS. 4A and 4B. Four fixing assemblies are used to fix the tubular experimental object, and each fixing assembly is composed of a bolt 10 and a pressing plate 11. The position of the pressing plate 11 can be adjusted by the knob on the bolt 10. Figure 2 、 3 For a sheet-shaped experimental object such as an artificial valve, the sample loading cavity shown in FIGS. 5A and 5B can be selected. Four fixing assemblies are used to fix the sheet-shaped experimental object, and each fixing assembly is composed of a bolt 10 and a spring clamp 12. The position of the spring clamp 12 can be adjusted by the knob on the bolt 10, and the spring clamp 12 can naturally clamp the sheet-shaped experimental object. Figure 4 、 5

[0068] For example, the artificial blood vessel is pressed by the four fixing assemblies to prevent it from moving with the circulating experimental medium.

[0069] The heart valve is clamped by the spring clamp, and the four spring clamps clamp and unfold the heart valve.

[0070] In other embodiments, the sample loading cavity 1 can also have other shapes such as a square shape or an oval shape, and the shape is not limited in the present solution.

[0071] In an optional embodiment, a heating device control panel 5 is arranged on the heating device 4, and the heating device control panel 5 is used to control the heating device 4 and display heating-related parameters. A liquid driving device control panel 7 is arranged on the liquid driving device 6, and the liquid driving device control panel 7 is used to set the control parameters of the liquid driving device 6 and display the flow rate and pressure data of the circulating pipeline 2.

[0072] The two control panels are respectively used to control the start and stop of the device and set some parameters. For example, the temperature and time settings of the heating device 4 are controlled by the heating device control panel 5, which can realize a simulated 37℃ environment in the human body for real-time degradation testing, or select a temperature higher than 37℃ but lower than the melting point or softening range of the polymer for accelerated degradation testing.

[0073] The liquid driving device 6 is responsible for providing stable and continuous experimental medium flow power to ensure smooth circulation of the experimental medium in the circulating system. The liquid driving device control panel 7 on the liquid driving device 6 can realize the control of the flow, flow rate, direction and pressure of the circulation.

[0074] Embodiment 2

[0075] The embodiment 2 further provides a sample collection method for analyzing the dissociated components of the implanted interventional material, which comprises the following steps

[0076] ​Based on the implementation of the example 1 of the plant into the material dissociation composition analysis sample collection device, including the following steps:

[0077] The polymer medical device to be tested is loaded into the sample loading cavity 1 through the fixing assembly;

[0078] The liquid driving device 6 and the heating device 4 are opened, the flow, flow rate, direction, and pressure are set, the experimental medium is heated (if necessary), the circulation is started, and the experiment is started;

[0079] At the predetermined time node, the experimental medium is flowed out by adjusting the valve position of the three-way switch 3, and the collection of the experimental medium sample is completed.

[0080] In a more specific embodiment, according to the shape characteristics of the experimental object, the corresponding sample loading cavity 1 is selected. Before use, the integrity of the device is checked to ensure that the seal is tight and no liquid leaks during the circulation process.

[0081] The experimental object is fixed in the sample loading cavity 1, and the sample loading cavity 1 is connected with the circulation pipeline 2. The rotary valve of the three-way switch 3 is adjusted to the appropriate position, the experimental medium required for the experiment is injected into the circulation pipeline 2. Then the first end of the three-way switch 3 is connected with the circulation pipeline 2, the second end is connected with the external collection device, and the third end can be connected with the drug syringe according to the needs.

[0082] The switch of the heating device 4 is opened, and the heating device control panel 5 is adjusted according to the experimental requirements. The switch of the liquid driving device 6 is opened, and the liquid driving device control panel 7 is adjusted according to the experimental requirements to realize the control of the flow, flow rate, direction, and pressure of the circulation. After the circulation is stable, the pressure sensing switch 8 is opened. The liquid storage bottle 9 is filled with experimental medium.

[0083] When the experiment reaches the expected time node, the sample is collected by adjusting the three-way switch 3. After the collection is completed, when the actual pressure of the circulation pipeline is lower than the set pressure value, the switch is in an open state, the experimental medium in the liquid storage bottle 9 is sucked into the circulation pipeline, the reduced experimental medium is supplemented, and the preset pressure is restored. After the pressure of the circulation pipeline is restored to the preset value, the pressure sensing switch 8 is automatically closed.

[0084] If it is necessary to study the influence of other drugs on the degradation process of the medical device, the drug can be injected into the circulation pipeline 2 through the three-way switch 3, and the drug reacts with the experimental object in the sample loading cavity 1. Similarly, when the experiment reaches the expected time node, the sample is collected by adjusting the three-way switch 3. The pressure sensing switch 8 and the liquid storage bottle 9 supplement the experimental medium.

[0085] In the description of the specification, the description of the terms "one embodiment", "an example", "a specific example" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the utility model. In the specification, the illustrative description of the above terms does not necessarily mean the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0086] It can be known by common technical knowledge that the utility model can be realized by other embodiments without departing from the spirit or essential characteristics thereof. Therefore, the above disclosed embodiments are only illustrative in all aspects, and are not the only ones. All changes within the scope of the utility model or within the scope equivalent to the utility model are included in the utility model.

Claims

1. A sample collection device for analyzing the dissociative components of implantable materials, characterized in that, The application relates to a closed circulation experiment pipeline device. The closed circulation experiment pipeline device comprises a circulation pipeline (2); a sample loading cavity (1), a heating device (4) and a liquid driving device (6) which are connected in communication on the circulation pipeline (2); the sample loading cavity (1), the heating device (4) and the liquid driving device (6) constitute a closed circulation experiment pipeline through the circulation pipeline (2); a heating device control panel (5) is arranged on the heating device (4) and is used for controlling the heating device (4) and displaying heating related parameters; a liquid driving device control panel (7) is arranged on the liquid driving device (6) and is used for setting control parameters of the liquid driving device (6) and displaying flow rate and pressure data of the circulation pipeline (2); and experimental medium is filled in the closed circulation experiment pipeline. The closed circulation experiment pipeline device comprises a circulation pipeline (2); a sample loading cavity (1), a heating device (4) and a liquid driving device (6) which are connected in communication on the circulation pipeline (2); the sample loading cavity (1), the heating device (4) and the liquid driving device (6) constitute a closed circulation experiment pipeline through the circulation pipeline (2); a heating device control panel (5) is arranged on the heating device (4) and is used for controlling the heating device (4) and displaying heating related parameters; a liquid driving device control panel (7) is arranged on the liquid driving device (6) and is used for setting control parameters of the liquid driving device (6) and displaying flow rate and pressure data of the circulation pipeline (2); and experimental medium is filled in the closed circulation experiment pipeline. A fixing assembly is arranged on the sample loading cavity (1) and is used for loading a polymer medical instrument to be experimented into the sample loading cavity (1). A first branch (21) is arranged on any section of the circulation pipeline (2), the first branch (21) is communicated with a three-way switch (3), the three-way switch (3) is communicated with the first branch (21), an external sampling device and a medicine injector, and the three-way switch (3) is used for sample / medicine injection and sample collection. A second branch (22) is arranged on any section of the circulation pipeline (2), the second branch (22) is communicated with the circulation pipeline (2) and an external liquid storage bottle (9), and a pressure sensing switch (8) is arranged on the second branch (22).

2. The sample collection device for dissociated component analysis of an implant material according to claim 1, wherein The fixing assembly comprises a distance adjusting member and a contact mounting member; the distance adjusting member is mounted on the sample loading cavity (1), the contact mounting member is arranged in the sample loading cavity (1), and the contact mounting member is connected with the distance adjusting member and can move under the adjustment of the distance adjusting member.

3. The interventional material dissociation analysis sample collection device according to claim 1, wherein, The distance adjusting member is a bolt (10) and the contact mounting member is an extrusion plate (11).

4. The sample collection device for dissociated component analysis of an implant material according to claim 3, wherein The bolt (10) is rotationally connected on the sample loading cavity (1), and a first end of the bolt (10) is located in the sample loading cavity (1) and is mounted with the extrusion plate (11). The distance adjusting member is a bolt (10) and the contact mounting member is a spring clamp (12).

5. The sample collection device for dissociated component analysis of an implant material according to claim 3, wherein The bolt (10) is rotationally connected on the sample loading cavity (1), and a first end of the bolt (10) is located in the sample loading cavity (1) and is mounted with the spring clamp (12). The fixing assembly comprises at least two pairs of fixing assemblies, and each pair of fixing assemblies is oppositely arranged.

6. The interventional material dissociation analysis sample collection device according to claim 1, wherein, A knob is arranged on a second end of the bolt (10).

7. The sample collection device of claim 4 or 5, wherein the sample collection device is configured to collect a sample of dissociated components of the interventional material. A sealing member is arranged at a position where the bolt (10) is connected with the sample loading cavity (1).

8. The sample collection device for dissociated component analysis of an implant material according to claim 4 or 5, wherein The sample loading cavity (1) is a cylindrical sealed structure.

9. The interventional material dissociation analysis sample collection device according to claim 1, wherein, An operation port is arranged on the cylindrical sealed structure, and a sealing door is arranged at the operation port.

10. The interventional material dissociation analysis sample collection device according to claim 9, wherein, ​

Images