Condensation dewatering device for cephalosporin bulk drugs

Abstract

The utility model relates to a condensing and dewatering device for cephalosporin bulk drugs, which comprises a reaction kettle provided with a steam exhaust port and a reflux inlet, a stirrer used for stirring a mixture in the reaction kettle, and a heating part used for heating the reaction kettle, in addition, a condenser, a separator and the reaction kettle are sequentially arranged from top to bottom; the upper end and the lower end of the condenser are communicated with the steam exhaust port and an inlet of the separator respectively, the refrigerant supply end is communicated with a refrigerant inlet and a refrigerant outlet of the condenser, and an upper-layer outlet of the separator is communicated with the backflow port. The temperature monitoring unit comprises a computer unit, a first temperature sensor, a second temperature sensor and a first temperature controller, the first temperature sensor and the second temperature sensor are electrically connected with the computer unit, the first temperature sensor detects the temperature of steam exhausted from the steam exhaust port, the second temperature sensor is located at the refrigerant outlet, and the first temperature controller controls the temperature of supplied refrigerants. The heating power of the heating part can be adjusted based on the temperature of the steam, and the temperature of the supplied refrigerant is automatically adjusted in combination with the temperature of the refrigerant after heat exchange.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of medicine production, in particular to a condensation water removal device for cephalosporin raw material. BACKGROUND

[0002] Cephalosporin drugs are a kind of antibiotics with broad-spectrum antibacterial activity, which can be used for treating various infectious diseases. Due to the complexity of its production process, it needs high professional technology and equipment support, and also needs to follow strict quality control standards, so its production cost is relatively high. In the production process of cephalosporin drugs, anhydrous reaction is generally carried out, and water removal needs to be carried out before anhydrous reaction. The pros and cons of water removal effect will obviously affect the yield of anhydrous reaction.

[0003] The inventor found through a large number of practices that the current water removal device is to pass the heated steam into the condenser to condense and liquefy, and then remove the condensed liquid. This water removal device has the following defects: on the one hand, due to the reasons such as manual control of heating temperature and condensation temperature according to experience, few temperature detection points, etc., the precision of temperature control is relatively rough, the delay of temperature control action is obvious, it is difficult to accurately judge the condensation effect of the condenser and the heating effect of the heating unit, and it is impossible to timely and accurately correct the distortion and deviation caused by equipment aging, condenser replacement, etc., resulting in poor water removal effect and unstable content; on the other hand, part of the raw materials participating in the anhydrous reaction will also be lost in the form of steam, which also leads to loss of raw materials. CONTENT OF THE UTILITY MODEL

[0004] Therefore, the utility model aims to provide a condensation water removal device for cephalosporin raw material, which condenses the steam evaporated from the reaction kettle into a mixed liquid and flows into the separator for separation by setting the condenser, and monitors the temperature of the steam discharged from the steam discharge port and the temperature of the condenser by setting the temperature monitoring unit. On the one hand, the device can adjust the heating power of the heating part of the reaction kettle based on the temperature of the steam, realize the targeted adjustment of the heating power of the heating part according to the saturated vapor pressure of different solvents in the solvent system in the reaction kettle, ensure that the target solvent that needs to be evaporated can be fully gasified, and adjust the size of the steam quantity on this basis; on the other hand, the device can automatically adjust the temperature of the refrigerant supplied by the refrigerant supply end based on the temperature of the steam and the temperature of the refrigerant after heat exchange.

[0005] The utility model discloses a kind of cephalosporin raw materials' condensing water-removing device, including reactor, agitator, heating part, condenser, refrigerant supply end, separator and temperature monitoring unit;The reactor is equipped with steam exhaust and reflux port, the agitator is fixed on the reactor, the agitator is used to stir mixture in the reactor, the heating part is fixed on the bottom of the reactor, the condenser and the separator are located outside the reactor, the condenser, the separator and the reactor are sequentially arranged from top to bottom, the upper end of the condenser is communicated with the steam exhaust by pipeline, the lower end of the condenser is communicated with the mixed liquid inlet of the separator by pipeline, the condenser is also equipped with refrigerant outlet and refrigerant inlet sequentially arranged from top to bottom, the refrigerant supply end is communicated with the refrigerant inlet and the refrigerant outlet by pipeline, the separator is equipped with upper outlet and lower outlet, and the upper outlet is communicated with the reflux port;The temperature monitoring unit includes computer unit and first temperature sensor, second temperature sensor and first temperature controller electrically connected with the computer unit, the first temperature sensor is located on the pipeline communicated with the steam exhaust and the condenser, the second temperature sensor is located at the refrigerant outlet, and the first temperature controller is electrically connected with refrigerant supply end, and the first temperature controller controls the temperature of refrigerant supplied by the refrigerant supply end.

[0006] The condensing water-removing device of cephalosporin raw materials, by setting condenser, the steam evaporated from reactor is condensed into mixed liquid and flows into separator for separation, by setting temperature monitoring unit, the temperature of steam discharged from steam exhaust and the temperature of condenser are monitored, on the one hand, the device can adjust the heating power of heating part of reactor based on the temperature of steam, realize that the heating power of heating part is adjusted according to the saturated vapor pressure of different solvents in solvent system in reactor, ensure that the target solvent needing to evaporate can be fully gasified, and on this basis, the size of steam quantity is adjusted, on the other hand, the device can automatically adjust the temperature of refrigerant supplied by refrigerant supply end based on the temperature of steam and the temperature of refrigerant after heat exchange.

[0007] Further, the temperature controller further includes third temperature sensor and second temperature controller electrically connected with the computer unit, the third temperature sensor detects the heating temperature of the heating part, and the second temperature controller controls the heating temperature of the heating part. Third temperature sensor and second temperature controller are arranged, so that the device can automatically adjust the heating temperature of heating part based on steam temperature and the actual heating temperature of heating part detected, and then ensure that the target solvent in reactor can be fully gasified.

[0008] Further, the temperature controller further comprises a fourth temperature sensor electrically connected with the computer unit, the fourth temperature sensor detects the temperature of the mixture in the reaction kettle. The fourth temperature sensor is arranged to enable the device to automatically adjust the heating temperature of the heating part according to the actual temperature of the mixture in the reaction kettle, so as to cope with the temperature fluctuation of the mixture in the reaction kettle caused by the refluxing solvent, and enable the device to more stably vaporize the target solvent.

[0009] Further, the temperature controller further comprises a fifth temperature sensor electrically connected with the computer unit, the fifth temperature sensor is located at the refrigerant inlet. The fifth temperature sensor measures the temperature of the refrigerant at the refrigerant inlet, which facilitates more accurate monitoring and analysis of the condensing effect of the condenser, and further adjusts the temperature of the refrigerant to ensure the condensing effect.

[0010] Further, two glass view jars are further included, the glass view jars are respectively communicated with the upper outlet and the lower outlet through pipelines. The glass view jars arranged at the two liquid outlets of the separator are beneficial to the judgment of the water removal effect by the on-site personnel.

[0011] Further, a steam regulating valve is further included, two ends of the steam regulating valve are respectively communicated with the upper end of the condenser and the steam outlet through pipelines, and a control end of the steam regulating valve is electrically connected with the computer unit. The steam regulating valve further ensures the condensing effect of the steam in the condenser by adjusting the amount of steam.

[0012] Further, the heating part comprises a jacket and a heat source supply part, the jacket is arranged at the bottom of the reaction kettle, and the jacket is provided with a heat source inlet and a heat source outlet communicated with the heat source supply part.

[0013] Further, the temperature controller further comprises a third temperature sensor and a second temperature controller electrically connected with the computer unit, the third temperature sensor detects the temperature at the heat source inlet, and the second temperature controller controls the temperature of the heat source supplied by the heat source supply part.

[0014] Further, the stirrer comprises a stirring motor and a stirring paddle, the stirring motor is fixed to the top of the reaction kettle, one end of the stirring paddle for stirring is located in the reaction kettle, and the other end of the stirring paddle is in transmission connection with the output shaft of the stirring motor.

[0015] Further, a first receiver is further included, the first receiver is communicated with the lower outlet through a pipeline.

[0016] Further, a second receiver is further included, the second receiver is communicated with the upper outlet through a pipeline.

[0017] The beneficial effects of the present application are:

[0018] 1. By setting a condenser to condense the steam evaporated from the reaction kettle into a mixture and flow into a separator for separation, and by setting a temperature monitoring unit to monitor the temperature of the steam discharged from the steam discharge port and the temperature of the condenser, on the one hand, the device can adjust the heating power of the heating part of the reaction kettle based on the temperature of the steam, so as to adjust the heating power of the heating part according to the saturated vapor pressure of different solvents in the solvent system in the reaction kettle, and to ensure that the target solvent that needs to be evaporated can be fully gasified, and on this basis, the size of the steam quantity is adjusted, on the other hand, the device can automatically adjust the temperature of the refrigerant supplied by the refrigerant supply end based on the temperature of the steam and the temperature of the refrigerant after heat exchange.

[0019] 2. By setting a third temperature sensor and a second temperature controller, the device can automatically adjust the heating temperature of the heating part based on the steam temperature and the actual heating temperature of the heating part detected, and further ensure that the target solvent in the reaction kettle can be fully gasified.

[0020] 3. By setting a fourth temperature sensor, the device can automatically adjust the heating temperature of the heating part according to the actual temperature of the mixture in the reaction kettle, so as to cope with the temperature fluctuation of the mixture in the reaction kettle caused by the refluxed solvent, and make the device more stably gasify the target solvent.

[0021] 4. By setting a fifth temperature sensor to measure the temperature of the refrigerant at the refrigerant inlet, the condensing effect of the condenser can be more accurately monitored and analyzed, and the temperature of the refrigerant can be adjusted to ensure the condensing effect.

[0022] 5. Glass view cups are arranged at the two liquid discharge ports of the separator, which is beneficial to the on-site personnel to judge the water removal effect.

[0023] In order to better understand and implement, the present application is described in detail below in conjunction with the drawings. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 The structure diagram of the condensation and water removal device for the cephalosporin raw material medicine of an embodiment;

[0025] Figure 2 The structure diagram of the condensation and water removal device for the cephalosporin raw material medicine of an embodiment;

[0026] Among them, the reaction kettle 1, the vacuum port 11, the steam discharge port 12, the reflux port 13, the stirrer 2, the jacket 3, the heat source inlet 31, the heat source outlet 32, the condenser 4, the separator 5, the temperature monitoring unit 6, the first temperature sensor 61, the second temperature sensor 62, the third temperature sensor 63, the fourth temperature sensor 64, the fifth temperature sensor 65, and the glass view cup 7. DETAILED DESCRIPTION

[0027] It should be noted that the described embodiments are merely some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of protection of the present application.

[0028] The terms used in the embodiments of the present application are merely for the purpose of describing the specific embodiments, and are not intended to limit the embodiments of the present application. The singular forms "a", "an" and "the" used in the embodiments of the present application and the appended claims are also intended to include the plural forms, unless the context clearly indicates otherwise. It should also be understood that the term "and / or" used herein means and includes any or all possible combinations of one or more associated listed items.

[0029] The following description relates to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The implementations described in the following exemplary embodiments do not represent all implementations consistent with the present application. Instead, they are merely examples of apparatuses and methods consistent with some aspects of the present application, as detailed in the appended claims. In the description of the present application, it should be understood that the terms "first", "second", "third", etc. are only used to distinguish similar objects, and do not necessarily describe a specific order or sequence, nor can they be understood as indicating or implying relative importance. For those of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0030] In addition, in the description of the present application, "a plurality of" means two or more, unless otherwise specified. The "and / or" describes the association between the associated objects, which means that there can be three relationships, for example, A and / or B, which can represent the three cases of A alone, A and B together, and B alone. The character " / " generally represents that the associated objects before and after are in an "or" relationship.

[0031] It should be understood that the embodiments of the present application are not limited to the precise structures already described and shown in the drawings, and various modifications and changes can be made without departing from the scope thereof. The scope of the embodiments of the present application is limited only by the appended claims.

[0032] The utility model embodiment a kind of cephalosporin raw material's condensation water removal device, please refer to Figure 1, including a reaction kettle 1, a stirrer 2, a heating part, a condenser 4, a refrigerant supply end, a separator 5 and a temperature monitoring unit 6; the top of the reaction kettle 1 is provided with a vacuum port 11, a steam discharge port 12 and a reflux port 13, the vacuum port 11 is used for communication with an external vacuumizing device to make the inside of the device enter a high vacuum state, the steam discharge port 12 is used for discharging steam generated by evaporation of solvent inside the reaction kettle due to heating, it should be noted that the steam in the present application includes organic solvents, water and other gaseous substances formed by relatively small droplets and gasification due to heating, and is not limited to water vapor in the conventional sense, the reflux port 13 is used for refluxing gaseous and liquid solvents after the condenser 4 into the reaction kettle, the stirrer 2 is fixedly penetrated into the reaction kettle 1 and is used for stirring the mixture in the reaction kettle 1, specifically, the stirrer 2 of the embodiment includes a stirring motor and a stirring paddle, the stirring motor is fixed to the top of the reaction kettle 1, one end of the stirring paddle for stirring is located in the reaction kettle 1 and is arranged close to the bottom of the reaction kettle 1, the other end of the stirring paddle is penetratingly connected with the output shaft of the stirring motor through the top of the reaction kettle 1, so that the output shaft of the stirring motor drives the stirring paddle to rotate when the stirring motor operates, thereby stirring the mixture in the reaction kettle 1, the heating part is fixed to the bottom of the reaction kettle 1, the heating part of the embodiment includes a jacket 3 and a heat source supply part, the jacket 3 is arranged on the bottom of the reaction kettle 1, the jacket 3 is provided with a heat source inlet 31 and a heat source outlet 32 which are in communication with the heat source supply part, and the heat source of the embodiment is steam;

[0033] The condenser 4 and the separator 5 are both located outside the reaction kettle 1, and the condenser 4, the separator 5 and the reaction kettle 1 are arranged in sequence from top to bottom, the upper end of the condenser 4 is provided with a steam inlet and a refrigerant outlet, the condenser 4 is provided with a lower end condensate inlet and an upper end refrigerant outlet, wherein the steam inlet and the condensate outlet of the reaction kettle are located at both ends of the same heat exchange flow path of the condenser 4, the refrigerant inlet and the refrigerant outlet are located at both ends of another heat exchange flow path of the condenser 4, the steam inlet is communicated with the steam discharge port 12 through a pipeline, the condensate outlet is communicated with the mixed liquid inlet of the separator 5 through a pipeline, and the refrigerant supply end is communicated with the refrigerant inlet and the refrigerant outlet through a pipeline, the refrigerant supply end inputs low-temperature refrigerant from the refrigerant inlet into the condenser 4 of the device, and receives and processes the heat-exchanged refrigerant flowing out from the refrigerant outlet, so that the processed refrigerant meets the temperature requirement and is re-input into the condenser 4 for heat exchange;

[0034] The separator 5 is provided with a mixed liquid inlet, an upper outlet and a lower outlet, the mixed liquid inlet is located at the top of the separator 5, and the upper outlet and the lower outlet are both located at the bottom of the separator 5, the upper outlet is communicated with the reflux port 13 and a valve through a pipeline, the valve can be used for liquid discharge, maintenance and sampling detection, and the lower outlet is communicated with another valve through a pipeline, and the valve is mainly used for liquid discharge;

[0035] The temperature monitoring unit 6 comprises a computer unit and a first temperature sensor 61, a second temperature sensor 62, a third temperature sensor 63, a fourth temperature sensor 64, a fifth temperature sensor 65, a first temperature controller and a second temperature sensor 62 electrically connected with the computer unit; the first temperature sensor 61 is arranged on a pipeline connecting the steam outlet 12 with the steam inlet and close to the steam inlet, which is conducive to ensuring that the temperature of the steam entering the condenser 4 reaches the requirement; the second temperature sensor 62 is arranged on a pipeline connecting the refrigerant supply end with the refrigerant outlet and close to the refrigerant outlet; the third temperature sensor 63 is arranged on a pipeline connecting the heat source supply part with the heat source inlet 31 and close to the heat source inlet 31, so as to more accurately obtain the temperature of the heat source for heating the reaction kettle 1; the fourth temperature sensor 64 is arranged in the reaction kettle 1 and close to the bottom of the reaction kettle 1, so as to more accurately obtain the temperature of the mixture in the reaction kettle 1; the fifth temperature sensor 65 is arranged on a pipeline connecting the refrigerant supply end with the refrigerant inlet and close to the refrigerant inlet, so as to more accurately obtain the temperature of the refrigerant entering the condenser 4; the first temperature controller is electrically connected with the refrigerant supply end, and can control the temperature of the refrigerant supplied by the refrigerant supply end; the second temperature controller is electrically connected with the jacket 3, specifically the heat source supply part in the embodiment, and controls the heating temperature of the jacket 3, specifically the temperature of the heat source supplied by the heat source supply part in the embodiment;

[0036] In the application scenario that the solvent in the mixture in the reaction kettle 1 contains toluene, dichloromethane and water, and it is required to retain toluene and dichloromethane and remove water, the use process of the condensation water removal device for the cephalosporin bulk drug in the embodiment of the utility model is as follows: the operation of the stirrer 2 is kept, a suitable vacuumizing equipment is used to make the inside of the device enter a high vacuum state through the vacuum port 11, the coolant at a preset condensation temperature is introduced into the condenser 4, the temperature of the coolant outlet after subsequent heat exchange can still make dichloromethane, toluene and water condense, and then the temperature of the jacket is set at a preset heating temperature, so that dichloromethane, toluene and water can all be gasified and the temperature of the steam including dichloromethane, toluene and water before entering the condenser 4 can also meet the requirement of gasification of the three, and then it is ensured that dichloromethane, toluene and water are all in a fully gasified state before entering the condenser 4, and the incomplete water removal condition is avoided as much as possible, and it should be noted that the preset condensation temperature and the preset heating temperature can be obtained through experiments in the device for different systems, the mixed phase liquefied after the condenser 4 falls into the separator 5 and is stratified, due to the special structure of the separator 5, the water phase in the lower layer flows out from the lower layer outlet, and the oil phase in the upper layer flows out from the upper layer outlet and returns to the reaction kettle 1 to circulate water removal. In the process of circulating water removal, when the temperature monitoring unit 6 detects that the temperature in the reaction kettle 1 decreases due to some reasons (for example, the oil phase returned causes the temperature to decrease), the temperature of the jacket heating can be controlled to increase, so as to ensure that dichloromethane, toluene and water are all in a fully gasified state before entering the condenser 4; in the adjusting process, when the temperature monitoring unit 6 detects that the temperature of the coolant inlet is abnormal, the temperature of the coolant outlet is abnormal, and the temperature difference between the coolant inlet and the coolant outlet is abnormal, the temperature of the coolant supplied by the coolant supply end can be controlled to decrease, the complete condensation of water is ensured in priority, and the water removal effect is ensured. The condensation water removal device for the cephalosporin bulk drug in the embodiment of the utility model sets the condenser 4 to condense the steam discharged from the reaction kettle 1 into a mixed liquid and flow into the separator 5 for separation, sets the temperature monitoring unit 6, so that the device can monitor the temperature of the steam discharged from the steam discharge port 12, the temperature of the mixture in the reaction kettle 1, the temperature of the jacket heating and the temperature of the condenser 4, adjusts the heating power of the jacket based on this to ensure that the target solvent can be fully gasified, and automatically adjusts the temperature of the coolant based on this to ensure that the water can be fully liquefied, and then the water discharge effect is ensured and the stability of the water removal effect is ensured.

[0037] In one embodiment, referring to Figure 2 The condensation water removal device for the cephalosporin bulk drug further comprises two glass view bulbs 7, which are respectively communicated with the pipelines of the upper layer outlet and the valve and the pipelines of the lower layer outlet and the valve. The glass view bulbs 7 are arranged at the two liquid discharge ports of the separator 5, which is beneficial to the on-site personnel to judge the water removal effect and record different phenomena corresponding to different water removal stages, so as to improve the accuracy of the on-site personnel to identify the water removal effect.

[0038] In one embodiment, the condensation water removal device for cephem raw materials further comprises a steam regulating valve, two ends of the steam regulating valve are respectively communicated with the steam inlet of the condenser 4 and the steam outlet 12 of the reaction kettle 1 through pipelines, and the control end of the steam regulating valve is electrically connected with the computer unit. The steam regulating valve further ensures the condensation effect of the steam in the condenser 4 by adjusting the amount of steam.

[0039] In one embodiment, the condensation water removal device for cephem raw materials further comprises a first receiver, which is communicated with the lower outlet through a pipeline.

[0040] In one embodiment, the condensation water removal device for cephem raw materials further comprises a second receiver, which is communicated with the upper outlet through a pipeline.

[0041] The beneficial effects of the present application are:

[0042] 1. The condenser 4 is arranged to condense the steam discharged from the reaction kettle 1 into a mixture and flow into the separator 5 for separation. The temperature monitoring unit 6 is arranged to enable the device to monitor the temperature of the steam discharged from the steam outlet 12 and the temperature of the condenser 4. On the one hand, the device can adjust the heating power of the heating part based on the temperature of the steam, so as to adjust the heating power of the heating part according to the saturated vapor pressure of different solvents in the solvent system in the reaction kettle 1, so as to ensure that the target solvent that needs to be evaporated can be fully vaporized, and on this basis, the size of the steam amount is adjusted. On the other hand, the device can automatically adjust the temperature of the refrigerant supplied by the refrigerant supply end based on the temperature of the steam and the temperature of the refrigerant after heat exchange.

[0043] 2. The third temperature sensor 63 and the second temperature controller are arranged to enable the device to automatically adjust the heating temperature of the jacket based on the steam temperature and the actual heating temperature of the jacket detected, so as to ensure that the target solvent in the reaction kettle 1 can be fully vaporized.

[0044] 3. The fourth temperature sensor 64 is arranged to enable the device to automatically adjust the heating temperature of the jacket according to the actual temperature of the mixture in the reaction kettle 1, so as to cope with the temperature fluctuation of the mixture in the reaction kettle 1 caused by the refluxed solvent, and enable the device to more stably vaporize the target solvent.

[0045] 4. The fifth temperature sensor 65 is arranged to measure the temperature of the refrigerant at the refrigerant inlet, so as to more accurately monitor and analyze the condensation effect of the condenser 4, and then adjust the temperature of the refrigerant to ensure the condensation effect.

[0046] 5. The glass viewing cup 7 is arranged at the two liquid outlets of the separator 5, which is beneficial to the on-site personnel to judge the water removal effect and collect moisture.

[0047] The above-described embodiments only express several implementation manners of the utility model, the description is more specific and detailed, but can not therefore be understood as the limitation of the utility model patent range. It should be pointed out that for ordinary skilled person in the art, without departing from the concept of the utility model, several modifications and improvements can be made, and the utility model also intends to include these changes and modifications.

Claims

1. A condensing water removal device for cephem bulk drug, characterized by, The temperature controller further comprises a third temperature sensor and a second temperature controller electrically connected with the computer unit, the third temperature sensor detects the heating temperature of the heating part, and the second temperature controller controls the heating temperature of the heating part.

2. The apparatus for condensing and removing water from cefaclor bulk drug according to claim 1, wherein The temperature controller further comprises a fourth temperature sensor electrically connected with the computer unit, and the fourth temperature sensor detects the temperature of the mixture in the reaction kettle.

3. The apparatus for condensing and removing water from the head cephalosporin raw material according to claim 2, wherein The temperature controller further comprises a fifth temperature sensor electrically connected with the computer unit, and the fifth temperature sensor is located at the refrigerant inlet.

4. The apparatus for condensing and removing water from the head cephalosporin raw material according to claim 1, wherein Further comprising two glass view pots, and the two glass view pots are respectively communicated with the upper layer outlet and the lower layer outlet through pipelines.

5. The apparatus for condensing and removing water from the head cephalosporin raw material according to claim 1, wherein Further comprising a steam regulating valve, two ends of the steam regulating valve are respectively communicated with the upper end of the condenser and the steam outlet through pipelines, and a control end of the steam regulating valve is electrically connected with the computer unit.

6. The apparatus for condensing and removing water from the head cephalosporin raw material according to claim 1, wherein The heating part comprises a jacket and a heat source supply part, the jacket is covered on the bottom of the reaction kettle, and the jacket is provided with a heat source inlet and a heat source outlet communicated with the heat source supply part.

7. The apparatus for condensing and removing water from the head cephalosporin raw material according to claim 1, wherein The temperature controller further comprises a third temperature sensor and a second temperature controller electrically connected with the computer unit, the third temperature sensor detects the heating temperature of the heating part, and the second temperature controller controls the heating temperature of the heating part.

8. The apparatus for condensing and removing water from the head cephalosporin raw material according to claim 7, wherein The stirrer comprises a stirring motor and a stirring paddle, the stirring motor is fixed on the top of the reaction kettle, one end of the stirring paddle for stirring is located in the reaction kettle, and the other end of the stirring paddle is in transmission connection with the output shaft of the stirring motor.

9. The apparatus for condensing and removing water from the head cephalosporin raw material according to claim 1, wherein ​ 10. The apparatus for condensing and removing water from the head cephalosporin raw material according to claim 1, wherein A first receiver and a second receiver are also included, the first receiver being in communication with the lower outlet by piping, and the second receiver being in communication with the upper outlet by piping.

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