Double-foot balance pain-measuring test mouse cage
By designing a bipedal balance test cage adapted to mice of different sizes, the problem of mice's inability to maintain balance for a long time was solved, achieving a high-precision inflammatory pain test, simplifying experimental procedures and improving the reliability of results.
Patent Information
- Application Number
- CN202422948400.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-02
- Publication Date
- 2025-12-30
- Estimated Expiration
- 2034-12-02
AI Technical Summary
Mice have difficulty maintaining a bipedal balance posture for extended periods in their natural state, which makes it difficult for existing testing devices to accurately reflect hind paw inflammatory pain, and the training process is also time-consuming.
A bipedal balance pain test cage was designed, comprising a base plate, a base plate, a flat pedal, a vertical plate, and an inclined pedal. It is equipped with a pressure sensor and an adjustable baffle structure to simulate the natural standing posture of mice, providing comfortable support. The cage also reduces interference through guide posts and cover plates, and is suitable for mice of different sizes.
It improves the accuracy and reliability of experimental data, ensures that mice maintain their posture in a natural state, simplifies experimental procedures, adapts to mice of different sizes, reduces observational interference, and improves the accuracy of experimental results.
Smart Images
Figure CN223730516U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to test equipment technical field, concretely is a kind of two-foot balance pain test mouse cage. BACKGROUND
[0002] Mouse forefoot is placed on front inclined plane, hind foot is placed on the left and right two flat plates respectively, the pressure of two feet of mouse is measured, the condition of mouse hind foot inflammatory pain (such as left foot pain, left foot less force, right side pressure is greater than left side) is reflected, but, natural mouse will not do this work, or unable to maintain for a long time (such as 3 minutes), so it needs to adapt to mouse before normal test, but many mice cannot reach the posture requirement in training process, need to spend a lot of time, therefore a two-foot balance pain test mouse cage is presented. UTILITY MODEL CONTENTS
[0003] The utility model aims at providing a two-foot balance pain test mouse cage to solve the problems in the above background.
[0004] To achieve the above object, the utility model provides the following technical scheme: a two-foot balance pain test mouse cage, including bottom plate, the bottom plate is fixedly connected with base plate, the upper surface of base plate is symmetrically provided with two flat treadle, two flat treadle and base plate are respectively provided with pressure sensor between them;
[0005] The upper surface of bottom plate is fixedly provided with two vertical plates for supporting the left and right feet of mouse respectively, two vertical plates are parallelly arranged, and there is a space for placing mouse between two vertical plates, an inclined treadle is fixed between two vertical plates for supporting the forefoot of mouse, the lower end of inclined treadle is connected at the connecting place of bottom plate and front side of base plate, the rear end of two vertical plates is fixedly connected with rear baffle respectively, a channel capable of extending the tail of mouse is arranged between two rear baffles, and the upper movable cover of two vertical plates is provided with cover plate for placing mouse from the top.
[0006] Among them, one baffle is arranged on the opposite surface of two vertical plates, the baffles are parallel to the vertical plates, a plurality of guide columns are fixed on the side wall of each baffle, the plurality of guide columns are slidingly connected on the side wall of the same side vertical plate, by pushing and pulling the guide column, the guide column can slide in the vertical plate, at this time, the baffles will displace relative to the vertical plates, at this time, the distance between two baffles changes.
[0007] Preferably, sleeve is fixedly connected on the outer wall of vertical plate, any guide column is slidingly sleeved in the inside of sleeve, top pressing bolt is engagedly connected on the sleeve, the threaded end of top pressing bolt penetrates through sleeve and movably presses on the side wall of guide column.
[0008] Preferably, the rear end of the cover plate is fixedly connected with a gate plate, the gate plate is vertically arranged with the cover plate, and a U-shaped hole is formed in the central position of the lower end of the gate plate.
[0009] When the cover plate covers the upper part of the vertical plate, the gate plate is attached to the backstop, and the size of the passage at this position can be reduced by lowering the gate plate, thereby reducing the influence of the mouse turning around on the posture, and the U-shaped hole in the gate plate can fix the tail of the mouse.
[0010] Preferably, a plurality of air holes are formed in the surface of the inclined tread plate.
[0011] Preferably, the upper surface of the inclined tread plate is uniformly distributed with raised lines, which can reduce the slippage of the forelimbs of the mouse on the inclined surface, provide a fulcrum to make the posture of the mouse more comfortable, and make the mouse adapt faster and increase the time of posture maintenance for measurement.
[0012] Preferably, a through groove is formed in the bottom of the vertical plate and the backstop, and a "correction rod" is combined for use, the correction rod can be inserted into the position where the mouse rear foot is placed from the through grooves on both sides, and the sponge at the front end of the correction rod reduces excessive mechanical stimulation to prevent the mouse from appearing in a stressed state.
[0013] Preferably, a wire slot is formed in the lower surface of the bottom plate, and a wire for electrically connecting the pressure sensor with the outside is arranged in the wire slot.
[0014] Compared with the prior art, the utility model has the beneficial effects that: the two flat tread plates symmetrically arranged on the bottom plate and the base plate not only provide support for the mouse to stand, but also the built-in pressure sensor can monitor and record the pressure distribution of the mouse rear foot in real time, so as to accurately reflect the inflammatory pain state of the mouse rear foot and improve the accuracy of experimental data.
[0015] In addition, the combination of the two vertical plates and the inclined inclined tread plate in the device simulates the posture of the mouse when standing naturally, which not only ensures the comfort of the mouse, but also facilitates the smooth operation of the experiment. The backstop movably arranged on the vertical plate can be adjusted by sliding the guide column, which can meet the needs of mice of different sizes and ensure the wide applicability of the experiment. At the same time, the design of the dark cover plate effectively reduces the observation interference of the mouse on the measurement personnel, helps the mouse to maintain a natural state, and improves the reliability of the experimental results. BRIEF DESCRIPTION OF DRAWINGS
[0016] Figure 1 It is a schematic diagram of the overall structure of the utility model;
[0017] Figure 2 It is an explosion view of the bottom plate, vertical plate and cover plate of the utility model;
[0018] Figure 3This is a structural schematic diagram of the base plate, upright plate, baffle and guide column of this utility model;
[0019] Figure 4 This is a schematic diagram of the structure of the base plate, substrate, and wire groove of this utility model;
[0020] Figure 5 This is a schematic diagram of the structure of the base plate, flat pedal and pressure sensor of this utility model;
[0021] Figure 6 This is a structural diagram of the upright plate, inclined footboard, and baffle of this utility model.
[0022] In the diagram: 1. Base plate, 2. Base plate, 3. Flat pedal, 4. Pressure sensor, 5. Vertical plate, 6. Slanted pedal, 601. Raised texture, 7. Rear baffle, 8. Baffle, 9. Guide post, 10. Cover plate, 11. Sleeve, 12. Top pressure bolt, 13. Gate plate, 14. U-shaped hole, 15. Vent hole, 16. Through groove, 17. Cable groove. Detailed Implementation
[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0024] Please see Figures 1-6 This utility model provides a technical solution: a bipedal balance pain test mouse cage, including a base plate 1, a base plate 2 fixedly connected to the base plate 1, two flat pedals 3 symmetrically arranged on the upper surface of the base plate 2, and pressure sensors 4 respectively arranged between the two flat pedals 3 and the base plate 2.
[0025] Two upright plates 5 are symmetrically fixed on the upper surface of the base plate 1 to support the left and right feet of the mouse respectively. The two upright plates 5 are arranged in parallel, and there is a space between the two upright plates 5 for placing the mouse. An inclined footrest 6 is fixed between the two upright plates 5 to support the front feet of the mouse. The lower end of the footrest 6 is connected to the connection between the base plate 1 and the front side of the base plate 2. The rear ends of the two upright plates 5 are respectively fixedly connected to the rear end of the two upright plates 7. A channel is provided between the two rear end plates 7 to allow the mouse's tail to extend. A cover plate 10 is movably covered above the two upright plates 5 to allow the mouse to jump out from above. The cover plate 10 is dark in color. Since the mouse is easy to observe the measuring personnel and cannot maintain its posture, the dark color of the cover plate 10 can reduce this interference while not hindering the observation of the mouse.
[0026] Each of the two upright plates 5 has a baffle 8 on its opposite surface. The baffle 8 is parallel to the upright plate 3. Multiple guide posts 9 are fixed on the side wall of each baffle 8. The multiple guide posts 9 are slidably connected to the side wall of the upright plate 5 on the same side. By pushing and pulling the guide posts 9, the guide posts 9 can slide within the upright plate 5. At this time, the baffle 8 will be displaced relative to the upright plate 5. The distance between the two baffles 8 changes. By adjusting the distance between the two baffles 8, mice of different sizes can be placed. During the training of the mouse's bipedal balance, it can correct the misalignment of the mouse's left and right feet on the two flat pedals 3 below.
[0027] When in use, a mouse is placed in the device, with the mouse positioned between two baffles 8. The mouse's forelegs are placed on the front inclined pedal 6, and its hind legs are placed on the two lower flat pedals 3. The pressure sensor 4 under the flat pedal 3 is used to measure the pressure on the mouse's two feet, reflecting the inflammatory pain in the mouse's hind feet. For example, if the left foot is painful, the left foot is exerting less force, and the pressure on the right side is greater than that on the left side.
[0028] like Figure 6 As shown, in order to prevent the baffle 8 from moving freely on the upright plate 5, specifically, a sleeve 11 is fixedly connected to the outer wall of the upright plate 5, and any guide post 9 is slidably sleeved inside the sleeve 11. A top-pressing bolt 12 is engaged on the sleeve 11, and the threaded end of the top-pressing bolt 12 passes through the sleeve 11 and presses against the side wall of the guide post 9.
[0029] like Figure 1 and Figure 2 As shown, in order to fix the mouse's tail, specifically, a gate plate 13 is fixedly connected to the rear end of the cover plate 10. The gate plate 13 is set perpendicular to the cover plate 10, and a U-shaped hole 14 is opened at the center of the lower end of the gate plate 13.
[0030] When the cover plate 10 is placed on top of the upright plate 5, the gate plate 13 is attached to the rear baffle 7. By lowering the gate plate 13, the size of the passage can be reduced, reducing the mouse's turning and affecting its posture. In addition, the U-shaped hole on the gate plate 13 can provide a certain fixation effect on the mouse's tail.
[0031] like Figures 1-3 As shown, in order to increase ventilation and ensure the mouse's breathing, specifically, the surface of the inclined foot pedal 6 is provided with multiple ventilation holes 15. When the mouse is placed inside the device and maintains the correct posture, the mouse's mouth and nose are located at the inclined foot pedal 6. Adding ventilation holes 15 at the mouse's mouth and nose position can help increase the mouse's posture comfort and help the mouse maintain the posture.
[0032] In addition, the surface of the cover plate 10 may also be provided with multiple ventilation holes 15 to ensure smooth breathing for the mice.
[0033] like Figure 2 , Figure 3 and Figure 6 As shown, in order to facilitate the placement of the mouse's forelimbs on the inclined footplate 6 and prevent the mouse's forelimbs from slipping on the inclined footplate 6, specifically, the upper surface of the inclined footplate 6 is uniformly distributed with raised textures 601. The raised textures 601 can reduce the slippage of the mouse's forelimbs on the inclined surface, provide a fulcrum to make the mouse's posture more comfortable, allow it to adapt more quickly, and increase the time it can maintain the posture for easier measurement.
[0034] like Figure 1 As shown, in order to correct the posture of the mouse's hind paws, specifically, the bottom of the upright plate 5 and the baffle 8 are provided with through grooves 16, which are used in conjunction with a "correction rod" (ordinary plastic rod with the front end covered by sponge). The correction rod can be inserted from the through grooves 16 on both sides to correct the position of the mouse's hind paws. The sponge at the front end of the correction rod reduces excessive mechanical stimulation and prevents the mouse from experiencing stress.
[0035] like Figure 4 As shown, in order to transmit the signal of the pressure sensor 4 to the outside, specifically, a wire groove 17 is provided on the lower surface of the base plate 1, and the wire groove 17 is provided with a wire for electrically connecting the pressure sensor 4 to the outside.
[0036] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A bipedal balance dolorimetry test cage comprising a floor (1), characterised in that: The bottom plate (1) is fixedly connected with a base plate (2), and the upper surface of the base plate (2) is symmetrically provided with two flat pedals (3); pressure sensors (4) are arranged between the two flat pedals (3) and the base plate (2) respectively. The upper surface of the bottom plate (1) is symmetrically fixed with two vertical plates (5) for supporting the left and right feet of the mouse respectively, and an inclined inclined pedal (6) is fixed between the two vertical plates (5) for supporting the front feet of the mouse; the rear ends of the two vertical plates (5) are fixedly connected with rear baffles (7), a channel capable of extending the tail of the mouse is arranged between the two rear baffles (7), and a cover plate (10) for placing the mouse from the top is arranged above the two vertical plates (5). Wherein, one baffle (8) is arranged on the opposite surface of the two vertical plates (5), a plurality of guide columns (9) are fixed on the side wall of each baffle (8), and the plurality of guide columns (9) are slidingly connected to the side wall of the same side vertical plate (5). The rear end of the cover plate (10) is fixedly connected with a gate plate (13), the gate plate (13) is arranged vertically with the cover plate (10), and a U-shaped hole (14) is formed in the center of the lower end of the gate plate (13). When the cover plate (10) is covered on the vertical plate (5), the gate plate (13) is attached to the rear baffle (7), a plurality of air holes (15) are formed on the surface of the inclined pedal (6), the air holes (15) are increased at the position of the mouse's mouth and nose on the inclined pedal (6), the upper surface of the inclined pedal (6) is uniformly distributed with convex lines (601), and the bottom of the vertical plate (5) and the baffle (8) is provided with a through groove (16), the through groove (16) is used in combination with a correction rod, and the correction rod extends into the position for placing the rear feet of the mouse from the through grooves (16) on both sides.
2. The bipedal balance pain testing mouse cage of claim 1, wherein: The outer wall of the vertical plate (5) is fixedly connected with a sleeve (11), any guide column (9) is slidingly sleeved in the sleeve (11), the sleeve (11) is engagedly connected with a jacking bolt (12), and the threaded end of the jacking bolt (12) penetrates through the sleeve (11) and is movably jacked on the side wall of the guide column (9).
3. The bipedal balance pain testing mouse cage of claim 1, wherein: The lower surface of the bottom plate (1) is provided with a wire slot (17), and the wire slot (17) is provided with wires for electrically connecting the pressure sensors (4) with the outside.