Chromatographic column head with fine hole fluid distribution cover

Abstract

The utility model provides a chromatographic column head with a pore fluid distribution cover, which comprises a column head bottom plate for storing and discharging liquid and a column head top plate covering the top of the column head bottom plate and used for injecting liquid and exhausting, and a water injection pipe for injecting water into the column head bottom plate is arranged in the center of the top of the column head top plate. A groove used for storing liquid is formed in the column head bottom plate, a plurality of liquid drainage holes communicated with the outside are formed in the bottom of the groove in an arrayed mode, a liquid distribution disc structure with the same projection area as the groove is arranged in the groove, and the liquid distribution disc structure is in an arc shape. The circle center of the liquid distribution disc structure and the axis of the water injection pipe are collinear, the liquid distribution disc structure comprises a water avoiding area arranged under the water injection pipe and a liquid distribution area arranged around the water avoiding area, and the area of the water avoiding area is larger than or equal to the projection area of an inner hole of the water injection pipe. A plurality of liquid separation holes are formed in the liquid separation area around the water avoiding area.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and in particular to a chromatography column head with a fine-pore fluid distribution hood. Background Technology

[0002] Pressing the packing material is an essential process for using chromatography columns.

[0003] The principle of chromatography column packing is to inject purified water into the column head, guide the purified water to the support mesh at the bottom of the column head, distribute the purified water across the entire column head surface, and then allow the water to drip evenly from the filter screen to wash the packing.

[0004] In existing technologies, electric and manual chromatography columns flush the packing material by passing water through the injection pipe and relying on the support mesh and filter screen to distribute the water to the entire column head. However, it is difficult to distribute the water evenly across the entire column surface using only the support mesh and filter screen. Furthermore, since the water is injected into the chromatography column through the injection pipe, the water flow will spread outwards from the point of entry, which inevitably results in a larger water flow in the middle than around the edges, with almost no water flowing into the outermost edge. This creates a concave surface at the center of the packing material corresponding to the injection pipe. Utility Model Content

[0005] Therefore, the purpose of this invention is to provide a chromatography column head with a fine-pore fluid distribution hood, which can effectively solve the shortcomings of the prior art.

[0006] A chromatography column head with a fine-pore fluid distribution hood includes a column head base plate for liquid storage and drainage, and a column head top plate covering the top of the column head base plate for liquid injection and venting. A water injection pipe for injecting water into the column head base plate is disposed at the center of the top of the column head top plate. A groove for liquid storage is disposed within the column head base plate. A plurality of drainage holes communicating with the outside are arranged at the bottom of the groove. A distribution plate structure with the same projected area as the groove is disposed within the groove. The distribution plate structure is arc-shaped, and its center is collinear with the axis of the water injection pipe. The distribution plate structure includes a water-avoiding zone disposed directly below the water injection pipe and a distribution zone surrounding the water-avoiding zone. The area of ​​the water-avoiding zone is greater than or equal to the projected area of ​​the inner hole of the water injection pipe. A plurality of distribution holes are disposed around the water-avoiding zone in the distribution zone.

[0007] Furthermore, an exhaust structure is provided at the top of the column head plate, and the exhaust structure is located on one side of the water injection pipe.

[0008] Furthermore, the venting structure includes a vent hole connecting to the outside and into the groove, a first sealing element disposed on the inner wall of the vent hole, and a plug for blocking the vent hole, wherein the diameter of the vent hole is smaller than the diameter of the water injection pipe.

[0009] Furthermore, a filter screen is installed inside the water injection pipe to slow down the liquid flow rate.

[0010] Furthermore, a sealing plate is fitted at the bottom of the column head base plate to prevent liquid from being discharged from the drain hole.

[0011] Furthermore, a groove is provided on the cylindrical outer surface of the column base plate, and the sealing plate is fastened to the column base plate through the groove.

[0012] Furthermore, a second seal is provided within the slot.

[0013] Furthermore, the diameter of the dispensing hole gradually increases along the center of the dispensing plate towards the outer edge of the dispensing plate.

[0014] Furthermore, the diameter of the liquid separating hole is between 2mm and 3mm.

[0015] Furthermore, the diameter of the drain hole is 1 mm.

[0016] Compared with the prior art, the beneficial effects of this utility model are as follows: By arranging the liquid distribution plate structure in an arc shape, liquid is injected into the column head base plate through the water injection pipe. When the liquid is distributed downwards through the liquid distribution plate structure, the height difference of the liquid level at different positions will cause different pressures. The liquid level is higher and the pressure is greater in the part of the distribution zone closer to the edge, and the distribution is faster. The liquid level is lower and the pressure is less in the part of the distribution zone closer to the water-avoiding zone, and the distribution is slower. The arc-shaped design creates a liquid level difference to compensate for the defect of faster distribution in the middle and slower distribution at the edges caused by the liquid spreading to the surrounding areas during the injection process. Furthermore, there are no separation holes in the water-avoiding zone. The purpose of this is to prevent the liquid from directly washing the center of the separation plate structure when it enters from the water injection pipe, causing the liquid velocity in the middle to be greater than that at the edge after separation, resulting in uneven separation. After the liquid is separated from the separation plate structure, the liquid velocity and flow rate of each part are roughly the same. Then, after passing through the inside of the groove, it is separated again through the drain hole. The entire separation process is completed, thus solving the problem that the water flow in the middle of the chromatography column is greater than that around the perimeter, and that there is almost no water flowing at the very edge. This also avoids the formation of a concave surface at the center of the packing material corresponding to the water injection pipe. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of the chromatography column head with a fine-pore fluid distribution hood in an embodiment of this utility model;

[0018] Figure 2 This is a schematic diagram showing the unfolded column head of the chromatography column with a fine-pore fluid distribution hood in an embodiment of this utility model;

[0019] Figure 3 This is a schematic cross-sectional view of the column head of a chromatography column with a fine-pore fluid distribution hood in an embodiment of this utility model;

[0020] Figure 4 This is a top view of the liquid distribution plate structure in an embodiment of this utility model;

[0021] Explanation of key component symbols:

[0022] Column head top plate 10 Drain hole 22 Water injection pipe 11 Liquid distribution disc structure 23 Filter 12 Flood Shelter 24 Exhaust structure 13 Separation area 25 Exhaust port 14 Separation hole 26 First sealing element 15 Card slot 27 plug 16 Second seal 28 Column base plate 20 sealing plate 30 groove 21

[0023] The following detailed description, in conjunction with the accompanying drawings, will further illustrate this utility model. Detailed Implementation

[0024] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. Several embodiments of this utility model are shown in the drawings. However, this utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that the disclosure of this utility model will be more thorough and complete.

[0025] It should be noted that when a component is said to be "fixed to" another component, it can be directly on the other component or there may be an intervening component. When a component is said to be "connected to" another component, it can be directly connected to the other component or there may be an intervening component. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this document are for illustrative purposes only.

[0026] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0027] Please see Figures 1 to 4The chromatography column head with a fine-pore fluid distribution hood in this embodiment includes a column head base plate 20 for liquid storage and drainage, and a column head top plate 10 covering the top of the column head base plate 20 for liquid injection and venting. A water injection pipe 11 for injecting water into the column head base plate 20 is provided at the center of the top of the column head top plate 10. A groove 21 for liquid storage is provided inside the column head base plate 20. A plurality of drainage holes 22 communicating with the outside are arranged at the bottom of the groove 21. A drainage hole 22 is provided inside the groove 21. A liquid distribution plate structure 23 with the same projected area as the groove 21 is provided. The liquid distribution plate structure 23 is arc-shaped, and the center of the liquid distribution plate structure 23 is collinear with the axis of the water injection pipe 11. The liquid distribution plate structure 23 includes a water-avoiding area 24 located directly below the water injection pipe 11 and a liquid distribution area 25 arranged around the water-avoiding area 24. The area of ​​the water-avoiding area 24 is greater than or equal to the projected area of ​​the inner hole of the water injection pipe 11. A plurality of liquid distribution holes 26 are arranged around the water-avoiding area 24 in the liquid distribution area 25.

[0028] Understandably, by arranging the liquid distribution plate structure 23 in an arc shape, liquid is injected into the groove 21 through the water injection pipe 11. When the liquid is distributed downwards through the liquid distribution plate structure 23, the height difference of the liquid level at different positions will cause different pressures. The liquid level is higher and the pressure is greater in the liquid distribution area 25 closer to the edge, resulting in faster distribution. Conversely, the liquid level is lower and the pressure is less in the liquid distribution area closer to the water-avoiding zone 24, resulting in slower distribution. The arc-shaped design creates a liquid level difference to compensate for the defect of faster distribution in the middle and slower distribution at the edges caused by the liquid spreading to the surrounding areas during the injection process. Furthermore, in the water-avoiding zone 24... The absence of the separating hole 26 is intended to prevent liquid from directly scouring the center of the separating plate structure 23 when entering from the water injection pipe 11, thus avoiding uneven liquid distribution due to the higher flow velocity in the middle compared to the edges. After liquid is separated from the separating plate structure 23, the flow velocity and flow rate of each part are approximately the same. Then, after passing through the inside of the groove 21, liquid is separated again through the drain hole 22, completing the entire separation process. This solves the problem that the water flow in the middle of the chromatography column is greater than that around the perimeter, and almost no water flows through the edges, preventing the formation of a concave surface at the center of the packing material corresponding to the water injection pipe 11.

[0029] Furthermore, an exhaust structure 13 is provided on the top of the column head plate 10, and the exhaust structure 13 is located on one side of the water injection pipe 11.

[0030] Furthermore, the venting structure 13 includes a venting hole 14 communicating with the outside to the groove 21, a first sealing member 15 disposed on the inner wall of the venting hole 13, and a plug 15 for blocking the venting hole 14. The diameter of the venting hole 13 is smaller than the diameter of the water injection pipe 11.

[0031] Understandably, the interior of this invention needs to be vented before the liquid separation process to prevent air bubbles from forming during the liquid injection process and blocking the liquid separation hole 26 or the liquid drain hole 22.

[0032] Furthermore, a sealing plate 30 is also fitted at the bottom of the column base plate 20 to prevent liquid from being discharged from the drain hole 22.

[0033] Furthermore, a groove 27 is provided on the cylindrical outer surface of the column base plate 20, and the sealing plate 30 is fastened to the column base plate 20 through the groove 27.

[0034] Specifically, in this embodiment, the sealing plate 30 is a silicone sealing plate.

[0035] Understandably, firstly, the plug 16 is removed, and a sealing surface is formed by installing the sealing plate 30 on the column head base plate 20. Then, purified water is injected from the water injection pipe 20. Because the bottom is sealed by the sealing plate 30, the purified water cannot flow out from the drain hole 22. When the liquid level rises to the point where the purified water overflows from the vent hole 14, the internal air is completely discharged. The plug 16 is then used to block the vent hole 14, and the venting is completed.

[0036] It should be noted that, specifically in this embodiment, the diameter of the water injection pipe is 4mm-7mm, and the diameter of the vent hole 13 is 1mm smaller than the diameter of the water injection pipe 11.

[0037] It is understandable that by setting the diameter of the vent hole 13 to be smaller than the diameter of the water injection pipe 11, the internal pressure of the present invention can be increased during venting to facilitate the discharge of air.

[0038] Furthermore, a second sealing element 28 is provided in the slot 27.

[0039] It is understandable that by providing the second seal 28 in the slot 27, leakage of the sealing plate 30 during the liquid injection process is prevented, thereby enhancing the airtightness of this utility model.

[0040] Furthermore, a filter screen 12 is provided inside the water injection pipe 11 to slow down the liquid flow rate.

[0041] Understandably, the filter 12 is configured to slow down the flow rate of the injected liquid.

[0042] Furthermore, the diameter of the liquid distribution hole 26 gradually increases along the center of the liquid distribution plate 23 toward the outer edge of the liquid distribution plate 23.

[0043] Understandably, by gradually increasing the diameter of the dispensing hole 26 along the center of the dispensing plate 23 toward the outer edge of the dispensing plate 23, the dispensing speed of the dispensing holes farther from the center of the dispensing plate 23 can be increased, and the further away from the center of the dispensing plate 23, the greater the increase in speed.

[0044] Furthermore, the diameter of the liquid distribution hole 26 is between 2mm and 3mm.

[0045] Furthermore, the diameter of the drain hole 22 is 1 mm.

[0046] It should be noted that by setting the diameter of the drain hole 22 to be smaller than that of the distribution hole 26, the distribution speed of the distribution hole 26 is greater than that of the drain hole 22. This is because the distribution hole 26 only needs to distribute the liquid roughly evenly, and then the liquid is further distributed through the drain hole 22, thus achieving the effect of uniform liquid distribution.

[0047] In summary, the chromatography column head with a fine-pore fluid distribution hood in the above embodiments of this utility model, by arranging the separating disk structure in an arc shape, injects liquid into the column head base plate through a water injection pipe. When the liquid is separated downwards through the separating disk structure, the different height differences of the liquid level at different positions will cause different pressures. The liquid level is higher and the pressure is greater in the part of the separating zone closer to the edge, and the separation is faster. The liquid level is lower and the pressure is less in the part of the separating zone closer to the water-avoiding zone, and the separation is slower. The arc-shaped design creates a liquid level difference to offset the faster separation in the middle and the faster separation at the edges caused by the liquid diffusion to the surrounding areas during the injection process. The design addresses the drawback of slow separation and the absence of separation holes in the water-avoiding zone. This is to prevent the water flow from directly washing over the center of the separation plate structure when the liquid enters from the water injection pipe, which would cause the flow velocity in the center of the separated liquid to be greater than that at the edges, resulting in uneven separation. After the liquid is separated from the separation plate structure, the flow velocity and flow rate of each part are roughly the same. Then, after passing through the groove and the drain hole, the liquid is separated again, and the entire separation process is completed. This solves the problem that the water flow in the center of the chromatography column is greater than that around the perimeter, and that there is almost no water flowing at the very edge, thus avoiding the formation of a concave surface at the center of the packing material corresponding to the water injection pipe.

[0048] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0049] The embodiments described above are merely illustrative of several implementations of this utility model, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of this utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. A chromatography column head having a fϊne pore fluid distribution cover, characterized in that, The application relates to a liquid distribution device, which comprises a column bottom plate for storing and discharging liquid, a column top plate arranged on the top of the column bottom plate for liquid injection and air discharge, a water injection pipe arranged on the top center of the column top plate for injecting water into the column bottom plate, a groove arranged in the column bottom plate for storing liquid, a plurality of liquid discharge holes arranged on the bottom of the groove for discharging liquid to the outside, a liquid distribution disc structure arranged in the groove and having the same projection area as the groove, wherein the liquid distribution disc structure is in the shape of a circular arc, the center of the liquid distribution disc structure is collinear with the axis of the water injection pipe, the liquid distribution disc structure comprises a water-avoiding area arranged directly below the water injection pipe and a liquid distribution area arranged around the water-avoiding area, the area of the water-avoiding area is greater than or equal to the projection area of the inner hole of the water injection pipe, and a plurality of liquid distribution holes are arranged around the water-avoiding area in the liquid distribution area.

2. The chromatography column head with a fritted fluid distribution cap of claim 1, wherein, An air discharge structure is further arranged on the top of the column top plate and arranged on one side of the water injection pipe.

3. The chromatography column head with a fritted fluid distribution cap of claim 2, wherein, The air discharge structure comprises an air discharge hole for connecting the outside to the groove, a first sealing element arranged on the inner wall of the air discharge hole and a plug for plugging the air discharge hole, and the diameter of the air discharge hole is smaller than the diameter of the water injection pipe.

4. The chromatography column head with a fritted fluid distribution cap of claim 1, wherein, A filter screen for slowing down the flow rate of liquid is arranged in the water injection pipe.

5. The chromatography column head with a fritted fluid distribution cap of claim 1, wherein, A sealing plate for preventing liquid from being discharged from the liquid discharge hole is further arranged on the bottom of the column bottom plate.

6. The chromatography column head with a fritted fluid distribution cap of claim 5, wherein, A clamping groove is arranged on the cylindrical outer surface of the column bottom plate, and the sealing plate is buckled on the column bottom plate through the clamping groove.

7. The chromatography column head with a fritted fluid distribution cap of claim 6, wherein, A second sealing element is arranged in the clamping groove.

8. The chromatography column head with a fritted fluid distribution cap of claim 1, wherein, The diameter of the liquid distribution hole gradually increases along the extension from the center of the liquid distribution disc to the outside of the liquid distribution disc.

9. The chromatography column head with a fritted fluid distribution cap of claim 1, wherein, The diameter of the liquid distribution hole is 2-3 mm.

10. The chromatography column head with a fritted fluid distribution cap of claim 1, wherein, The diameter of the liquid discharge hole is 1 mm.

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