Urinary catheter for detecting hemeroflavin in urine

By designing a urine catheter containing potassium ferrocyanide and hydrochloric acid solution, the detection of hemosiderin in urine was achieved under sealed conditions, solving the problem of harmful gas release from chemical reagents and improving the safety and efficiency of the detection.

CN223742473UActive Publication Date: 2025-12-30TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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Patent Information

Application Number
CN202423132428.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-12-18
Publication Date
2025-12-30
Estimated Expiration
2034-12-18

AI Technical Summary

Technical Problem

Existing technologies for detecting hemosiderin in urine present a challenge in balancing safety and ease of operation, especially when testing healthcare workers. The use of chemical reagents such as Prussian blue can release highly toxic gases during the Prussian blue reaction, potentially harming the health of healthcare workers.

Method used

Design a urinary catheter with a pre-filled cavity containing potassium ferrocyanide solution and hydrochloric acid solution. By tightening the cap, the solutions are mixed in a sealed state to form a mixed solution. The presence of hemosiderin is determined by observing the blue precipitate, while avoiding gas release.

Benefits of technology

This technology enables the detection of hemosiderin in urine under sealed conditions, avoiding exposure of medical personnel to harmful gases, simplifying the operation process, and improving detection efficiency and safety.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses a ureter for detecting hemeroflavin in urine. The ureter comprises a bottle body, a bottle cap and a piston rod, a first preset cavity and a second preset cavity are formed in the bottle body, and detection solutions are respectively preset in the first preset cavity and the second preset cavity; the bottom of the piston rod extends outwards to form a first branch rod and a second branch rod, and the bottom ends of the first branch rod and the second branch rod are provided with a first piston and a second piston respectively. And the first piston and the second piston are respectively arranged in the first preset cavity and the second preset cavity. During detection, urine to be detected is taken and added into the bottle body, a potassium ferrocyanide solution and a hydrochloric acid solution automatically flow out of the preset cavity to form a mixed solution with the urine while the bottle cap is screwed, then the mixed solution precipitates in the precipitation cavity, and whether blue precipitates exist or not is observed so as to judge a detection result. The two preset solutions are mixed in a sealed state, and gas generated after mixing cannot be released into air, so that the medical staff is prevented from being in contact with the gas during detection, and the health of the medical staff is prevented from being damaged.
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Description

TECHNICAL FIELD

[0001] The embodiment of the utility model belongs to urine detection technical field, more particularly, relate to a kind of for detecting urine ferric hematin's urinary tube. BACKGROUND

[0002] Ferric hematin is a ferritin polymer stored in cells, usually processed and stored by macrophages after red blood cell breakdown. When there is excessive red blood cell destruction or chronic bleeding in the body, it can cause deposition of ferric hematin in tissues. Ferric hematin in urine is usually caused by renal tubular injury or intravascular hemolysis. The detection of ferric hematin in urine is usually used to determine whether there is chronic intravascular hemolysis or hemolytic anemia, kidney disease caused by destruction of red blood cells in the kidney, pulmonary congestion and pulmonary infarction caused by heart failure and other pathological conditions.

[0003] In clinical practice, doctors will choose appropriate methods for detection according to specific circumstances, and make diagnosis combined with patient's medical history and other laboratory test results. The methods for detecting ferric hematin in urine mainly include the following: 1. Microscopic examination: centrifuge urine sample, then observe precipitate under microscope. If there are a large number of ferric hematin-containing particles, brown or yellow particles can be seen in urine sediment. This method is relatively simple, but the sensitivity is low, and it may not be able to detect small amounts of ferric hematin. 2. Chemical test: use chemical reagents such as Prussian blue staining method to detect the presence of iron. Prussian blue reaction is a method specific to ferric hematin and iron-containing substances, which can be used for qualitative or semi-quantitative analysis. Mix urine sample with reagent, if blue appears, it means positive result, indicating the presence of ferric hematin. 3. Spectral analysis: for example, spectrophotometer can be used to measure the change of absorbance at specific wavelength, so as to quantitatively determine the iron content in urine. This requires more complex equipment and technology, but provides more accurate results. 4. Immunological method: use anti-ferritin antibody to perform enzyme-linked immunosorbent assay (ELISA) or other similar immunoassay techniques to detect ferritin level in urine. This method has high sensitivity and specificity. 5. Magnetic selective analysis: based on the magnetic properties of ferric hematin, selective separation and detection of ferric hematin in urine can be achieved.

[0004] Among them, in the conventional operation method of chemical test, the operation is carried out in an open glass container, and after mixing potassium ferrocyanide with hydrochloric acid, hydrogen cyanide gas will be released. Hydrogen cyanide is a highly toxic gas, and long-term exposure can cause cancer. When a large number of detections are carried out by medical staff, the amount of inhalation will increase, affecting the health of medical staff. Therefore, a urinary tube for detecting ferric hematin in urine is needed, which can detect ferric hematin in urine in a sealed state, prevent medical staff from contacting reagents, reduce the risk of illness, simplify the operation steps of detection and improve work efficiency. Utility Model Content

[0005] To address the aforementioned deficiencies or improvement needs of existing technologies, this utility model provides a urinary catheter for detecting hemosiderin in urine. Equal volumes of potassium ferrocyanide solution and hydrochloric acid solution are pre-placed in a first and a second pre-placed chamber, respectively. During testing, the urine sample is added to the bottle, and while tightening the cap, the potassium ferrocyanide solution and hydrochloric acid solution automatically flow out from the pre-placed chambers, forming a mixed solution with the urine. The mixed solution is then allowed to precipitate in the precipitation chamber, and the presence of a blue precipitate is observed to determine the test result. The mixing of the two pre-placed solutions is carried out in a sealed state, preventing the gas generated after mixing from being released into the air, thus avoiding contact with medical personnel during testing and ensuring their health is not harmed.

[0006] To achieve the above objectives, this utility model provides a urine catheter for detecting hemosiderin in urine, comprising: a bottle body, a bottle cap, and a piston rod;

[0007] The bottle body is provided with a first pre-placed cavity and a second pre-placed cavity, each containing a detection solution;

[0008] The bottom of the piston rod extends outward to form a first branch rod and a second branch rod, and the bottom ends of the first piston and the second piston are respectively provided.

[0009] The first piston and the second piston are respectively disposed in the first preset cavity and the second preset cavity.

[0010] Furthermore, the first and second pre-set cavities are arranged circumferentially along the inner wall of the bottle, both of which have semi-circular cross-sections and are separated by a partition.

[0011] The first and second pre-formed cavities have openings at the top. The upper cavities of the two pre-formed cavities are equidistant from the bottle body, and the lower cavities gradually narrow downwards, making their bottom surfaces conical.

[0012] Furthermore, a discharge groove is formed on the bottom conical surface of the first and second pre-set cavities, and a temporary blocking plate is provided in the discharge groove. The temporary blocking plate is provided with a rubber plug, which is interference-fitted into the discharge groove.

[0013] Furthermore, the bottle body is also equipped with a filter plate, which divides the space inside the bottle body into a mixing chamber and a sedimentation chamber, and the filter plate is provided with multiple large filter holes.

[0014] Furthermore, at least two of each of the first and second branch poles are provided;

[0015] The first piston has the same cross-sectional shape as the upper cavity of the first preset cavity;

[0016] The second sub-rod has the same upper cavity section shape as the second preset cavity.

[0017] Further, the first preset cavity and the second preset cavity are both provided with a baffle at the cavity opening.

[0018] The baffle limits the first piston and the second piston in the first preset cavity and the second preset cavity.

[0019] Further, the first piston and the second piston are both provided with a rubber layer on the surface.

[0020] Further, the bottle cap is connected with the bottle mouth of the bottle body through threads, and a push rod is arranged at the center.

[0021] The bottle cap is provided with a deep cavity at the center.

[0022] The push rod is provided with a limiting groove, the top of the piston rod is arranged in the limiting groove, and the top of the piston rod and the limiting groove are smoothly connected.

[0023] Further, the bottle body is provided with a connecting table arranged in the circumferential direction at the bottle mouth, and the bottle cap is connected through the connecting table.

[0024] The bottle cap and the end surface of the connecting table are further provided with a connecting buckle, so that temporary fixation is formed between the bottle cap and the bottle body.

[0025] Further, the detection solution comprises potassium ferrocyanide and hydrochloric acid solution.

[0026] Overall, compared with the prior art, the above technical scheme conceived by the utility model can achieve the following beneficial effects:

[0027] 1. The urine tube of the utility model, the potassium ferrocyanide solution and the hydrochloric acid solution are respectively preset in the first preset cavity and the second preset cavity in equal volumes, when detection is performed, the urine to be detected is added into the bottle body, the bottle cap is screwed at the same time, the potassium ferrocyanide solution and the hydrochloric acid solution automatically flow out of the preset cavity, form a mixed solution with the urine, and then the mixed solution is precipitated in the precipitation cavity, whether there is blue precipitation is observed, so that the detection result is judged. The mixing of the two preset solutions is performed in a sealed state, the gas generated after mixing cannot be released into the air, the health of medical staff is ensured not to be damaged when the medical staff performs detection.

[0028] 2. The urine tube of the utility model, before use, the bottle cap 2 and the end surface of the connecting table are connected through the connecting buckle, temporary fixation connection is formed between the bottle cap 2 and the bottle body 1, relative rotation between the bottle cap 2 and the bottle body 1 due to vibration during transportation is prevented, the temporary baffle 16 is prevented from being lifted off in advance due to the pressure of the piston rod 3, and the potassium ferrocyanide and the hydrochloric acid solution are prevented from being leaked in advance.

[0029] 3. The urinary tube of the utility model, potassium ferrocyanide and hydrochloric acid solution are stored in the first preset cavity and the second preset cavity respectively, and are sealed and stored through the piston and the temporary baffle, and leakage does not occur, facilitating transportation after manufacture.

[0030] 4. The urinary tube of the utility model is provided with the filter plate with large filter holes between the mixing cavity and the sedimentation cavity, so that the precipitate is smoothly precipitated into the sedimentation cavity, and the temporary baffle that falls off is blocked in the mixing cavity by the filter plate, avoiding the influence of the observation of the precipitate in the sedimentation cavity. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1 It is a structure sectional view of the urinary tube for detecting hematin in urine before use in the utility model embodiment;

[0032] Figure 2 It is a structure sectional view of the urinary tube for detecting hematin in urine before use in the utility model embodiment; Figure 1 It is an enlarged view of part b in the utility model;

[0033] Figure 3 It is an enlarged view of part a in the utility model; Figure 1 It is an enlarged view of part a in the utility model;

[0034] Figure 4 It is a top view of the internal structure of the urinary tube bottle body for detecting hematin in urine in the utility model embodiment;

[0035] Figure 5 It is a position relation diagram of the first preset cavity and the second preset cavity in the urinary tube for detecting hematin in urine in the utility model embodiment;

[0036] Figure 6 It is a temporary baffle structure schematic diagram of the urinary tube for detecting hematin in urine in the utility model embodiment;

[0037] Figure 7 It is a structure sectional view of the urinary tube for detecting hematin in urine after use in the utility model embodiment.

[0038] In all the drawings, same reference signs represent same technical features, specifically: 1-bottle body, 11-mixing cavity, 12-first preset cavity, 13-second preset cavity, 14-sedimentation cavity, 15-filter plate, 16-temporary baffle, 2-bottle cap, 21-thrust rod, 22-gasket, 3-piston rod, 31-first branch rod, 32-second branch rod, 33-first piston, 34-second piston, 4-connection buckle. DETAILED DESCRIPTION

[0039] In order to make the purpose, technical scheme and advantages of the utility model clearer and more apparent, the utility model will be further described in detail below in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the utility model and are not used to limit the utility model. In addition, the technical features involved in each embodiment of the utility model described below can be combined with each other as long as they do not conflict with each other.

[0040] Example 1

[0041] As Figures 1-7 shown, the utility model embodiment provides a urine tube for detecting hematin in urine, including: bottle body 1, bottle cap 2 and piston rod 3. The bottle body 1 is equipped with first preset cavity 12 and second preset cavity 13, wherein respectively preset with potassium ferrocyanide and hydrochloric acid solution, by adding the urine to be detected in the bottle body, the potassium ferrocyanide and hydrochloric acid solution in the first preset cavity 12 and the second preset cavity 13 are released and mixed with the urine, after shaking and mixing, the precipitate is precipitated at the bottom of the bottle body 1 for observation, to judge whether the urine contains hematin, realize the detection of urine using potassium ferrocyanide and hydrochloric acid solution in a closed environment, avoid the harmful gas generated after mixing from being emitted to the air, and ensure that the health of medical staff is not damaged.

[0042] The first pre-setting cavity 12 and the second pre-setting cavity 13 are arranged in the bottle body 1, and are arranged along the inner wall of the bottle body 1. The cross sections of the first pre-setting cavity 12 and the second pre-setting cavity 13 are both semi-circular, and the first pre-setting cavity 12 and the second pre-setting cavity 13 are separated by a partition plate. The top of the first pre-setting cavity 12 and the second pre-setting cavity 13 is provided with an opening. The distance between the upper cavity of the two pre-setting cavities and the bottle body 1 is equal, and the lower cavity gradually narrows downward, so that the bottom surface is a conical surface. The bottom conical surface of the first pre-setting cavity 12 and the second pre-setting cavity 13 is provided with a discharging groove, and a temporary baffle 16 is arranged in the discharging groove. The temporary baffle 16 is provided with a rubber plug. The rubber plug is in interference fit in the discharging groove, so that the potassium ferrocyanide and the hydrochloric acid solution are temporarily sealed in the first pre-setting cavity 12 and the second pre-setting cavity 13. The bottle body 1 is also provided with a filter plate 15, which divides the space in the bottle body 1 into a mixing cavity 11 and a sedimentation cavity 14. The filter plate 15 is provided with a plurality of large filter holes. The bottle mouth of the bottle body 1 is added with urine to be detected. Pressure is applied to the first pre-setting cavity 12 and the second pre-setting cavity 13, so that the temporary baffle 16 at the bottom falls off. The potassium ferrocyanide and the hydrochloric acid solution flow into the mixing cavity 11 from the discharging grooves of the first pre-setting cavity 12 and the second pre-setting cavity 13, respectively. After the two solutions are fully mixed with the urine, the precipitate sinks to the sedimentation cavity 14 through the filter plate 15 after standing. Whether there is blue precipitate is observed in the sedimentation cavity 14. Because the filter plate 15 with large filter holes is arranged between the mixing cavity 11 and the sedimentation cavity 14, the precipitate can sink smoothly to the sedimentation cavity 14, and the temporary baffle 16 that falls off is blocked in the mixing cavity 11 by the filter plate 15, so as to avoid affecting the observation of the precipitate in the sedimentation cavity 14.

[0043] The top of the first pre-setting cavity 12 and the second pre-setting cavity 13 is provided with a piston rod 3. The bottom of the piston rod 3 extends outwardly to form a first branch rod 31 and a second branch rod 32. The first branch rod 31 and the second branch rod 32 are each provided with at least two. The bottom end of the first branch rod 31 is provided with a first piston 33. The first piston 33 is arranged in the first pre-setting cavity 12, and the cross section shape of the upper cavity of the first pre-setting cavity 12 is the same as that of the first piston 33. The cavity opening of the first pre-setting cavity 12 is also provided with a baffle to prevent the first piston 33 from falling out. The bottom end of the second branch rod 32 is provided with a second piston 34. The second piston 34 is arranged in the second pre-setting cavity 13, and the cross section shape of the upper cavity of the second pre-setting cavity 13 is the same as that of the second piston 34. The cavity opening of the second pre-setting cavity 13 is also provided with a baffle to prevent the second piston 34 from falling out. The surfaces of the first piston 33 and the second piston 34 are both provided with a rubber layer to ensure the sealing between the first pre-setting cavity 12 and the second pre-setting cavity 13 and the cavity wall. The top of the piston rod 3 is arranged at the center position of the bottle body 1.

[0044] The bottle cap 2 is connected with the bottle mouth of the bottle body 1 through thread, and a center of the bottle cap 2 is provided with a push rod 21, the push rod 21 is provided with a limiting groove, a top of the piston rod 3 is arranged in the limiting groove, and the top of the piston rod 3 is connected with the limiting groove in a smooth mode.

[0045] In an initial state, the bottle mouth of the bottle body 1 is arranged only at a cap mouth of the bottle cap 2, the bottle mouth of the bottle body 1 is provided with a connecting table arranged in a circumferential direction, and the bottle cap 2 is connected with the connecting table. The bottle cap 2 is also provided with a connecting buckle 4 at an end face of the connecting table, so that temporary fixing is formed between the bottle cap 2 and the bottle body 1. Potassium ferrocyanide and hydrochloric acid solution are respectively stored in the first preset cavity 12 and the second preset cavity 13, and the storage is sealed and leakage does not occur, so that transportation after manufacturing is facilitated. The connecting buckle 4 prevents relative rotation between the bottle cap 2 and the bottle body 1 due to vibration during transportation, so that the piston rod 3 is pressed to make the temporary blocking plate 16 fall off in advance, and potassium ferrocyanide and hydrochloric acid solution is leaked in advance.

[0046] In use, the bottle cap 2 is rotated to disconnect the connecting buckle 4, the bottle cap 2 is separated from the bottle body 1, and after the bottle mouth is added with urine to be detected, the bottle cap 2 is screwed, reaches the initial state, and is continuously screwed to make the bottle mouth of the bottle body 1 continuously move to the cavity in the bottle cap 2. At this time, the push rod 21 pushes the piston rod 3 to move downward, drives the first piston 33 and the second piston 34 to move to the bottom in the first preset cavity 12 and the second preset cavity 13, provides pressure to the solution therein, and under the action of the pressure, the temporary blocking plate 16 is separated from the discharging groove, so that potassium ferrocyanide and hydrochloric acid solution and the urine to be detected are mixed in the mixing cavity 11.

[0047] When urine detection is performed, the following steps are performed: a, after the bottle cap 2 is opened and the urine to be detected is added in the bottle body 1, the bottle cap 2 is closed to the initial state position, that is, the lower edge of the bottle cap 2 is flush with the lower edge of the connecting table, after centrifugation, the bottle cap 2 is opened to remove supernatant of the urine to be detected; b, after the bottle cap 2 is closed to the initial state position, the bottle cap 2 is continuously screwed, the push rod 21 pushes the piston rod 3 to move downward to apply pressure to the solution pre-stored in the first preset cavity 12 and the second preset cavity 13, the temporary blocking plate 16 is separated from the discharging groove, so that potassium ferrocyanide and hydrochloric acid solution and the urine to be detected are mixed in the mixing cavity 11; c, after mixing is completed, the mixture is shaken, is left for 30 min, is centrifuged again, the bottle cap is opened to remove supernatant of the mixed solution, and the precipitate is observed.

[0048] It is easy for those skilled in the art to understand that the above description is only a preferred embodiment of the present application, and is not used to limit the present application, and any modification, equivalent replacement and improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. A urine tube for detecting hematin in urine, characterized by, The utility model relates to a bottle body (1), a bottle cap (2) and a piston rod (3), the bottle body (1) is provided with a first preset cavity (12) and a second preset cavity (13) in which detection solution is respectively preset, the bottom of the piston rod (3) extends outwards a first branch rod (31) and a second branch rod (32), and the bottom ends of the first branch rod (31) and the second branch rod (32) are respectively provided with a first piston (33) and a second piston (34), the first piston (33) and the second piston (34) are respectively arranged in the first preset cavity (12) and the second preset cavity (13). The first preset cavity (12) and the second preset cavity (13) are circumferentially arranged along the inner wall of the bottle body (1), and the cross sections of the first preset cavity (12) and the second preset cavity (13) are both semicircular, and the first preset cavity (12) and the second preset cavity (13) are separated by a partition plate. The top of the first preset cavity (12) and the second preset cavity (13) is provided with an opening, the distance between the upper cavity of the two preset cavities and the bottle body (1) is equal, and the lower cavity gradually narrows downwards, so that the bottom surface is a conical surface. A discharge groove is formed on the bottom conical surface of the first preset cavity (12) and the second preset cavity (13), a temporary baffle (16) is arranged in the discharge groove, and a rubber plug is arranged on the temporary baffle (16), which is in interference fit in the discharge groove. The bottle body (1) is also provided with a filter plate (15), which divides the space in the bottle body (1) into a mixing cavity (11) and a sedimentation cavity (14), and a plurality of large filter holes are arranged on the filter plate (15).

2. The urine tube for detecting hematin in urine according to claim 1, wherein The first branch rod (31) and the second branch rod (32) are each provided with at least two. The cross section shape of the upper cavity of the first preset cavity (12) is the same as that of the first piston (33).

3. The urine tube for detecting hematin in urine according to claim 2, wherein The cross section shape of the upper cavity of the second preset cavity (13) is the same as that of the second branch rod (32).

4. The urine tube for detecting hematin in urine according to claim 3, wherein A baffle is arranged at the cavity opening of the first preset cavity (12) and the second preset cavity (13).

5. The urine tube for detecting hematin in urine according to any one of claims 1 to 4, characterized in that, The baffle limits the first piston (33) and the second piston (34) in the first preset cavity (12) and the second preset cavity (13). A rubber layer is arranged on the surface of the first piston (33) and the second piston (34). The bottle cap (2) is connected with the bottle opening of the bottle body (1) by threads, and a push rod (21) is arranged at the center thereof.

6. The urine tube for detecting hematin in urine according to claim 5, wherein A deep cavity is arranged in the bottle cap (2). A limiting groove is arranged on the push rod (21), the top of the piston rod (3) is arranged in the limiting groove, and the top of the piston rod (3) is smoothly connected with the limiting groove.

7. The urine tube for detecting hematin in urine according to claim 6, wherein A connecting table is arranged at the bottle opening of the bottle body (1) in a circumferential direction, and the bottle cap (2) is connected with the connecting table.

8. The urine tube for detecting hematin in urine according to any one of claims 1 to 4, characterized by, A connecting buckle (4) is further arranged at the end face of the connecting table, so that temporary fixation is formed between the bottle cap (2) and the bottle body (1). The detection solution comprises potassium ferrocyanide and hydrochloric acid solution. ​ 9. The urinary catheter for detecting hematin in urine according to claim 8, wherein ​ ​ 10. The urine tube for detecting hematin in urine according to any one of claims 1 to 4, characterized by, ​