Transdermal diffusion experiment device

Abstract

The utility model discloses a transdermal diffusion experiment device which comprises a base, an anti-rotation limiting gasket and a pressing ring. A diffusion chamber is formed in the base, and a circle of step surface is arranged on the inner side wall of the base. The anti-rotation limiting gasket is arranged on the step face in a non-relative-rotation mode. The pressing ring is detachably installed above the anti-rotation limiting gasket. A liquid channel and an exhaust channel which are communicated with the diffusion cavity are formed in the outer wall of the base at intervals, the liquid channel extends to one side of the diffusion cavity from the outer wall of the base, and the bottom wall of the part, close to the diffusion cavity, of the liquid channel is flush with the bottom wall of the diffusion cavity. The exhaust channel extends to the outer wall of the base from the other side of the diffusion cavity, and the top wall of the part, close to the diffusion cavity, of the exhaust channel is flush with the top opening of the diffusion cavity. And a transdermal test membrane is detachably clamped between the opposite surfaces of the step surface and the anti-rotation limiting gasket. The transdermal diffusion experiment device disclosed by the utility model has the advantages of small volume of the diffusion chamber and convenience in use.

Description

TECHNICAL FIELD

[0001] The utility model relates to experimental equipment related technical field, especially in a kind of transdermal diffusion experimental device. BACKGROUND

[0002] Transdermal diffusion cell is used to test the speed and degree of skin external drug preparation penetrating membrane or skin. It is mainly composed of sample chamber, membrane or skin and receiving chamber. Based on the test method of transdermal diffusion, sample penetrates into the receiving medium of the receiving cell through the membrane or skin at the bottom of the sample cell, and the release or penetration effect of sample is evaluated by quantitative detection of receiving medium.

[0003] In actual application process, the solubility of drug in receiving medium, the effective contact area of drug or receiving medium and membrane or skin have important influence on test process. The solubility problem of drug poses great challenge to current transdermal test method. At present, the current situation of drug development is: more and more poorly soluble drugs, very low transdermal amount, and drug developers often encounter too low drug concentration in diffusion cell to be quantitatively detected by conventional HPLC (high performance liquid chromatography) or UPLC (ultra performance liquid chromatography) method. Therefore, it is necessary to optimize the current transdermal test method, to create favorable conditions for drug transdermal or transmembrane, and to improve the effective concentration of drug in diffusion cell, to adapt to the development trend of skin external drug product.

[0004] However, the diffusion cell volume of the existing transdermal diffusion test device is set to be large, with an external sampling arm or external pipeline, and the sampling inner cavity volume is large, which is not conducive to improving the effective concentration of drug in receiving medium. The height of the receiving chamber cavity in the existing diffusion cell is larger than the cross-sectional diameter, so that the contact area of unit volume receiving medium and membrane or skin is low, which is not conducive to drug diffusion, so the transdermal diffusion test device in the prior art has the problems of large volume, not conducive to improving the effective concentration of drug in medium, and the use of external sampling arm and external pipeline is required, which is inconvenient to use. UTILITY MODEL CONTENT

[0005] The purpose of the present application is to solve the problems of large volume, not conducive to improving the effective concentration of drug in medium and inconvenient use of transdermal diffusion test device in the prior art.

[0006] To solve the above technical problems, the present application discloses a transdermal diffusion experimental device, which comprises a base, an anti-rotation limiting gasket and a pressure ring.

[0007] The base is internally formed with a diffusion chamber, the diffusion chamber is provided with a top opening, and a step surface is arranged on the inner side wall of the base along the circumference of the base. The anti-rotation limiting washer is arranged on the step surface in a non-rotatable manner. The pressing ring is detachably mounted above the anti-rotation limiting washer.

[0008] Liquid channels and exhaust channels are arranged on the outer wall of the base in a spaced manner and communicate with the diffusion chamber. The liquid channels extend from the outer wall of the base to one side of the diffusion chamber, and the channel bottom wall near the diffusion chamber is flush with the bottom wall of the diffusion chamber. The exhaust channels extend from the other side of the diffusion chamber to the outer wall of the base, and the channel top wall near the diffusion chamber is flush with the top opening of the diffusion chamber. The step surface and the opposite surface of the anti-rotation limiting washer form a clamping part, and the clamping part detachably clamps the transdermal test film covering the top opening of the diffusion chamber.

[0009] According to the technical scheme, the liquid channels and the exhaust channels are arranged on the outer wall of the base, that is, the liquid channels and the exhaust channels are arranged on the existing outer wall of the base. Compared with the existing sampling arm and sampling pipeline structure extending outward, the outer wall of the device does not have any outward structure, which significantly reduces the volume of the device and the volume of the diffusion chamber, and the structure and volume are smaller and more compact, the occupation of external space is reduced, and the device is more convenient to use, which is beneficial to more efficient layout in limited experimental or production environment. After canceling the external structure, the stability and reliability of the device are higher, and the service life is higher.

[0010] Further, the transdermal diffusion test device disclosed in the application comprises a base, an anti-rotation limiting washer, and a pressing ring. A complete test device can be assembled by simply assembling a plurality of components. During the transdermal test, the transdermal test film is placed in the clamping part formed between the step surface and the opposite surface of the anti-rotation limiting washer to perform the test. The device has the advantages of simple structure, batch production, and standardization. The operation process is simplified during assembly and use, thereby reducing the operation time and workload and reducing the operation difficulty and complexity.

[0011] In addition, in the transdermal diffusion test device disclosed in the application, the channel bottom wall near the diffusion chamber of the liquid channel is flush with the bottom wall of the diffusion chamber, which can take out all the liquid in the diffusion chamber each time, avoids liquid residue in the diffusion chamber affecting the experimental precision and accuracy, the channel top wall near the diffusion chamber of the exhaust channel is flush with the top opening of the diffusion chamber, which can more quickly and effectively exhaust the bubbles, reduce the bubble residue, and further improve the transdermal efficiency.

[0012] Further preferably, in the application, the diffusion chamber in the base is a cylindrical cavity, the anti-rotation protrusion is arranged on the anti-rotation limiting washer, the anti-rotation limiting washer is prevented from rotating during installation, and the compression ring and the base are connected in a threaded manner, so that the assembly is more simple and convenient.

[0013] Still further preferably, the inner diameter of the diffusion chamber in the application gradually increases from the side of the bottom wall to the side of the top opening, so that the transdermal experiment is more effectively performed.

[0014] The utility model discloses still disclose a kind of transdermal test method applied to the transdermal diffusion experimental device, and the method comprises:

[0015] S1, selecting transdermal test film used in experiment, then transdermal test film is placed on the step surface of base;

[0016] S2, anti-rotation limiting washer is placed on the step surface, above transdermal test film, and the anti-rotation protrusion of anti-rotation limiting washer and anti-rotation limiting groove are connected and limited, when anti-rotation limiting washer is placed on the step surface, transdermal test film is located in the clamping portion formed between the step surface and the opposite surface of anti-rotation limiting washer, and transdermal test film covers the top opening of diffusion chamber;

[0017] S3, compression ring is installed and tightened in the inner ring of base by rotating installation base, and compression ring is pressed on the top of anti-rotation limiting washer;

[0018] S4, drug preparation is applied on the upper surface of transdermal test film, and receiving medium is injected into diffusion chamber from liquid channel by infusion needle, when receiving medium is injected by infusion needle, the spherical or conical protrusion arranged on the head of infusion needle is matched with the inner peripheral contour of variable-diameter infusion port of liquid channel, or drug preparation is applied on the upper surface of transdermal test film after the temperature and state of transdermal test film in diffusion tank are balanced by injecting receiving medium by infusion needle;

[0019] S5, liquid taking needle is used to suck receiving medium when taking liquid, or infusion needle is used to suck receiving medium.

[0020] In the above method, the cover ring can be placed above the base to cover the liquid channel and the exhaust channel for use according to needs. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 The utility model discloses a transdermal diffusion test device cover provided with a cover ring for transdermal diffusion test device 1 of embodiment 1;

[0022] Figure 2A schematic diagram of the transdermal diffusion testing device and infusion needle provided in Embodiment 1 of this utility model;

[0023] Figure 3 A half-sectional schematic diagram of the base of the transdermal diffusion testing device provided in Embodiment 1 of this utility model;

[0024] Figure 4 This is a schematic diagram of the exploded structure of the transdermal diffusion testing device provided in Embodiment 1 of this utility model;

[0025] Figure 5 A schematic diagram of the transdermal diffusion testing device provided in Embodiment 2 of this utility model when the cover ring is attached;

[0026] Figure 6 This is a schematic diagram of the exploded structure of the transdermal diffusion testing device provided in Embodiment 2 of this utility model;

[0027] Figure 7 A flowchart illustrating the transdermal diffusion method of the transdermal diffusion testing device provided in Embodiment 1 of this utility model;

[0028] Figure 8 This is an exploded structural diagram of the transdermal diffusion testing device provided in Embodiment 3 of this utility model;

[0029] Figure 9 This is a schematic diagram of the assembly structure of the transdermal diffusion testing device provided in Embodiment 3 of this utility model.

[0030] Explanation of reference numerals in the attached figures:

[0031] 100. Base;

[0032] 110. Diffusion chamber;

[0033] 111. Top opening;

[0034] 120. Stepped surface; 130. Outer wall; 140. Anti-rotation limiting groove;

[0035] 150. First base; 160. Second base; 170. Sealing ring; 180. Protrusion; 190. Internal thread;

[0036] 101. Auxiliary step surface; 102. Height direction of the base; 103. Snap-fit ​​fixing part; 104. Anti-rotation slot; 105. Snap-fit ​​protrusion;

[0037] 200. Transdermal experimental membrane;

[0038] 300. Anti-rotation limit washer;

[0039] 310. Anti-rotation protrusion; 320. Clamping part;

[0040] 400, pressure ring;

[0041] 410, positioning hole; 420, external thread;

[0042] 500, liquid channel;

[0043] 510, first liquid channel; 520, second liquid channel; 530, variable-diameter infusion channel;

[0044] 600, exhaust channel;

[0045] 610, first exhaust channel; 620, second exhaust channel;

[0046] 700, rotating mounting base;

[0047] 710, positioning protrusion;

[0048] 800, cover ring;

[0049] 900, infusion needle;

[0050] 910, infusion hole; 920, protrusion;

[0051] A, inner diameter size of diffusion chamber; B, height size of diffusion chamber. DETAILED DESCRIPTION

[0052] As mentioned in the background of the present application, the existing transdermal diffusion test cell or test device is set to have a large structure volume, and all have an external sampling arm or require external pipelines. For example, some need to be provided with a sampling arm for sampling, some need to be provided with external pipelines, liquid inlet pipelines and liquid outlet pipelines, and some other external structures, etc. These structures increase the volume and space occupied by the transdermal device or the transdermal diffusion cell, especially when in use, attention should be paid to the external structure, which further increases the complexity of operation, and the operator needs to use more delicate operation skills to ensure the accuracy of sampling. During the operation process, the sampling arm may be disturbed by the external environment, such as temperature fluctuation, vibration, etc., thereby affecting the stability of sampling. The sampling arms may interfere with each other during use or experiment, increasing the maintenance cost of the equipment. And the existing diffusion cell is mostly set to have a large volume, which cannot be used for small-volume transdermal testing, so the existing transdermal diffusion test cell has the problem of inconvenient use.

[0053] In order to solve the problems of inconvenient use and inability to perform small volume transdermal test of the transdermal diffusion test cell in the prior art, the transdermal diffusion experiment device provided by the application is small in size and good in transdermal experiment effect, the sampling arm and external pipeline of the existing diffusion cell are cancelled, and multiple components are assembled for use, so that maintenance and repair are facilitated, and batch production, batch experiment or sales can be performed. Next, the specific structure of the transdermal diffusion test device disclosed in the application will be explained in detail.

[0054] Embodiment 1

[0055] The embodiment discloses a transdermal diffusion experiment device, please refer to Figure 1 The transdermal diffusion experiment device provided by the application comprises a detachable base 100, an anti-rotation limiting gasket 300 and a compression ring 400 (the cover ring 800 in Figure 1 can be selected according to requirements), and specifically, the base 100, the transdermal experiment film 200, the anti-rotation limiting gasket 300 and the compression ring 400 are assembled in sequence to obtain a transdermal diffusion experiment device. The transdermal experiment film 200 can be an artificial synthetic film, an animal or human skin film, such as a polyvinylidene fluoride film, a cellulose film, a polypropylene film, a mouse skin film, a pig skin film and a human skin film. When different transdermal experiment films 200 are required for different transdermal test experiments, the corresponding transdermal experiment film 200 is disassembled, reassembled and replaced.

[0056] The base 100 of the application is formed with a diffusion chamber 110, the diffusion chamber 110 is provided with a top opening 111, and the top opening 111 of the diffusion chamber 110 can be seen from Figure 3 , and a step surface 120 is arranged on the inner side wall of the base 100 along the circumference of the base 100. Those skilled in the art should understand that the diffusion chamber 110 is a cavity formed in the base 100, which can be any structure shape, as long as it has a top opening 111 open to the outside. In the embodiment, the diffusion chamber 110 is preferably a cylindrical cavity. Further, in the application, the base 100 is also in a columnar structure, for example, the base 100 can be arranged in a square columnar, circular columnar or other structure. In a preferred implementation manner disclosed in the embodiment, the base 100 is also arranged in a cylindrical shape, and the diffusion chamber 110 is a cavity arranged at the top middle part of the base 100. Those skilled in the art should understand that in some specific experimental processes, the diffusion chamber 110 can also be referred to as a receiving chamber.

[0057] Please refer to Figure 1 and Figure 2, the anti-rotation limiting washer 300 is arranged on the stepped surface 120 in a non-rotatable manner, the anti-rotation limiting washer 300 is arranged as a thin sheet ring washer similar to the shape of the stepped surface 120, for example, when viewed from above the anti-rotation limiting washer 300 and the stepped surface 120 are coincident, when the stepped surface 120 is in a circular ring shape, the anti-rotation limiting washer 300 is also arranged as a thin sheet ring washer in a circular ring shape, for example, the thickness of the anti-rotation limiting washer 300 can be in the range of 0.2-2mm. The pressing ring 400 is detachably arranged above the anti-rotation limiting washer 300, the pressing ring 400 is also arranged as a ring structure similar to the shape of the stepped surface 120, and when viewed from above the pressing ring 400, the anti-rotation limiting washer 300 and the stepped surface 120 are coincident, when the stepped surface 120 is in a circular ring shape, the pressing ring 400 is also arranged in a circular ring shape, and because the pressing ring 400 is used to press and fix the anti-rotation limiting washer, in one preferred implementation, the thickness of the pressing ring 400 is greater than the thickness of the anti-rotation limiting washer 300.

[0058] The stepped surface 120 and the opposite surface of the anti-rotation limiting washer 300 form a clamping portion 320, which detachably clamps the transdermal test film 200 covering the top opening 111 of the diffusion chamber 110. Referring to Figure 1 and Figure 4 It should be understood by those skilled in the art that the opposite surfaces of the stepped surface 120 and the anti-rotation limiting washer 300 forming the clamping portion 320 refer to the upper surface of the stepped surface 120 and the lower surface of the anti-rotation limiting washer 300 forming the clamping portion 320 in the installed state or Figure 1 as shown, the clamping portion 320 has a small gap and is used to clamp the transdermal test film 200, that is, the clamping portion 320 formed between the opposite surfaces of the stepped surface 120 and the anti-rotation limiting washer 300 can more stably clamp and fix the transdermal test film 200 for drug transdermal test.

[0059] And because the stepped surface 120 is in a circular ring shape in this embodiment, the anti-rotation limiting washer 300 is also in a circular ring shape, so the clamping portion 320 is also formed in a ring shape, the transdermal test film 200 is in a circular sheet structure, and the outer diameter of the transdermal test film 200 is equal to or slightly smaller than the outer diameter of the stepped surface 120, to ensure that the transdermal test film 200 is stably clamped and fixed in the clamping portion 320, it should be understood that the shape of the clamping portion is determined by the stepped surface 120 and the anti-rotation limiting washer 300, for example, when the stepped surface 120 and the anti-rotation limiting washer 300 are in a square ring structure, the clamping portion 320 is also in a square ring shape, those skilled in the art can design and adjust according to actual needs, which is not specifically limited in this embodiment.

[0060] When the transdermal test is needed, the transdermal test film 200 is placed between the upper surface of the stepped surface 120 and the lower surface of the anti-rotation limiting washer 300, the transdermal test film 200 covers the top opening of the diffusion chamber 110, specifically, the transdermal test film 200 is placed on the stepped surface 120 first, then the anti-rotation limiting washer 300 is placed, the transdermal test film 200 is tightly attached to the anti-rotation limiting washer 300, and the peripheral edge of the transdermal test film 200 is clamped and fixed by the clamping portion 320, more specifically, the clamping portion 320 can fix and clamp the part of the annular peripheral edge of the transdermal test film 200, the middle part of the transdermal test film 200 covers the top opening 111 of the diffusion chamber 110, when the clamping portion 320 does not place the transdermal test film 200, the stepped surface 120 and the anti-rotation limiting washer 300 form the opposite surfaces of the clamping portion 320.

[0061] It should be noted that in the present embodiment, reference is made to Figure 4 and Figure 1 When assembling the device for transdermal test, the transdermal test film 200 is placed on the stepped surface 120 first, the transdermal test film 200 covers the top opening 111 of the diffusion chamber 110 (see Figure 2 ), an important step in the transdermal test is to place the transdermal test film 200 on the stepped surface 120 of the base 100, further see Figure 3 and Figure 4 In the present embodiment, the one circle of stepped surfaces 120 arranged circumferentially on the base 100 is a circular annular stepped surface, which has such a structure that the shape of the circular annular stepped surface 120 is adapted to the shape of the circular transdermal test film 200, when installing and placing the transdermal test film 200, the transdermal test film 200 can be accurately and quickly placed on the stepped surface 120 and cover the top opening 111 of the diffusion chamber 110, in the actual transdermal test process, the experimenter can select different transdermal test films according to the test to be performed, and after the transdermal test film 200 is placed, the inside of the diffusion chamber 110 becomes a relatively closed chamber, during the transdermal test after the device is assembled, the test drug or test medicine is placed above the transdermal test film 200, and the receiving medium, which can be a solvent or physiological saline, is in the diffusion chamber 110, then the transdermal test is performed.

[0062] Further, in some common transdermal tests, the clamping portion 320 generally clamps only one transdermal test film 200 for testing, in other transdermal tests, the clamping portion 320 can clamp two or more than two same transdermal test films 200 for testing, or can clamp two or more than two different transdermal test films 200 for testing, the person skilled in the art can use according to the actual needs, which is not limited in the present embodiment.

[0063] The rotation-preventing limiting washer 300 needs to play a rotation-preventing positioning effect, so the rotation-preventing limiting washer 300 must be placed above the transdermal test membrane 200 in a non-rotatable (such as clamping and the like) manner. Specifically, in a preferred implementation manner disclosed in the embodiment, the rotation-preventing limiting washer 300 is set as a circular ring and has a relatively thin thickness, and the side of the rotation-preventing limiting washer 300 close to the transdermal test membrane 200 is tightly attached to the transdermal test membrane 200 or the stepped surface 120 (in a state where the transdermal test membrane 200 is not placed). The outer circle of the rotation-preventing limiting washer 300 is provided with at least one rotation-preventing protrusion 310, and the inner side wall of the base 100 is provided with a rotation-preventing limiting groove 140 matched with the rotation-preventing protrusion 310. For example, one, two, three, four or even more rotation-preventing protrusions 310 can be provided. In the preferred implementation manner disclosed in the embodiment, three rotation-preventing protrusions 310 are provided, and the rotation-preventing positioning effect is better. Figure 4 The thickness of the rotation-preventing limiting washer 300 is preferably set in the range of 0.2-2 mm, and the material can be set as polytetrafluoroethylene, rubber, silicone or other materials with good flexibility and toughness, so as to achieve the protection and fixing effect on the transdermal test membrane 200.

[0064] The compression ring 400 and the base 100 can be fixed in various detachable connection manners such as clamping, threaded connection and the like. For example, when clamping is used for connection, a clamping protrusion is arranged on the outer side wall of the compression ring 400, and a clamping groove is arranged at the corresponding position of the inner side wall of the base 100, and the clamping protrusion and the clamping groove are matched to be fixed. Alternatively, threaded grooves can be arranged at the corresponding positions of the outer side wall of the compression ring 400 and the inner side wall of the base 100 for connection. Please refer to Figure 4 The compression ring 400 and the base 100 are preferably connected in a threaded connection manner in the embodiment. The outer side wall of the compression ring 400 is provided with an outer thread 420, and the inner side wall of the base 100 is provided with an inner thread 190 matched with the outer thread. In the axial direction of the base 100, the rotation-preventing limiting washer 300 and the inner side wall of the compression ring 400 are flush with the inner side wall of the diffusion chamber 110. When the compression ring 400 is fastened on the base 100, the rotation-preventing limiting washer 300 can provide an additional resistance to ensure that the compression ring 400 and the transdermal test membrane 200 are kept in the correct position. In the axial direction of the base 100, the rotation-preventing limiting washer 300 and the inner side wall of the compression ring 400 are flush with the inner side wall of the diffusion chamber 110. Such a design can keep the inside of the device smooth and flat, and ensure that the transdermal diffusion area remains consistent.

[0065] Further compared with the existing diffusion tank is by means of a clamp to clamp the supply tank and the receiving tank, in the experimental operation is prone to relative sliding, resulting in displacement, the upper tank and the lower tank are misaligned, thereby affecting the diffusion area, in the application, the threaded connection is used for connection, which can be precisely aligned, has better sealing performance and no risk of relative sliding, and provides a stable transdermal test environment in the transdermal test process.

[0066] Because the pressure ring 400 is installed in a threaded connection manner in the embodiment, in order to facilitate installation and disassembly of the pressure ring 400, see Figure 4 A rotating mounting seat 700 is further arranged, which actually plays a role of assisting in screwing the pressure ring 400, the rotating mounting seat 700 is matched with the pressure ring 400, and a positioning protrusion 710 is arranged on one side of the rotating mounting seat 700. A positioning hole 410 is further arranged on the side, away from the anti-rotation limiting washer 300, of the pressure ring 400, the positioning protrusion 710 is matched and connected with the positioning hole 410, and then rotating the rotating mounting seat 700 can simultaneously rotate the pressure ring 400 to be screwed or unscrewed. In order to improve the effect of assisting in screwing, preferably, the number of the positioning protrusion 710 and the positioning hole 410 is 2 or more than 2, and a person skilled in the art can design and select according to actual needs, which is not limited in the embodiment.

[0067] In a preferred implementation manner disclosed in the embodiment, the width dimension of the stepped surface 120, the circular ring width dimension of the anti-rotation limiting washer 300 and the circular ring width dimension of the pressure ring 400 are the same, for example, are all set to 4 mm, 5 mm, 6 mm or the like, which is not limited in the embodiment. Because the pressure ring 400 plays a threaded fixing role, the number of threads on the pressure ring 400 should be greater than 0.5 turns. In addition, because the thickness of the pressure ring 400 determines the upper limit of the thickness of the filled medicament, the thickness of the pressure ring 400 should be sufficient to fill the thickness, and therefore the thickness of the pressure ring 400 is not less than 1 mm, for example, is any value within 2-6 mm, for example, 2 mm, 4 mm, 6 mm or the like. A person skilled in the art can adjust and design according to actual needs, which is not limited in the embodiment.

[0068] Further preferably, see Figure 1 and Figure 3The outer wall 130 of the base 100 is provided with liquid channels 500 and exhaust channels 600 in intervals, which are in communication with the diffusion chamber 110. The liquid channels 500 and the exhaust channels 600 are provided with two holes at the top of the outer wall 130 of the base 100. The liquid channels 500 extend from the outer wall 130 of the base 100 to one side of the diffusion chamber 110, and the channel bottom wall near the diffusion chamber 110 is flush with the bottom wall of the diffusion chamber 110. This structure is beneficial to taking out the receiving medium in the diffusion chamber 110 when taking liquid. The exhaust channels 600 extend from the other side of the diffusion chamber 110 to the outer wall 130 of the base 100, and the channel top wall near the diffusion chamber 110 is flush with the top opening 111 of the diffusion chamber 110. In other words, the channel top wall near the diffusion chamber 110 of the exhaust channels 600 is infinitely close to the transdermal experiment film 200 in the horizontal plane. This structure is beneficial to discharging bubbles.

[0069] It should be noted that the liquid channels 500 in the embodiment have a dual role. The liquid channels 500 can be used as infusion channels and can also be used as liquid taking channels. Please refer to Figure 2 When used as infusion channels, the receiving medium is injected from the liquid channels 500 into the diffusion chamber 110 through the infusion needle 900. When sampling of the receiving liquid is needed, the receiving liquid is sucked out through the liquid taking needle.

[0070] Further, the liquid channels 500 and the exhaust channels 600 are provided on the outer wall 130 of the base 100 in intervals. In the embodiment, the liquid channels 500 and the exhaust channels 600 are preferably provided opposite to each other at an interval angle of 180 degrees. Those skilled in the art can adjust the positions of the liquid channels 500 and the exhaust channels 600 according to actual needs, which are not limited in the embodiment.

[0071] With the above structure, the liquid channels 500 and the exhaust channels 600 are provided on the outer wall 130 of the base 100, that is, the liquid channels 500 and the exhaust channels 600 are provided on the existing outer wall 130 of the base 100. Compared with the existing sampling arm and sampling pipeline structure, the outer wall 130 of the device does not have any outward extension structure, which significantly reduces the volume of the device, and the structure, volume and size are smaller and more compact. The device also reduces the occupation of external space, which is beneficial to more efficient layout in a space-limited heating device or experimental environment, and can be more conveniently integrated with other equipment for use. The device has high stability and reliability, is not easily affected by the external environment, and has a long service life.

[0072] Further, the transdermal diffusion test device disclosed in the application comprises a base 100, an anti-rotation limiting washer 300 and a pressing ring 400, which are simply assembled by using multiple components and placed after installing the transdermal test film 200 to realize the complete device, have the advantages of simple structure, standardization and batch production, and also simplify the operation process, reduce the operation time and workload, and reduce the operation difficulty and complexity during assembly and use. Similarly, the safety and hygiene are also higher.

[0073] Further, in the transdermal diffusion test device disclosed in the application, the part of the liquid channel 500 close to the bottom wall of the diffusion chamber 110 is flush with the bottom wall of the diffusion chamber 110, which can take out all the liquid in the diffusion chamber 110 each time, avoids the influence of liquid residue in the diffusion chamber 110 on the experimental precision and accuracy, and the part of the exhaust channel 600 close to the diffusion chamber 110 is flush with the top opening 111 of the diffusion chamber 110, which can more quickly and effectively exhaust the bubbles, reduce the bubble residue, and thus improve the transdermal efficiency.

[0074] Next, the specific settings of the liquid channel 500 and the exhaust channel 600 disclosed in the application are further explained and described:

[0075] In the embodiment, the liquid channel 500 and the exhaust channel 600 are each provided with one, and are arranged in opposite and spaced-apart manners on the two sides of the outer wall 130 of the base 100, for example Figure 1 and Figure 2 As shown in the cross-sectional view along one of the axial directions, the liquid channel 500 and the exhaust channel 600 can be seen at the same time, and because the liquid channel 500 is used for liquid delivery and liquid taking, the bottom of the liquid channel 500 is flush with the bottom of the diffusion chamber 110, and the exhaust channel 600 is basically flush with the top of the diffusion chamber 110. It should be noted that in other implementation manners, the liquid channel 500 and the exhaust channel 600 are not limited to one, for example, when the exhaust requirement is high, two, three or other number of exhaust channels 600 can be arranged in a spaced-apart manner, and similarly, the liquid channel 500 can also be provided with two, three or other number according to the requirements, which is not limited in the embodiment.

[0076] Further, referring to Figure 1 and Figure 3 The liquid channel 500 comprises a first liquid channel 510 and a second liquid channel 520 which are provided in the outer wall 130 of the base 100 and are in communication with each other. Please refer to Figure 3In the cross-sectional view taken along the axial direction of the base 100, the first liquid channel 510 and the second liquid channel 520 are in "L" shape, wherein the first liquid channel 510 extends along the axial direction of the base 100, the top opening 111 of the first liquid channel 510 is on the top wall of the base 100, and the first liquid channel 510 comprises a variable-diameter liquid delivery passage 530 which is gradually reduced in diameter along the liquid flow direction, for example, the variable-diameter liquid delivery passage 530 can be provided in the shape of a funnel, a horn or other variable-diameter structure. The second liquid channel 520 extends along the radial direction of the base 100, one side opening of the second liquid channel 520 is in communication with the outlet end of the first liquid channel 510, the other side opening is in communication with the diffusion chamber 110, and the bottom wall is flush with the bottom wall of the diffusion chamber 110, that is, the variable-diameter liquid delivery passage 530, the first liquid channel 510 and the second liquid channel 520 in the liquid channel 500 are in communication in turn and finally in communication with the diffusion chamber 110.

[0077] Preferably, the inner diameter of the first liquid channel 510 and the second liquid channel 520 is not more than 5 mm, for example, it can be provided as 1 mm, 1.5 mm, 3 mm, 5 mm, etc., more preferably not more than 1.5 mm, and those skilled in the art can design and adjust according to actual needs, which is not the only limitation in this embodiment.

[0078] Specifically, in this embodiment, the variable-diameter liquid delivery passage 530 provided at the top of the first liquid channel 510 is in the shape of a horn, which is provided to facilitate the adaptation with the infusion needle 900. The middle part of the infusion needle 900 is provided with an infusion hole 910, and the head part of the infusion needle 900 is provided with a spherical or conical protrusion 920, the outer shape of which is adapted to the inner peripheral contour of the variable-diameter liquid delivery port (horn port) of the liquid channel 500. When the infusion needle 900 is used to deliver the receiving medium into the diffusion chamber 110, the receiving medium first flows downward through the first liquid channel 510, and then flows into the diffusion chamber 110 through the second liquid channel 520. When it is necessary to take the liquid, a liquid taking needle (not shown in the figure) can be used. It should be noted that in this embodiment, the outer diameter of the liquid taking needle is smaller than the inner diameter of the first liquid channel 510 and the second liquid channel 520, so that the liquid taking needle can pass through to the bottom of the second liquid channel 520, and because the bottom of the second liquid channel 520 is flush with the bottom wall of the diffusion chamber 110, the liquid taking needle can take out all the receiving medium inside. When the liquid taking is completed, the liquid taking needle can not be used, but the infusion needle 900 can be used to continue sampling, and the receiving medium flows through the second liquid channel 520, the first liquid channel 510 and is sucked into the infusion needle 900. Because the inner diameters of the second liquid channel 520 and the first liquid channel 510 are very small, when the head part of the liquid taking needle is changed to closely fit the horn port of the variable-diameter liquid delivery passage 530, all the receiving medium inside can be taken out.

[0079] In this embodiment, the first liquid channel 510 and the second liquid channel 520 are arranged in an "L" shape, which effectively utilizes the space and makes the liquid flow path more reasonable. Neither additional structures are arranged outside the base 100, nor the diffusion behavior inside the base 100 is affected. The "L" shape of the first liquid channel 510 and the second liquid channel 520 also helps to stir or further process the liquid inside the base 100. The variable-diameter infusion passage 530 arranged at the top has a diameter gradually decreasing along the direction of liquid flow. This design allows the infusion needle 900 to be pressed tightly even if there is a certain error in alignment with the first liquid channel 510.

[0080] The side opening of the second liquid channel 520 communicates with the outlet end of the first liquid channel 510, ensuring that the liquid can smoothly enter the second liquid channel 520 from the first liquid channel 510. The other side opening communicates with the diffusion chamber 110, which helps the liquid to be further dispersed or mixed in the diffusion chamber 110. The bottom wall is flush with the bottom wall of the diffusion chamber 110. In addition to the effect of liquid extraction and infusion, it also helps to keep the liquid distribution in the diffusion chamber 110 uniform. That is, the liquid in the second liquid channel 520 can flow into the diffusion chamber 110, avoiding the accumulation or formation of dead angles of the liquid in the chamber.

[0081] Please refer to Figure 3 The exhaust channel 600 includes a first exhaust channel 610 and a second exhaust channel 620 arranged in the outer wall 130 of the base 100 and communicating with each other. The exhaust channel 600 and the liquid channel 500 are arranged on opposite sides in the radial direction of the base 100. The first exhaust channel 610 extends along the radial direction of the base 100. The side opening of the first exhaust channel 610 communicates with the diffusion chamber 110, and the top wall is flush with the top opening 111 of the diffusion chamber 110. The second exhaust channel 620 is arranged along the axial direction of the base 100. The side opening of the first exhaust channel 610 communicates with the other end of the first exhaust channel 610, and the other side opening extends to the top wall of the base 100. The diameter of the first exhaust channel 610 is larger than that of the second exhaust channel 620.

[0082] Further, it should be noted that in this embodiment, the liquid channel 500 and the exhaust channel 600 have a height difference along the height direction of the diffusion chamber 110, as shown in Figure 3, the relative height of the second liquid channel 520 of the liquid channel 500 is lower than the first exhaust channel 610 of the exhaust channel 600, which is designed based on the needs of liquid infusion or extraction and the needs of exhaust, the bottom wall of the second liquid channel 520 is flush with the diffusion chamber 110, which helps to extract the receiving medium, and the top wall of the first exhaust channel 610 is flush with the top opening 111 of the diffusion chamber 110, which helps to remove the bubbles.

[0083] In this embodiment, the exhaust channel 600 includes a first exhaust channel 610 and a second exhaust channel 620, which can effectively utilize the space of the base 100 while ensuring smooth gas discharge, and the top wall is flush with the top opening 111 of the diffusion chamber 110, which helps the bubbles in the diffusion chamber 110 to float into the first exhaust channel 610 when the diffusion tank is tilted to make the second exhaust channel 620 upward, avoiding gas accumulation or dead angle in the chamber, specifically because the bubbles will float upward, when floating to the top of the diffusion chamber 110, if not removed in time, it will affect the contact of the top transdermal experimental film 200 and the receiving medium, and even possible accumulation in the chamber or dead angle area, and the top wall is flush with the top opening 111 of the diffusion chamber 110, the bubbles will flow to one side of the first exhaust channel 610 and the second exhaust channel 620, and then be discharged along the second exhaust channel 620, thereby achieving the beneficial effect of avoiding gas accumulation or dead angle in the chamber.

[0084] Further, the diameter of the first exhaust channel 610 is larger than the diameter of the second exhaust channel 620, which helps larger bubbles to enter the exhaust channel 600 from the diffusion chamber 110, improves the gas discharge efficiency, and also as previously described, the diameter of the first exhaust channel 610 is set to be larger, which can further avoid gas accumulation or dead angle in the chamber (exhaust channel 600 area). For example, in this embodiment, the diameter of the first exhaust channel 610 is set to 3mm, 4mm, etc., and the diameter of the second exhaust channel 620 is set to only 1.5mm, 2mm, etc.

[0085] In another preferred implementation, the first exhaust channel 610 can also be set to be flat, such as oval, waist-shaped hole, which increases the contact area of the bubble discharge, and such a setting structure can further improve the exhaust efficiency.

[0086] The embodiment of the present embodiment also discloses a transdermal diffusion experiment device, which further comprises a cover ring 800 (see Figure 1The cover ring 800 is removably arranged on the top of the base 100, the lower end surface of the cover ring 800 is tightly fitted with the top wall of the base 100, and at least covers the liquid passage 500 and the exhaust passage 600 to prevent the solvent in the receiving liquid from volatilizing through the openings of the liquid passage 500 and the exhaust passage 600. It should be noted that the cover ring 800 is selected according to actual needs, for example, during the transdermal experiment, the liquid passage 500 and the exhaust passage 600 need to be covered, and the cover ring 800 is placed on the top of the base 100, so that the liquid passage 500 and the exhaust passage 600 are covered by the cover ring 800.

[0087] Further, to solve the problem that the height of the receiving chamber in the existing diffusion cell is larger than the cross-sectional diameter, so that the contact area of the unit volume of the receiving medium with the membrane or the skin is low, which is not conducive to drug diffusion, the inner diameter of the diffusion chamber 110 is set to be larger than the height of the diffusion chamber 110.

[0088] The transdermal diffusion experiment device disclosed in the embodiment has the following advantages: Figure 2 For convenience of marking, the identification arrow of the inner diameter A of the diffusion chamber 110 is marked on the upper side. In one preferred implementation, the inner diameter A of the diffusion chamber 110 is larger than the height B of the diffusion chamber 110. The purpose of this setting is to increase the contact area of the receiving medium and the transdermal diffusion membrane in the diffusion chamber 110, which can be achieved even with a small volume, and the height can be reduced. In one preferred implementation, the inner diameter of the diffusion chamber 110 is slightly smaller than the diameter of the transdermal diffusion membrane and larger than the height of the diffusion chamber 110. For example, in one implementation, the inner diameter of the diffusion chamber 110 can be set to be between 10 mm and 30 mm, and the height of the diffusion chamber 110 can be in the range of 3 mm to 8 mm. The embodiment is not limited to this. Figure 2 As shown in the cross-sectional view, the inner side wall of the diffusion chamber 110 is in the shape of an inverted trapezoid. This can more effectively perform the transdermal experiment.

[0089] Further, when performing a small-volume diffusion experiment, the diameter and height of the diffusion chamber 110 can be reduced, and the inner diameter of the diffusion chamber 110 gradually increases from the bottom wall side to the top opening 111 side, so as to reduce the actual effective volume, so that the effective volume of the diffusion chamber 110 is in the range of 0.2 ml to 5 ml, for example, the effective volume can be 0.2 ml, 0.8 ml, 3 ml, 5 ml, etc. The volume is smaller and more compact, and can meet the test of a smaller dose.

[0090] The transdermal diffusion experiment device disclosed in the embodiment further comprises a magnetic rotor. The magnetic rotor is placed in the diffusion chamber 110, specifically, the magnetic rotor is placed in the diffusion chamber 110 before the transdermal experiment film 200 is placed in the diffusion chamber 110. The magnetic rotor can rotate in the diffusion chamber 110 under the action of a magnetic field to stir the receiving medium in the diffusion chamber 110, thereby improving the efficiency of transdermal diffusion or transdermal reaction. Further, the magnetic rotor can be replaced with different volumes, so that the volume of the receiving medium in the diffusion chamber 110 can be further adjusted to obtain receiving liquid with different concentrations. More preferably, the diffusion chamber 110 and the magnetic rotor with variable diameters in the embodiment can have an effective volume in the range of 0.2 mL-2 mL, for example, the effective volume can be 0.2 ml, 0.8 ml, 1.2 ml, 2 ml, etc. after the magnetic rotor is placed, so as to reduce the volume of the receiving medium and increase the drug content in the receiving medium.

[0091] Finally, the assembly and experimental steps of the transdermal diffusion experiment device disclosed in the embodiment are briefly described as follows:

[0092] First, when the transdermal diffusion experiment device is assembled, the first step is to select the transdermal experiment film 200 required for the experiment. Then, the second step is to place the transdermal experiment film 200 on the stepped surface 120 of the base 100 (if the magnetic rotor is used, the magnetic rotor is first placed in the diffusion chamber 110), the third step is to place the anti-rotation limiting gasket 300 on the stepped surface 120 above the transdermal experiment film 200, and the anti-rotation limiting gasket 300 is clamped and limited by the anti-rotation limiting groove 140 and the anti-rotation protrusion 310 during the placement process. At this time, the transdermal experiment film 200 is located in the clamping part 320 between the stepped surface 120 and the anti-rotation limiting gasket 300. The fourth step is to tighten the pressure ring 400 in the inner circle of the base 100 by rotating the installation seat 700, and the pressure ring 400 is tightly installed on the top of the anti-rotation limiting gasket 300, thereby completing the assembly process of the transdermal diffusion experiment device.

[0093] When the transdermal experiment is performed, the drug preparation can be applied to the upper surface of the transdermal experiment film 200 according to the requirements, or the receiving medium can be injected into the diffusion chamber 110 through the infusion needle 900 and the liquid channel 500. When the cover ring 800 is used, the cover ring 800 is placed on the top of the base 100 for the experiment, for example, in a magnetic field, the magnetic rotor is driven by the magnetic field to stir to improve the mixing efficiency. After diffusion, the receiving medium is taken out by the liquid taking needle for concentration test, etc. The experiment can also be simultaneously batched for multiple experiments, for example, six or twelve groups are simultaneously used for parallel experiments. The embodiment does not make specific limitations on this.

[0094] Further, the embodiment further comprises a method applied to the transdermal diffusion experiment device, please refer to Figure 7 The method comprises the following steps:

[0095] S1, select the transdermal test membrane 200 used in the experiment, and then place the transdermal test membrane 200 on the stepped surface 120 of the base 100;

[0096] S2, place the anti-rotation limiting washer 300 on the stepped surface 120 above the transdermal test membrane 200, and the anti-rotation limiting washer 300 is limited by the anti-rotation protrusion 310 and the anti-rotation limiting groove 140. When the anti-rotation limiting washer 300 is placed on the stepped surface 120, the transdermal test membrane 200 is located in the clamping part 320 formed between the opposite surfaces of the stepped surface 120 and the anti-rotation limiting washer 300, and the transdermal test membrane 200 covers the top opening 111 of the diffusion chamber 110;

[0097] S3, the compression ring 400 is installed and tightened on the inner ring of the base 100 and the top of the anti-rotation limiting washer 300 by rotating the mounting seat 700;

[0098] S4, the drug preparation is applied to the upper surface of the transdermal test membrane 200, and the receiving medium is injected into the diffusion chamber 110 through the liquid channel by the infusion needle 900. When the infusion needle 900 is used to inject the medium liquid, the spherical or conical protrusion 920 provided on the head of the infusion needle 900 is matched with the inner peripheral contour of the variable-diameter infusion port 530 of the liquid channel 500, or the drug preparation is applied to the upper surface of the transdermal test membrane 200 after the temperature and state of the transdermal test membrane 200 in the diffusion tank are balanced after the receiving medium is injected by the infusion needle 900;

[0099] S5, when taking liquid or after the experiment is completed, the receiving medium is sucked by using the liquid taking needle directly to the bottom of the second liquid channel 520, or the receiving medium is sucked by using the infusion needle 900;

[0100] In the above method, the cover ring 800 can be placed above the base 100 to cover the liquid channel 500 and the exhaust channel 600 according to the needs. In the above method, the magnetic rotor can also be installed in the diffusion chamber 110 before the transdermal test membrane 200 is placed. Further, in step S4, the time, order, dose, etc. of applying the drug preparation or injecting the receiving medium can be adjusted by the person skilled in the art according to the actual experimental needs, which is not limited in this embodiment. In step S4, the liquid surface of the medium injected into the diffusion chamber 110 is preferably flush with the transdermal test membrane 200.

[0101] Example 2

[0102] It should be noted that the structure and working mode of the transdermal diffusion experiment device disclosed in the embodiment are the same as those of embodiment 1, and the only difference is that the structure of the base 100 in the embodiment is different from that in embodiment 1. The base 100 in embodiment 1 is an integrated base 100, and the base 100 in the embodiment includes a detachable first base 150 and a second base 160.

[0103] Specifically, please refer to Figure 5 and Figure 6 In the transdermal diffusion experiment device disclosed in the embodiment, the base 100 includes a first base 150 and a second base 160 which are arranged in sequence along the axial direction and detachably connected to each other, the first base 150 is arranged on the top wall of the second base 160, and a sealing ring 170 is arranged between the first base 150 and the second base 160. In a preferred implementation, the first base 150 is in the form of a hollow cylinder, the second base 160 is provided with a protruding portion 180 in the middle which is adapted to the inner wall of the lower end of the first base 150, and the protruding portion 180 is in the form of a cylinder. In order to facilitate the installation of the sealing ring 170, a step and a mounting groove for installing the sealing ring 170 are provided on the protruding portion 180 in the embodiment, so as to improve the sealing performance of the first base 150 and the second base 160. In addition, only one connection mode of the split first base 150 and the second base 160 is shown in the embodiment, and those skilled in the art can adjust and design according to actual needs, which is not limited in the embodiment.

[0104] Further preferably, the first base 150 is made of any one of acrylic material, quartz, crystal, tempered glass, plastic, and ceramic, and preferably made of transparent acrylic material, quartz, crystal, tempered glass, and transparent plastic. The second base 160 is made of any one of metal material with good heat conductivity, quartz, crystal, tempered glass, ceramic, acrylic material, and plastic. The inner side wall of the first base 150 is provided with internal threads, the protruding portion 180 is provided with external threads which are adapted to the internal threads, and the sealing ring 170 is sleeved on the protruding portion 180.

[0105] With the above structure, the first base 150 is preferably made of acrylic material, quartz, crystal, or tempered glass, which has good transparency, chemical stability, and light weight. The first base 150 made of acrylic material, quartz, crystal, or tempered glass can be used for visual observation and recording during transdermal diffusion. The first base 150 and the second base 160 are connected by threads and the sealing ring 170, which can ensure firm connection and reliable sealing between the first base 150 and the second base 160, prevent loosening, and ensure reliable sealing and further prevent leakage of the receiving medium.

[0106] That is, in some specific needs, the base 100 in the embodiment can be assembled in two parts, for example, when there is a need for visual observation, the first base 150 on the upper part can be set as acrylic or tempered glass to meet different experimental requirements. For example, when there is a higher demand for heat conduction, the second base 160 on the lower part is set as a metal material base. The experimental use method of the transdermal diffusion experimental device disclosed in Embodiment 2 is basically the same as that in Embodiment 1, and the difference is only that in the present embodiment, the first base 150 and the second base 160 are installed and the connection is sealed before the experiment.

[0107] Embodiment 3

[0108] The embodiment also discloses a transdermal diffusion experimental device. It should be noted that the transdermal diffusion experimental device disclosed in the embodiment is basically the same as that in Embodiments 1 and 2, and includes the base 100, the anti-rotation limiting gasket 300, the compression ring 400, and the cover ring 800 which is selected according to the needs. The difference is that in the present embodiment, the auxiliary step surface 101 is arranged on the outer wall of the base 100 along the outer periphery of the base 100. It should be noted that in order to distinguish from Embodiments 1 and 2, the height direction of the base 100 is indicated as shown by the arrow 102 in Figure 8 In the height direction of the base 100, the auxiliary step surface 101 is flush with the step surface 120. And the openings of the liquid channel 500 and the exhaust channel 600 are both arranged on the auxiliary step surface 101.

[0109] It should be noted that please refer to Figure 2 and Figure 5In the schemes disclosed in Embodiment 1 and Embodiment 2, the top opening of the liquid channel 500 and the exhaust channel 600 are both higher than the height of the transdermal experiment film 200 and the step surface 120, and the most commonly used experimental scenario in the transdermal experiment process is that the liquid level of the receiving medium in the diffusion chamber 110 is in contact with the transdermal experiment film 200, so as to simulate the transdermal experiment process. Therefore, in the setting mode of Embodiment 1 and Embodiment 2, a certain volume of receiving medium needs to be accurately injected to make the liquid level of the receiving medium in the diffusion chamber 110 flush with the transdermal experiment film 200. When the liquid level in the liquid channel 500 is higher than the height of the transdermal experiment film 200 and the step surface 120, the excess receiving medium needs to be sucked away by the infusion needle 900, otherwise based on the principle of communicating vessels, the receiving medium in the liquid channel 500 will gradually enter the diffusion chamber 110. When the liquid level in the liquid channel 500 is flush with the liquid level of the receiving medium in the diffusion chamber 110, the liquid level of the receiving medium will exceed the transdermal experiment film 200, resulting in direct contact between the receiving medium and the drug, thereby affecting the experimental accuracy and even unable to perform the transdermal experiment. Therefore, Embodiment 1 and Embodiment 2 have high accuracy requirements for the liquid level of the receiving medium in the diffusion chamber 110.

[0110] In the present embodiment, the auxiliary step surface 101 and the step surface 120 are flush, and the transdermal experiment film 200 placed on the step surface 120 is basically flush with the step surface 120. The top openings of the liquid channel 500 and the exhaust channel 600 are flush with the auxiliary step surface 101. Therefore, in the height direction of the base 100, the transdermal experiment film 200 is basically flush with the top opening of the liquid channel 500. Taking the injection of the receiving medium in the liquid channel 500 as an example, the receiving medium is injected from the liquid channel 500 to the diffusion chamber 110 by the infusion needle 900, and the injection of the receiving medium is stopped when the diffusion chamber 110 is filled with the receiving medium or the receiving medium is flush with the transdermal experiment film 200. Therefore, the receiving medium and the transdermal experiment film 200 can always be flush when the receiving medium is injected into the diffusion chamber 110 each time, thereby accurately simulating the transdermal experiment process. Further, the flush of the auxiliary step surface 101 and the step surface 120 helps to maintain the stability and position of the receiving medium and the transdermal experiment film 200 during the experiment, preventing experimental errors caused by changes in the liquid level of the receiving medium. Moreover, the injection of the receiving medium is also simpler and more convenient. When the liquid level in the liquid channel 500 on the auxiliary step surface 101 is flush with the auxiliary step surface 101, the liquid level of the receiving medium in the diffusion chamber 110 is also flush with the transdermal experiment film 200.

[0111] Further preferably, please refer to Figure 8The base 100 further comprises a clamping fixing portion 103 protruding from the inner periphery of the auxiliary stepped surface 101 and around the stepped surface 120. The clamping fixing portion 103 is annular in shape, the anti-rotation limiting washer 300 is non-rotatably fitted to the inner side of the clamping fixing portion 103, and the inner wall of the clamping fixing portion 103 is detachably fitted with the outer wall of the compression ring 400.

[0112] It should be noted that the anti-rotation limiting washer 300 is arranged in the same manner as in Embodiment 1 and Embodiment 2, i.e., non-rotatably fitted to the inner side of the clamping fixing portion 103. A clamping portion 320 for clamping the transdermal test film is formed between the anti-rotation limiting washer 300 and the stepped surface 120. The compression ring 400 is arranged to be movable along the inner wall of the clamping fixing portion 103 (in the same direction as the height direction of the base) while the inner wall of the clamping fixing portion 103 is detachably fitted with the outer wall of the compression ring 400. That is, the compression ring 400 is movable along the inner wall of the clamping fixing portion 103 in the height direction during installation and disassembly. Therefore, the compression ring 400 and the inner wall of the clamping fixing portion 103 can be detachably connected by a threaded connection or by a clamping protrusion and a sliding groove. Those skilled in the art can design and select according to actual needs, and this embodiment does not make specific limitations.

[0113] Further preferably, the diffusion chamber 110 in the base 100 is a cylindrical cavity. The clamping fixing portion 103 is annular and protrudes from the auxiliary stepped surface 101, and is provided with a plurality of anti-rotation clamping grooves 104, for example, 2, 3, 4 or more. The anti-rotation limiting washer 300 is annular and is provided with at least one clamping protrusion 105 on the outer peripheral side wall, which is fitted into a corresponding anti-rotation clamping groove 104. The inner wall of the clamping fixing portion 103 and the outer wall of the compression ring are detachably fitted together by a threaded connection. The detachable connection of the compression ring 400 disclosed in this embodiment is the same as in Embodiment 1 and Embodiment 2, i.e., detachable connection by a threaded connection. The compression ring can also be screwed into place using the rotating mounting seat 700, and can also be screwed out using the functional rotating mounting seat 700.

[0114] Further referring to Figure 8 In a preferred implementation disclosed in this embodiment, the clamping fixing portion 103 is provided with three anti-rotation clamping grooves 104, and each anti-rotation clamping groove 104 extends through the clamping fixing portion 103 in the height direction of the base 100. In this way, each clamping protrusion 105 of the anti-rotation limiting washer 300 is fitted into an anti-rotation clamping groove 104 and then moved along the anti-rotation clamping groove 104 to abut against the stepped surface 120.

[0115] Finally, the installation and use of the transdermal diffusion experiment device disclosed in the embodiment are also briefly described:

[0116] First, the first base 150 and the second base 160 are assembled into one, ensuring that the bottom of the diffusion chamber 110 is sealed, then the transdermal experiment film 200 used for the experiment is selected and placed on the stepped surface 120 of the base 100, then the clamping protrusion 105 of the anti-rotation limiting washer 300 and the anti-rotation clamping groove 104 are matched and clamped to limit the placement on the stepped surface 120 above the transdermal experiment film 200, when the anti-rotation limiting washer 300 is placed on the stepped surface 120, the transdermal experiment film 200 is located in the clamping part 320 formed between the opposite surfaces of the stepped surface 120 and the anti-rotation limiting washer 300, and the transdermal experiment film 200 covers the top opening 111 of the diffusion chamber 110, the pressure ring 400 is screwed and installed on the inner wall of the clamping fixed part 103 through the rotating mounting seat 700, the drug preparation is applied to the upper surface of the transdermal experiment film 200, and the receiving medium is injected into the diffusion chamber 110 from the liquid channel 500 through the infusion needle 900, when the liquid level in the liquid channel 500 approaches the top opening, the liquid level in the diffusion chamber 110 is attached to or flush with the transdermal experiment film 200, then the transdermal experiment is performed, or the drug preparation is applied to the upper surface of the transdermal experiment film 200 after the temperature and state of the transdermal experiment film 200 in the diffusion tank are balanced, the receiving medium is sucked by using the liquid taking needle directly to the bottom of the liquid channel 500 when taking liquid or after the experiment is completed, or the receiving medium is sucked by using the infusion needle 900, the cover ring 800 can be placed on the auxiliary stepped surface 101 to cover the liquid channel 500 and the exhaust channel 600 for use, and the time, sequence, dose, etc. of applying the drug preparation or injecting the receiving medium can be adjusted by those skilled in the art according to the actual experimental requirements, which is not limited by the embodiment.

[0117] It should be noted that in addition to the specific embodiments described above, those skilled in the art can easily understand other advantages and effects of the present application from the disclosure. Although the description of the present application will be introduced together with the preferred embodiments, this does not mean that the features of the present application are limited to this embodiment. On the contrary, the purpose of introducing the present application with the embodiment is to cover other options or modifications that can be extended based on the claims of the present application. In order to provide a deep understanding of the present application, many specific details are included in the above description, and the present application can also be implemented without using these details. In addition, in order to avoid confusion or obscure the focus of the present application, some specific details will be omitted in the description. It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0118] It should be noted that in the present specification, similar reference numbers and letters represent similar items in the following drawings, thus, once an item is defined in one drawing, it does not need to be further defined and explained in the subsequent drawings.

[0119] In the description of the present embodiment, it should be noted that the terms "upper", "lower", "inner", "bottom" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the utility model product is usually placed, which is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the utility model.

[0120] The terms "first", "second", and the like are only used for differentiation in description, and cannot be understood as indicating or implying relative importance.

[0121] In the description of the present embodiment, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set", "connected", "connected" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium, or it can be connected inside two elements. For those skilled in the art, the specific meaning of the above terms in the present embodiment can be understood according to the specific circumstances.

[0122] Although the utility model has been illustrated and described with reference to certain preferred embodiments thereof, it should be understood by those skilled in the art that the above is a further detailed description of the utility model in combination with specific embodiments, and cannot be considered as a limitation on the specific implementation of the utility model. Those skilled in the art can make various changes in form and details, including making a number of simple inferences or substitutions, without departing from the spirit and scope of the utility model.

Claims

1. A transdermal diffusion test device, characterized by, The application relates to a base with a diffusion chamber formed in the base, wherein the diffusion chamber is provided with a top opening and a step surface is arranged on the inner side wall of the base along the circumference of the base; a rotation-preventing limiting washer is arranged on the step surface in a rotation-preventing manner; a compression ring is detachably arranged above the rotation-preventing limiting washer; wherein a liquid channel and an exhaust channel are arranged on the outer wall of the base in a spaced manner and are communicated with the diffusion chamber; the liquid channel extends from the outer wall of the base to one side of the diffusion chamber, and the channel bottom wall near the diffusion chamber is flush with the bottom wall of the diffusion chamber; the exhaust channel extends from the other side of the diffusion chamber to the outer wall of the base, and the channel top wall near the diffusion chamber is flush with the top opening of the diffusion chamber; wherein a clamping part is formed between the step surface and the opposite surface of the rotation-preventing limiting washer, and the clamping part detachably clamps a transdermal test film covering the top opening of the diffusion chamber; the liquid channel comprises a first liquid channel and a second liquid channel which are arranged in the outer wall of the base and are communicated with each other; and in a sectional view taken along the axial direction of the base, the first liquid channel and the second liquid channel are in an "L" shape, wherein the first liquid channel extends along the axial direction of the base, the top opening of the first liquid channel is arranged on the top wall of the base, and the first liquid channel comprises a variable-diameter liquid delivery channel which is gradually reduced in diameter along the liquid flow direction; the second liquid channel extends along the radial direction of the base, one side opening of the second liquid channel is communicated with the outlet end of the first liquid channel, the other side opening of the second liquid channel is communicated with the diffusion chamber, and the bottom wall of the second liquid channel is flush with the bottom wall of the diffusion chamber; the exhaust channel comprises a first exhaust channel and a second exhaust channel which are arranged in the outer wall of the base and are communicated with each other; wherein the exhaust channel and the liquid channel are arranged on opposite sides in the radial direction of the base; the first exhaust channel extends along the radial direction of the base, one side opening of the first exhaust channel is communicated with the diffusion chamber, and the top wall of the first exhaust channel is flush with the top opening of the diffusion chamber; the second exhaust channel is arranged along the axial direction of the base, one side opening of the first exhaust channel is communicated with the other end of the first exhaust channel, and the other side opening of the second exhaust channel extends to the top wall of the base; and the diameter size of the first exhaust channel is greater than that of the second exhaust channel; the diffusion chamber in the base is in a cylindrical cavity shape; the rotation-preventing limiting washer is in a circular ring shape, wherein the outer ring of the rotation-preventing limiting washer is provided with at least one rotation-preventing protrusion; the inner side wall of the base is provided with a rotation-preventing limiting groove matched with the rotation-preventing protrusion; the outer side wall of the compression ring is provided with an outer thread, and the inner side wall of the base is provided with an inner thread matched with the outer thread; wherein the inner side wall of the rotation-preventing limiting washer and the compression ring is flush with the inner side wall of the diffusion chamber in the axial direction of the base; and the compression ring is detachably arranged on the rotation-preventing limiting washer in a rotation-preventing manner. ​ ​ ​ ​ ​ 2. The transdermal diffusion test device according to claim 1, wherein ​ ​ 3. The transdermal diffusion test device according to claim 2, wherein ​ ​ ​ ​ 4. The transdermal diffusion test device of claim 1, wherein ​ ​ ​ 5. The transdermal diffusion test device according to claim 4, wherein ​ ​ Further comprising a rotating mounting base, which is matched with the compression ring, and one side of the rotating mounting base is provided with a positioning protrusion, and the side of the compression ring away from the anti-rotation limiting washer is also provided with a positioning hole, and the positioning protrusion is matched and connected with the positioning hole.

6. The transdermal diffusion testing device of claim 1, wherein, Further comprising a cover ring, which is removably arranged on the top of the base, and the lower end surface of the cover ring is tightly combined with the top wall of the base, and at least covers the liquid channel and the exhaust channel.

7. The transdermal diffusion testing device of claim 1, wherein, Along the axial direction of the base, the inner diameter of the diffusion chamber gradually increases from the side of the bottom wall to the top opening side; and The volume of the diffusion chamber is in the range of 0.2-5ml.

8. The transdermal diffusion testing device of claim 1, wherein, The base comprises a first base and a second base which are arranged in sequence along the axial direction and are detachably connected with each other, the first base is arranged on the top wall of the second base, and a sealing ring is arranged between the first base and the second base; wherein The first base is internally cylindrical, and the second base is provided with a protruding portion in the middle which is matched with the lower end inner wall of the first base, and the protruding portion is cylindrical.

9. The transdermal diffusion test device of claim 8, wherein, The first base is made of any one of acrylic material, quartz, crystal, tempered glass, plastic, and ceramic, and the second base is made of any one of metal material, quartz, crystal, tempered glass, ceramic, acrylic material, and plastic; and The inner side wall of the first base is provided with internal threads, the protruding portion is provided with external threads which are matched with the internal threads, and the sealing ring is sleeved on the protruding portion.

10. The transdermal diffusion testing device of claim 1, wherein, Further comprising a magnetic rotor, which is located in the diffusion chamber; and Further comprising an infusion needle, the middle part of the infusion needle is provided with an infusion hole, the head of the infusion needle is provided with a spherical or conical protrusion, and the shape of the spherical or conical protrusion is matched with the inner contour of the variable-diameter infusion port of the liquid channel.

11. The transdermal diffusion testing device of claim 1, wherein, The outer wall of the base is provided with an auxiliary step surface along the outer periphery of the base, and the auxiliary step surface is flush with the step surface in the height direction of the base; and The openings of the liquid channel and the exhaust channel are both arranged on the auxiliary step surface.

12. The transdermal diffusion test device of claim 11, wherein, The base further comprises a clamping fixing portion which protrudes from the inner periphery of the auxiliary step surface around the step surface; wherein The clamping fixing portion is annular as a whole, the anti-rotation limiting washer is matched with the inner side of the clamping fixing portion without relative rotation, and the inner wall of the clamping fixing portion is detachably matched with the outer wall of the compression ring.

13. The transdermal diffusion test device of claim 12, wherein, Wherein The diffusion chamber in the base is a cylindrical cavity; The clamping fixing portion is annular and is provided with a plurality of anti-rotation clamping grooves along the circumferential direction, the anti-rotation limiting washer is annular and is provided with at least one clamping protrusion on the outer peripheral side wall, and the clamping protrusion is matched in the corresponding one of the anti-rotation clamping grooves; and The inner wall of the clamping fixing portion and the outer wall of the compression ring are detachably matched together through threaded connection.

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