Device for promoting type II collagen and freund's adjuvant to be fully mixed

Abstract

The utility model discloses a device for promoting full mixing of type II collagen and a freund's adjuvant. The device comprises a container, an injector and a connecting pipe, holes are formed in the two sides of the container, and a low-temperature medium can be injected into the container. The tube bodies of the injectors are arranged inside the container through the hole sites, the operating ends of the injectors are arranged outside the container, and the two injectors are connected through the connecting tube; the outer wall of the tube body of the injector and the tube wall of the connecting tube are coated or wound with a shading material, or the outer wall of the container is coated with a shading material. The syringes are arranged in the holes in the two sides of the container, the low-temperature medium is injected into the container, the outer walls of the tube bodies of the syringes and the tube wall of the connecting tube are coated or wound with the shading materials, or the outer wall of the container is coated with the shading materials, and therefore a low-temperature shading environment is provided to promote fusion.

Description

Technical Field

[0001] This utility model relates to the field of emulsification equipment technology, specifically to a device for promoting the thorough mixing of type II collagen and Freund's adjuvant. Background Technology

[0002] When constructing a rat or mouse model of rheumatoid arthritis, a mixed emulsion of type II collagen and complete Freund's adjuvant is typically prepared and injected into the tail of the rat or mouse. Traditionally, type II collagen and complete Freund's adjuvant are mixed using a mixer. However, the shear force and localized temperature rise generated by traditional mixers can easily lead to denaturation of type II collagen. Therefore, injectable mixers are now commonly used to mix type II collagen and complete Freund's adjuvant.

[0003] Currently, syringes containing type II collagen and complete Freund's adjuvant are typically connected via a mixing tube. The plungers of the two syringes are then pushed and pulled back and forth, causing the type II collagen and complete Freund's adjuvant to move and mix within the two syringes. While existing methods using injectable mixers to mix type II collagen and complete Freund's adjuvant can avoid the effects of shear forces and localized high temperatures on type II collagen, the optimal mixing temperature for type II collagen is between 2°C and 8°C. Above 8°C, the stability of type II collagen is affected. Furthermore, both type II collagen and complete Freund's adjuvant are susceptible to ultraviolet radiation. Therefore, existing injectable mixers struggle to provide the low-temperature, light-protected environment required for mixing type II collagen and complete Freund's adjuvant.

[0004] Therefore, the existing method of mixing type II collagen and complete Freund's adjuvant using an injection mixer has the risk of unsuccessful emulsification when mixing type II collagen and complete Freund's adjuvant due to the difficulty in providing a stable low-temperature and light-proof environment. Utility Model Content

[0005] The purpose of this invention is to provide a device for promoting the full mixing of type II collagen and Freund's adjuvant, in order to solve the technical problem in the prior art where the difficulty in providing a stable low-temperature and light-proof environment leads to the risk of unsuccessful emulsification when mixing type II collagen and Freund's adjuvant completely.

[0006] To solve the above-mentioned technical problems, this utility model specifically provides the following technical solution:

[0007] A device for promoting thorough mixing of type II collagen and Freund's adjuvant includes a container, wherein two syringes are mounted on the container through pre-set holes on both sides, and a connecting tube is provided between the two syringes;

[0008] The operating end of the syringe is located outside the container, and the syringe barrel is located inside the container;

[0009] The container is filled with a cryogenic medium, and the syringe and the connecting tube are both submerged in the cryogenic medium. The outer wall of the syringe tube and the wall of the connecting tube are coated or wrapped with a light-shielding material, or the outer wall of the container is coated with a light-shielding material, to provide a cryogenic and light-proof environment to promote mixing.

[0010] As a preferred embodiment of this utility model, the two ends of the connecting tube are provided with sleeves, which are used to fit the nipple of the syringe, and each sleeve is provided with a fixing clip.

[0011] The connecting pipe has an exhaust port at one end near one of the sleeve openings, and a switch is provided on the exhaust port.

[0012] As a preferred embodiment of the present invention, the container includes a box body, a box lid is provided at the upper opening of the box body, and the hole is formed in the side wall of the box body;

[0013] When the lid is opened, the low-temperature medium can be added through the opening at the top of the box.

[0014] As a preferred embodiment of this utility model, a rubber ring is provided in the hole, and the rubber ring is in close contact with the body of the syringe to seal the hole in conjunction with the body of the syringe.

[0015] As a preferred embodiment of this utility model, two retainers are provided inside the container, which fix the syringe barrel inside the container after the syringe is inserted.

[0016] In a preferred embodiment of this utility model, the fixture includes a bracket, which is fixed to the bottom of the container, and a fixing ring is provided on the bracket, the fixing ring being coaxially arranged with the hole.

[0017] After the syringe barrel is fully inserted into the container, the syringe barrel is inserted into the retaining ring, which locks it in place.

[0018] Compared with the prior art, this utility model has the following advantages:

[0019] This invention provides a low-temperature, light-proof environment to promote fusion by placing a syringe in the holes on both sides of a container, injecting a low-temperature medium into the container, and coating or wrapping the outer wall of the syringe tube and the connecting tube with a light-shielding material, or coating the outer wall of the container with a light-shielding material. Attached Figure Description

[0020] To more clearly illustrate the embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are merely exemplary, and those skilled in the art can derive other embodiments based on the provided drawings without creative effort.

[0021] Figure 1 A schematic diagram of the structure of a device for promoting thorough mixing of type II collagen and Freund's adjuvant in an embodiment of this utility model;

[0022] Figure 2 A schematic diagram of the connecting pipe is provided for an embodiment of this utility model.

[0023] The labels in the diagram represent the following:

[0024] 1-Container; 2-Syringe; 3-Connecting tube;

[0025] 11-Hole position; 12-Cryogenic medium; 13-Box body; 14-Box cover; 15-Fixer; 31-Sleeve opening; 32-Exhaust port;

[0026] 111-Rubber ring; 151-Bracket; 152-Retaining ring; 311-Retaining clip; 321-Switch. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0028] like Figure 1 As shown, this utility model provides a device for promoting the thorough mixing of type II collagen and Freund's adjuvant, including a container 1, with two syringes 2 installed in the container 1 through preset holes 11 on both sides, and a connecting tube 3 connecting the two syringes 2.

[0029] The operating end of syringe 2 is located outside container 1, and the tube of syringe 2 is located inside container 1;

[0030] The container 1 is filled with a low-temperature medium 12, and the syringe 2 and the connecting tube 3 are both submerged in the low-temperature medium 12. The outer wall of the syringe 2 and the wall of the connecting tube 3 are coated or wrapped with a light-shielding material, or the outer wall of the container 1 is coated with a light-shielding material, so as to provide a low-temperature and light-proof environment to promote mixing.

[0031] This embodiment provides a low-temperature, light-proof environment to promote mixing by providing holes 11 on both sides of the container 1 and placing the tubes of two syringes 2 through the holes 11 inside the container 1. The two syringes 2 are connected by a connecting tube 3. The container 1 is filled with a low-temperature medium, and light-shielding material is coated or wrapped around the outer wall of the syringe 2 tube and the tube wall of the connecting tube 3, or light-shielding material is coated on the outer wall of the container 1.

[0032] Compared to existing injection mixing devices, this embodiment provides a low-temperature and light-proof environment for mixing by placing the syringe 2 inside the container 1 through the orifice 11, and by coating or wrapping the outer wall of the syringe 2 and the connecting tube 3 with light-shielding material, or by coating the outer wall of the container 1 with light-shielding material, thereby promoting mixing.

[0033] To achieve the connection of the two syringes 2 and to purge the gas from the connecting tube 3 after connection, the following preferred embodiments are provided.

[0034] like Figure 2 As shown, the two ends of the connecting tube 3 are provided with sleeves 31, which are used to attach the nipples of the syringe 2. Each sleeve 31 is provided with a fixing clip 311.

[0035] Among them, the end of the connecting pipe 3 near one of the sleeves 31 is provided with an exhaust port 32, and a switch 321 is provided on the exhaust port 32.

[0036] Specifically, after fixing the sleeve 31 to the nipples of the two syringes 2 respectively by fixing the clamp 311, the air in the connecting tube 3 can be expelled by turning on the switch 321 and slowly pushing the syringe 2 away from the exhaust port 32. After the air in the connecting tube 3 is expelled, the switch 321 can be turned off to mix, thereby avoiding the air affecting the stability of the mixture.

[0037] In order to enable the syringe 2 to be installed inside the container 1 and to inject a cryogenic medium into the container 1 after installation, the following preferred embodiments are proposed.

[0038] like Figure 1 As shown, container 1 includes a box body 13, a lid 14 is provided at the upper opening of the box body 13, and a hole 11 is formed in the side wall of the box body 13.

[0039] When the lid 14 is opened, the low-temperature medium 12 can be added through the opening at the top of the box body 13.

[0040] Specifically, opening the lid 14 opens the interior of the container 1, allowing the syringe 2 and connecting tube 3 to be installed and the air to be vented. Then, a cryogenic medium can be injected into the container 1.

[0041] To prevent the cryogenic medium from overflowing from the orifice 11 during the mixing process, the following preferred embodiments are proposed.

[0042] like Figure 1 As shown, a rubber ring 111 is provided in the hole 11. The rubber ring 111 is in close contact with the body of the syringe 2 to seal the hole 11.

[0043] Specifically, the rubber ring 111 seals the gap between the syringe 2 tube and the orifice 11, thereby preventing the low-temperature medium from overflowing.

[0044] Since the syringe 2 plunger needs to be pulled back and forth during mixing, in order to prevent the syringe 2 from coming off due to insufficient friction of the rubber ring 111, the syringe 2 is further fixed, and the following preferred embodiment is proposed.

[0045] like Figure 1 As shown, two retainers 15 are provided inside the container 1. After the syringe is inserted, the retainers 15 fix the syringe 2 tube inside the container 1.

[0046] The fixture 15 includes a bracket 151, which is fixed to the bottom of the container 1. A fixing ring 152 is provided on the bracket 151, and the fixing ring 152 is coaxially arranged with the hole 11.

[0047] After the syringe 2 is fully inserted into the container 1, the syringe 2 is inserted into the retaining ring 152, which locks it in place.

[0048] Specifically, the two syringes 2 can be fixed inside the container 1 by the retaining ring 152, and the axis of the syringes 2 and the hole 11 can be kept aligned.

[0049] In this embodiment, when using the device, first open the box cover 14, insert the tubes of the two syringes 2 into the container 1 through the holes 11, and fix the tubes of the syringes 2 with the fixing rings 152. Put the sleeve 31 on the nipple of the syringe 2 and fix it with the fixing clip 311. Open the switch 321 of the vent 32 to vent, and after venting, close the switch 321 and inject the low temperature medium into the container 1. Then close the box cover 14, and mix the syringes 2 by repeatedly pulling the plungers.

[0050] The above embodiments are merely exemplary embodiments of this application and are not intended to limit this application. The scope of protection of this application is defined by the claims. Those skilled in the art can make various modifications or equivalent substitutions to this application within its substance and scope of protection, and such modifications or equivalent substitutions should also be considered to fall within the scope of protection of this application.

Claims

1. A device for promoting thorough mixing of type II collagen and Freund's adjuvant, characterized in that, Includes a container (1), which has two syringes (2) installed through pre-set holes (11) on both sides, and the two syringes (2) are connected by a connecting tube (3); The operating end of the syringe (2) is located outside the container (1), and the tube of the syringe (2) is located inside the container (1); The container (1) is filled with a low-temperature medium (12), and the syringe (2) and the connecting tube (3) are both submerged in the low-temperature medium (12). The outer wall of the syringe (2) and the wall of the connecting tube (3) are coated or wrapped with a light-shielding material, or the outer wall of the container (1) is coated with a light-shielding material, so as to provide a low-temperature and light-shielding environment to promote mixing.

2. The device for promoting thorough mixing of type II collagen and Freund's adjuvant according to claim 1, characterized in that, The connecting tube (3) is provided with sleeves (31) at both ends. The sleeves (31) are used to fit the nipple of the syringe (2). Each sleeve (31) is provided with a fixing clip (311). The connecting pipe (3) has an exhaust port (32) at one end near one of the sleeves (31), and a switch (321) is provided on the exhaust port (32).

3. The device for promoting thorough mixing of type II collagen and Freund's adjuvant according to claim 2, characterized in that, The container (1) includes a box body (13), and a lid (14) is provided at the upper opening of the box body (13). The hole (11) is formed on the side wall of the box body (13). When the lid (14) is opened, the low-temperature medium (12) can be added through the upper opening of the box body (13).

4. The device for promoting thorough mixing of type II collagen and Freund's adjuvant according to claim 3, characterized in that, A rubber ring (111) is provided in the hole (11), and the rubber ring (111) is in close contact with the body of the syringe (2) to seal the hole (11) with the body of the syringe (2).

5. The device for promoting thorough mixing of type II collagen and Freund's adjuvant according to claim 4, characterized in that, Two retainers (15) are provided inside the container (1). After the syringe is inserted, the retainers (15) fix the body of the syringe (2) inside the container (1).

6. The apparatus for promoting thorough mixing of type II collagen and Freund's adjuvant according to claim 5, characterized in that, The fixture (15) includes a bracket (151) which is fixed to the bottom of the container (1). A fixing ring (152) is provided on the bracket (151) and the fixing ring (152) is coaxially arranged with the hole (11). After the syringe (2) is fully inserted into the container (1), the syringe (2) is inserted into the retaining ring (152), which locks it in place.

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