Capsule administration device for rhesus monkey

Abstract

The utility model relates to a capsule dosing device for rhesus monkeys, which comprises a thick tube and a thin tube, the thin tube is movably mounted in the thick tube in a penetrating manner, and a claw-shaped clamp is arranged at the bottom of the thick tube; the claw-shaped clamp comprises mounting blocks, the mounting blocks are fixedly mounted on the left inner wall and the right inner wall of the thick pipe correspondingly, first springs are fixedly mounted at the bottoms of the two mounting blocks correspondingly, a movable block is fixedly mounted between the bottoms of the two first springs, and a connecting rod is movably mounted at the bottom of the movable block; and adjusting plates are movably mounted at the bottoms of the connecting rods. The capsule administration device for the rhesus monkey can prevent the rhesus monkey from crushing the capsule to influence the accuracy of the administration amount and the drug absorption, so that the success rate of capsule administration can reach 100%, the test quality is ensured, and effective reference is provided for clinical medication; and moreover, the possibility that the teeth of the rhesus monkey hurt people during capsule administration can be effectively avoided, and the safety of people is guaranteed to the greatest extent.

Description

Technical Field

[0001] This utility model relates to the field of laboratory animal equipment technology, specifically a capsule drug delivery device for rhesus monkeys. Background Technology

[0002] Rhesus monkeys are mammals belonging to the genus *Macaques* in the family Cercopithecidae of the order Primates. They possess high intelligence and complex social behaviors. As a primate with up to 94% genetic similarity to humans, they occupy an important position in the fields of psychology and biomedical research. In medical research, it is necessary to feed rhesus monkeys capsules to simulate the effects of human drug administration in order to evaluate the safety and effectiveness of drugs. By administering specific drugs or pathogens, researchers can simulate and study the disease responses of rhesus monkeys, providing a scientific basis for the prevention and treatment of human diseases.

[0003] In existing rhesus monkey drug delivery technology, the common method is to manually or using basic tools to insert the capsule into the monkey's mouth. This method has some obvious drawbacks and risks: because rhesus monkeys have a strong chewing instinct, they often involuntarily chew the capsule with their teeth during the drug delivery process. This behavior not only destroys the integrity of the capsule, but may also lead to leakage of the drug or uneven distribution due to chewing, thus affecting the accurate dosage entering the monkey's digestive system. As a result, the accuracy of experimental data and the evaluation of drug efficacy are interfered with, leading to unreliable experimental results. Furthermore, their teeth may cause injury to personnel during drug delivery, increasing the risk during the work process. Therefore, a capsule drug delivery device for rhesus monkeys is proposed to solve the above problems. Utility Model Content

[0004] To achieve the above objectives, this utility model provides the following technical solution: a capsule drug delivery device for rhesus monkeys, comprising a thick tube and a thin tube, wherein the thin tube is movably installed inside the thick tube, and a claw-shaped clamp is provided at the bottom of the thick tube;

[0005] The claw-shaped clamp includes mounting blocks. Mounting blocks are fixedly mounted on the left and right inner walls of the thick tube. Spring 1 is fixedly mounted on the bottom of each of the two mounting blocks. A movable block is fixedly mounted between the bottoms of the two spring 1s. A connecting rod is movably mounted on the bottom of the movable block. An adjusting plate is movably mounted on the bottom of each connecting rod. Spring 2 is fixedly mounted between the adjusting plate and the inner wall of the thick tube. A traction rope is fixedly mounted on the top of the movable block.

[0006] Furthermore, the outer surface of the movable block is slidably connected to the inner wall of the thick tube, and a circular hole is provided in the middle of the movable block, with the diameter of the circular hole being slightly larger than the outer diameter of the thin tube.

[0007] Furthermore, there are three connecting rods and three adjusting plates, and the three connecting rods and three adjusting plates are distributed at equal distances at the bottom of the movable block. The three connecting rods are rotatably installed between the movable block and the corresponding adjusting plate.

[0008] Furthermore, a pull ring is fixedly installed at the top of the live traction rope, and the outer diameter of the pull ring is larger than the inner diameter of the thick tube.

[0009] Furthermore, the thin tube has openings at both ends, the thick tube has an inlet at the top, and the bottom of the thin tube is conical.

[0010] Furthermore, both the thick and thin tubes are made of PVC, and the length of the thin tube is greater than the length of the thick tube.

[0011] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0012] This rhesus monkey capsule administration device avoids the rhesus monkeys from breaking the capsules, which would affect the accuracy of the dosage and drug absorption. It can achieve a 100% success rate in capsule administration, ensuring the quality of the experiment and providing an effective reference for clinical drug use. Furthermore, it can effectively avoid the possibility of the rhesus monkeys injuring humans with their teeth during capsule administration, thus maximizing human safety. Attached Figure Description

[0013] Fig. 1 This is a three-dimensional structural diagram of the present invention;

[0014] Fig. 2 This is a cross-sectional view of the thick tube of this utility model;

[0015] Fig. 3 This is a three-dimensional structural diagram of the movable block and adjusting plate of this utility model.

[0016] In the diagram: 1. Thick tube; 2. Thin tube; 3. Claw-shaped clamp; 301. Mounting block; 302. Spring 1; 303. Movable block; 304. Connecting rod; 305. Adjusting plate; 306. Spring 2; 307. Traction rope. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0018] Please see Figs. 1-3In this embodiment, a capsule drug delivery device for rhesus monkeys includes a thick tube 1 and a thin tube 2. The thin tube 2 is installed through the inside of the thick tube 1, and a claw-shaped clamp 3 is provided at the bottom of the thick tube 1.

[0019] Both the thick tube 1 and the thin tube 2 have circular cross-sections. The top of the thick tube 1 has an inlet, and the other end has a claw-shaped clamp 3. The inner and outer walls of the thick tube 1 are smooth.

[0020] Both ends of the thin tube 2 have openings. One end is connected to the syringe, and the other end is opened through the inlet on the thick tube 1 and can enter the stomach of the rhesus monkey. The end that enters the stomach is conical and smaller than the diameter of the capsule.

[0021] Both the thick tube 1 and the thin tube 2 are made of medical PVC material and are flexible. The thin tube 2 is longer than the thick tube 1, and the length of the thin tube can be determined according to the number of capsules to be administered at one time.

[0022] In use, the rhesus monkey is first secured to a monkey chair, with one person holding its head so that its mouth is slightly open. A thick tube 1 is inserted into the monkey's esophagus through its mouth. A thin tube 2, with its conical end coated with lubricant, is then inserted into the thick tube 1 through the inlet. The thin tube 2 then enters the monkey's stomach. The other end of the thin tube 2 is connected to a syringe, and the contents are aspirated. If food residue is found, it confirms that both the thick tube 1 and thin tube 2 have entered the stomach. The thin tube 2 is then removed, and the capsule is placed into the thick tube 1. The conical end of the thin tube 2 is then inserted into the thick tube 1 again, pushing the capsule into the stomach. Finally, both the thick tube 1 and thin tube 2 are pulled out together. This process ensures the capsule remains intact during delivery and accurately pushes it into the monkey's stomach, reducing direct contact between the operator and the monkey and significantly lowering safety risks.

[0023] The claw-shaped clamp 3 includes mounting blocks 301. Mounting blocks 301 are fixedly mounted on the left and right inner walls of the thick pipe 1. Spring 302 is fixedly mounted on the bottom of each of the two mounting blocks 301. Movable block 303 is fixedly mounted between the bottoms of the two springs 302. Connecting rod 304 is movably mounted on the bottom of the movable block 303. Adjusting plate 305 is movably mounted on the bottom of each connecting rod 304. Spring 306 is fixedly mounted between the adjusting plate 305 and the inner wall of the thick pipe 1. Traction rope 307 is fixedly mounted on the top of the movable block 303.

[0024] During the process of inserting the thick tube 1 orally into the esophagus of the rhesus monkey and into its stomach, the claw-shaped clamp 3 is in a closed state. At this time, the three adjusting plates 305 are closely adjacent to each other, forming a converging shape. On the one hand, this prevents damage to the outer wall of the digestive tract during insertion, protects the internal organs of the rhesus monkey from unnecessary harm, and ensures that the capsule will not accidentally fall off or be exposed before reaching the stomach, thus avoiding the release of the drug at a non-target location. On the other hand, it can prevent food residue and / or gastric juice from entering the thick tube 1.

[0025] Once the thick tube 1 accurately reaches the target position in the stomach, the three adjusting plates 305 unfold outwards. At this time, the thin tube 2 can smoothly pass through the space formed between the three adjusting plates 305, accurately pushing the capsule into the stomach. This ensures that the drug can be released in the appropriate position, thereby maximizing its efficacy and also ensuring the accuracy and reliability of the experiment.

[0026] The working principle of the claw-shaped clamp 3 is as follows: Under normal circumstances, spring 1 302 and spring 2 306 are in a naturally expanded state, and the three adjusting plates 305 are in a state of mutual contact, closing the bottom of the thick tube 1. When it is necessary to expand the three adjusting plates 305, the traction rope 307 is pulled upward by the pull ring. The traction rope 307 drives the movable block 303 to slide upward, squeezing the spring 1 302. The movable block 303 drives the three connecting rods 304 to rotate. The three connecting rods 304 drive the three adjusting plates 305 to rotate outward, squeezing the spring 2 306. At this time, the bottom of the thick tube 1 is opened.

[0027] In summary, this rhesus monkey capsule administration device avoids the rhesus monkeys from crushing the capsules, which would affect the accuracy of the dosage and drug absorption. It can achieve a 100% success rate in capsule administration, ensuring the quality of the experiment and providing an effective reference for clinical drug use. Furthermore, it can effectively avoid the possibility of the rhesus monkeys injuring humans with their teeth during capsule administration, thus maximizing human safety.

[0028] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0029] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A capsule administration device for rhesus monkeys comprising a thick tube (1) and a thin tube (2), characterized in that: The inside of the thick pipe (1) is movably provided with a thin pipe (2), and the bottom of the thick pipe (1) is provided with a claw-shaped clamp (3). The claw-shaped clamp (3) comprises a mounting block (301), the left and right inner walls of the thick pipe (1) are fixedly provided with the mounting block (301), the bottom of the two mounting blocks (301) is fixedly provided with a spring (302), the bottom of the two springs (302) is fixedly provided with a movable block (303), the bottom of the movable block (303) is movably provided with a connecting rod (304), the bottom of the connecting rod (304) is movably provided with an adjusting plate (305), the adjusting plate (305) and the inner wall of the thick pipe (1) are fixedly provided with a spring (306), and the top of the movable block (303) is fixedly provided with a traction rope (307).

2. A capsule delivery device for rhesus monkeys according to claim 1, characterized in that: The outer surface of the movable block (303) is slidably connected with the inner wall of the thick pipe (1), the middle of the movable block (303) is provided with a circular hole, and the diameter of the circular hole is slightly larger than the outer diameter of the thin pipe (2).

3. The capsule delivery device for rhesus monkeys according to claim 1, characterized in that: The number of the connecting rod (304) and the adjusting plate (305) is three, and the three connecting rods (304) and the three adjusting plates (305) are equidistantly distributed on the bottom of the movable block (303), and the three connecting rods (304) are rotatably installed between the movable block (303) and the corresponding adjusting plate (305).

4. The capsule delivery device for rhesus monkeys according to claim 1, characterized by: The top of the traction rope (307) is fixedly provided with a pull ring, and the outer diameter of the pull ring is larger than the inner diameter of the thick pipe (1).

5. The capsule delivery device for rhesus monkeys according to claim 1, characterized by: The two ends of the thin pipe (2) are provided with openings, the top of the thick pipe (1) is provided with a pipe inlet, and the bottom of the thin pipe (2) is conical.

6. The capsule delivery device for rhesus monkeys according to claim 1, characterized by: The thick pipe (1) and the thin pipe (2) are made of medical PVC, and the length of the thin pipe (2) is greater than the length of the thick pipe (1).

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