Exosome extraction kit

Abstract

The utility model discloses an exosome extraction kit and relates to the technical field of medical instruments. The kit comprises a kit shell, a carrying grip is fixedly connected to the side face of the kit shell, a power bin is formed in the kit shell, and a reagent sealing mechanism is arranged in the kit shell. When reagent tubes need to be stored, a worker places the reagent tubes in the reagent storage seat through the kit shell, then a rotating wheel is screwed, the reagent tubes enter the kit shell through meshing between a transmission gear and a rack moving plate, meanwhile, a threaded transmission shaft drives a reagent sealing plate to move downwards, and the reagent tubes are stored in the reagent storage seat. According to the reagent tube sealing device, the reagent tube in the reagent storage seat is overlapped with the reagent sealing plate, the reagent tube enters the fixed inlaying groove, and the reagent tube is fixedly sealed, so that the effect of sealing the reagent tube is achieved, and the reagent tube is effectively prevented from leaking during placement.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of medical devices, especially relates to a exosome extraction kit. BACKGROUND

[0002] Exosomes are phospholipid bilayer-enclosed vesicles released into the extracellular environment after fusion of intracellular multivesicular bodies with the plasma membrane, with a diameter of about 40-100 nm. Exosomes naturally exist in body fluids, including blood, saliva, urine, cerebrospinal fluid and breast milk.

[0003] According to the exosome extraction kit (public number: CN 217171413U) of the publicity: including main box body, the one end of main box body top is equipped with the installation mouth, the transparent baffle is slidably inserted in the installation mouth, the one end of transparent baffle penetrates the inner wall of installation mouth and is fixedly connected with the clamping block, the outer wall of main box body is equipped with the sliding slot, the supporting rod is fixedly connected in the sliding slot, the L-shaped clamping rod is slidably sleeved on the supporting rod, the clamping block is equipped with the clamping groove corresponding with L-shaped clamping rod, the main box body is rotatably connected with the rotating disc through the fixed rod, the rotating disc is fixedly connected with a plurality of supporting sleeves on the top edge, the bottom of main box body is equipped with the cavity corresponding with fixed rod, the one end of fixed rod in the cavity is fixedly sleeved with the first gear.

[0004] In the above application, the reagent tube is stored in the main box body, and the sealing function of the reagent tube is difficult to solve, which leads to leakage during the storage of the reagent tube, therefore we propose a exosome extraction kit. Utility model content

[0005] The utility model discloses a exosome extraction kit, through the mutual cooperation between the screw transmission shaft of reagent sealing mechanism, reagent storage seat and reagent sealing plate and other components, when needing to store reagent tube, the staff places reagent tube in reagent storage seat inside through reagent kit shell, then twists rotating wheel, makes reagent storage seat move and drive reagent tube enter reagent kit shell inside through the meshing between transmission gear and rack moving plate, and screw transmission shaft drives reagent sealing plate to move down, makes reagent tube in reagent storage seat coincide with reagent sealing plate, and reagent tube enters fixed inlay groove inside, fixes and seals reagent tube, and this design reaches the effect that reagent tube is sealed, effectively prevents reagent tube from leaking in placement, and solves the existing problem.

[0006] To solve the above technical problems, the utility model is realized by the following technical schemes:

[0007] The utility model discloses an exosome extraction kit, including reagent box casing, the side fixedly connected with carrying handle of reagent box casing, the inside of reagent box casing is equipped with power store, the inside of reagent box casing is provided with reagent sealing mechanism,

[0008] The reagent sealing mechanism includes a threaded transmission shaft, the circumference of the threaded transmission shaft is through the top of the reagent box casing, and is rotatably connected with the top of the reagent box casing, one end of the threaded transmission shaft is fixedly connected with a rotating wheel, the end of the threaded transmission shaft away from the bottom of the rotating wheel is fixedly connected with a rotating shaft, the circumference of the rotating shaft is fixedly penetrated with a transmission gear, the inside of the reagent box casing is provided with a sliding groove, the sliding groove is slidably connected with a rack moving plate, and the top of the rack moving plate is fixedly connected with a reagent storage seat.

[0009] Further, the circumference of the threaded transmission shaft is threadedly connected with a threaded sleeve, the side of the threaded sleeve is fixedly connected with a moving rod, the inside of the reagent box casing is provided with a moving groove, the side of the moving rod is slidably connected with the inside of the moving groove, and the end of the moving rod away from the side of the threaded sleeve is fixedly connected with a reagent sealing plate.

[0010] Further, the bottom of the reagent sealing plate is provided with a fixed inlaid groove, the circumference of the threaded transmission shaft is fixedly penetrated with a limiting plate, and the fixed inlaid groove can stably fix each reagent tube without shaking, and the limiting plate limits the displacement distance of the threaded sleeve.

[0011] Further, the circumference of the transmission gear is meshed with the side of the rack moving plate, the number of the carrying handles is two, and the carrying handles are mutually symmetrical along the vertical central axis of the reagent box casing, the transmission gear is meshed with the side of the rack moving plate to ensure that the rotation of the transmission gear can drive the rack moving plate to move, and the number of the carrying handles is two, and the carrying handles are mutually symmetrical along the vertical central axis of the reagent box casing to facilitate the transportation of the reagent box casing by workers.

[0012] Further, the inside of the kit shell is provided with a locking mechanism, the locking mechanism comprises a driving bevel gear, the top of the driving bevel gear is fixedly penetrated on the circumferential surface of the rotating shaft, the inner wall of the power bin is rotationally connected with a supporting shaft, the circumferential surface of the supporting shaft is fixedly penetrated with a driven bevel gear, the circumferential surface of the supporting shaft is provided with a chain, the circumferential surface of the supporting shaft is drivingly connected with a control shaft through the chain, the circumferential surface of the control shaft is rotationally connected with the top of the kit shell, the circumferential surface of the control shaft is fixedly connected with a locking plate, the inside of the kit shell is provided with the locking mechanism, and the locking mechanism is used for locking the kit shell, preventing sundries from entering the inside of the kit shell through the kit shell inlet and causing damage to the reagent tube.

[0013] Further, the side surface of the locking plate is fixedly connected with a spring locking buckle, and the top of the kit shell is provided with a locking groove, so that the locking plate is more stably locked through the spring locking buckle and the locking groove.

[0014] Further, the circumferential surface of the supporting shaft and the inside of the chain are engaged with each other, and the inside of the chain and the circumferential surface of the control shaft are engaged with each other, so that the supporting shaft can drive the control shaft to rotate through the chain.

[0015] The utility model has the following beneficial effects:

[0016] 1, the utility model discloses a threaded transmission shaft, reagent storage seat and reagent sealing plate and other components between the mutual cooperation of reagent sealing mechanism, when needing to store reagent tube, the staff puts reagent tube through reagent kit shell and places in reagent storage seat inside, then twists rotating wheel, engages between transmission gear and rack moving plate, makes reagent storage seat move and drives reagent tube to enter reagent kit shell inside, simultaneously, threaded transmission shaft drives reagent sealing plate to move down, makes reagent tube in reagent storage seat and reagent sealing plate coincide, reagent tube enters fixed inlay groove inside, fixes and seals reagent tube, and this design reaches the effect that reagent tube is sealed, effectively prevents reagent tube from leaking in placement.

[0017] 2, the utility model discloses the mutual cooperation of driving bevel gear, locking plate and spring locking buckle and other components between the locking mechanism, simultaneously, through the engagement between driving bevel gear and driven bevel gear, when reagent sealing mechanism starts, makes locking plate rotate counterclockwise and seals reagent kit shell inlet, locking plate rotates and drives spring locking buckle to move, makes spring locking buckle enter locking groove inside, and then locks locking plate, and this design reaches the effect that reagent kit is locked, effectively prevents sundries from entering reagent kit shell inside through reagent kit shell inlet and causing damage to reagent tube.

[0018] Of course, any product implementing the utility model does not necessarily need to achieve all the advantages described above. Attached Figure Description

[0019] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a structural schematic diagram of the overall three-dimensional appearance of the reagent kit of this utility model;

[0021] Figure 2 This is a schematic diagram of the overall three-dimensional cross-section of the reagent kit of this utility model;

[0022] Figure 3 This utility model Figure 2 A three-dimensional magnified structural diagram of A in the diagram;

[0023] Figure 4 This utility model Figure 2 A three-dimensional magnified structural diagram of B.

[0024] The attached diagram lists the components represented by each number as follows:

[0025] 1. Reagent kit shell; 2. Carrying handle; 3. Power chamber; 4. Reagent sealing mechanism; 41. Threaded drive shaft; 42. Rotating wheel; 43. Rotating shaft; 44. Transmission gear; 45. Slide groove; 46. Rack and pinion moving plate; 47. Reagent storage base; 48. Threaded sleeve; 49. Moving rod; 410. Moving groove; 411. Reagent sealing plate; 412. Fixed embedding groove; 413. Limiting plate; 5. Locking mechanism; 51. Driving bevel gear; 52. Support shaft; 53. Driven bevel gear; 54. Chain; 55. Control shaft; 56. Locking plate; 57. Spring locking buckle; 58. Locking groove. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present utility model.

[0027] Please see Figures 1-4The utility model relates to an exosome extraction kit, including reagent box shell 1, the side fixed connection of reagent box shell 1 has the carrying handle 2, the inside of reagent box shell 1 is equipped with power bin 3, and the inside of reagent box shell 1 is provided with reagent sealing mechanism 4,

[0028] The reagent sealing mechanism 4 includes a threaded transmission shaft 41, the circumference of the threaded transmission shaft 41 is through the top of the reagent box shell 1, and is rotatably connected with the top of the reagent box shell 1, one end of the threaded transmission shaft 41 is fixedly connected with a rotating wheel 42, the end of the threaded transmission shaft 41 away from the bottom of the rotating wheel 42 is fixedly connected with a rotating shaft 43, the circumference of the rotating shaft 43 is fixedly penetrated with a transmission gear 44, the inside of the reagent box shell 1 is provided with a sliding groove 45, the inside of the sliding groove 45 is slidably connected with a rack moving plate 46, the top of the rack moving plate 46 is fixedly connected with a reagent storage seat 47.

[0029] The circumference of the threaded transmission shaft 41 is threadedly connected with a threaded sleeve 48, the side of the threaded sleeve 48 is fixedly connected with a moving rod 49, the inside of the reagent box shell 1 is provided with a moving groove 410, the side of the moving rod 49 is slidably connected with the inside of the moving groove 410, the end of the moving rod 49 away from the side of the threaded sleeve 48 is fixedly connected with a reagent sealing plate 411, which seals the outlet of the reagent tube and fixes the reagent tube at the same time, providing double protection.

[0030] The bottom of the reagent sealing plate 411 is provided with a fixed inlaid groove 412, the circumference of the threaded transmission shaft 41 is fixedly penetrated with a limiting plate 413, the fixed inlaid groove 412 can stably fix each reagent tube without shaking, and the limiting plate 413 limits the displacement distance of the threaded sleeve 48.

[0031] The circumference of the transmission gear 44 is meshed with the side of the rack moving plate 46, the number of the carrying handle 2 is two, and is mutually symmetrical along the vertical central axis of the reagent box shell 1, the circumference of the transmission gear 44 is meshed with the side of the rack moving plate 46, which ensures that the rotation of the transmission gear 44 can drive the rack moving plate 46 to move, and the number of the carrying handle 2 is two, and is mutually symmetrical along the vertical central axis of the reagent box shell 1, which facilitates the transportation of the reagent box shell 1 by the staff.

[0032] The inside of the reagent box shell 1 is provided with a locking mechanism 5, the locking mechanism 5 comprises a driving bevel gear 51, the top of the driving bevel gear 51 is fixedly penetrated on the circumferential surface of the rotating shaft 43, the inner wall of the power bin 3 is rotationally connected with a supporting shaft 52, the circumferential surface of the supporting shaft 52 is fixedly penetrated with a driven bevel gear 53, the circumferential surface of the supporting shaft 52 is provided with a chain 54, the circumferential surface of the supporting shaft 52 is drivingly connected with a control shaft 55 through the chain 54, the circumferential surface of the control shaft 55 is rotationally connected with the top of the reagent box shell 1, the circumferential surface of the control shaft 55 is fixedly connected with a locking plate 56, the inside of the reagent box shell 1 is provided with the locking mechanism 5, which is used for locking the reagent box shell 1, preventing sundries from entering the inside of the reagent box shell 1 through the entrance of the reagent box shell 1 to damage the reagent tube.

[0033] The side surface of the locking plate 56 is fixedly connected with a spring locking buckle 57, the top of the reagent box shell 1 is provided with a locking groove 58, the spring locking buckle 57 and the locking groove 58 make the locking plate 56 more stably locked.

[0034] The circumferential surface of the supporting shaft 52 and the inside of the chain 54 are mutually engaged, the inside of the chain 54 and the circumferential surface of the control shaft 55 are mutually engaged, so that the supporting shaft 52 can drive the control shaft 55 to rotate through the chain 54.

[0035] One specific application of the embodiment is that when the reagent tube needs to be stored, the worker places the reagent tube in the reagent storage seat 47 through the reagent box shell 1, then twists the rotating wheel 42, the rotating wheel 42 rotates clockwise, the rotating wheel 42 drives the rotating shaft 43 to rotate clockwise through the threaded transmission shaft 41, the rotating shaft 43 drives the transmission gear 44 to rotate clockwise, the transmission gear 44 and the rack moving plate 46 are engaged, so that the transmission gear 44 drives the rack moving plate 46 to move left and right, the rack moving plate 46 drives the reagent storage seat 47 to move left and right, the reagent storage seat 47 drives the reagent tube to enter the inside of the reagent box shell 1, at the same time, the threaded transmission shaft 41 drives the threaded sleeve 48 to move downward, the threaded sleeve 48 drives the moving rod 49 to move downward in the moving groove 410, the moving rod 49 drives the reagent sealing plate 411 to move downward, so that the reagent tube in the reagent storage seat 47 coincides with the reagent sealing plate 411, the reagent tube enters the fixed inlaid groove 412 to be fixed and sealed.

[0036] In order to prevent sundries from entering the inside of the reagent tube through the entrance of the kit shell 1, the reagent sealing mechanism 4 is started, the rotating shaft 43 rotates clockwise to drive the driving bevel gear 51 to rotate clockwise, the driving bevel gear 51 and the driven bevel gear 53 are engaged, the driving bevel gear 51 drives the supporting shaft 52 to rotate counterclockwise through the driven bevel gear 53, the supporting shaft 52 rotates counterclockwise to drive the control shaft 55 to rotate counterclockwise through the chain 54, the control shaft 55 rotates counterclockwise to drive the locking plate 56 to rotate counterclockwise to seal the entrance of the kit shell 1, the locking plate 56 rotates to drive the spring locking buckle 57 to move, so that the spring locking buckle 57 enters the inside of the locking groove 58, and the locking plate 56 is locked.

[0037] In the description of the present specification, the description of the terms "one embodiment", "example", "specific example" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0038] The preferred embodiments of the above disclosed application are only used to help explain the application. The preferred embodiments do not describe all the details, nor limit the application to the specific embodiments described. Obviously, according to the content of the present specification, many modifications and changes can be made. The present specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the application, so that those skilled in the art can well understand and utilize the application. The application is limited by the claims and their entire scope and equivalents.

Claims

1. An exosome extraction kit, characterized by, The utility model provides a reagent box, including the shell (1) of reagent box, the side fixed connection of shell (1) carries the handle (2), the inside of shell (1) is opened power compartment (3), the inside of shell (1) is provided with reagent sealing mechanism (4), The reagent sealing mechanism (4) includes a threaded transmission shaft (41), the circumferential surface of the threaded transmission shaft (41) penetrates the top of the reagent box shell (1), and is rotatably connected with the top of the reagent box shell (1), one end of the threaded transmission shaft (41) is fixedly connected with a rotating wheel (42), the end of the threaded transmission shaft (41) away from the bottom of the rotating wheel (42) is fixedly connected with a rotating shaft (43), the circumferential surface of the rotating shaft (43) is fixedly penetrated with a transmission gear (44), the inside of the reagent box shell (1) is opened with a sliding groove (45), the inside of the sliding groove (45) is slidably connected with a rack moving plate (46), the top of the rack moving plate (46) is fixedly connected with a reagent storage seat (47).

2. The exosome extraction kit of claim 1, wherein, The circumferential surface of the threaded transmission shaft (41) is threadedly connected with a threaded sleeve (48), the side of the threaded sleeve (48) is fixedly connected with a moving rod (49), the inside of the reagent box shell (1) is opened with a moving groove (410), the side of the moving rod (49) is slidably connected with the inside of the moving groove (410), the end of the moving rod (49) away from the side of the threaded sleeve (48) is fixedly connected with a reagent sealing plate (411).

3. The exosome extraction kit of claim 2, wherein, The bottom of the reagent sealing plate (411) is opened with a fixed inlaid groove (412), the circumferential surface of the threaded transmission shaft (41) is fixedly penetrated with a limiting plate (413).

4. The exosome extraction kit of claim 1, wherein, The circumferential surface of the transmission gear (44) and the side of the rack moving plate (46) are mutually engaged, the number of the carrying handle (2) is two, and they are mutually symmetrical along the vertical central axis of the reagent box shell (1).

5. The exosome extraction kit of claim 1, wherein, The inside of the reagent box shell (1) is provided with a locking mechanism (5), the locking mechanism (5) includes a driving bevel gear (51), the top of the driving bevel gear (51) is fixedly penetrated on the circumferential surface of the rotating shaft (43), the inner wall of the power compartment (3) is rotatably connected with a support shaft (52), the circumferential surface of the support shaft (52) is fixedly penetrated with a driven bevel gear (53), the circumferential surface of the support shaft (52) is provided with a chain (54), the circumferential surface of the support shaft (52) is drivingly connected with a control shaft (55) through the chain (54), the circumferential surface of the control shaft (55) is rotatably connected with the top of the reagent box shell (1), the circumferential surface of the control shaft (55) is fixedly connected with a locking plate (56).

6. The exosome extraction kit of claim 5, wherein, The side of the locking plate (56) is fixedly connected with a spring locking buckle (57), the top of the reagent box shell (1) is opened with a locking groove (58).

7. The exosome extraction kit of claim 5, wherein, The circumferential surface of the support shaft (52) and the inside of the chain (54) are mutually engaged, the inside of the chain (54) and the circumferential surface of the control shaft (55) are mutually engaged.

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