Cell separation equipment

Abstract

The utility model relates to cell separation equipment, and relates to the technical field of cell treatment. The cell separation equipment comprises a magnetic driving device and a consumable barrel, wherein the consumable barrel is detachably connected with the magnetic driving device; the consumable barrel comprises an inner barrel and an outer barrel; the inner cylinder is coaxially arranged in the outer cylinder at an interval and is rotatably connected with the outer cylinder; a filter membrane is arranged in at least partial area of the side surface of the outer wall of the inner cylinder; the outer cylinder is provided with a liquid inlet, a liquid outlet and a waste liquid opening; the liquid inlet is communicated to a gap area between the filter membrane and the outer cylinder; the liquid outlet is communicated to a gap area between the inner cylinder and the filter membrane; the waste liquid port is communicated to a gap area between the filter membrane and the outer cylinder; and the magnetic driving device drives the inner cylinder to rotate. According to the utility model, the to-be-treated liquid can be continuously supplemented and cell sap and waste liquid can be continuously discharged in the working process, so that the technical effect of continuously separating the cell sap is achieved.

Description

TECHNICAL FIELD

[0001] The utility model relates to cell processing technical field especially relates to a cell separation equipment. BACKGROUND

[0002] In prior art, full-automatic cell processing mode adopts ordinary consumables and centrifugal mode. When centrifugal purification is needed, it needs to be carried out in batches. After liquid is injected into consumables, liquid sending is stopped and centrifugal is carried out. After the end, it can be extracted and replaced. The liquid volume of one processing is less. The processing liquid needs to contact with structure or the replacement of centrifugal consumables is more cumbersome. The time is longer. SUMMARY

[0003] The utility model provides a kind of cell separation equipment to solve at least one technical problem in the above background technique.

[0004] The utility model provides a kind of cell separation equipment, including magnetic drive device and consumable cylinder, the consumable cylinder with the magnetic drive device is detachably connected;The consumable cylinder includes inner tube and outer tube;The inner tube is coaxially spaced apart and is arranged in the outer tube, and with the outer tube rotatable connection;The side of the outer wall of the inner tube is at least partially region and is provided with filter membrane;The outer tube is equipped with liquid inlet, liquid outlet and waste liquid port;The liquid inlet is communicated to the clearance area between the filter membrane and the outer tube;The liquid outlet is communicated to the clearance area between the inner tube and the filter membrane;The waste liquid port is communicated to the clearance area between the filter membrane and the outer tube;Wherein, the magnetic drive device is used to drive the inner tube rotation.

[0005] Further technical solutions are that the magnetic drive device includes drive motor, transmission unit and magnetic ring;The drive motor is connected with transmission unit, and the transmission unit is connected with the magnetic ring;Wherein, the drive motor drives the magnetic ring rotation by the transmission unit.

[0006] Further technical solutions are that the consumable cylinder further includes magnetic attraction block, and the magnetic attraction block is fixedly connected with the inner tube.

[0007] Further technical solutions are that the transmission unit includes synchronous belt, driving wheel and driven wheel, the synchronous belt is sleeved between the driving wheel and the driven wheel, the driving wheel is connected with the drive motor, the driven wheel is connected with the magnetic ring, and the magnetic ring is arranged on one side of the magnetic attraction block.

[0008] Further technical solutions are that the transmission unit further includes rotating main shaft, one end of the rotating main shaft is connected with the driven wheel through bearing, and the other end of the rotating main shaft is connected with the magnetic ring.

[0009] Further, the technical scheme is further comprising a support column and a mounting seat, the mounting seat is arranged on the support column, and the driving wheel and the driven wheel are arranged on the mounting seat.

[0010] Further, the technical scheme is further comprising an upper cover, the upper cover covers the driven wheel and is connected with the mounting seat.

[0011] Further, the technical scheme is further comprising a motor flange, the driving motor is connected with the mounting seat through the motor flange, and the driving motor is arranged on the upper side of the driving wheel.

[0012] Further, the technical scheme is further comprising an adjusting block, the adjusting block is fixedly connected with the motor flange, and the adjusting block is connected with the mounting seat through an adjusting screw.

[0013] Further, the technical scheme is further comprising a bottom cover, the bottom cover covers the magnetic ring and is connected with the mounting seat.

[0014] Compared with the prior art, the above technical scheme provided by the embodiment of the utility model has the following advantages:

[0015] In the technical scheme of the embodiment of the utility model, the cell separation equipment comprises a magnetic driving device and a consumable cylinder, the consumable cylinder is detachably connected with the magnetic driving device, the consumable cylinder comprises an inner cylinder and an outer cylinder, the side surface of the outer wall of the inner cylinder is provided with a filter membrane in at least a partial region, the inner cylinder is coaxially and spacedly arranged in the outer cylinder and is rotatably connected with the outer cylinder, the outer cylinder is provided with a liquid inlet, a liquid outlet and a waste liquid outlet, the liquid inlet is communicated to the gap region between the inner cylinder and the outer cylinder, the liquid outlet is communicated to the inner cylinder, the waste liquid outlet is communicated to the gap region between the inner cylinder and the outer cylinder, and the magnetic driving device is used for driving the inner cylinder to rotate.The utility model can continuously supplement the liquid to be treated in the working process, simultaneously discharges the separated cell liquid and waste liquid in real time, thereby realizing uninterrupted continuous treatment, achieving the technical effect of continuously separating and treating the cell liquid and greatly improving the treatment efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0016] The drawings incorporated into the description and forming part of the description show embodiments consistent with the utility model and, together with the description, serve to explain the principle of the utility model.

[0017] In order to more clearly illustrate the technical scheme in the embodiments of the utility model or the prior art, the drawings needed to be used in the embodiment or the prior art description will be briefly introduced as follows, and obviously, other drawings can be obtained by those skilled in the art without creative labor.

[0018] One or more embodiments are illustrated by way of example in the drawings hereof, which are not intended to limit the embodiments to the views presented in such drawings. Elements having the same reference number designates an identical part throughout the drawings. The drawings in which the embodiments are not necessarily to scale, presenting a generalized illustration of various aspects and embodiments of the present application.

[0019] Figure 1 An exploded view of the cell separation device provided by the embodiments of the present application;

[0020] Figure 2 A structural schematic view of the cell separation device provided by the embodiments of the present application;

[0021] Figure 3 A structural schematic view of the consumable cartridge of the cell separation device provided by the embodiments of the present application;

[0022] Figure 4 A sectional view along H-H of the consumable cartridge in Figure 3

[0023] Figure 5 An enlarged schematic view of part A in Figure 4

[0024] Reference signs

[0025] Drive motor 1, motor flange 2, driving wheel 3, mounting seat 4, support column 5, adjusting block 6, upper housing 7, synchronous belt 8, bearing 9, rotating main shaft 10, magnetic ring 11, bottom housing 12, consumable cartridge 13, driven wheel 14, inner cylinder 15, outer cylinder 16, liquid inlet 17, waste liquid outlet 18, liquid outlet 19, rotating shaft 20, magnetic attraction block 21, adjusting screw 22, filter membrane 23. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme of the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0027] ​​The disclosure below provides many different embodiments or examples for implementing different structures of the present application. In order to simplify the disclosure of the present application, the components and settings of specific examples are described below. Of course, they are only examples and the purpose is not to limit the present application. In addition, the present application can refer to the same reference numerals and / or letters in different examples. Such repetition is for the purpose of simplification and clarity, and does not indicate the relationship between the various embodiments and / or settings discussed.

[0028] For the convenience of description, spatial relative terms can be used in the text to describe the relative position relationship or motion condition of one element or feature with respect to another element or feature as shown in the figure, such as "internal", "external", "inboard", "outboard", "under", "below", "on", "above", "front", "back", etc. Such spatial relative terms are intended to include different orientations of the device in use or operation in addition to the orientation depicted in the figure. For example, if the device in the figure is flipped over or the posture is changed or the motion state is changed, the directional indications will also change accordingly, for example: the element described as "under" or "below" other elements or features will be oriented as "above" or "above" other elements or features. Therefore, the example term "below" can include both up and down positions. The device can be additionally oriented (rotated 90 degrees or in other directions) and the spatial relative relationship descriptors used in the text are interpreted accordingly.

[0029] In order to solve the technical problems of low efficiency and inability to continuously process cell liquid separation of consumables in the prior art, the present application provides a cell separation device, which can realize continuous processing of cell liquid separation and has the advantages of high efficiency.

[0030] Referring to Figures 1-5 The cell separation device provided by the embodiment of the present application comprises a magnetic driving device and a consumable barrel 13, and the specific structure is introduced as follows:

[0031] The consumable barrel 13 is detachably connected with the magnetic driving device, for example, by plug-in connection; the consumable barrel 13 comprises an inner barrel 15 and an outer barrel 16; at least part of the side surface of the outer wall of the inner barrel 15 is provided with a filter membrane 23. The filter membrane 23 with appropriate parameters can be selected according to actual needs to allow impurity substances to pass through, while cells cannot pass through, so as to realize cell separation. In other embodiments, the positions of the outlet port 19 and the waste liquid port 18 can also be exchanged according to the separation needs, which is not limited by the present application.

[0032] Further referring to Figures 3-5The inner cylinder 15 is coaxially and spacedly arranged in the outer cylinder 16 and rotatably connected with the outer cylinder 16, for example, the inner cylinder 15 is coaxially and spacedly arranged in the outer cylinder 16 through the rotating shaft 20 and rotatably connected with the outer cylinder 16. The inner cylinder 15 and the outer cylinder 16 have a gap; that is, the filter membrane 23 is arranged in the gap region between the inner cylinder 15 and the outer cylinder 16, and the gap region between the inner cylinder 15 and the outer cylinder 16 is divided into two gap regions by the filter membrane 23.

[0033] The outer cylinder 16 is provided with a liquid inlet 17, a waste liquid outlet 18 and a liquid outlet 19; the liquid inlet 17 is communicated to the gap region between the filter membrane 23 and the outer cylinder 16; the waste liquid outlet 18 is communicated to the gap region between the inner cylinder 15 and the filter membrane 23; and the liquid outlet 19 is communicated to the gap region between the filter membrane 23 and the outer cylinder 16. Specifically, the liquid inlet 17 is arranged at the middle upper part of the outer cylinder 16, and the waste liquid outlet 18 and the liquid outlet 19 are arranged at the lower part of the outer cylinder 16. The magnetic driving device is used to drive the rotation of the inner cylinder 15.

[0034] In operation, the outer cylinder 16 remains stable and does not move, the liquid to be treated enters the gap region between the filter membrane 23 and the outer cylinder 16 from the liquid inlet 17, the magnetic driving device drives the rotation of the inner cylinder 15, the inner cylinder 15 and the outer cylinder 16 generate a flow rate difference, so that the impurities enter the gap region between the filter membrane 23 and the inner cylinder 15 through the filter membrane 23, while the cells are blocked and cannot pass through, thereby realizing the separation of the cells in the liquid, the separated cell liquid is discharged through the liquid outlet 19, and the impurities are discharged through the waste liquid outlet 18. During the operation, the liquid to be treated can be continuously supplemented and the cell liquid and waste liquid can be continuously discharged, so as to achieve the technical effect of continuously separating and processing the cell liquid.

[0035] The technical scheme of the embodiment of the utility model discloses, cell separation equipment includes magnetic drive device and consumable cylinder 13, consumable cylinder 13 with magnetic drive device detachable connection, consumable cylinder 13 includes inner tube 15 and outer tube 16, the lateral wall of inner tube 15 is filter membrane at least partial area, inner tube 15 is coaxially spaced and located in outer tube 16, and with outer tube 16 rotatable connection, outer tube 16 is equipped with liquid inlet 17, waste liquid port 18 and liquid outlet 19, liquid inlet 17 is communicated to the clearance area between inner tube 15 and outer tube 16, waste liquid port 18 is communicated to inner tube 15, liquid outlet 19 is communicated to the clearance area between inner tube 15 and outer tube 16, wherein, the magnetic drive device is used to drive inner tube 15 rotation, the utility model discloses can realize the continuous replenishment of the liquid to be handled in working process, simultaneously, the cell liquid and waste liquid after separation are discharged in real time, to realize uninterrupted continuous processing, reach the technical effect of continuously carrying out cell liquid separation processing, greatly improve the processing efficiency.Compared with prior art, the utility model realizes continuous separation by the rotation of inner tube driven by magnetic force, avoids the problem of frequent replacement of consumables.

[0036] In some embodiments, for example in the present embodiment, the magnetic drive device includes a drive motor 1, a transmission unit and a magnetic ring 11, the drive motor 1 is connected with the transmission unit, the transmission unit is connected with the magnetic ring 11, wherein the drive motor 1 drives the magnetic ring 11 to rotate through the transmission unit. Specifically, the transmission unit plays the role of power transmission, and transmits the power of the drive motor 1 to the magnetic ring 11 to drive the magnetic ring 11 to rotate, and the magnetic ring 11 drives the inner tube 15 to rotate.

[0037] Further, the consumable cylinder 13 further includes a magnetic attraction block 21, and the magnetic attraction block 21 is fixedly connected with the inner tube 15. Specifically, when the magnetic ring 11 rotates, the magnetic attraction block 21 is driven to rotate, thereby driving the inner tube 15 to rotate.

[0038] Further, the transmission unit includes a synchronous belt 8, a driving wheel 3 and a driven wheel 14, the synchronous belt 8 is sleeved between the driving wheel 3 and the driven wheel 14, the driving wheel 3 is connected with the drive motor 1, the driven wheel 14 is connected with the magnetic ring 11, and the magnetic ring 11 is arranged on one side of the magnetic attraction block 21. Specifically, the drive motor 1 drives the driving wheel 3 to rotate, the driving wheel 3 drives the driven wheel 14 to rotate through the synchronous belt 8, the driven wheel 14 drives the magnetic ring 11 to rotate, and the magnetic ring 11 drives the inner tube 15 to rotate.

[0039] Further, the transmission unit further comprises a rotating main shaft 10, one end of the rotating main shaft 10 is connected with the driven wheel 14 through a bearing 9, and the other end of the rotating main shaft 10 is connected with the magnetic ring 11. Specifically, the rotating main shaft 10 plays a role of transmitting the power of the driven wheel 14. The bearing 9 is connected to the mounting base 4, the rotating main shaft 10 is connected to the bearing 9, and the magnetic ring 11 is fixed to the rotating main shaft 10.

[0040] Further, the cell separation device further comprises a support column 5 and a mounting base 4, the mounting base 4 is arranged on the support column 5, and the driving wheel 3 and the driven wheel 14 are arranged on the mounting base 4. The support column 5 plays a role of overall support and can be arranged on a mounting platform. The mounting base 4 plays a role of mounting carrier and is used for mounting components of the cell separation device.

[0041] Further, the cell separation device further comprises an upper cover 7, the upper cover 7 covers the driven wheel 14 and is connected with the mounting base 4. Specifically, the upper cover 7 plays a role of protecting components and can improve the appearance.

[0042] Further, the cell separation device further comprises a motor flange 2, the driving motor 1 is connected with the mounting base 4 through the motor flange 2, and the driving motor 1 is arranged on the upper side of the driving wheel 3 and is convenient to be connected with the driving wheel 3. The motor flange 2 plays a role of mounting the driving motor 1 to the mounting base 4.

[0043] Further, the cell separation device further comprises an adjusting block 6, the adjusting block 6 is fixedly connected with the motor flange 2, and the adjusting block 6 is connected with the mounting base 4 through an adjusting screw 22. The position of the motor flange 2 on the mounting base 4 can be adjusted through the adjusting screw 22, so as to adjust the tightness of the synchronous belt 8. After the adjusting screw 22 is adjusted, the motor flange 2 is fixedly connected with the mounting base 4, for example, through fasteners, and the adjusting screw 22 is fixed through a fastening screw.

[0044] Further, the cell separation device further comprises a bottom cover 12, the bottom cover 12 covers the magnetic ring 11 and is connected with the mounting base 4. Specifically, the upper cover 7 plays a role of protecting components and can improve the appearance.

[0045] In the above embodiments, the description of each embodiment has its own focus, and the parts not described in detail in a certain embodiment can be referred to the related description of other embodiments.

[0046] In the description of the utility model, it is understood that the directions or positional relationships indicated by the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like are the directions or positional relationships shown based on the drawings, and are only for the convenience of describing the utility model and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the utility model.

[0047] In addition, the terms "first" and "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first" and "second" can explicitly or implicitly include one or more of the features. In the description of the utility model, the meaning of "multiple" is two or more than two, unless otherwise specifically limited.

[0048] In the utility model, unless otherwise specifically defined and limited, the terms "mounting", "connection", "connection", "fixing" and the like should be understood broadly, for example, it can be connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication or interaction relationship between two elements. For ordinary skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0049] In the utility model, unless otherwise specifically defined and limited, the "upper" or "lower" of the first feature to the second feature can include that the first and second features are in direct contact, or the first and second features are not in direct contact but are in contact through another feature between them. Moreover, the "upper", "upper" and "upper" of the first feature to the second feature include that the first feature is directly above and obliquely above the second feature, or only indicates that the horizontal height of the first feature is higher than that of the second feature. The "below", "below" and "below" of the first feature to the second feature include that the first feature is directly below and obliquely below the second feature, or only indicates that the horizontal height of the first feature is less than that of the second feature.

[0050] In the description of the present specification, the description referring to the terms "one embodiment", "some embodiments", "an example", "a specific example", or "some examples" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms should not be understood as necessarily referring to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in the present specification.

[0051] Obviously, those skilled in the art can make various modifications and variations to the present application without departing from the spirit and scope of the present application. Thus, these modifications and variations of the present application are intended to be included within the scope of the claims of the present application and equivalents thereof. Therefore, the present application is intended to include these modifications and variations.

[0052] The above is a specific embodiment of the present application, but the protection scope of the present application is not limited to this. Any person skilled in the art can easily think of various equivalent modifications or replacements within the technical range disclosed by the present application, and these modifications or replacements should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A cell separation apparatus, characterized by, The application relates to a magnetic driving device and a consumable cylinder, wherein the consumable cylinder is detachably connected with the magnetic driving device; the consumable cylinder comprises an inner cylinder and an outer cylinder; the inner cylinder is coaxially and spacedly arranged in the outer cylinder and is rotatably connected with the outer cylinder; a filter membrane is arranged on the side surface of the outer wall of the inner cylinder at least in a partial region; the outer cylinder is provided with a liquid inlet, a liquid outlet and a waste liquid outlet; the liquid inlet is communicated with the gap region between the filter membrane and the outer cylinder; the liquid outlet is communicated with the gap region between the inner cylinder and the filter membrane; the waste liquid outlet is communicated with the gap region between the filter membrane and the outer cylinder; wherein the magnetic driving device is used for driving the inner cylinder to rotate.

2. The cell separation device of claim 1, wherein, The magnetic driving device comprises a driving motor, a transmission unit and a magnetic ring; the driving motor is connected with the transmission unit, and the transmission unit is connected with the magnetic ring; wherein the driving motor drives the magnetic ring to rotate through the transmission unit.

3. The cell separation device of claim 2, wherein, The consumable cylinder further comprises a magnetic suction block which is fixedly connected with the inner cylinder.

4. The cell separation device of claim 3, wherein, The transmission unit comprises a synchronous belt, a driving wheel and a driven wheel; the synchronous belt is sleeved between the driving wheel and the driven wheel; the driving wheel is connected with the driving motor; the driven wheel is connected with the magnetic ring; and the magnetic ring is arranged on one side of the magnetic suction block.

5. The cell separation device of claim 4, wherein, The transmission unit further comprises a rotating main shaft; one end of the rotating main shaft is connected with the driven wheel through a bearing; and the other end of the rotating main shaft is connected with the magnetic ring.

6. The cell separation device of claim 4, wherein, The application further comprises a supporting column and a mounting seat; the mounting seat is arranged on the supporting column; the driving wheel and the driven wheel are arranged on the mounting seat.

7. The cell separation device of claim 6, wherein, The application further comprises an upper cover; the upper cover covers the driven wheel and is connected with the mounting seat.

8. The cell separation device of claim 6, wherein, The application further comprises a motor flange; the driving motor is connected with the mounting seat through the motor flange; and the driving motor is arranged on the upper side of the driving wheel.

9. The cell separation device of claim 8, wherein, The application further comprises an adjusting block; the adjusting block is fixedly connected with the motor flange; and the adjusting block is connected with the mounting seat through adjusting screws.

10. The cell separation device of claim 6, wherein, The application further comprises a bottom cover; the bottom cover covers the magnetic ring and is connected with the mounting seat.

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