Atomizer capable of being applied to particle solution with lipid membrane structure
By optimizing the nozzle design of the nebulizer, the impact of mechanical force on the lipid membrane structure particle solution is buffered and reduced, solving the stability and efficacy issues of existing nebulizers for nanoliposomes and exosome solutions, and achieving better therapeutic effects.
Patent Information
- Application Number
- CN202520142234.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-21
- Publication Date
- 2026-01-27
- Estimated Expiration
- 2035-01-21
AI Technical Summary
Existing nebulizers lack proper structural design, which leads to mechanical stress (such as shear force) on solutions with lipid membrane structures (such as nanoliposomes or exosome solutions), affecting their stability and efficacy.
An atomizer was designed, including a nozzle, a liquid chamber, and an atomizing module. The nozzle plate has multiple holes, which gradually decrease in size from the inlet to the outlet. The cross-sections of the buffer section and the spray section are designed with specific angles and shapes to buffer the transmission of mechanical energy. The spray section is bowl-shaped to form an elastic bottom wall and reduce adverse effects on particles.
It effectively prevents damage to the lipid membrane structure during the spraying process of the particulate solution, thus improving the therapeutic effect and making it suitable for a variety of medical and non-medical applications.
Smart Images
Figure CN223832655U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to an atomizer, and more particularly to an atomizer applicable to particle solutions with a lipid membrane structure. Background Technology
[0002] Lipid-based nanoparticles (LNPs) are widely regarded as a versatile drug delivery system. They offer numerous advantages, such as rapid absorption, improved drug bioavailability, reduced toxicity risks, and prevention of drug hydrolysis and oxidation, making them a highly promising drug carrier technology. Currently, various nanoliposomes are being used in clinical treatment.
[0003] Stability is a core requirement for nanoliposomes. Various external factors such as radiation and high temperature can lead to instability in nanoliposomes. In addition, mechanical stress (such as shear force) may also damage the membrane structure of nanoliposomes, reducing their encapsulation efficiency.
[0004] Exosomes, with their bilayered phospholipid membrane structure, are specialized lipid-membrane active vesicles secreted by stem cells. They are extremely small molecular particles, ranging from 50 to 200 nanometers. Exosomes also represent a highly promising drug development technology. However, the factors mentioned above can also have adverse effects on exosomes.
[0005] However, due to the lack of proper structural design in existing nebulizers, the mechanical stress (such as shear force) generated when they are used with solutions of particles with lipid membrane structures (such as nanoliposome solutions or exosome solutions) may significantly affect the therapeutic effect of the above solutions. Utility Model Content
[0006] The purpose of this invention is to provide an atomizer that can be applied to particle solutions with a lipid membrane structure.
[0007] This invention provides an atomizer applicable to solutions of particles with a lipid membrane structure, comprising a nozzle, a liquid chamber, and an atomization module. The nozzle includes a mist outlet tube. The liquid chamber has an opening and is disposed within the nozzle, serving to contain the solution of particles with a lipid membrane structure. The atomization module is disposed within the nozzle and includes a vibrating plate and a nozzle orifice plate. The nozzle orifice plate is disposed on the central hole of the vibrating plate and covers the opening. The nozzle orifice plate has multiple holes, the diameter of which gradually decreases from the inlet to the outlet.
[0008] In one embodiment, each hole includes a buffer portion and an ejection portion, the ejection portion being adjacent to the outlet of the hole.
[0009] In one embodiment, the cross-section of the ejector portion is bowl-shaped.
[0010] In one embodiment, the cross-section of the buffer section is two inclined planes.
[0011] In one embodiment, the angle between the inclined plane and the horizontal plane is greater than 45 degrees and less than 90 degrees.
[0012] In one embodiment, a bottom wall is provided around the outlet of the hole.
[0013] In one embodiment, the vibrating sheet is a piezoelectric sheet.
[0014] In one embodiment, the nozzle plate is made of an elastic material.
[0015] In one embodiment, the atomizer also includes a body, with the nozzle disposed on the body.
[0016] In one embodiment, the atomizer further includes an ultrasonic drive circuit disposed in the body and used to drive the vibrating plate to vibrate.
[0017] The present invention can be applied to nebulizers containing particulate solutions with lipid membrane structures, and may have one or more of the following advantages:
[0018] (1) In one embodiment of this utility model, the atomizer includes a nozzle, a liquid chamber, and an atomization module. The nozzle includes a mist outlet tube. The liquid chamber has an opening and is disposed in the nozzle, and is used to contain a solution of particles with a lipid membrane structure. The atomization module is disposed in the nozzle and includes a vibrating plate and a nozzle plate. The nozzle plate is disposed on the central hole of the vibrating plate and covers the opening. The nozzle plate has multiple holes, and the diameter of each hole gradually decreases from the inlet to the outlet. The above-mentioned nozzle plate structure design can be applied to solutions of particles with lipid membrane structures (such as nanoliposome solutions, exosome solutions, etc.), so the atomizer can meet the needs of practical applications.
[0019] (2) In one embodiment of this utility model, each hole of the spray nozzle includes a buffer section and a spraying section, with the spraying section adjacent to the outlet of the hole. The cross-section of the buffer section consists of two inclined planes, with each inclined plane forming an angle greater than 45 degrees and less than 90 degrees with the horizontal plane. The cross-section of the spraying section is bowl-shaped. Through the above-described hole structure design, the mechanical energy transfer (such as shear force) when the solution is sprayed out of the hole can be significantly buffered to prevent adverse effects on particles (such as nanoliposomes, exosomes, etc.) in the solution. Therefore, the solution can achieve excellent therapeutic effects.
[0020] (3) In one embodiment of this utility model, each hole of the spray nozzle has a buffer portion and a spray portion. The cross-section of the spray portion is bowl-shaped, forming a bottom wall around the outlet of the hole. The aforementioned bottom wall structure has a certain degree of elasticity, which can further reduce the mechanical energy transfer (such as shear force) when the solution is sprayed out of the hole, so as to prevent adverse effects on particles (such as nanoliposomes, exosomes, etc.) in the solution. Therefore, the solution can achieve excellent therapeutic effects. Attached Figure Description
[0021] Figure 1 This is a perspective view of an embodiment of the present invention, applicable to a nebulizer for a particle solution with a lipid membrane structure.
[0022] Figure 2A This is a perspective view of an atomizing module of an atomizer applicable to a nebulizer containing a lipid membrane structure particle solution, according to an embodiment of the present invention.
[0023] Figure 2B This is a diagram showing the combination of a vibrating plate and a nozzle plate in an atomizer for a particle solution with a lipid membrane structure, according to an embodiment of the present invention.
[0024] Figure 3 This is a cross-sectional view of the nozzle plate of an atomizing module that can be applied to an atomizer with a lipid membrane structure particle solution, according to an embodiment of the present invention.
[0025] Figure 4 This is a schematic diagram of the nozzle plate of an atomizing module applicable to a nebulizer with a lipid membrane structure particle solution, according to an embodiment of the present invention.
[0026] Figure 5 This is a schematic diagram illustrating the usage state of an atomizer applicable to a particle solution with a lipid membrane structure, according to an embodiment of the present invention.
[0027] Explanation of reference numerals in the attached drawings: 1-Atomizer; 11-Nozzle; 111-Mist outlet pipe; 12-Liquid chamber; 13-Atomization module; 131-Housing shell; 132-Vibrating plate; 133-Nozzle plate; 14-Body; 141-Control key; 15-Ultrasonic drive circuit; HS-Orifice; P1-Buffer section; P2-Ejection section; HP-Horizontal plane; BG-Bottom wall; M1-Particle solution with lipid membrane structure; M2-Atomized agent; θ1-Included angle. Detailed Implementation
[0028] The following description, with reference to the accompanying drawings, illustrates an embodiment of an nebulizer applicable to a lipid membrane structure particle solution according to the present invention. For clarity and convenience, the dimensions and proportions of the components in the drawings may be exaggerated or reduced. In the following description and / or claims, when an element is referred to as "connected" or "coupled" to another element, it may be directly connected or coupled to that other element or there may be an intervening element; when an element is referred to as "directly connected" or "directly coupled" to another element, there is no intervening element. Other terms used to describe the relationship between elements or layers should be interpreted in the same manner. For ease of understanding, the same elements in the following embodiments are indicated by the same symbols.
[0029] Please see Figure 1 , Figure 2A and Figure 2B As shown. Figure 1 This is a perspective view of an embodiment of the present invention, applicable to a nebulizer for a particle solution with a lipid membrane structure. Figure 2A This is a perspective view of an atomizing module of an atomizer applicable to a nebulizer containing a lipid membrane structure particle solution, according to an embodiment of the present invention. Figure 2B This is a diagram showing the combination of a vibrating plate and a nozzle plate in an nebulizer applicable to a solution of particles with a lipid membrane structure, according to an embodiment of the present invention. As shown in the figure, the nebulizer 1 includes a nozzle 11, a liquid chamber 12, an atomization module 13, a body 14, and an ultrasonic drive circuit 15.
[0030] The nozzle 11 is located on the body 14 and includes a mist outlet pipe 111.
[0031] The liquid chamber 12 has an opening and is disposed within the nozzle 11. The liquid chamber 12 contains a solution of particles with a lipid membrane structure. The aforementioned solution of particles with a lipid membrane structure refers to solutions of various particles with lipid membrane structures. For example, this solution may be, but is not limited to, nanoliposome solutions, exosome solutions, etc., and can be applied to various medical or non-medical uses, such as traditional Chinese medicine (pharmaceuticals), Western medicine (pharmaceuticals), veterinary medicine (pharmaceuticals), pet healthcare, or medical aesthetic products.
[0032] The atomizing module 13 is disposed in the nozzle 11 and connected to the opening of the liquid chamber 12.
[0033] An ultrasonic drive circuit 15 is housed in the body 14 and connected to the atomizing module 13. The body 14 has a control button 141. The user can activate the ultrasonic drive circuit 15 by pressing the control button 141. Then, the ultrasonic drive circuit 15 drives the atomizing module 13 to vibrate at high speed to produce a solution of particles with a lipid membrane structure, thus generating atomized particles. Finally, the atomized particles are ejected from the mist outlet 111 of the nozzle 11 for the user to inhale.
[0034] The atomizing module 13 includes a housing 131, a vibrating plate 132, and a nozzle plate 133. The vibrating plate 132 and the nozzle plate 133 are disposed within the housing 131, with the nozzle plate 133 positioned over the central hole of the vibrating plate 132 and covering the opening of the liquid chamber 12. The vibrating plate 132 may be a piezoelectric element, while the nozzle plate 133 may be made of an elastic material, giving it a certain degree of elasticity. In one embodiment, the nozzle plate 133 may be made of plastic. In another embodiment, the nozzle plate 133 may also be made of metal, such as aluminum, copper, or stainless steel.
[0035] Of course, this embodiment is only for illustrative purposes and is not intended to limit the scope of this utility model. Equivalent modifications or alterations made based on this embodiment that can be applied to atomizer 1 with a lipid membrane structure particle solution should still be included within the patent scope of this utility model.
[0036] Please see Figure 3 and Figure 4 As shown, and please refer to the following: Figure 1 As shown in Figure 2. Figure 3 This is a cross-sectional view of the nozzle plate of an atomizing module that can be applied to an atomizer with a lipid membrane structure particle solution, according to an embodiment of the present invention. Figure 4 This is a schematic diagram of the nozzle plate of an atomizing module applicable to an atomizer containing a lipid membrane structure particle solution, according to an embodiment of the present invention. Figure 3 As shown, the nozzle plate 133 has multiple holes HS, and the diameter of each hole HS gradually decreases from the inlet of the hole HS to the outlet of the hole HS.
[0037] Each orifice HS includes a buffer section P1 and an ejector section P2. The ejector section P2 is adjacent to the outlet of the orifice HS. The cross-sectional shapes of the buffer section P1 and the ejector section P2 can be seen in the figure. The cross-section of the buffer section P1 consists of two inclined planes, and the angle between either inclined plane and the horizontal plane HP (which is parallel to the bottom surface of the nozzle plate 133) is greater than 45 degrees and less than 90 degrees. Furthermore, the cross-section of the ejector section P2 is bowl-shaped, forming a bottom wall BG around the outlet of the orifice HS.
[0038] like Figure 4As shown, when the user presses the control key 141 to activate the ultrasonic drive circuit 15, the ultrasonic drive circuit 15 drives the atomizing module 13 to vibrate at high speed to produce a solution of lipid membrane structure particles M1 (the above-mentioned solution of lipid membrane structure particles M1 refers to solutions of various particles with lipid membrane structures, such as nanoliposome solutions, exosome solutions, etc.). The solution of lipid membrane structure particles M1 passes through the holes HS of the nozzle plate 133 to generate atomized particles M2, which are then sprayed out from the mist outlet pipe 111 of the nozzle 11. The above-mentioned hole structure design allows for a significant buffering of the mechanical force energy transfer (such as shear force) when the solution of lipid membrane structure particles M1 is sprayed out through the holes HS, thus avoiding damage to the membrane structure of the particles in the solution of lipid membrane structure particles M1.
[0039] Furthermore, because the cross-section of the ejector portion P2 of the nozzle plate 133 is bowl-shaped, an extremely thin bottom wall BG is formed around the outlet of each orifice HS. Therefore, the structure of the aforementioned bottom wall BG has a certain degree of elasticity, allowing it to slightly bend outwards when the lipid membrane structure particle solution M1 is ejected from the orifice HS, further reducing the mechanical energy transfer (such as shear force) during ejection of the lipid membrane structure particle solution M1, thus preventing damage to the membrane structure of the particles within the lipid membrane structure particle solution M1. Therefore, if the lipid membrane structure particle solution M1 is a nanoliposome solution, the aforementioned pore structure design can prevent damage to the membrane structure of the particles within the nanoliposome solution, thereby improving the encapsulation efficiency of the nanoliposome solution and simultaneously enhancing therapeutic efficacy. If the lipid membrane structure particle solution M1 is an exosome solution, the aforementioned pore structure design can also prevent adverse effects on the particles within the exosome solution and simultaneously enhance therapeutic efficacy.
[0040] Therefore, the atomized medication M2 sprayed by nebulizer 1 can achieve better therapeutic effects. Thus, nebulizer 1 can be applied to various internal and surgical medical applications, such as respiratory, otolaryngology, pediatrics, ophthalmology, veterinary medicine, and other medical-related applications. In addition, nebulizer 1 can also be applied to various non-medical applications, such as aesthetic medicine, health care, pet health care, and other health or beauty-related applications. Therefore, nebulizer 1 can meet the needs of practical applications.
[0041] Of course, this embodiment is only for illustrative purposes and is not intended to limit the patent scope of this utility model. Equivalent modifications or alterations made based on this embodiment that can be applied to atomizer 1 with a lipid membrane structure particle solution should still be included within the patent scope of this utility model.
[0042] It is worth mentioning that, due to the lack of appropriate structural design in existing nebulizers, the mechanical stress (such as shear force) generated when used with solutions of particles with lipid membrane structures may damage the membrane structure, significantly affecting the therapeutic effect. In contrast, according to an embodiment of this invention, the nebulizer includes a nozzle, a liquid chamber, and an nebulization module. The nozzle includes a mist outlet tube. The liquid chamber has an opening and is disposed within the nozzle, used to contain a solution of particles with lipid membrane structures. The nebulization module is disposed within the nozzle and includes a vibrating plate and a nozzle plate. The nozzle plate is disposed on the central hole of the vibrating plate and covers the opening. The nozzle plate has multiple holes, the diameter of which gradually decreases from the inlet to the outlet. The above-mentioned nozzle plate structural design can be applied to solutions of various particles with lipid membrane structures (such as nanoliposome solutions, exosome solutions, etc.), thus the nebulizer can meet the needs of practical applications.
[0043] Furthermore, according to embodiments of this invention, each hole in the nozzle plate includes a buffer section and an ejection section, with the ejection section adjacent to the outlet of the hole. The cross-section of the buffer section consists of two inclined planes, each with an angle greater than 45 degrees and less than 90 degrees between its angle and the horizontal plane. The cross-section of the ejection section is bowl-shaped. Through the above-described hole structure design, the mechanical energy transfer (such as shear force) of the lipid membrane structure particle solution ejected from the holes can be significantly buffered, preventing adverse effects on the particles (such as nanoliposomes, exosomes, etc.) within the solution. Therefore, the solution can achieve excellent therapeutic effects.
[0044] Furthermore, according to embodiments of this invention, each hole in the nozzle plate includes a buffer section and an ejection section. The ejection section has a bowl-shaped cross-section, forming a bottom wall around the outlet of the hole. This bottom wall structure has a certain degree of elasticity, which can further reduce the mechanical energy transfer (such as shear force) when the solution is ejected from the hole, thus preventing adverse effects on particles (such as nanoliposomes, exosomes, etc.) within the solution. Therefore, the solution can achieve excellent therapeutic effects.
[0045] Please see Figure 5 The diagram shown illustrates the usage state of an nebulizer for a solution of particles with a lipid membrane structure, according to an embodiment of this invention. Please also refer to... Figures 1-4 As shown in the figure, when the user presses the control key 141 to start the ultrasonic drive circuit 15, the ultrasonic drive circuit 15 drives the atomization module 13 to vibrate at high speed to atomize the lipid membrane structure particle solution M1. The lipid membrane structure particle solution M1 can generate atomized particles M2 by passing through the holes HS of the nozzle plate 133, and is sprayed out by the mist outlet pipe 111 of the nozzle 11.
[0046] As mentioned earlier, through the perforated structure design of the nozzle plate 133, the mechanical energy transfer (such as shear force) of the lipid membrane structure particle solution M1 when it is ejected from the perforations HS is significantly buffered. This prevents damage to the membrane structure of the particles within the lipid membrane structure particle solution M1 due to mechanical energy transfer. Therefore, the lipid membrane structure particle solution M1 achieves excellent therapeutic effects. Thus, the nebulizer 1 can be applied to various internal and surgical medical applications, such as respiratory, otolaryngology, pediatrics, ophthalmology, veterinary medicine, and other medical-related applications. Furthermore, the nebulizer 1 can also be applied to various non-medical applications, such as aesthetic medicine, health care, pet health care, and other health or beauty-related applications. Therefore, the nebulizer 1 achieves high practicality.
[0047] Of course, this embodiment is only for illustrative purposes and is not intended to limit the scope of this utility model. Equivalent modifications or alterations made based on this embodiment that can be applied to atomizer 1 with a lipid membrane structure particle solution should still be included within the patent scope of this utility model.
[0048] In summary, according to the embodiments of this utility model, the atomizer includes a nozzle, a liquid chamber, and an atomization module. The nozzle includes a mist outlet tube. The liquid chamber has an opening and is disposed within the nozzle, and is used to contain a solution of particles with a lipid membrane structure. The atomization module is disposed within the nozzle and includes a vibrating plate and a nozzle plate. The nozzle plate is disposed on the central hole of the vibrating plate and covers the opening. The nozzle plate has multiple holes, and the diameter of each hole gradually decreases from the inlet to the outlet. The above-described nozzle plate structure design can be applied to solutions of various particles with lipid membrane structures (such as nanoliposome solutions, exosome solutions, etc.), thus the atomizer can meet the needs of practical applications.
[0049] Furthermore, according to embodiments of this invention, each hole in the spray nozzle includes a buffer section and a spraying section, with the spraying section adjacent to the outlet of the hole. The cross-section of the buffer section consists of two inclined planes, each with an angle greater than 45 degrees and less than 90 degrees between its angle and the horizontal plane. The cross-section of the spraying section is bowl-shaped. Through the above-described hole structure design, the mechanical energy transfer (such as shear force) when the solution is sprayed from the holes can be significantly buffered, preventing adverse effects on particles (such as nanoliposomes, exosomes, etc.) within the solution. Therefore, the solution can achieve excellent therapeutic effects.
[0050] Furthermore, according to embodiments of this invention, each hole in the nozzle plate has a buffer section and an ejection section. The ejection section has a bowl-shaped cross-section, forming a bottom wall around the outlet of the hole. This bottom wall structure has a certain degree of elasticity, which can further reduce the mechanical energy transfer (such as shear force) when the solution is ejected from the hole, thus preventing adverse effects on particles (such as nanoliposomes, exosomes, etc.) within the solution. Therefore, the solution can achieve excellent therapeutic effects.
[0051] The above description is merely illustrative and not restrictive. Any equivalent modifications or alterations made without departing from the spirit and scope of this utility model should be included within the protection scope of this utility model.
Claims
1. An atomizer applicable to solutions of particles with a lipid membrane structure, characterized in that, Include: The nozzle includes a mist outlet tube; A liquid chamber, having an opening, is disposed in the nozzle and is used to contain a solution of particles having a lipid membrane structure; as well as An atomizing module is disposed in the nozzle and includes a vibrating plate and a nozzle plate. The nozzle plate is disposed on the central hole of the vibrating plate and covers the opening. The nozzle plate has multiple holes, and the diameter of each hole gradually decreases from the inlet to the outlet.
2. The nebulizer as described in claim 1, applicable to particle solutions with a lipid membrane structure, characterized in that: Each hole includes a buffer section and an ejection section, the ejection section being adjacent to the outlet of the hole.
3. The nebulizer as described in claim 2, applicable to particulate solutions with a lipid membrane structure, characterized in that: The cross-section of the ejector portion is bowl-shaped.
4. The nebulizer as described in claim 2, applicable to particulate solutions with a lipid membrane structure, characterized in that: The cross-section of the buffer section consists of two inclined planes.
5. The nebulizer as described in claim 4, applicable to particulate solutions with a lipid membrane structure, characterized in that: The angle between each of the inclined planes and the horizontal plane is greater than 45 degrees and less than 90 degrees.
6. The nebulizer as described in claim 1, applicable to particulate solutions with a lipid membrane structure, characterized in that: The outlet of the hole is surrounded by a bottom wall.
7. The nebulizer as described in claim 1, applicable to particle solutions with a lipid membrane structure, characterized in that: The vibrating plate is a piezoelectric plate.
8. The nebulizer as described in claim 1, applicable to particle solutions with a lipid membrane structure, characterized in that: The nozzle plate is made of an elastic material.
9. The nebulizer as described in claim 1, applicable to particulate solutions with a lipid membrane structure, characterized in that: It also includes the body, on which the nozzle is mounted.
10. The nebulizer as described in claim 9, applicable to particle solutions with a lipid membrane structure, characterized in that: It also includes an ultrasonic drive circuit, which is disposed in the body and used to drive the vibrating plate to vibrate.