Liquid closed sampler for reaction kettle or fermentation tank

Abstract

The utility model relates to the technical field of medicine production sampling equipment, and discloses a closed liquid sampler for a reaction kettle or a fermentation tank, which comprises a feeding pipe, a feeding valve is connected to the top end of the feeding pipe through a bolt, a cavity cylinder is arranged at the top end of the feeding valve, an upper end plate is arranged at the top end of the cavity cylinder, and a lower end plate is arranged at the top end of the upper end plate. A three-way pipe is fixedly connected to the top end of the upper end plate, a vacuum valve is fixedly connected to the right end of the three-way pipe, a nitrogen valve is fixedly connected to the left end of the three-way pipe, a sampling pipe is fixedly connected to the right side of the cavity cylinder, and a sampling valve is fixedly connected to the middle of the sampling pipe. After the inner cavity of the sampling bottle is full, the sampling valve is closed, the nitrogen valve is slowly opened to empty the inner cavity of the cavity cylinder, at the moment, materials in the inner cavity of the cavity cylinder flow back to the reaction kettle or the fermentation tank due to the gravity of the materials, and then the sampling bottle is taken down and sealed, so that the problems that the sample is exposed, and the sampling effect is poor are solved. The sample pollution and the environment pollution can be caused.

Description

Technical Field

[0001] This utility model relates to the field of sampling equipment technology in pharmaceutical production, and more specifically, to a closed liquid sampler for use in reaction vessels or fermentation tanks. Background Technology

[0002] In pharmaceutical manufacturing, process control and finished product sampling analysis are unavoidable issues. During sampling, it is crucial to prevent sample contamination and odor leakage that could pollute the environment or harm human health. Currently, many companies still use open sampling methods, such as suspending samples through a manhole with a rope attached to the top of the sampling bottle, or installing a sampling valve at the bottom of the reactor to place the sample into an open sampling bottle. This open sampling not only leads to sample contamination and accuracy deviations but also poses threats to the safety of sampling personnel and environmental pollution. Utility Model Content

[0003] To overcome the shortcomings of the prior art, this utility model provides a closed liquid sampler for reaction vessels or fermenters, which has the advantage of avoiding open sampling.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a closed liquid sampler for a reaction vessel or fermentation tank, comprising a feed pipe, a feed valve bolted to the top end of the feed pipe, a cavity cylinder provided at the top end of the feed valve, an upper end plate provided at the top end of the cavity cylinder, a three-way pipe fixedly connected to the top end of the upper end plate, a vacuum valve fixedly connected to the right end of the three-way pipe, a nitrogen valve fixedly connected to the left end of the three-way pipe, a sampling tube fixedly connected to the right side of the cavity cylinder, a sampling valve fixedly connected to the middle of the sampling tube, and a sampling bottle threadedly connected to the bottom of the inner cavity of the sampling tube.

[0005] As a preferred technical solution of this utility model, the cavity cylinder is made of glass, and the feed valve, vacuum valve, nitrogen valve and sampling valve are all made of stainless steel. The feed valve, vacuum valve, nitrogen valve and sampling valve are all ball valves. The feed valve has a hollow structure and is in communication with the inner cavity of the cavity cylinder.

[0006] As a preferred embodiment of this utility model, the bottom end of the three-way pipe is connected to the inner cavity of the cavity cylinder.

[0007] As a preferred embodiment of this utility model, a cross rod is fixedly connected to the bottom of the inner cavity of the feed pipe, and the feed pipe communicates with the inner cavity of the feed valve.

[0008] As a preferred embodiment of this utility model, the internal volume of the feed valve is more than twice the volume of the sampling bottle, the sampling tube is L-shaped, the inner cavity of the upper end plate is threaded with a mounting screw, and the upper end plate is threadedly connected to the top of the feed valve through the mounting screw.

[0009] As a preferred embodiment of this utility model, a threaded tube is fixedly connected to the top of the sampling bottle, and a threaded groove is provided at the bottom of the inner cavity of the sampling tube, with the threaded tube and the threaded groove being threadedly connected.

[0010] As a preferred technical solution of this utility model, a sealing ring is provided at the connection between the upper end plate and the cavity cylinder. There are three sealing rings in total, which are respectively provided at the connection between the upper end plate and the cavity cylinder, the connection between the cavity cylinder and the feed valve, and the connection between the feed pipe and the feed valve.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0012] 1. This utility model solves the problem of sample exposure leading to sample contamination and environmental pollution by closing all valves, first opening the sampling valve and vacuum valve, then closing the vacuum valve and slowly opening the feed valve. The vacuum suction in the cavity draws material from the reactor or fermenter into the cavity and along the sampling tube into the sampling bottle. Once the sampling bottle is empty, the sampling valve is closed, and the nitrogen valve is slowly opened to ventilate the cavity. The material then flows back into the reactor or fermenter due to gravity. The sampling bottle can then be removed and sealed.

[0013] 2. This utility model, constructed from a combination of glass and stainless steel, achieves a simple structure, good corrosion resistance, and wide applicability. The glass sampling chamber and sampling bottle allow for direct observation of the material's state within the bottle. The chamber is connected to the inner cavity of the sampling tube, allowing material to be collected along the sampling tube into the sampling bottle's inner cavity during vacuum extraction of the material from the feed valve. Furthermore, the crossbar at the bottom of the feed tube prevents large particles from entering the inner cavity and causing blockage. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model;

[0015] Figure 2 This is a schematic diagram of the connection of the cavity tube in this utility model.

[0016] Figure 3This is a schematic diagram of the connection of the sampling tube in this utility model.

[0017] Figure 4 This utility model Figure 3 Enlarged connection diagram at point A in the middle;

[0018] Figure 5 This is a schematic diagram of the cross-shaped rod connection of the present invention.

[0019] In the diagram: 1. Feed pipe; 2. Feed valve; 3. Cavity cylinder; 4. Mounting screw; 5. Upper end plate; 6. T-connector; 7. Vacuum valve; 8. Nitrogen valve; 9. Cross rod; 10. Sampling pipe; 11. Sampling valve; 12. Sampling bottle; 13. Sealing ring. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] like Figures 1 to 5 As shown, this utility model provides a liquid-sealed sampler for a reaction vessel or fermentation tank, including a feed pipe 1, a feed valve 2 bolted to the top end of the feed pipe 1, a cavity cylinder 3 at the top end of the feed valve 2, an upper end plate 5 at the top end of the cavity cylinder 3, a three-way pipe 6 fixedly connected to the top end of the upper end plate 5, a vacuum valve 7 fixedly connected to the right end of the three-way pipe 6, a nitrogen valve 8 fixedly connected to the left end of the three-way pipe 6, a sampling pipe 10 fixedly connected to the right side of the cavity cylinder 3, a sampling valve 11 fixedly connected to the middle of the sampling pipe 10, and a sampling bottle 12 threadedly connected to the bottom of the inner cavity of the sampling pipe 10.

[0022] By inserting the feed pipe 1 downwards into the reactor or fermenter to connect it to the interior, then connecting the bottom end of the feed valve 2 to the top end of the feed pipe 1, connecting the cavity cylinder 3 to the top end of the feed valve 2, and connecting the upper end plate 5 to the top end of the cavity cylinder 3, the sampling bottle 12 is then threaded onto the bottom of the sampling tube 10. In use, first close all valves, then open the sampling valve 11 and the vacuum valve 7 to create a vacuum inside the cavity cylinder 3. Next, close the vacuum valve 7 and slowly open the feed valve 2. The vacuum suction inside the cavity 3 draws the material from the reactor or fermenter into the cavity 3 and into the sampling bottle 12 along the sampling tube 10. When the material in the sampling bottle 12 has been collected, the sampling valve 11 is closed and the nitrogen valve 8 is slowly opened to empty the cavity 3. At this time, the material in the cavity 3 flows back into the reactor or fermenter due to its own gravity. Then the sampling bottle 12 can be removed and sealed, which solves the problem of sample exposure, which can cause sample contamination and environmental pollution.

[0023] Among them, the cavity cylinder 3 is made of glass, the feed valve 2, vacuum valve 7, nitrogen valve 8, and sampling valve 11 are all stainless steel, the feed valve 2, vacuum valve 7, nitrogen valve 8, and sampling valve 11 are all ball valves, the feed valve 2 is a hollow structure, and the sampling bottle 12 is connected to the inner cavity of the cavity cylinder 3.

[0024] This utility model is constructed using a combination of glass and stainless steel, achieving a simple structure, good corrosion resistance, and wide applicability. Through the glass sampling chamber 3 and sampling bottle 12, the material state inside the sampling bottle can be directly observed. Furthermore, the chamber 3 is connected to the inner cavity of the sampling tube 10, so that when the inner cavity of the feed valve 2 is vacuum-extracted, the material can also enter the inner cavity of the sampling bottle 12 along the sampling tube 10 for collection.

[0025] The bottom end of the three-way pipe 6 is connected to the inner cavity of the cavity cylinder 3;

[0026] The bottom end of the three-way pipe 6 is connected to the inner cavity of the cavity cylinder 3, allowing the inner cavity of the cavity cylinder 3 to enter a vacuum state.

[0027] Among them, a cross rod 9 is fixedly connected to the bottom of the inner cavity of the feed pipe 1, and the inner cavity of the feed pipe 1 is connected to the inner cavity of the feed valve 2.

[0028] The cross bar 9 at the bottom of the inner cavity of the feed pipe 1 can block large particles when the feed pipe 1 needs to sample material. This prevents large particles from entering the inner cavity of the feed pipe 1 and causing the feed pipe 1 to become blocked.

[0029] The internal volume of the feed valve 2 is more than twice the volume of the sampling bottle 12. The sampling tube 10 is L-shaped. The inner cavity of the upper end plate 5 is threaded with the mounting screw 4. The upper end plate 5 is threadedly connected to the top of the feed valve 2 through the mounting screw 4.

[0030] The volume inside the feed valve 2 is more than twice the volume of the sampling bottle 12, which allows the cavity cylinder 3 to generate sufficient suction to draw up the material from the reactor or fermenter. The sampling operation is characterized by safety and high success rate.

[0031] Among them, the top of the sampling bottle 12 is fixedly connected to a threaded tube, and the bottom of the inner cavity of the sampling tube 10 is provided with a threaded groove, and the threaded tube is threadedly connected to the threaded groove.

[0032] The sampling bottle 12 is connected to the sampling tube 10 by a threaded tube at the top. After sampling, the sampling bottle 12 is unscrewed from the bottom of the sampling tube 10, and then the outer cap is screwed onto the threaded tube to seal the sampling bottle 12.

[0033] Among them, a sealing ring 13 is provided at the connection between the upper end plate 5 and the cavity cylinder 3. There are three sealing rings 13 in total. The three sealing rings 13 are respectively provided at the connection between the upper end plate 5 and the cavity cylinder 3, the connection between the cavity cylinder 3 and the feed valve 2, and the connection between the feed pipe 1 and the feed valve 2.

[0034] By using multiple sealing rings 13, the sealing performance of this invention during connection is greatly improved.

[0035] The working principle and usage process of this utility model are as follows: Insert the feed pipe 1 downward into the reactor or fermentation tank to make it communicate with the inside. Before use, the length of the feed pipe 1 is determined by the height of the liquid level of the material in the reactor or fermentation tank. Then connect the bottom end of the feed valve 2 to the top end of the feed pipe 1, connect the cavity cylinder 3 to the top end of the feed valve 2, connect the upper end plate 5 to the top end of the cavity cylinder 3, and then thread the sampling bottle 12 to the bottom of the sampling tube 10.

[0036] Next, close all valves, then open sampling valve 11 and vacuum valve 7 to create a vacuum in the inner cavity of chamber 3. Slowly open feed valve 2. At this time, the liquid material in the reactor or fermenter is drawn into the inner cavity of chamber 3 along feed pipe 1 and feed valve 2 due to the vacuum suction of chamber 3. At this time, some large pieces of material are isolated by sealing ring 13 and enter the sampling bottle 12. After the material fills the sampling bottle 12, close sampling valve 11 and then open nitrogen valve 8 to vent. Then, the excess material in the inner cavity of chamber 3 flows back into the reactor or fermenter due to its own gravity. Then, remove sampling bottle 12 and seal it with screw cap.

[0037] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0038] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A closed liquid sampler for a reactor or fermenter, comprising a feed pipe (1), characterized in that: The top end of the feed pipe (1) is bolted to a feed valve (2), the top end of the feed valve (2) is provided with a cavity cylinder (3), the top end of the cavity cylinder (3) is provided with an upper end plate (5), the top end of the upper end plate (5) is fixedly connected to a three-way pipe (6), the right end of the three-way pipe (6) is fixedly connected to a vacuum valve (7), the left end of the three-way pipe (6) is fixedly connected to a nitrogen valve (8), the right side of the cavity cylinder (3) is fixedly connected to a sampling pipe (10), the middle part of the sampling pipe (10) is fixedly connected to a sampling valve (11), and the bottom of the inner cavity of the sampling pipe (10) is threadedly connected to a sampling bottle (12).

2. A closed liquid sampler for a reaction vessel or fermenter according to claim 1, characterized in that: The cavity tube (3) is made of glass. The feed valve (2), vacuum valve (7), nitrogen valve (8), and sampling valve (11) are all made of stainless steel. The feed valve (2), vacuum valve (7), nitrogen valve (8), and sampling valve (11) are all ball valves. The feed valve (2) is a hollow structure and is connected to the inner cavity of the cavity tube (3).

3. A closed liquid sampler for a reaction vessel or fermentation tank according to claim 2, characterized in that: The bottom end of the three-way pipe (6) is connected to the inner cavity of the cavity tube (3).

4. A closed-loop liquid sampler for a reaction vessel or fermenter according to claim 2, characterized in that: A cross rod (9) is fixedly connected to the bottom of the inner cavity of the feed pipe (1), and the inner cavity of the feed pipe (1) is connected to the feed valve (2).

5. A closed liquid sampler for a reaction vessel or fermenter according to claim 4, characterized in that: The internal volume of the feed valve (2) is more than twice the volume of the sampling bottle (12). The sampling tube (10) is L-shaped. The inner cavity of the upper end plate (5) is threaded with a mounting screw (4). The upper end plate (5) is threadedly connected to the top of the feed valve (2) through the mounting screw (4).

6. A closed-loop liquid sampler for a reaction vessel or fermenter according to claim 4, characterized in that: The top of the sampling bottle (12) is fixedly connected to a threaded tube, and the bottom of the inner cavity of the sampling tube (10) is provided with a threaded groove, and the threaded tube is threadedly connected to the threaded groove.

7. A closed liquid sampler for a reaction vessel or fermenter according to claim 6, characterized in that: A sealing ring (13) is provided at the connection between the upper end plate (5) and the cavity cylinder (3). There are three sealing rings (13). The three sealing rings (13) are respectively located at the connection between the upper end plate (5) and the cavity cylinder (3), the connection between the cavity cylinder (3) and the feed valve (2), and the connection between the feed pipe (1) and the feed valve (2).

Images