Multi-layer co-extrusion film type disposable 3D biological reaction bag

Abstract

The utility model discloses a multi-layer co-extrusion film type disposable 3D biological reaction bag which comprises a bag body, a feeding opening is formed in the top of the bag body, a stirring assembly, a drain valve and a bag buckle are arranged at the bottom of the bag body, a bag body film is made of multi-layer co-extrusion films and comprises a bag body top film, a bag body bottom film and two bag body side films, the bag body top film, the bag body bottom film and the two bag body side films are folded firstly, and then the bag body top film, the bag body bottom film and the two bag body side films are folded secondly. And then the two parts are hermetically connected in a hot welding manner to form a complete accommodating space. According to the mode, the disposable 3D biological reaction bag adopts 11 layers of co-extrusion films, the welding temperature is close to the melting point of a plastic part, the compatibility, the welding strength and the production stability are improved, the qualified rate and the quality of products are enhanced, the overall strength of the reaction bag is improved, the reaction bag is prevented from being scratched, falling and leaking, meanwhile, the bag is convenient to grab and not prone to sliding off, and the sterile culture environment in the bag is ensured; and the product quality and safety are improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological reaction bag technical field, especially a kind of multilayer co-extrusion film disposable 3D biological reaction bag. BACKGROUND

[0002] The disposable biological reaction bag of current market widely applies multilayer film of Rilutek or 7-layer co-extrusion film of 9101 of home-made, and this kind of film material has multilayer structure, and each layer material has different performance and function.

[0003] However, the 3D bag made of this kind of film material in the industry has the following defects:

[0004] 1, the welding temperature of film material in the industry is generally lower than the temperature of plastic piece welding, which can cause film material welding to wear or welding to be not firm, thereby causing leakage, reducing yield, and causing culture environment to be contaminated;

[0005] 2, film material is soft, and the strength is insufficient, and if full of culture solution falls to the ground, it can cause drop injury and cause rupture. INVENTION CONTENTS

[0006] The utility model mainly solves the technical problem to provide a kind of multilayer co-extrusion film disposable 3D biological reaction bag, adopts 11-layer co-extrusion film, welding temperature is close to plastic piece melting point, can improve compatibility, welding strength and production stability, enhance product pass rate and quality, reaction bag overall strength increases, prevent scratch drop leakage, simultaneously convenient to grasp not easy to slide, ensure that bag is sterile culture environment, improve product quality and safety.

[0007] To solve the above technical problems, one technical scheme of the utility model is to provide a kind of multilayer co-extrusion film disposable 3D biological reaction bag, comprising:

[0008] Bag body, by multilayer co-extrusion film, including bag body top film, bag body bottom film and two pieces of bag body side film, bag body top film, bag body bottom film and two pieces of bag body side film are first folded and then sealed and connected by heat welding between each other to form a complete containing space;

[0009] Feed inlet: set at the top of bag body, for feeding material to the bag body;

[0010] Stirring assembly, including stirring seat set at the bottom of bag body and stirring paddle installed on stirring seat, for stirring liquid medicine in bag body;

[0011] Liquid discharge valve, set at the bottom of bag body, for external connection liquid discharge system to realize liquid discharge in bag body;

[0012] Bag buckle, set at the bottom of bag body, for external connection functional assembly.

[0013] In a preferred embodiment of the present application, the bag body is in a cylindrical or polyhedral shape.

[0014] In a preferred embodiment of the present application, the size of the accommodating space inside the bag body is 10-2000L.

[0015] In a preferred embodiment of the present application, the size of the accommodating space inside the bag body is 200L.

[0016] In a preferred embodiment of the present application, the bag body top film, the bag body bottom film and the bag body side film are all provided with two parallel creases, and the two creases divide the corresponding film into one rectangular base film area and two triangular base film areas.

[0017] In a preferred embodiment of the present application, the two triangular base film areas can be freely folded along the creases, and the folding angle is 0-180°.

[0018] In a preferred embodiment of the present application, the outer side edges of the rectangular base film area and the triangular base film area form a welding edge.

[0019] In a preferred embodiment of the present application, the two triangular base film areas are folded towards each other by 90° along the creases.

[0020] In a preferred embodiment of the present application, a blind plate is further sealingly connected to the feeding port.

[0021] In a preferred embodiment of the present application, the functional assembly can include a pipeline assembly, a monitoring assembly or a control assembly.

[0022] The present application has the advantages that: 11-layer co-extrusion film material is adopted, welding is performed close to the melting point temperature of the plastic part, the compatibility is improved, the welding strength is strengthened, the strength of the whole bag body is further improved, the production efficiency and production quality are improved, when the reaction bag faces potential risks such as falling and scratching, leakage can be effectively prevented, the safety and reliability of the product are ensured, and an excellent disposable sterile environment can be provided for the culture of cell drugs or other liquid medicines. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor, and the drawings include:

[0024] Figure 1is a structure schematic view of a preferred embodiment of the multi-layer co-extrusion film type disposable 3D biological reaction bag of the utility model;

[0025] Figure 2 is a structure schematic view of a preferred embodiment of the bag body top film of the utility model;

[0026] Figure 3 is a structure schematic view of a preferred embodiment of the bag body bottom film of the utility model;

[0027] Figure 4 is a structure schematic view of a preferred embodiment of the bag body side film of the utility model;

[0028] The marks of components in the drawings are as follows:

[0029] 1, bag body, 11, bag body top film, 12, bag body bottom film, 13, bag body side film, 2, feeding port, 3, liquid discharge valve, 4, bag buckle, 5, stirring seat, 6, stirring paddle, 7, crease, 8, welding edge, 9, blind plate. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be described clearly and completely below in combination with the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, rather than all the embodiments. The components of the embodiments of the utility model described and shown in the drawings can be arranged and designed in various different configurations.

[0031] Therefore, the following detailed description of the embodiments of the utility model provided in the drawings is not intended to limit the scope of the claimed utility model, but only represents selected embodiments of the utility model. Based on the embodiments in the utility model, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of protection of the utility model.

[0032] The utility model relates to a kind of multi-layer co-extrusion film type disposable 3D biological reaction bag, it is applicable to the culture of cell medicine or other liquid medicine in medical pharmacy.

[0033] Please refer to Figures 1-4 , the multi-layer co-extrusion film type disposable 3D biological reaction bag, including bag body 1, the bag body 1 top is provided with feeding port 2, bag body bottom is provided with stirring assembly, liquid discharge valve 3 and bag buckle 4.

[0034] Specifically, first is bag body 1, the film material of bag body 1 adopts multi-layer co-extrusion film, the multi-layer co-extrusion film adopts the multi-layer composite film for high-barrier disposable biological reactor with patent number 2023225547801, hereinafter will not be repeated.

[0035] The high-barrier multilayer composite film for disposable bioreactor has excellent performance, barrier property and friction resistance. The melting point of the film material is close to that of the welded plastic part, which improves the compatibility and welding strength, thereby improving the bag strength and avoiding the risk of bag rupture and leakage.

[0036] The bag of the embodiment includes a bag top film 11, a bag bottom film 12 and two bag side films 13. The bag top film 11, the bag bottom film 12 and the two bag side films 13 are sealed and connected to each other by heat welding to form a complete containing space.

[0037] The bag 1 is in a cylindrical or polyhedral shape, and the specific shape is selected according to the actual application scene and user demand.

[0038] The size of the internal containing space of the bag is also variable to meet the biological reaction process of different scales and needs, and the size of the containing space ranges from 10 to 2000L.

[0039] Preferably, in a specific application scenario, the containing space of the bag 1 can be set to 200 liters to match the specific biological reaction conditions and process requirements.

[0040] In detail, the bag top film 11, the bag bottom film 12 and the bag side film 13 are each provided with two parallel creases 7, and the two creases 7 divide the corresponding film into one rectangular base film area and two triangular base film areas.

[0041] The two triangular base film areas can be freely and flexibly folded along the creases 7 at an angle of 0-180° to adapt to different liquid storage needs and increase the flexibility and practicality of the bag.

[0042] Preferably, the two triangular base film areas are folded towards each other along the creases at an angle of 90°. This folding method is not only simple and easy to implement, but also effectively increases the stability and supportability of the bag, making it more suitable for storing and transporting heavy liquids or biological reaction materials.

[0043] The outer sides of the rectangular base film area and the triangular base film area form a welding edge 8 to ensure the overall sealing and structural stability of the bag 1.

[0044] The melting temperature of the bag top film 11, the bag bottom film 12 and the bag side film 13 made of the above-mentioned co-extruded film is close to the melting temperature of the plastic, which can produce a higher quality welding result, and the film material has roughness, which can have better grabbing ability and not slip.

[0045] Secondly, the feeding port 2 is used for feeding materials into the bag. In order to ensure the sealing, a blind plate 9 is sealingly installed on the feeding port.

[0046] In addition, the stirring assembly comprises a stirring base 5 arranged at the bottom of the bag body 1 and a stirring paddle 6 mounted on the stirring base 5, so that the liquid in the bag body 1 can be effectively mixed and stirred. The liquid discharge valve 3 can be conveniently connected with an external liquid discharge pipeline to realize the discharge of the liquid in the bag body 1. The bag buckle 4 is used to connect the functional assembly, so as to expand the use function thereof.

[0047] Preferably, the functional assembly can comprise a pipeline assembly, a monitoring assembly or a control assembly, and the types of the functional assembly are diversified, and through reasonable configuration and selection of the functional assembly, the efficient, stable and safe operation of the biological reaction process can be realized.

[0048] The preparation process of the disposable biological reaction bag is as follows:

[0049] Firstly, according to the size specification of the required product, the corresponding size of the bag body top film 11 sheet, the bag body bottom film 12 sheet and the bag body side film 13 sheet is accurately cut, and the folding marks 7 are reserved on the cut film sheet;

[0050] Secondly, the folding marks 7 are folded to form the required three-dimensional shape, and after the folding is in place, the outer side edges of the corresponding film sheets are spliced together to ensure that the splicing part is flat and wrinkle-free;

[0051] Then, the 3D bag body is sealed and sutured by a hot welding method: the film sheet at the splicing part is heated to a molten state, and in the molten state, the film sheets diffuse and cross-link with each other to form a firm welding edge 8, thereby forming the required 3D bag.

[0052] The disposable biological reaction bag has the following beneficial effects:

[0053] The production efficiency is improved: the welding temperature of the 11-layer co-extrusion film is close to the welding temperature of the welded plastic parts, the compatibility is improved, the welding strength is strengthened, the production stability is improved, and the qualified rate of the product and the adjustment and maintenance of the parameters are enhanced;

[0054] The product quality is improved: the inner layer can effectively isolate the reaction of the culture solution or the cultured cells and does not participate in any reaction of the cell liquid, and meanwhile, the overall strength is increased, so that the risk of bag body rupture and leakage caused by scratching and falling is effectively reduced;

[0055] The bag culture environment is ensured to be clean, and a sterile culture environment is provided, and meanwhile, the smoothness of the outer film has roughness compared with other film materials, so that the customer has better grabbing ability when using the product, and the product will not slip.

[0056] The above merely illustrates the embodiments of the present application, and does not limit the patent scope of the present application, and any equivalent structure or equivalent process transformation, or direct or indirect application in other related technical fields, are all included in the patent protection scope of the present application.

Claims

1. A multi-layer co-extruded disposable 3D bioreactor bag, characterized in that, The utility model relates to a bag body, which is composed of a plurality of layers of co-extruded films, including a bag body top film, a bag body bottom film and two pieces of bag body side films, the bag body top film, the bag body bottom film and the two pieces of bag body side films are first folded and then sealed and connected with each other by heat welding to form a complete containing space. A feeding port is arranged at the top of the bag body and used for feeding materials into the bag body. A stirring assembly is arranged at the bottom of the bag body and used for stirring the liquid in the bag body. A liquid discharge valve is arranged at the bottom of the bag body and used for connecting an external liquid discharge system to discharge the liquid in the bag body. A bag buckle is arranged at the bottom of the bag body and used for connecting a functional assembly. The bag body is in a cylindrical or polyhedral shape.

2. The multilayer co-extruded disposable 3D bioreactor bag according to claim 1, characterized in that, The containing space in the bag body has a size of 10-2000L.

3. The multilayer co-extruded disposable 3D bioreactor bag of claim 1, wherein, The containing space in the bag body has a size of 200L.

4. The multilayer co-extruded, disposable 3D bioreactor bag of claim 3, wherein, The bag body top film, the bag body bottom film and the bag body side films are each provided with two parallel creases, and the two creases divide the corresponding film into one rectangular base film area and two triangular base film areas.

5. The multilayer co-extruded, disposable 3D bioreactor bag of claim 1, wherein, The two triangular base film areas can be freely folded along the creases, and the folding angle is 0-180°.

6. The multilayer co-extruded, disposable 3D bioreactor bag of claim 5, wherein, The outer sides of the rectangular base film area and the triangular base film areas form welding edges.

7. The multilayer co-extruded, disposable 3D bioreactor bag of claim 5, wherein, The two triangular base film areas are folded towards each other by 90° along the creases.

8. The multilayer co-extruded, disposable 3D bioreactor bag of claim 6, wherein, A blind plate is further sealed and connected to the feeding port.

9. The multilayer co-extruded, disposable 3D bioreactor bag of claim 1, wherein, The functional assembly can include a pipeline assembly, a monitoring assembly or a control assembly.

10. The multilayer co-extruded, disposable 3D bioreactor bag of claim 1, wherein, ​

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