Optical device for immunochromatography analyzer
By setting up parallel fluorescence and colloidal gold detection optical paths in the immunoassay analyzer, the problem that existing devices can only detect one type of labeled substance has been solved, resulting in cost reduction and improved detection efficiency.
Patent Information
- Application Number
- CN202520206605.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-10
- Publication Date
- 2026-01-30
- Estimated Expiration
- 2035-02-10
AI Technical Summary
Existing immunoassay analyzers using optical devices can only measure reagent cards containing one type of labeled substance, resulting in high cost and low efficiency.
A first and second optical path are set up in parallel and partially overlapped in a housing, which are used for fluorescence and colloidal gold detection respectively. They are independently controlled by excitation light of different wavelengths to avoid interference.
It achieves accuracy and stability in the detection of fluorescence and colloidal gold, reduces equipment costs, and improves detection efficiency.
Smart Images
Figure CN223857217U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the technical field of optical equipment, specifically, an optical device for immunochromatographic analyzer. BACKGROUND
[0002] The immunochromatographic method is a rapid diagnosis technology that has been developed in recent years. It can be divided into fluorescence method and colloidal gold method according to the used marker. The colloidal gold method uses colloidal gold to have an absorption spectrum of 400-700 nm, wherein 3-20 nm gold particles have an absorption peak at about 525 nm, and quantitative analysis can be realized by measuring the absorption spectrum. The fluorescence method uses fluorescent substances as markers, each of which has a selective excitation wavelength and a specific emission wavelength.
[0003] The existing optical device for the immunological analyzer basically only has one fluorescence light path or colloidal gold light path, and can only measure one kind of reagent card marked with corresponding substances. The general mold forming has high precision, and is one of the preferred ways for installing and fixing optical elements in the light path, but the mold opening cost is high. INVENTION CONTENTS
[0004] The utility model discloses a kind of optical devices for immunochromatographic analyzer, it can respectively test fluorescence immunochromatographic detection card and colloidal gold detection card, can effectively reduce cost, improve work efficiency.
[0005] The utility model discloses an optical device for immunochromatographic analyzer, including shell, first passageway being horizontally arranged in the shell, second passageway being vertically arranged in the end of the first passageway, and third passageway being vertically arranged and being connected with the middle part of the first passageway in lower end;The first passageway and the second passageway form horizontal T shape;The first passageway and the second passageway form first light path;The third passageway, the first passageway and the second passageway form second light path.
[0006] Further, first light source, first plano-convex lens, first dichroic mirror, second dichroic mirror are sequentially arranged in the first passageway;The second dichroic mirror is located in the second passageway.
[0007] Further, photoelectric detector, optical filter, second dichroic mirror, second plano-convex lens, narrow slit are sequentially arranged from top to bottom in the second passageway;Test sample is arranged below the narrow slit.
[0008] Further, the third passageway includes second light source, third plano-convex lens sequentially arranged from top to bottom;The first dichroic mirror is arranged below the third plano-convex lens.
[0009] Further, the first light path comprises a first light source, a first plano-convex lens, a first dichroic mirror, a second dichroic mirror, a second plano-convex lens, a narrow slit, a filter, and a photodetector.
[0010] Further, the second light path comprises a second light source, a third plano-convex lens, a first dichroic mirror, a second dichroic mirror, a second plano-convex lens, a narrow slit, a filter, and a photodetector.
[0011] Further, the excitation light wavelength of the first light source is 520-530 nm, and the excitation light wavelength of the second light source is 360-370 nm.
[0012] Further, the cutoff wavelength of the first dichroic mirror is 400 nm, the cutoff wavelength of the second dichroic mirror is 540 nm, and the cutoff wavelength of the filter is 550 nm.
[0013] The optical device for the immunoassay analyzer has at least the following advantages and beneficial effects: the optical device for the immunoassay analyzer is provided with the first light path and the second light path which are parallel and partially overlapped in a shell, and the first light path and the second light path can be normally used, so that when the first light path and the second light path use excitation light of different wavelengths, they can be respectively used for two types of tests, such as fluorescence immunoassay detection and colloidal gold detection, and the two are independently controlled and will not interfere with each other, which can effectively ensure the accuracy of the test results and the stability of the test, and can effectively reduce the equipment cost and improve the detection efficiency. BRIEF DESCRIPTION OF DRAWINGS
[0014] Figure 1 The structure schematic view of the first light path provided for the utility model embodiment is shown in the figure.
[0015] Figure 2 The structure schematic view of the second light path provided for the utility model embodiment is shown in the figure.
[0016] Figure: 10 - shell, 11 - sample, 20 - first channel, 21 - first light source, 22 - first plano-convex lens, 23 - first dichroic mirror, 24 - second dichroic mirror, 30 - second channel, 31 - light point detector, 32 - filter, 33 - second plano-convex lens, 34 - narrow slit, 40 - third channel, 41 - second light source, 42 - third plano-convex lens. DETAILED DESCRIPTION
[0017] EMBODIMENT
[0018] The following is further illustrated in combination with specific embodiments, such as the accompanying Figure 1 - accompanying Figure 2As shown, the optical device for the immunochromatographic analyzer of the embodiment comprises a housing 10, a first channel 20 horizontally arranged in the housing 10, a second channel 30 vertically arranged at the end of the first channel 20, and a third channel 40 vertically arranged and connected with the middle part of the first channel 20 at the lower end. The first channel 20 and the second channel 30 form a horizontal T shape. The first channel 20 and the second channel 30 constitute a first light path. The third channel 40, the first channel 20 and the second channel 30 constitute a second light path. Specifically, the first light path and the second light path are arranged in parallel and partially overlap in one housing 10, and both the first light path and the second light path can be normally used. Therefore, when the first light path and the second light path use excitation lights of different wavelengths, they can be respectively used to perform two types of tests, such as fluorescent immunochromatographic detection cards and colloidal gold detection cards (the two types of detection cards are samples with different wavelength requirements), and both are independently controlled and do not interfere with each other, which can effectively ensure the accuracy of the test results and the stability of the test, and can effectively reduce the equipment cost and improve the detection efficiency.
[0019] The first channel 20 in the embodiment is sequentially provided with a first light source 21, a first plano-convex lens 22, a first dichroic mirror 23, and a second dichroic mirror 24. The second dichroic mirror 24 is located in the second channel 30. Specifically, the first plano-convex lens 22 is vertically arranged with the arc surface facing the first dichroic mirror 23, and the first dichroic mirror 23 and the second dichroic mirror 24 are both arranged at an angle of 45 degrees.
[0020] The second channel 30 in the embodiment is sequentially provided with a photodetector, a filter 32, the second dichroic mirror 24, a second plano-convex lens 33, and a narrow slit 34 from top to bottom. The test sample 11 is arranged directly below the narrow slit 34. Specifically, the second plano-convex lens 33 is horizontally arranged with the arc surface facing upward.
[0021] The third channel 40 in the embodiment comprises a second light source 41 and a third plano-convex lens 42 sequentially arranged from top to bottom. The first dichroic mirror 23 is arranged directly below the third plano-convex lens 42. Specifically, the third plano-convex lens 42 is horizontally arranged with the arc surface facing downward.
[0022] The first light path in the embodiment comprises the first light source 21, the first plano-convex lens 22, the first dichroic mirror 23, the second dichroic mirror 24, the second plano-convex lens 33, the narrow slit 34, the filter 32, and the photodetector. Specifically, the excitation light emitted by the first light source 21 in the first light path sequentially passes through the first plano-convex lens 22, the first dichroic mirror 23 (the light directly passes through), the second dichroic mirror 24 (the light is reflected by 90 degrees), the second plano-convex lens 33, the narrow slit 34, the sample 11, the narrow slit 34, the second plano-convex lens 33, the second dichroic mirror 24 (the light directly passes through), and the filter 32 before entering the photodetector (as shown in FIG. 2). Figure 1The first light path can be used to detect the sample 11.
[0023] The second light path in the embodiment comprises a second light source 41, a third plano-convex lens 42, a first dichroic mirror 23, a second dichroic mirror 24, a second plano-convex lens 33, a narrow slit 34, a filter 32, and a photodetector. Specifically, the excitation light emitted by the second light source 41 in the second light path passes through the third plano-convex lens 42, the first dichroic mirror 23 (the light is reflected by 90 degrees), the second dichroic mirror 24 (the light is reflected by 90 degrees), the second plano-convex lens 33, the narrow slit 34, the sample 11, the narrow slit 34, the second plano-convex lens 33, the second dichroic mirror 24 (the light directly passes through), and the filter 32 in sequence, and then enters the photodetector (as shown by the arrow in FIG. 4). Figure 2 The second light path can be used to detect the sample 11. It should be noted that only the light path structure in the housing 10 is adjusted and designed in the embodiment, and the structures such as the lenses, the light sources, and the detector involved and the related detection principles are all conventional devices and methods.
[0024] The excitation light wavelength of the first light source 21 in the embodiment is 520-530 nm, and the excitation light wavelength of the second light source 41 is 360-370 nm.
[0025] The cut-off wavelength of the first dichroic mirror 23 in the embodiment is 400 nm, the cut-off wavelength of the second dichroic mirror 24 is 540 nm, and the cut-off wavelength of the filter 32 is 550 nm.
[0026] In summary, the optical device for the immunochromatographic analyzer in the embodiment is provided with the first light path and the second light path which are parallel and partially overlapped in the housing 10, and both the first light path and the second light path can be normally used. Therefore, when the first light path and the second light path use excitation light of different wavelengths, they can be respectively used to perform two types of tests, such as fluorescence immunochromatographic detection and colloidal gold detection, and the two are independently controlled and do not interfere with each other, which can effectively ensure the accuracy of the test results and the stability of the test, and can effectively reduce the equipment cost and improve the detection efficiency.
[0027] The preferred embodiments of the present application are merely used for the description and should not be used to limit the present application. Any modification, equivalent replacement, improvement, and the like made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims
1. An optical device for an immunochromatographic analyzer, characterized by: The application relates to a shell (10), a first channel (20) horizontally arranged in the shell (10), a second channel (30) vertically arranged at the end of the first channel (20), and a third channel (40) vertically arranged and connected with the middle part of the first channel (20) at the lower end. The first channel (20) and the second channel (30) form a horizontal T shape; the first channel (20) and the second channel (30) constitute a first light path; the third channel (40), the first channel (20) and the second channel (30) constitute a second light path.
2. The optical device for immuno-chromatographic assay according to claim 1, characterized in that: A first light source (21), a first plano-convex lens (22), a first dichroic mirror (23) and a second dichroic mirror (24) are sequentially arranged in the first channel (20); the second dichroic mirror (24) is located in the second channel (30).
3. The optical device for an immunochromatographic analyzer according to claim 2, characterized by: A photodetector, a filter (32), the second dichroic mirror (24), a second plano-convex lens (33) and a narrow slit (34) are sequentially arranged in the second channel (30) from top to bottom; a test sample (11) is arranged below the narrow slit (34).
4. The optical device for immuno-chromatographic assay according to claim 3, characterized in that: The third channel (40) comprises a second light source (41) and a third plano-convex lens (42) sequentially arranged from top to bottom; the first dichroic mirror (23) is arranged below the third plano-convex lens (42).
5. The optical device for immuno-chromatographic assay according to claim 4, characterized in that: The first light path comprises the first light source (21), the first plano-convex lens (22), the first dichroic mirror (23), the second dichroic mirror (24), the second plano-convex lens (33), the narrow slit (34), the filter (32) and the photodetector.
6. The optical device for immuno-chromatographic assay according to claim 4, characterized in that: The second light path comprises the second light source (41), the third plano-convex lens (42), the first dichroic mirror (23), the second dichroic mirror (24), the second plano-convex lens (33), the narrow slit (34), the filter (32) and the photodetector.
7. The optical device for immuno-chromatographic assay according to claim 4, characterized in that: The excitation light wavelength of the first light source (21) is 520-530 nm; the excitation light wavelength of the second light source (41) is 360-370 nm.
8. The optical device for immuno-chromatographic assay according to claim 7, characterized in that: The cut-off wavelength of the first dichroic mirror (23) is 400 nm, the cut-off wavelength of the second dichroic mirror (24) is 540 nm, and the cut-off wavelength of the filter (32) is 550 nm.