Chitosan derivative refining device

Abstract

The utility model belongs to the technical field of separation devices, and particularly relates to a chitosan derivative refining device which comprises a first chromatographic column, the first chromatographic column is connected with a second chromatographic column, the first chromatographic column and the second chromatographic column are both filled with resin layers, the first chromatographic column is connected with a pre-filtering tank, a cooling tank and a concentration tank, a filtering assembly is arranged in the pre-filtering tank, and the cooling tank is connected with a water tank. The filter assembly comprises a plurality of filter screens, sprayers are arranged at the tops of the first chromatographic column and the second chromatographic column, washing agent pipelines are connected to the sprayers at the tops of the first chromatographic column and the second chromatographic column, and vacuum pumps are connected to the washing agent pipelines on the first chromatographic column and the second chromatographic column. According to the utility model, the chitosan derivative is concentrated, filtered and subjected to chromatography to obtain a pure chitosan solution, so that the purity of the chitosan derivative is improved.

Description

Technical Field

[0001] This utility model belongs to the field of separation device technology, specifically relating to a chitosan derivative purification device. Background Technology

[0002] Chitosan is a deacetylated product of the natural polysaccharide chitin, rich in amino and hydroxyl groups, and possesses excellent biological properties, including good biocompatibility, mucosal adhesion, blood compatibility, and biodegradability, as well as antioxidant and antibacterial properties. Chitosan derivatives obtained through chemical modification, such as cross-linking and grafting functional groups, can significantly enhance mechanical strength and chemical stability, meeting research needs in the pharmaceutical and chemical industries.

[0003] In the production process of chitosan derivatives, the refining process is particularly important. The refining equipment for chitosan derivatives is a mature modular industrial equipment. However, the refining equipment currently in use is greatly affected by the properties of the sample, has high operating costs, and is inconvenient to use and maintain. Utility Model Content

[0004] In view of the shortcomings of the prior art, the technical problem to be solved by this utility model is to provide a chitosan derivative refining device to achieve dual-effect filtration of chitosan derivatives, thereby improving filtration efficiency and product purity.

[0005] The technical solution adopted by this utility model to solve its technical problem is:

[0006] The chitosan derivative refining apparatus of this utility model includes a chromatography column one, which is connected to a chromatography column two. Both chromatography columns one and two are filled with resin layers. The chromatography column one is connected to a pre-filter tank, a cooling tank, and a concentration tank. The pre-filter tank is equipped with a filter assembly, which includes several filter screens. Both chromatography columns one and two are equipped with sprayers at the top. The sprayers at the top of both chromatography columns one and two are connected to rinsing agent pipes. The rinsing agent pipes on both chromatography columns one and two are connected to vacuum pumps.

[0007] in:

[0008] Both chromatography column one and chromatography column two are provided with pressure relief ports on their sides.

[0009] The size of the resin particles filling the interior of the first chromatography column is larger than that of the resin particles filling the interior of the second chromatography column.

[0010] The sprayer at the top of the first chromatography column is connected to the bottom of the pre-filter tank, and the sprayer at the top of the second chromatography column is connected to the bottom of the first chromatography column.

[0011] A pressure gauge is installed between the vacuum pump and the first chromatography column, and a pressure gauge is installed between the vacuum pump and the second chromatography column.

[0012] The cooling tank is equipped with a cooling coil inside, with a cooling inlet at the bottom and a cooling outlet at the top.

[0013] The concentration tank is equipped with a tube heat exchanger at the bottom.

[0014] The concentration tank is equipped with a steam outlet at the top.

[0015] The filter screen is designed in an arc shape with a lower center and higher edges.

[0016] The filter screens are arranged at intervals from top to bottom, and the pore size of the filter screens decreases sequentially. The average pore size of the filter screen at the bottom of the pre-filter tank is 0.5-1mm.

[0017] The beneficial effects of this utility model are:

[0018] This invention concentrates, filters, and chromatographically extracts chitosan derivatives to obtain a pure chitosan solution, thereby improving the purity of the chitosan derivatives. Concentration reduces the water content in the chitosan derivatives, increasing the efficiency of the chromatography process, reducing the amount of rinsing agent used, and saving costs. Filtration removes large particulate impurities, ensuring a significant reduction in impurity content in the chitosan derivative solution entering the chromatography stage, reducing the burden on the resin layers in chromatography columns one and two, and extending the service life of the resin layers. During chromatography, the rinsing pressure of the rinsing agent is adjusted by a vacuum pump, which promotes the chromatography rate of the chitosan derivative solution, enabling rapid discharge of the chitosan derivative solution and preventing impurities from being discharged with the chitosan derivative solution. This invention, through multi-stage synergy, greatly improves the purification rate of chitosan derivatives, and the chromatography process enhances the purity of the chitosan derivative product. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of this utility model;

[0020] Figure 2 This is a schematic diagram of the filter structure of this utility model;

[0021] In the diagram: 1. Chromatography column one; 2. Chromatography column two; 3. Filter screen; 4. Pre-filter tank; 5. Vacuum pump; 6. Cooling tank; 7. Concentrator; 8. Sprayer; 9. Shell and tube heat exchanger; 10. Pressure relief port; 11. Effluent pipeline; 101. Pressure gauge one; 201. Pressure gauge two; 601. Cooling coil. Detailed Implementation

[0022] The embodiments of this utility model will be further described below with reference to the accompanying drawings.

[0023] Example 1

[0024] like Figure 1-2 As shown, the chitosan derivative refining apparatus of this utility model includes a chromatography column 1, which is connected to a chromatography column 2. Both chromatography columns 1 and 2 are filled with resin layers. The chromatography column 1 is connected to a pre-filter tank 4, a cooling tank 6, and a concentration tank 7. The pre-filter tank 4 is equipped with a filter assembly, which includes several filter screens 3. Both chromatography columns 1 and 2 are equipped with sprayers 8 at the top. Both sprayers 8 at the top of chromatography columns 1 and 2 are connected to rinsing agent pipes 11. Both rinsing agent pipes 11 on chromatography columns 1 and 2 are connected to vacuum pumps 5.

[0025] Both chromatography column 1 and chromatography column 2 are equipped with pressure relief ports 10 on their sides.

[0026] The resin particles inside column 1 are larger than those inside column 2.

[0027] The sprayer 8 at the top of chromatography column 1 is connected to the bottom of the pre-filter tank 4, and the sprayer 8 at the top of chromatography column 2 is connected to the bottom of chromatography column 1.

[0028] A pressure gauge 101 is installed between vacuum pump 5 and chromatography column 1, and a pressure gauge 201 is installed between vacuum pump 5 and chromatography column 2.

[0029] The cooling tank 6 is equipped with a cooling coil 601 inside. The cooling coil 601 has a cooling inlet at the bottom and a cooling outlet at the top.

[0030] A tube heat exchanger 9 is installed at the bottom of the concentration tank 7.

[0031] The concentration tank 7 is equipped with a steam outlet at the top.

[0032] The filter screen 3 is designed in an arc shape with a lower center and higher edges.

[0033] Several filter screens 3 are arranged at intervals from top to bottom, and the pore size of the filter screens 3 decreases sequentially. The average pore size of the filter screens 3 at the bottom of the pre-filter tank 4 is 0.5-1mm.

[0034] Working principle and process:

[0035] After chitosan is modified to obtain a chitosan derivative mixed solution, the chitosan derivative mixed solution is sent to a concentration tank 7 for one-step heating to remove most of the water. The chitosan derivative mixed solution is then heat-exchanged through a shell-and-tube heat exchanger 9, circulating between the shell-and-tube heat exchanger 9 and the concentration tank 7. The retention time in the concentration tank 7 is short to avoid high-temperature denaturation of the chitosan derivatives. Subsequently, it is sent to a cooling tank 6 for cooling. The cooled chitosan derivative mixed solution is then filtered layer by layer to remove large particulate impurities. Subsequently, the chitosan derivative mixed solution is sent to chromatography column 1 and chromatography column 2 for two chromatographic filtrations to obtain a purified chitosan derivative solution. During chromatography, the vacuum pump 5 can adjust the rinsing rate of the rinsing agent pipeline 11. In chromatography column 1, the resin layer has a larger particle size, which can intercept larger particle impurities. Small particle impurities are intercepted by the smaller resin layer when entering chromatography column 2. The chitosan derivative solution is discharged from the bottom of chromatography column 2 for drying.

Claims

1. A chitosan derivative purification apparatus, comprising a chromatography column (1), characterized in that, A chromatography column (1) is connected to a chromatography column (2). Both chromatography columns (1) and (2) are filled with resin layers. A pre-filter tank (4), a cooling tank (6), and a concentration tank (7) are connected to a chromatography column (1). A filter assembly is installed inside the pre-filter tank (4). The filter assembly includes several filter screens (3). A sprayer (8) is installed at the top of both chromatography columns (1) and (2). A rinsing agent pipe (11) is connected to the sprayer (8) at the top of both chromatography columns (1) and (2). A vacuum pump (5) is connected to the rinsing agent pipe (11) on both chromatography columns (1) and (2).

2. The chitosan derivative refining apparatus according to claim 1, characterized in that, Both chromatography column 1 (1) and chromatography column 2 (2) are equipped with pressure relief ports (10) on their sides.

3. The chitosan derivative refining apparatus according to claim 1, characterized in that, The size of the resin particles inside the chromatography column 1 (1) is larger than that inside the chromatography column 2 (2).

4. The chitosan derivative refining apparatus according to claim 1, characterized in that, The sprayer (8) at the top of chromatography column 1 (1) is connected to the bottom of the pre-filter tank (4), and the sprayer (8) at the top of chromatography column 2 (2) is connected to the bottom of chromatography column 1 (1).

5. The chitosan derivative refining apparatus according to claim 1, characterized in that, A pressure gauge 1 (101) is installed between the vacuum pump (5) and the chromatography column 1 (1), and a pressure gauge 2 (201) is installed between the vacuum pump (5) and the chromatography column 2 (2).

6. The chitosan derivative refining apparatus according to claim 1, characterized in that, The cooling tank (6) is equipped with a cooling coil (601) inside. The cooling coil (601) has a cooling inlet at the bottom and a cooling outlet at the top.

7. The chitosan derivative refining apparatus according to claim 1, characterized in that, A tube heat exchanger (9) is installed at the bottom of the concentration tank (7).

8. The chitosan derivative refining apparatus according to claim 1, characterized in that, The concentration tank (7) is equipped with a steam outlet at the top.

9. The chitosan derivative refining apparatus according to claim 1, characterized in that, The filter screen (3) is set in an arc shape with a low center and a high edge.

10. The chitosan derivative refining apparatus according to claim 1, characterized in that, Several filter screens (3) are arranged at intervals from top to bottom, and the pore size of the filter screens (3) decreases in sequence. The average pore size of the filter screens (3) at the bottom of the pre-filter tank (4) is 0.5-1mm.

Images